Littattafan litattafai masu alaƙa a gida da kuma ƙasashen waje a cikin shirye-shiryen maganganu masu tsayar da shirye-shirye, shirye-shiryen saki a cikin fannoni na sabon tsari kamar su bioadhere. Saboda bambanci a cikin nauyi kwayoyin nauyi da danko na HPMC, yana da halaye da amfani da emulsification, m, thicking da fim-forming. Ana amfani dashi sosai a cikin shirye-shiryen magunguna kuma zai taka rawar gani a fagen shirye-shiryen. Tare da zurfin binciken kadarorinta da haɓaka fasahar samarwa, za a yi amfani da HPMC sosai a cikin binciken sabbin abubuwa masu magani, don inganta cigaban ci gaba na tsari.
methypyl methylcelose; Shirye-shiryen magunguna; magungunan magunguna.
Magungunan magunguna ba kawai tushen samar da shirye-shiryen shaye-tsire ba, amma kuma suna da alaƙa da wahalar aiwatar da magani, yanayin aiki, yanayin aiki, yanayin aiki, da kuma sabbin siffofin saki da sabbin hanyoyin gudanar da gudanarwa. da kusanci. Samuwar sabbin maganganu na harhada magunguna sau da yawa yana haɓaka haɓaka ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin ingancin inganci da ci gaban sabon siffofin sashi. Hydroxypyl methylcelose (HPMC) shine ɗayan shahararrun cirewa a gida da kasashen waje. Saboda nauyin kwayoyin halitta daban-daban na zane da danko, tana da ayyukan emulsifying, ɗaure, thickening, thickening, dakatar, da m. Fasali da amfani kamar coagulation da fina-finai ana amfani da su sosai a cikin fasahar magunguna. Wannan labarin yakan sake nazarin aikace-aikacen hydroxypropyl methylcellulhins (hpmc) a cikin tsari a cikin 'yan shekarun nan.
1.Asali kaddarorin HPMC
Tsarin Sletl Methyl (HPMC), tsarin kwayoyin yana c8h15o8- (C10 H18O6) N- C8H15o8) N- C8H15o8) N- c86 Ana iya samar da shi ta hanyoyi guda biyu: ɗayan shine sel na methyl na matakin da ya dace ana bi da shi da Oooh kuma daga nan aka mayar da shi tare da propylelene opylelene opyle baki a ƙarƙashin matsanancin zazzabi da matsi mai yawa. Lokaci na dauki dole ne ya wuce wanda ya isa ya ba da damar methyl da hydroxypropyl da haɗin ethhydrogcose na an haɗa shi da narkar da selulose, kuma zai iya kaiwa ga digiri da ake so; Sauran su ne bi da auduga ko katako na fiber na fiber, sannan kuma aka amsa tare da methane da propylene oplininated da propylene oplinlelene mawne da nasara, sannan ya kara tabbata da hakan. , an murƙushe shi zuwa kyakkyawan foda ko granules.
Launi na wannan samfurin shine fari ga mily farin fari, ƙanshi mai ban sha'awa, kuma fom ɗin shine mafi sauƙin foda mai sauƙi. Wannan samfurin za'a iya narkar da wannan samfurin a cikin ruwa don samar da bayyananne a Milky farin mafita tare da wani danko. Phenconvenver Phenomenversion Phenomenon zai iya faruwa saboda canjin zazzabi na mafita tare da wani taro.
