Hydroxypropyl methylcellulose (HPMC)ana amfani da shi azaman ɗaya daga cikin manyan abubuwan haɓaka magunguna a gida da waje. Ana iya amfani da HPMC azaman wakili na ƙirƙirar fim, m, wakili mai ɗorewa, wakili na dakatarwa, emulsifier, wakili mai tarwatsewa, da sauransu.
Kayayyakin kayan aikin harhada magunguna wani muhimmin bangare ne na shirye-shiryen harhada magunguna, kuma aikinsu shi ne tabbatar da cewa an jera magungunan zuwa kyallen takarda ta wata hanya da tsari, ta yadda za a fitar da kwayoyi a cikin jiki a wani lokaci da sauri. Sabili da haka, zaɓin abubuwan haɓaka masu dacewa shine ɗayan mahimman abubuwan da ke haifar da tasirin warkewa na shirye-shiryen magunguna.
1 Properties na HPMC
HPMC yana da halaye da yawa waɗanda sauran abubuwan haɓaka ba su da su. Yana da kyakkyawan narkewar ruwa a cikin ruwan sanyi. Matukar an zuba shi a cikin ruwan sanyi kuma an motsa shi kadan, zai iya narke a cikin bayani mai haske. A akasin wannan, shi ne m insoluble a cikin ruwan zafi sama da 60E kuma zai iya kawai narke. Shin ether ba na ionic cellulose ba ne, maganin sa ba shi da cajin ionic, da salts na ƙarfe ko mahaɗin kwayoyin ionic, don tabbatar da cewa HPMC baya amsawa tare da sauran albarkatun ƙasa a cikin tsarin samarwa. Tare da haɓaka mai ƙarfi mai ƙarfi, kuma tare da haɓaka tsarin ƙwayoyin ƙwayoyin cuta na matakin maye gurbin, ana haɓaka haɓakar haɓakar haɓakar haɓaka, ta yin amfani da HPMC azaman magungunan adjuvant, dangane da amfani da sauran magungunan gargajiya (sitaci, dextrin, sukari foda) kwayoyi, ingancin lokacin tasiri ya fi kwanciyar hankali. Yana da inertia metabolism. A matsayin kayan taimako na magunguna, ba za a iya daidaita shi ba ko shayarwa, don haka ba ya samar da adadin kuzari a magani da abinci. Yana da ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙayyadaddun kalori, marasa gishiri da magungunan marasa lafiya da abinci da masu ciwon sukari ke buƙata. HPMC ya fi kwanciyar hankali ga acid da alkali, amma idan ya wuce pH2 ~ 11 kuma an yi shi da zafi mafi girma ko lokacin ajiya ya fi tsayi, za a rage danko. Maganin ruwa mai ruwa-ruwa yana ba da ayyukan sama kuma yana gabatar da matsakaicin tashin hankali na saman da ƙimar tashin hankali tsakanin fuska. Yana da tasiri emulsification a cikin tsarin biyu-lokaci kuma ana iya amfani dashi azaman stabilizer mai tasiri da colloid mai kariya. Maganin ruwa mai ruwa yana da kyawawan kaddarorin samar da fim kuma yana da kayan shafa mai kyau don allunan da kwaya. Fim ɗin da aka samar da shi ba shi da launi kuma mai tauri. Hakanan za'a iya ƙara ƙarfinsa ta ƙara glycerol.
2.Application na HPMC a kwamfutar hannu samar
2.1 Inganta rushewa
Yin amfani da maganin ethanol na HPMC ko bayani mai ruwa a matsayin wakili na wetting don granulation, don inganta rushewar allunan, tasirin yana da ban mamaki, kuma an danna shi a cikin taurin fim ɗin ya fi kyau, bayyanar santsi. Solubility na Renimodipine kwamfutar hannu: solubility na m shine 17.34% da 28.84% lokacin da m shine 40% ethanol, 5% polyvinylpyrrolidone (40%) ethanol bayani, 1% sodium dodecyl sulfate (40%) ethanol bayani, 3% HPMC 10% sitaci ɓangaren litattafan almara, 3% HPMC bayani, 5% HPMC bayani, bi da bi. 30.84%, 75.46%, 84.5%, 88%. Rarraba adadin allunan piperic acid: lokacin da m shine 12% ethanol, 1% HPMC (40%) maganin ethanol, 2% HPMC (40%) maganin ethanol, 3% HPMC (40%) maganin ethanol, adadin rushewa shine 80.94% , 86.23%, 90.45%, 99.88%, bi da bi. Rarraba adadin allunan Cimetidine: lokacin da manne ya kasance 10% sitaci slurry da 3% HPMC (40%) maganin ethanol, adadin narkar da shi shine 76.2% da 97.54%, bi da bi.
Daga bayanan da ke sama, ana iya ganin cewa maganin ethanol da maganin ruwa na HPMC suna da tasiri na inganta rushewar kwayoyi, wanda shine mafi yawan sakamakon dakatarwa da aikin da aka yi na HPMC, yana rage tashin hankali tsakanin maganin da kuma magance matsalolin. m kwayoyi, ƙara danshi, wanda yake da kyau ga rushe kwayoyi.
2.2 Inganta ingancin sutura
HPMC a matsayin film forming abu, idan aka kwatanta da sauran film kafa kayan (acrylic guduro, polyethylene pyrrolidone), babban amfani shi ne ta ruwa solubility, ba sa bukatar Organic kaushi, aminci aiki, dace. KumaHPMCyana da ƙayyadaddun ƙayyadaddun danko iri-iri, zaɓin da ya dace, ingancin fim ɗin shafa, bayyanar yana da kyau fiye da sauran kayan. Ciprofloxacin hydrochloride Allunan farare ne na allunan da ke da haruffa masu gefe biyu. Wadannan kwaya don murfin fim na bakin ciki yana da wahala, ta hanyar gwaji, zaɓi danko na 50mpa # s na filastik mai narkewa mai ruwa, na iya rage damuwa na ciki na fim ɗin bakin ciki, kwamfutar hannu mai rufi ba tare da gada / gumi 0, 0, 0, 0 / orange kwasfa / permeability man, 0 / crack, kamar ingancin matsala, shafi ruwa film forming, mai kyau adhesion, da kuma kawo kalma baki ba tare da yayyo, legible, Daya - gefe mai haske, kyau. Idan aka kwatanta da ruwa mai rufi na gargajiya, wannan takardar sayan magani mai sauƙi ne kuma mai ma'ana, kuma farashin yana raguwa sosai.
Lokacin aikawa: Afrilu-25-2024