1. Tsarin yanayin HPMC
Hyfomomlose, turanci sunan hydroxypropyl methylcellulhin, a ceias hpmc. Tsarin jikinsa na C8h15o8- (C10HL8O6) n-c8hl5o8, kuma nauyin kwayoyin yana kusan 86,000. Wannan samfurin kayan abu ne mai narkewa, wanda shine ɓangaren ƙungiyar Methyl da ɓangaren polyhydroxypropyl ether na selulose. Za'a iya kerarre cikin hanyoyi guda biyu: shine shine kula da sel Prefulose na Metyl na dacewa tare da Nao, sannan ya amsa tare da propylene opylelene opylelene opylene opylene opylene opylene opylene opylene opylene opylene opylene opylene opylene opylene opylene opylene opylene opylene opylene. Dole ne a ci karo da amsawa don ba da izinin metyl da hydroxypropyl ƙungiyoyi zuwa haɗin kai da ether. A kamannin an haɗa shi da ramin zobe na silulose, kuma zai iya isa ga matsayin da ake so; Sauran su ne bi da auduga ko katako na fiber na soda, sannan kuma samu ta hanyar methane da propylelene dillali da kuma propylelene dillali da nasara, sannan kuma ya ci gaba, saka shi da kyau da kuma granule. HPMC wani iri-iri na tsire-tsire na halitta ne, kuma kuma shi ne ingantacciyar coarmaceutical, wanda ke da babban tushe. A halin yanzu, ana yi amfani da shi sosai a gida da kuma kasashen waje, kuma yana daya daga cikin magungunan magunguna tare da ƙimar amfani da shi a tsakanin magunguna masu amfani.
Launin wannan samfurin shine fari ga mily fari, wanda ba mai guba da m, kuma yana da m ko fibrous, mai sauƙin kwarara foda. Yana da ban tsoro a ƙarƙashin bayyanar haske da laima. Yana kumbura a cikin ruwan sanyi don samar da wani madara fari na mafita tare da wani matakin danko. Phenconvenver Phenomenversion Phenomenon zai iya faruwa saboda canjin zafin jiki na wani maida hankali na bayani. Abu ne mai sauqi ka narkewa a cikin 70% barasa ko Dimethyl Kutin, kuma ba zai narke cikin farin barasa, chlorixyhane ko ethoxyethane ba.
Hypromlochose yana da kwanciyar hankali lokacin da PH ke tsakanin 4.0 zuwa 8.0, kuma yana iya wanzuwa tsakanin 3.0 zuwa 11.0. Bayan adon kwana 10 a zazzabi na 20 ° C da kuma yanayin zafi na 80%, danshi ctionan danshi na HPMC shine 6.2%.
Saboda bambanci a cikin abubuwan da ke cikin abubuwan da ke cikin biyun a cikin tsarin hyppomoche, metoxy da hydroxypropyl, nau'ikan nau'ikan samfuran sun bayyana. A cikin takamaiman taro, nau'ikan samfurori daban daban suna da takamaiman danko da zazzabi na Ganewa, sabili da haka, yana da kaddarorin Gerialoli kuma ana iya amfani da su don dalilai daban-daban. Propputoesias na Propputoesias daban-daban ƙasashe suna da bayanai daban-daban daban-daban: Proppacopopoeia na Turai ya dogara ne da wasu nau'ikan nau'ikan abubuwan haɗin gwiwa da daban-daban na musanyawa na samfuran samfuran a kasuwa. An bayyana shi ta hanyar daraja. Naúrar MPA • S. Bayan ƙara lambobi 4 don nuna abun ciki da nau'in kowane mawuyacin hali, alal misali, lambobi biyu da suka gabata suna wakiltar ƙimar ƙimar Methoxyp kimanin kashi.
2.The hanyar narkar da HPMC a cikin ruwa
2.1 Hanyar ruwa mai zafi
Tunda hyppomomloco ba ya narke cikin ruwan zafi, ana iya rarrabe shi a cikin ruwan zafi a farkon matakin farko, sannan kuma lokacin da aka sanyaya, da aka sanyaya hanyoyi biyu kamar haka:
(1) Sanya adadin ruwan zafi da ake buƙata a cikin akwati kuma ya kai shi kusan 70 ℃. A hankali ƙara samfurin a karkashin jinkirin motsawa. A farkon, samfurin yana tashi a saman ruwa, sannan kuma hankali ya siffce wani slurry. Kwantar da slurry.