Saboda bambanci a cikin abubuwan da ke cikin waɗannan masu maye gurbinsu a cikin tsarin metoxy da hydroxypropyl, nau'ikan nau'ikan samfuran sun bayyana. A takamaiman taro, nau'ikan samfuran suna da takamaiman halaye. Dange da zazzabi na Heration, saboda haka ana iya amfani da kaddarorin daban kuma ana iya amfani da su don dalilai daban-daban. Pharmacipopoeia na ƙasashe daban-daban yana da ƙa'idodi daban-daban da wakilci na Turai da digiri na Turai sun dogara da lambobi daban-daban da yawa, kuma naúrar ta "MPA S". A cikin Amurka pharcopopeia, lambobi 4 aka kara bayan sunan da ya samu don nuna abun ciki da nau'in kowane methylcellopyl methylcellulopyl methylcellulopyl methylcellulopyl methylcellulopyl methylcellulopyl methylcellulopyl Kashi na ƙarshe, lambobi biyu na ƙarshe suna wakiltar kimanin kashi na kimanin hydroxypropyl.
Calcoxan's Hydroxypropyl methylcelose yana da jerin 3, wato jerin jerin, f jerin abubuwa da k E jerin ana amfani dasu azaman mayafin fim, don shafi kwamfutar hannu, rufe kwamfutar hannu cores; E, ana amfani da jerin FS a matsayin masu haɗin gwiwa da wakilan wasan kwaikwayon Ophthmalmic, masu dakatarwa, thicks don ruwa shirye-shirye, Allunan da kuma masu riƙe da granules; Ana amfani da jerin k a matsayin mafi yawan kayan maye da kayan sakin matrix na hydrophilic gel na jinkirin da kuma shirye-shiryen saki saki.
Masana'antun gida sun haɗa da Fuzhou No. 2 Factoran Markus, Huzhou Jinxian Coussical coussical Co., Ltd., Sichhou Luzhou Pharmaceutical chosemic Factical coussical Co., Ltd., Shandng Luzhou Pharmaceutical chosemic of Emschin masana'antu, da Ltd., Xi's Huan Chrismens, da sauransu.
2.Abbuwan amfãni na HPMC
HPMC ta zama ɗaya daga cikin abubuwan da aka fi amfani da su na magunguna na magunguna a gida da waje, saboda ƙasashen HPMC suna da fa'idodi waɗanda ke da cirewa ba su da.
2.1 Cold Cold
Solrable a cikin ruwan sanyi a ƙasa 40 ℃ ko 70% ethanol, m instolble a cikin ruwan zafi sama ℃, amma mafi gel.
2.2 Chemwly Inert
HPMC wani nau'in sel mai kyau ne, maganinta bashi da caji Ionic kuma baya hulɗa da salts na ƙarfe, saboda haka sauran complifis kwayoyin ba su amsawa da shi yayin samar da shirye-shirye.
2.3 Duri
Yana da in mun gwada ci gaba da acid da alkali, kuma ana iya adana na tsawon lokaci tsakanin PH 3 da 11 ba tare da canji mai mahimmanci ba. Maganin ruwa mai ruwa na HPMC yana da tasirin anti-mildew kuma yana kula da kwanciyar hankali mai kyau yayin ajiya na dogon lokaci. Proppical comptipips ta amfani da HPMC suna da ingancin inganci fiye da waɗanda suke amfani da compifient na gargajiya (kamar Dexgin, sitaci, da sauransu).
2.4 Gwaji Daidaitawa
Za'a iya canza nau'ikan danko daban na HPMC daban-daban na HPMC daban-daban, kuma ana iya canzawa gwargwadon dangantaka, kuma yana da kyakkyawar dangantaka mai kyau, don haka za a iya zaɓin dangantaka mai kyau bisa ga buƙatun.
2.5 metabolic da hadari
HPMC ba ta sha ko metabolized a cikin jiki, kuma baya bayar da zafi, saboda haka ba karamin tsari ne na aikin magunguna ba. 2.6 Gaba ɗaya ana la'akari da shi gabaɗaya cewa hpmc wani abu ne mai guba da mara haushi, na Mediya na mutuwa - 1, kuma medan na Median kashi don berayen ne 5. 2 G let KG - 1. Ruwan yau da kullun ba shi da lahani ga jikin ɗan adam.
