Ta yaya ake amfani da Hypromellose (HPMC) a cikin tsawaita-saki matrix Allunan?

A cikin masana'antar harhada magunguna, hypromelloseHPMC, METHOCEL ™) ana iya amfani dashi azaman filler, mai ɗaure, polymer shafi na kwamfutar hannu da maɓalli don sarrafa sakin ƙwayoyi. An yi amfani da Hypromellose a cikin allunan fiye da shekaru 60 kuma shine maɓalli mai mahimmanci wanda ake amfani dashi a cikin allunan gel matrix na hydrophilic.

Yawancin kamfanonin harhada magunguna suna amfani da hypromellose don sakin magunguna masu sarrafawa, musamman a cikin ƙirar allunan gel matrix na hydrophilic. Idan ya zo ga samfuran hypromellose, kuna iya yin mamakin yadda za ku zaɓi - musamman idan kuna neman wani abu mai aminci da dorewa don kasuwa ga abokan cinikin ku. A cikin wannan jagorar, zamuyi magana game da mahimman abubuwan da kuke buƙatar sani game da hypromellose.

Menene hypromellose?

Hypromellose, kuma aka sani dahydroxypropyl methylcellulose (HPMC), wani polymer ne da aka yi amfani da shi azaman kayan haɓaka magunguna don sarrafa sakin magunguna daga allunan hydrophilic gel matrix na baka.

Hypromellose wani abu ne na roba wanda aka samo daga cellulose, mafi yawan polymer a yanayi. Wasu daga cikin abubuwan gama gari sun haɗa da:

. mai narkewa a cikin ruwan sanyi

. insoluble a cikin ruwan zafi

. Nonionic

. Selectively mai narkewa a cikin kwayoyin kaushi

. Reversibility, thermal gel Properties

. Hydration da danko mai zaman kansa daga pH

. Surfactant

. mara guba

. Dadi da wari suna da laushi

. Enzyme juriya

. pH (2-13) kwanciyar hankali

. Ana iya amfani da shi azaman mai kauri, emulsifier, ɗaure, mai sarrafa ƙimar, tsohon fim

Menene Hydrophilic Gel Matrix Tablet?

Hydrophilic gel matrix kwamfutar hannu wani nau'i ne na sashi wanda zai iya sarrafa sakin miyagun ƙwayoyi daga kwamfutar hannu na dogon lokaci.

Hydrophilic gel matrix shirye-shiryen kwamfutar hannu:

. in mun gwada da sauki

. Yana buƙatar daidaitaccen kayan aikin matsawa na kwamfutar hannu kawai

. Hana zubar da kashi na miyagun ƙwayoyi

. Ƙarfin kwamfutar hannu ko ƙarfi bai shafe shi ba

. Ana iya daidaita sakin miyagun ƙwayoyi bisa ga adadin abubuwan haɓakawa da polymers

Yin amfani da hypromellose a cikin allunan gel-matrix na hydrophilic sun sami izini mai yawa na tsari, kuma hypromellose ya dace don amfani kuma yana da kyakkyawan rikodin aminci, wanda aka nuna ta hanyar bincike da yawa. Hypromellose ya zama mafi kyawun zaɓi ga kamfanonin harhada magunguna don haɓakawa da samar da allunan ci gaba mai dorewa.

Abubuwan Da Suka Shafi Sakin Magunguna Daga Matrix Allunan:

Lokacin zana kwamfutar hannu mai tsawaita-saki, akwai manyan abubuwa guda biyu da yakamata ayi la'akari: ƙira da sarrafawa. Hakanan akwai ƙananan abubuwan da za a yi la'akari da su lokacin ƙayyade ƙira da bayanin martaba na samfurin magani na ƙarshe.

Formula:

Mabuɗin abubuwan da za a yi la'akari don haɓakawa da wuri:

1. Polymer (nau'in maye gurbin, danko, adadin da girman barbashi)

2. Drugs (girman barbashi da solubility)

3. Bulking agents (slubility da sashi)

4. Sauran abubuwan kara kuzari (stabilizers da buffers)

Sana'a:

Waɗannan abubuwan suna da alaƙa da yadda ake kera maganin:

1. Hanyoyin samarwa

2. Girman kwamfutar hannu da Siffar

3. Ƙarfin kwamfutar hannu

4. yanayin pH

5. Shafi na fim

Yadda kwakwalwan kwarangwal ke aiki:

Hydrophilic gel matrix Allunan iya sarrafa saki da kwayoyi ta hanyar gel Layer, ciki har da biyu hanyoyin watsawa (mai narkewa aiki sinadaran) da kuma yashwa (insoluble aiki sinadaran), don haka danko na polymer yana da babban tasiri a kan saki profile. Yin amfani da hypromellose, kamfanonin harhada magunguna za su iya amfani da fasahar kwamfutar hannu na hydrophilic gel matrix don daidaita bayanin martaba na miyagun ƙwayoyi, samar da mafi inganci sashi da mafi kyawun yarda da haƙuri, don haka rage nauyin magani akan marasa lafiya. Hanyar shan magani sau ɗaya a rana yana da kyau ba shakka fiye da kwarewar shan allunan da yawa sau da yawa a rana.