A halin yanzu, balagagge albarkatun kasa na shuka capsules ne yafi hydroxypropyl methylcellulose (HPMC) da pullulan, da kuma hydroxypropyl sitaci kuma ana amfani da matsayin albarkatun kasa.
Tun farkon shekarun 2010,HPMCAn yi amfani da shi a cikin masana'antar masana'antar capsule na kasar Sin, kuma bisa ga kyakkyawan aikin sa, HPMC m capsules sun mamaye wani wuri a cikin kasuwar capsule, yana nuna buƙatu mai ƙarfi a cikin shekaru goma da suka gabata.
Dangane da bayanan masana'antu, a cikin 2020, adadin tallace-tallace na cikin gida na ƙananan capsules mai wuya zai kasance kusan capsules biliyan 200 (masana'antar harhada magunguna da masana'antar kiwon lafiya a hade), wanda adadin tallace-tallace na capsules na HPMC zai kasance kusan capsules biliyan 11.3 (ciki har da fitarwa). , karuwa da 4.2% akan 2019. %, lissafin kusan 5.5%. Masana'antar da ba ta da magunguna tana da kashi 93.0% na yawan amfani da capsules na HPMC a China, kuma haɓakar masana'antar samfuran kiwon lafiya ke haifar da siyar da capsules na HPMC.
Daga 2020 zuwa 2025, CAGR na capsules na HPMC tare da wakilan gelling ana tsammanin zai zama 6.7%, wanda ya fi girma girma na 3.8% na capsules na gelatin. Bugu da ƙari, buƙatar capsules na HPMC a cikin masana'antar kula da lafiyar gida ya fi na masana'antar harhada magunguna.HPMCcapsules na iya taimakawa tare da ƙalubalen sayan magani da kuma daidaita abubuwan al'adu da abubuwan abinci na masu amfani a duk duniya. Ko da yake a halin yanzu bukatar HPMC capsules yana da ƙasa sosai fiye da na gelatin capsules, yawan ci gaban da ake bukata ya fi na gelatin capsules.
1) Ƙirƙirar ƙira da tsari, ba tare da wakili na gelling ba; yana da mafi kyawun solubility, daidaitaccen hali na rushewa a cikin kafofin watsa labaru daban-daban, ba su shafi pH da ƙarfin ionic ba, kuma ya dace da bukatun pharmacopoeia na manyan ƙasashe da yankuna;
2) Don raunin alkaline abun ciki, inganta bioavailability da inganta sashi ingantawa tsari;
3) Bayyanar yana da kyau, kuma zaɓin launi ya fi yawa.
Soft capsule shiri ne da aka kafa ta hanyar rufe mai ko tushen dakatarwar mai a cikin kwandon capsule, kuma siffarsa zagaye ne, siffar zaitun, siffar kifin ƙarami, mai siffa, da sauransu. Ana siffanta shi ta hanyar narkar da ko dakatar da sinadarai masu aiki a ciki. man fetur, wanda ke da saurin farawa na aiki da haɓakar bioavailability fiye da yin kayan aiki iri ɗaya a cikin allunan, kuma an yi amfani da shi sosai wajen shirya kayayyakin kiwon lafiya da magunguna. A zamanin yau, capsules masu laushi tare da halaye daban-daban kamar su mai rufi, abin taunawa, famfo osmotic, ci gaba-saki, da kayan abinci mai laushi sun riga sun kasance a kasuwa. Harsashi mai laushin capsule ya ƙunshi colloid da ƙari na taimako. Daga cikin su, colloid irin su gelatin ko danko kayan lambu sune manyan abubuwan da aka gyara, kuma ingancin su kai tsaye yana shafar aikin capsules masu laushi. Misali, zubar da harsashi na capsule, mannewa, ƙaura na kayan abu, jinkirin tarwatsewa, da rushewar capsules masu laushi suna faruwa yayin ajiya Matsaloli kamar rashin bin doka suna da alaƙa da shi.
A halin yanzu, mafi yawan capsule kayan na Pharmaceutical taushi capsules a cikin ƙasata ne dabba gelatin, amma tare da zurfin ci gaba da aikace-aikace na gelatin taushi capsules, ta shortcomings da deficiency ya zama mafi shahara, kamar hadaddun tushen albarkatun kasa. da sauƙin haɗin kai tare da mahadi na aldehyde Matsaloli masu kyau kamar gajeren lokacin ajiya da kuma "sharar gida guda uku" da aka samar a cikin tsarin tsaftacewa na gelatin suna da tasiri mai yawa akan kare muhalli. Bugu da ƙari, akwai kuma matsalar taurin zuciya a cikin hunturu, wanda ke da mummunar tasiri akan ingancin shirye-shiryen. Kuma kayan lambu mai laushi capsules suna da ƙarancin tasiri akan yanayin da ke kewaye. Tare da barkewar cututtuka masu yaduwa na asalin dabbobi a duk faɗin duniya, al'ummomin duniya suna ƙara damuwa game da amincin kayayyakin dabbobi. Idan aka kwatanta da capsules gelatin na dabba, capsules na shuka suna da fa'idodi masu ban sha'awa dangane da zartarwa, aminci, kwanciyar hankali, da kariyar muhalli.
Ƙarahydroxypropyl methylcellulosezuwa ruwa da tarwatsa don samun mafita A; ƙara gelling agent, coagulant, plasticizer, opacifier da colorant zuwa ruwa da tarwatsa don samun mafita B; Mix mafita A da B, da zafi har zuwa 90 ~ 95 ° C, motsawa kuma ci gaba da dumi don 0.5 ~ 2h, kwantar da hankali zuwa 55 ~ 70 ° C, dumi kuma tsaya ga defoaming don samun manne;
Yadda ake saurin samun ruwan manne da sauri, tsarin gabaɗaya shine don zafi a hankali a cikin kettle na dogon lokaci,
Wasu masana'antun da sauri suna wucewa ta cikin injin colloid ta manne sinadarai
Lokacin aikawa: Afrilu-25-2024