3.Aikace-aikacen HPMC a cikin tsari
3.1 Kamar yadda kayan fim da kayan samar da fim
Ta amfani da HPMC azaman kwamfutar hannu mai ɗorawa-mai rufi, kwamfutar hannu mai rufi ba ta da fa'idodi a cikin ɗanɗano da kuma bayyanar da farfadowa, digiri na ruwa, rarrabuwa. , shafi ribar nauyi da sauran alamun ingantattu sun fi kyau. Ana amfani da darajan daraja na wannan samfurin azaman kayan ɗakunan ruwa na kayan kwalliya don tsarin zane, yawanci a maida hankali ne ga 2% zuwa 20%.
Zhang Lixing et al. An yi amfani da sakamako mai tasirin yanayin don inganta tsarin premix tare da HPMC a matsayin fim din. Takearancin kayan aikin fim HPMC, adadin polyvinylasa barasa da kuma abubuwan da aka kirkira suna da ma'anar binciken lissafi, kuma an gabatar da dangantakar bincike game da tsarin binciken lissafi, kuma a ƙarshe ingantaccen tsarin binciken an samo asali ne daga tsarin dubawa, kuma an sami alaƙar bincike game da tsarin binciken. Amfani da shi shine wakilin samar da fim din fim din yetypypyl methylcellulose (hpmce) 11.00 g, polyvinyl barasa 20.5.00 g, da ƙarfin aikin da ke cikin fim din ya kai mafi kyawun sakamako. Zhang Yuan ya inganta tsarin shiri, wanda aka yi amfani da HPMC a matsayin mai ban sha'awa don inganta yanayin shirye-shiryen da ta shirya don inganta yanayin shirye-shiryen da ta shirya don inganta matsalolinsa-mai tsabta, haɓaka allon saƙo, haɓaka ƙawarar kwamfutar hannu. Tsarin tsari mafi kyau da aka ƙaddara ta hanyar gwaje-gwajen orthogonal, wato, slurry maida hankali ne 2% HPHANOL ISLANSH A CIKIN MINATAR, DA TAFIYA TAFIYA A CIKIN SAUKI NA 15 min. Sakamakon Allunan da aka shirya ta hanyar Alamar -ated da sabon tsari da takardar sayan magani ya kasance sosai a bayyanar, tsari da aka samar da shi, da kuma ƙimar sayan kayan kwalliyar ta asali an inganta su. kai sama da 95%. Liang Meiyi, da sauransu kuma sunyi amfani da hydroxypropyl methylcellulopyl methylcellulophropyl methylelllulopheryl a matsayin kwamfutar hannu ta sanya kwamfutar hannu sanya kwamfutar hannu sanya kwamfutar hannu da kwamfutar hannu, bi da bi da bi. shafi sakin magani. Huang Yunan ya shirya allunan Jinin Dolli, kuma a yi amfani da HPMC zuwa shafi bayani na kumburi na kumburi, kuma murabbatar ta ce 5%. Ana iya ganin cewa HPMC za a iya amfani da hpmc a cikin tsarin bayar da magani na mallaka.
Rydroxypyl methyplulose ne kawai kyakkyawan kyakkyawan fim ɗin, amma kuma ana iya amfani dashi azaman kayan fim a cikin fim ɗin fim. Wang Tonshun da sauransu ana inganta su ga takardar mai lasisi na zina, da sassauci na propylexite glycol da aminci, kuma ana iya amfani da shi a matsayin takardar shaidar shirye-shiryen da aka shirya fim.
3.2 a matsayin m da watsawa
Ana amfani da matakin gyarawa na wannan samfurin azaman mai sanyaya da watsawa don allunan, kwayoyin da granuloles, da manyan kayan gani ana iya amfani da shi azaman mai ban sha'awa. Sashi ya bambanta da samfura daban-daban da buƙatu. Gabaɗaya, sashi na m goge don bushe allunan allunan ne 5%, da kuma sashi na bindind don rigar grinarth shine 2%.
