Hydroxypropyl methylcellulose (HPMC) polymer mai narkewa ne da aka saba amfani da shi, ana amfani da shi sosai a cikin magunguna, kayan kwalliya, abinci da filayen masana'antu, musamman a cikin shirye-shiryen gels. Kaddarorinsa na jiki da halayen rushewa suna da tasiri mai mahimmanci akan tasiri a cikin aikace-aikace daban-daban. The gelation zafin jiki na HPMC gel ne daya daga cikin key jiki Properties, wanda kai tsaye rinjayar da yi a daban-daban shirye-shirye, kamar sarrafawa saki, fim samuwar, kwanciyar hankali, da dai sauransu.
1. Tsarin da kaddarorin HPMC
HPMC polymer ce mai narkewa da ruwa da aka samu ta hanyar gabatar da wasu madogara guda biyu, hydroxypropyl da methyl, cikin kwarangwal na kwayar halitta ta cellulose. Tsarin kwayoyin halittarsa ya ƙunshi nau'ikan abubuwan maye: hydroxypropyl (-CH2CHOHCH3) da methyl (-CH3). Abubuwa kamar abun ciki na hydroxypropyl daban-daban, digiri na methylation, da digiri na polymerization zasu sami tasiri mai mahimmanci akan solubility, halayen gelling, da kaddarorin injiniya na HPMC.
A cikin maganin ruwa mai ruwa, AnxinCel®HPMC yana samar da ingantaccen maganin colloidal ta hanyar samar da haɗin gwiwar hydrogen tare da kwayoyin ruwa da hulɗa tare da kwarangwal na tushen cellulose. Lokacin da yanayin waje (kamar zafin jiki, ƙarfin ionic, da dai sauransu) ya canza, hulɗar tsakanin kwayoyin HPMC zai canza, yana haifar da gelation.
2. Ma'anar da kuma tasiri abubuwan da ke haifar da zafin jiki na gelation
Gelation zafin jiki (Gelation Temperature, T_gel) yana nufin zafin jiki a cikin abin da HPMC bayani fara canzawa daga ruwa zuwa m lokacin da bayani zafin jiki ya tashi zuwa wani matakin. A wannan zafin jiki, motsi na sarƙoƙi na kwayoyin HPMC za a iyakance, samar da tsarin cibiyar sadarwa mai girma uku, yana haifar da abu mai kama da gel.
Yanayin gelation na HPMC yana shafar abubuwa da yawa, ɗayan mahimman abubuwan shine abun ciki na hydroxypropyl. Baya ga abun ciki na hydroxypropyl, wasu abubuwan da ke shafar zafin gel sun haɗa da nauyin kwayoyin halitta, ƙaddamarwar bayani, ƙimar pH, nau'in ƙarfi, ƙarfin ionic, da dai sauransu.
3. Tasirin abun ciki na hydroxypropyl akan zafin gel na HPMC
3.1 Ƙara yawan abun ciki na hydroxypropyl yana haifar da karuwa a yawan zafin jiki na gel
Zazzabi na gelation na HPMC yana da alaƙa da kusanci da matakin maye gurbin hydroxypropyl a cikin kwayoyin sa. Yayin da abun ciki na hydroxypropyl ya karu, adadin masu maye gurbin hydrophilic akan sarkar kwayoyin halitta na HPMC yana ƙaruwa, yana haifar da ingantaccen hulɗa tsakanin kwayoyin halitta da ruwa. Wannan hulɗar yana haifar da sarƙoƙi na ƙwayoyin cuta su kara mikewa, ta yadda za su rage ƙarfin hulɗar tsakanin sassan kwayoyin. A cikin wani takamaiman kewayon maida hankali, haɓaka abun ciki na hydroxypropyl yana taimakawa haɓaka matakin hydration kuma yana haɓaka tsarin juna na sarƙoƙi na ƙwayoyin cuta, ta yadda za a iya samar da tsarin cibiyar sadarwa a yanayin zafi mafi girma. Sabili da haka, yawan zafin jiki na gelation yawanci yana ƙaruwa tare da haɓakar hydroxypropyl tare da haɓaka abun ciki.