Li houtao et al sake zagayowar da aka bi da Allunan Tindiazoleji. 8% polyvinylrololrolorda (PVP-K30), 40% syrup, 10% sitaci slurry, 2.0% aka bincika 50% ethanol a matsayin mai gabatar da kwamfyutocin tindiazolezolezolezolezolezolezolezolezolezolezuzole. Shirya Allunan Tindiazolezolezolezolezoleazole. Fitowar canje-canje na Albarkatun bayyanawa kuma bayan an kwatanta shi, da kuma faɗakarwar lokaci, iyakar lokacin rushewa da rushewa da allunan albashin sayan magani daban-daban. Sakamakon Allunan da 2.0% methylcellulopyl methylcellulopyl methylcellulose ya zama mai girma, kuma bayan rufin da aka gano, da kuma bayyanar tana da kyau. Saboda haka, allunan tinidazolezo da aka shirya tare da 2.0D% hpmc-k4 da 50% na ethanol kamar yadda ake amfani da ɗaukacin. Guan Shihaai yajin da aka kirkira na alluna na Fuangan, kuma manna na adherin, da digiri na 15% tare da hada-hadar, daidai, da fadakarwa a matsayin mahimmancin alamomi. , 5% cmc-na da 15% na HPMC bayani (5 MPA S). Sakamakon zanen gado da aka shirya ta kashi 50%, m planch 50% pvanol bayani, amma cmc-na mai santsi surface, 5% cmc-na da m a sarari, amma cmc-na da wuya da ƙarancin ƙarfi, wanda ba zai iya biyan bukatun saiti ba; 15% HPMC bayani (5 mpa), farfajiya na kwamfutar hannu mai santsi, da frabilation ya cancanci, da kuma ɗawainci yana da kyau, wanda zai iya biyan bukatun saiti. Saboda haka, HPMC (5 MPMC (5 mpa s) aka zaɓa a matsayin m.
3.3 a matsayin wakili na dakatarwa
Ana amfani da matakin girma na wannan samfurin azaman wakilin dakatarwa don shirya shirye-shiryen dakatarwar ruwa. Yana da kyakkyawan dakatar da sakamako, abu ne mai sauki, baya sanyawa ga bango, kuma yana da kyawawan abubuwan tasoshi. Rana na yau da kullun shine kashi 0.5% zuwa 1.5%. Song Tian et al. Anyi amfani da kayan polymer wanda ake amfani da shi (hydroxypropyl methylcellose, sodium carboxlulose, povidone, xanthan danko, da sauransu) kamar yadda wakilan dakatarwa don shirya tsere. Darewar Dakika. Ta hanyar tsinkayen tsayin daka na dakatarwa daban-daban, da kuma raunin tabbatar da rhisationheration da kuma kimantawa microscopic a karkashin gwajin da hanzarta an kuma bincika. Sakamakon dakatarwar bushe tare da 2% HPMC kamar yadda wakilin dakatarwa yana da tsari mai sauƙi da kwanciyar hankali mai kyau.
Idan aka kwatanta shi da sel methyl, hydroxypropyl metyl sellululose yana da halaye na samar da mafita ga mafita a matsayin wakili a cikin shirye-shiryen ophthmics a cikin shirye-shiryen dakatarwar Ophthmalm. Liu Jie Et et al. Amfani da HPMC, Slell Preallluloporopypyl (HPC), Carbomer 940, polyethylene glycol (feg), sodiurnation uphtommic dakatar da abubuwa daban-daban don zaba, sodiarancin ƙwayar cuta ta Ciclovir, sigari da sake aikawa da juyawa azaman dubawa alamu don tallata mafi kyawun wakili na dakatarwa. Sakamakon ya nuna cewa acyclovir ophthtic dakatar da shi da 0.05% HPMC a matsayin mai dakatarwar ruwa, maimaitawa yana da kyau, kuma shirye-shiryen jima'i yana ƙaruwa.
3.4 a matsayin maigida, jinkirin da wakilin saki da kuma wakili mai tsara
Babban bayanin daraja na wannan samfurin ana amfani dashi don shirye-shiryen saki gel matrix na dasawa kan allunan saki, kuma yana da tasirin jinkirin sakin magani. Ganosa shine 10% zuwa 80%. Ana amfani da babban grad da aka yi amfani da su azaman parkens don dorewa-saki ko shirye-shiryen saki. A farkon kashi na da ake buƙata don warkewa game da irin wannan allunan ana iya samun sauri, sannan aka ci gaba da sakamakon sakin ciki, kuma ana kiyaye ingantaccen magungunan da aka sarrafawa a jiki. . An Hydroxypyl methylcelrose an hydrated don samar da gel Layer lokacin da ya dace da ruwa. Hanyar sakin magani daga kwamfutar hannu matrix yafi haɗa da yaduwar gel na gel da kuma lalacewa na gel Layer. Jung Bo Shim Et Al Shirya Allunan Saki na Dogara tare da HPMC a matsayin abin da aka Saki.
Hakanan ana amfani da hydroxyproperyl da yawa a cikin sakin matrix na ci gaba na gargajiya na gargajiya na kasar Sin, kuma yawancin shirye-shiryen gargajiya suna amfani da maganin gargajiya. Liu Wen et al. Amfani da 15% Hydroxypoys 15% HydroxypOropyl methylcellulose kamar yadda matrix abu, 1% LOCALIELLINELINELE Dectarqi Dicers, kuma ya shirya Jingfang ta Chengqi Decongs. Samfurin shine daidaitawar hoto. Tsarin abun da ke ciki na dabara yana da sauƙi, shirye-shiryen sakin abu ne, kuma bayanan saki yana da kwanciyar hankali, wanda ya cika bukatun na magunguna na kasar Sin. Tang Guanguang et al. Azafalin Astragalus na Astragalus azaman miyagun ƙwayoyin cuta, da aka shirya allunan matrix na cikin kayan magani, da kuma bincika abubuwan da ake gudanar da abubuwan da aka saki daga ingantattun magungunan gargajiya na kasar Sin a cikin allunan gargajiya na HPMC. Sakamako azaman sashi na HPMC ya karu, sakin Astragalosde ya ragu, da kuma kashi na saki na miyagun ƙwayoyi suna da dangantaka kusan kusan matrix. A cikin HyprommeLocecocece HPMC Tablt, akwai wata dangantaka tsakanin sakin kayan gargajiya mai tasiri na maganin gargajiya na kasar Sin, da kuma sakin na sinadarai monomer yayi kama da shi. Hydroxypyl methyplellulose bai dace da mahaɗan hydrophilic ba, har ma don abubuwa masu hydrophilics. Liu Guihua ya yi amfani da 17% Hydroxypyl methylcellulose (hpmack15m) kamar yadda aka samu matrix na sakin matrix ta rigar granulation da hanyar tebur. Tasirin saki ya kasance a bayyane, kuma tsarin shiri ya tabbata da kuma mai yiwuwa.
Ba a amfani da Hydroxypropyl methypollhese ne kawai ya shafi allunan matsin-sakan da aka samu da kuma ingantattun magungunan gargajiya ba, har ma da ƙarin amfani a cikin shirye-shiryen magungunan gargajiya na kasar Sin. Wu Huichao et al. Amfani da 20% Hydroxypyl methyl Sellulose (hpmck4m) azaman kayan matsakaiciyar Matrix na TAFIYA YADDA ZAI YI SAN CIGABA DA AIKI NA 12 hours. Saponin Rg1, Ginsenosside RB1 da Panax Notoginseg safar R1, kuma lissafin sakin magani ya dace don yin nazarin sakin kwayoyi ƙwayoyi. Sakamakon tsarin kwayoyi na magani ya ba da izinin daidaitaccen daidaitaccen tsari da kuma daidaituwa na Ritger, wanda ba faduwar halittu ba ta hanyar lalacewa ta kwarangwal.