HPMC tare da babban abun ciki na hydroxypropyl (kamar HPMC K15M) yana ƙoƙarin nuna yanayin zafi mai girma a daidai wannan taro fiye da AnxinCel®HPMC tare da ƙananan abun ciki na hydroxypropyl (kamar HPMC K4M). Wannan shi ne saboda babban abun ciki na hydroxypropyl yana sa ya fi wahala ga kwayoyin don yin hulɗa da samar da hanyoyin sadarwa a ƙananan yanayin zafi, suna buƙatar yanayin zafi mafi girma don shawo kan wannan hydration da inganta hulɗar intermolecular don samar da tsarin cibiyar sadarwa mai girma uku. .
3.2 Dangantaka tsakanin abun ciki na hydroxypropyl da maida hankali
Matsakaicin bayani shima muhimmin abu ne da ke shafar zafin gelation na HPMC. A cikin manyan hanyoyin samar da hankali na HPMC, hulɗar intermolecular sun fi ƙarfi, don haka zazzabi na gelation na iya zama mafi girma ko da abun ciki na hydroxypropyl ya ragu. A ƙananan ƙididdiga, hulɗar tsakanin kwayoyin HPMC ba shi da ƙarfi, kuma maganin yana da yuwuwar gel a ƙananan yanayin zafi.
Lokacin da abun ciki na hydroxypropyl ya karu, kodayake hydrophilicity yana ƙaruwa, ana buƙatar zafin jiki mafi girma don samar da gel. Musamman ma a ƙarƙashin ƙananan yanayi, yawan zafin jiki na gelation yana ƙaruwa sosai. Wannan shi ne saboda HPMC tare da babban abun ciki na hydroxypropyl ya fi wuya a haifar da hulɗar tsakanin sassan kwayoyin halitta ta hanyar canje-canjen zafin jiki, kuma tsarin gelation yana buƙatar ƙarin ƙarfin zafi don shawo kan tasirin hydration.
3.3 Tasirin abun ciki na hydroxypropyl akan tsarin gelation
A cikin wani takamaiman kewayon abun ciki na hydroxypropyl, tsarin gelation yana mamaye hulɗar tsakanin hydration da sarƙoƙi na ƙwayoyin cuta. Lokacin da abun ciki na hydroxypropyl a cikin kwayoyin HPMC ya ragu, hydration yana da rauni, hulɗar tsakanin kwayoyin halitta yana da karfi, kuma ƙananan zafin jiki na iya inganta samuwar gel. Lokacin da abun ciki na hydroxypropyl ya fi girma, hydration yana inganta sosai, hulɗar tsakanin sassan kwayoyin halitta ya zama mai rauni, kuma yawan zafin jiki na gelation yana ƙaruwa.
Maɗaukakin abun ciki na hydroxypropyl na iya haifar da karuwa a cikin dankowar maganin HPMC, canjin da wani lokaci yana ƙara yawan zafin jiki na gelation.
Abun ciki na Hydroxypropyl yana da tasiri mai mahimmanci akan yanayin gelation naHPMC. Yayin da abun ciki na hydroxypropyl ya karu, hydrophilicity na HPMC yana ƙaruwa kuma hulɗar tsakanin sassan kwayoyin halitta yana raunana, don haka yawan zafin jiki na gelation yana ƙaruwa. Ana iya bayyana wannan al'amari ta hanyar haɗin gwiwa tsakanin hydration da sarƙoƙi na kwayoyin halitta. Ta hanyar daidaita abun ciki na hydroxypropyl na HPMC, ana iya samun daidaitaccen kula da zafin jiki na gelation, ta haka inganta aikin HPMC a cikin magunguna, abinci da sauran aikace-aikacen masana'antu.
Lokacin aikawa: Janairu-04-2025