3.5 Manne mai kariya kamar kauri da Colloid
Lokacin da ana amfani da wannan samfurin azaman mai kauri, da aka saba yawan cakuda shine 0.45% zuwa 1.0%. Hakanan zai iya ƙara kwanciyar hankali na manne mai kariya, samar da kariya mai kariya, yana hana barbashi daga mai tsaro da kuma rikicewa, ta hakan ta hana samuwar kayan kwalliya. Concearshe na gama gari shine kashi 0.5% zuwa 1.5%.
Wang Zhadi et al. Amfani da hanyar Designal Designal na L9 OrtHogonal na gwaji don bincika tsarin tsarin cin abinci na magunguna Edema. A ingantaccen tsarin aiwatarwa na ƙarshe na carbon Carbon Peuma za su iya inganta ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta ruwa ta Hydroxyl (HPMC ta taimaka wajen haɓaka Carbon Carbon Carbon. Zhang Zhiqiang et al. An kirkiro levofloxacacarin hydrochlloride ophthymic shirye-shiryen amfani da gel tare da cigroxol a matsayin mai dorrix methylcellulose a matsayin wakili na methekening. Ingantaccen magani ta hanyar gwaji, a ƙarshe ya sami ingantaccen magani na magani 0.1 g, carbopol acium acium dodon 0.55 chloride, 0.03 g na ethyl paraben, da kuma an ƙara ruwa don yin 100 ml. A cikin gwajin, marubucin ya bincika hydroxypropyl methyllulogulopyl methocel jerin couptionassididdigar Kamfanin daban-daban, kuma sakamakon ya zaɓi HPMC E50 LV. Thickener don ph-m levofloxacacin hydrochlanede gels ta kaiwa.
3.6 a matsayin kayan capsule
Yawancin lokaci, kayan harsashi na capsules shine gelatin. Tsarin samarwa na capsule harsashi mai sauki ne, amma akwai wasu matsaloli da kuma mugayen magunguna, da kuma jinkirin rarrabuwa da harsashi a lokacin ajiya. Saboda haka, hydroxypropyl methylcelpyl methylcelos ana amfani dashi azaman madadin gelatin capsules don shirye-shiryen masana'antar capsules, wanda ya inganta a gida da kuma kasashen waje.
Yin amfani da Thophylline azaman maganin sarrafawa, podczeck et al. An gano cewa yawan ɓulfan ƙwayoyin cuta na capsules tare da hydroxypropyl methylcellulpyl methylcellulo harsashi ya fi na gelatin capsules. Dalilin bincike shi ne cewa rarraba HPMC shine rarrabuwar kawunan gaba daya a lokaci guda, yayin da rarraba HPMC ta fi dacewa da Capaske na farko, sannan kuma ta janye kame-karamar Capsule ita ce mafi dacewa ga kafaffen karawa. Chiwele et al. Hakanan an sami irin wannan lokacin da kuma idan aka kwatanta rushe gelatin, Gelatin / polyethylene glycol da hpmc bawo. Sakamakon binciken ya nuna cewa bassan hpmc sun narkar da cikin sauri a ƙarƙashin yanayin PH, yayin da Gelatin Capsules ya yi tasiri sosai ta yanayin ph. Tang Yue et al. Screened sabon nau'in capsule na kwasfa mai ƙarancin ƙwayar cuta blank bushe foda tsarin mai ɗaukar nauyi. Idan aka kwatanta da capsule harsashi na hydroxypropyl methylcellulophropyl metule na gelatin, kwanciyar hankali na capsule da aka bincika harsasai a karkashin yanayi daban-daban yanayi. Sakamakon binciken ya nuna cewa idan aka kwatanta da Gelatin Capsules, HPMC Capsulle bawo ne mafi kyau a cikin kwanciyar hankali, don haka a sami ƙananan danshi juriya ga capsules don bushewar wuta.
3.7 a matsayin bioadheve
Fasahar bioadheiion tana amfani da compifies tare da polymers na bioadhevive. Ta hanyar bin ga mucoalacin nazarin halittu, yana inganta ci gaba da girman lambar sadarwa tsakanin shiri da mucosa, saboda cutar da mucosa ta sake su don cimma manufar magani. Ana amfani dashi sosai a halin yanzu. Lura da cututtuka na gastrointestinal fili, farji, baka mucosa da sauran sassan.
Fasahar biormesinal na ciki shine sabon tsarin isar da magani a cikin 'yan shekarun nan. Ba wai kawai tsawanta lokacin zama na shirye-shiryen miyagun ƙwayoyi a cikin gastrointestinal fili ba, amma kuma yana inganta ƙwayar ƙwayar cuta a cikin ƙananan ƙwayoyin cuta na hanji. Wei Keda et al. Ka ɓoye sayen kwamfutar hannu ta kwamfutar hannu tare da siminti na HPmck4m da Carbomer 940 a matsayin abubuwan binciken da aka yi, da kuma simulated na da aka sanya bioflm ta hanyar ingancin ruwa a cikin jakar filastik. , kuma a ƙarshe ya zaɓi abun ciki na HPMCK40 da Carbomer 940 ya zama 15 da 27,8 mg a cikin ingantaccen tsarin takardar izini na Ncaebt) na iya shirya mahimmancin kayan aiki na Ncaebt) na iya yin amfani da haɓaka ga adheion na shiri zuwa nama.
Shirye-shiryen biorheive na baka sune sabon nau'in isar da tsarin samar da magani wanda aka yi nazari a cikin 'yan shekarun nan. Shirye-shiryen biorhesive na baka na iya mika magani ga wani bangare na abin da ya shafa na baka, wanda ba wai kawai tsawanta lokacin zama na miyagun ƙwayoyi ba, amma kuma yana kare bakin mucosa. Mafi kyawun tasirin warkewa da inganta cututtukan ƙwayar cuta. Xue Xiaoyan et al. Ingantawa da samar da Allunan insulin baki, Chitosan, Carbomer 934P, Hydroxypyl methylcellulopyl methylcellulopyl methylcellulopyl methylcellulose (daskararre, musicing don shirya insulin na baki. Adves sau biyu takardar takarda. Kwamfutar insulin na insulin na insulin na insulin na belin insulin yana da torulo-kamar tsari, wanda yake da kyau ga sakin insulin, kuma yana da kariyar mai kariya ta hydrophobic, wanda zai iya tabbatar da asarar miyagun ƙwayoyi. Hao Jifu et al. Har ila yau, shirya launin shuɗi mai launin shuɗi-rawaya na amfani da faci na Baiji ta amfani da Mallaka Baiji, HPMC da Carbomer a matsayin kayan bioadheve.
A cikin tsarin bayarwa na farji na farji, ana amfani da fasahar bioadheion sosai. Zhu yuting et al. Amfani da Carbomer (CP) da HPMC a matsayin kayan masarufi da dorewa-sakin matrix da dosultalis da ragi, da kuma lokacin kumburi da kashi da yawa a cikin yanayin farji na garwashin wucin gadi. , an bincika sayan magani ta dace kamar CP-hpmc1: 1, shirye-shiryen adon takarda yana da kyakkyawan aikin m, kuma tsari ya zama mai sauƙi kuma mai sauƙi.
3.8 a matsayin taken
A matsayinka na m shiri, gel yana da jerin fa'idodi kamar aminci, kyakkyawa, mai saukaka tsabtatawa, low comprat tsari, da kuma dacewa shiri tare da kwayoyi. Shugabanci na ci gaba. Misali, Gel TraderMal ne sabon tsari na sashi wanda aka yi nazarin shi a cikin 'yan shekarun nan. Ba zai iya nisantar lalata magunguna a cikin gastrointestiints na ciki kuma rage ƙaƙƙarfan ƙaƙƙarfan ƙwayar cuta na jini, amma kuma ya zama ɗayan tsarin sakin magani don shawo kan tasirin magunguna. .
Zhu jingjie et al. Nazarin tasirin matrices daban-daban akan saki na barcin scutellarina (980nf) da hydroxypropyl methylellulose (980nf) da hydroxyprilyl methylellulose (scutlо15m) da Scutellarin da ya dace da Scutellarin. Gel matrix na barasa farasa. Sakamakon gwaji ya nuna cewa 1. 0% Carbomer, 1. 5% Carbomer + 1. 0% Carbomer a matsayin Carbomc, 1. 0% Carbomer kamar yadda gel matrix biyu ya dace da scutelarin giya. A yayin gwajin, an gano cewa HPMC na iya canza yanayin sakin magani na Carbomer Gel Matromer da 1.0% Carbomer matrix. Dalilin na iya zama cewa HPMC tana fadada da sauri, da kuma fadada saurin gwajin abin da aka yi na Carbomer Gel, don haka hanzarta ƙididdigar sakin magani. Zhao WeCui et al. Amfani da Carbomer-934 da Hydroxypoyl methylcellulose kamar damisa don shirya Ophthalmic gel. Tsarin shiri ne mai sauki kuma mai yiwuwa, kuma ingancin yayi la'akari da gel na "pharmatoopoeia" (2010 bugu) bukatun inganci.
3.9 tsinkayen mai kaho na tsarin kirkirar kai
Tsarin isar da kayan miyagun ƙwayoyin cuta (smedds) wani sabon nau'in isar da kayan magani na baka, wanda shine hadarin miyagun ƙwayoyi, tsayayyen lokaci, emulsifier da coulsifier. A abun da ke tattare da sayan magani mai sauki ne, kuma aminci da kwanciyar hankali suna da kyau. Don talauci mai narkewa mai narkewa, kayan fiber polymer na ruwa, kamar HPMC, pvel), da sauransu, ana ƙara ƙara kwayoyi a cikin micratsion da ƙwayoyin cuta da haɓaka rashin ƙarfi da haɓaka bioavailability.
Peng Xuan et al. An shirya wani silibinin ya mallaki kansa tsarin bayar da magani (S-Sedds). Oxyethylene Hydrogened Castor Man (Cremophor RH40), 12% Caprylic Colrylic acid Glythol Glychifier, da 50 Mg emulc 1 HPMC. Dingara HPMC zuwa SSDDs na iya maye gurbin silibariniyya kyauta don narke S-SDDS da kuma hana silibinin daga progabar daga progabar daga Candthiating fitar. Idan aka kwatanta da tsarin gargajiya na al'ada, yawanci ana ƙara yawan surfactant don hana Excular miyagun ƙwayoyi. Bugu da kari na HPMC na iya kiyaye warwarewar silibinin a cikin rushewar subsiint da kullun, rage emulsification a cikin tsarin kirkirar kai. sashi na wakili.
4.Kawai
Ana iya ganin cewa HPMC an yi amfani da shi sosai a cikin shirye-shiryenta na zahiri, sunadarai da nazarin halittu, amma HPMC kuma yana da kasawa da yawa a cikin shirye-shirye, kamar su sabon abu na pre- da kuma fannoni-fashewa. methyl methancrylate) don inganta. At the same time, some researchers investigated the application of osmotic theory in HPMC by preparing carbamazepine sustained-release tablets and verapamil hydrochloride sustained-release tablets to further study its release mechanism. A wata kalma, ƙarin masu bincike suna yin ayyuka da yawa don ingantacciyar aikace-aikacen HPMC a cikin shirye-shiryenta da haɓaka nazarin kayan aikinta da haɓaka siffofin sashi da kuma sabbin siffofin sashi da kuma sabbin siffofin sashi. A cikin binciken tsarin magunguna, sannan kuma inganta ci gaba da ci gaban kantin magani.
Lokaci: Oct-08-2022