(2) ƙara 1/3 ko 2/3 na yawan ruwa a cikin kwandon kuma yana zafi zuwa 70 ° C don watsa samfurin slurry, sannan kuma ƙara sauran adadin ruwan sanyi ko ruwan kankara A ruwan zafi slurry a cikin slurry, kwantar da cakuda bayan motsawa.
2.2 foda
Barbashi foda da sauran kayan kwalliya na daidai ko mafi girma adadin suna rarrabe ta bushe da bushe bushe, sannan a ƙara ruwa a narke. A wannan lokacin, ana iya narkar da hyppomochose ba tare da agglomeration ba.
3. Abincewar HPMC
3.1 Cold ruwan sanyi
Yana da narkewa a cikin ruwan sanyi a ƙasa 40 ° C ko 70% Ethanol. Yana da ban mamaki a cikin ruwan zafi sama da 60 ° C, amma ana iya juyawa.
3.2 sunadarai
Hypromchose (HPMC) wani nau'in sel mai kyau na ionic. Maganinta bashi da caji Ionic kuma baya hulɗa da salts na ƙarfe ko ionic kwayoyin halitta. Saboda haka, wasu masu complifies ba su amsawa da shi yayin aiwatarwa.
3.3 Duri
Yana da ban tsoro ga acid da alkali, kuma ana iya adanar na tsawon lokaci tsakanin PH 3 zuwa 1l, kuma dankalin ta ba shi da canji. Maganin ruwa mai ruwa na ruwa mai amfani da ruwa na ruwa (HPMAC) yana da tasirin rigakafi kuma yana iya kula da kyakkyawan yanayin gani yayin ajiya na dogon lokaci. Proppical comptipips ta amfani da HPMC suna da ingancin inganci fiye da waɗanda suke amfani da compifient na gargajiya (kamar Dexgin, sitaci, da sauransu).
3.4 Daftacewa na danko
Za'a iya hade da kayan haɗin gwiwa daban-daban na HPMC daban-daban na HPMC daban-daban, kuma amsar ta na iya canzawa bisa ga wani doka, kuma yana da kyakkyawar dangantaka mai kyau, don haka yana da kyakkyawar dangantaka mai kyau, don haka yana da kyakkyawar dangantaka mai kyau, don haka yana da kyakkyawar dangantaka mai kyau, don haka yana da kyakkyawar dangantaka mai kyau, don haka yana da kyakkyawar dangantaka mai kyau, don haka yana da kyakkyawar dangantaka mai kyau.
3.5 metabolis inertia
HPMC ba'a sha ko metabolized a cikin jiki, kuma baya samar da adadin kuzari, saboda haka lafiya cheadtient don shirye-shiryen magani.
3.6 tsaro
Gabaɗaya an yi imani da cewa hpmc wani abu ne mai guba da mara haushi. A cikin Mice na Mice na Mice shine 5g / kg, kuma Median na mutuwa na Mediya don berayen ne 5.2g / kg. Resarar yau da kullun ba shi da lahani ga jikin ɗan adam.
4. Aikace-aikacen HPMC a cikin shirye-shirye
4.1 AMFANI DA AS FASAHA KYAUTA DA FASAHA
Ana amfani da hypromlose (HPMC) azaman fim-mai rufi kwamfutar hannu. Idan aka kwatanta da Allon mai rufi na gargajiya kamar Allunan mai rufi da aka rufe su ba su da wani bayyananne damar dandano da bayyanar danshi da kuma wasu alamomin inganci sun fi kyau. Ana amfani da darajan daraja na wannan samfurin a matsayin kayan fim mai narkewa don allunan da kwayoyin, kuma ana amfani da matakin babban bayani a matsayin kayan fim don tsarin na kwayoyin halitta. Amfani da maida hankali ne yawanci 2.0% -20%.
4.2 a matsayin m da watsawa
Za'a iya amfani da matakin girma na wannan samfurin azaman mai sanyaya da watsawa don allunan, ƙwayoyin, da kuma granulles, da granulles, da granulles, da kuma granules. Sashi ya bambanta da samfura daban-daban da buƙatu. Gabaɗaya, adadin mai ba da aka yi amfani da bushewar allunan grani shine 5%, kuma adadin Binder da aka yi amfani da shi don rigar graning shine 2%.
4.3 a matsayin wakili mai dakatarwa
Wakilin dakatarwa shine kayan gel na viscous tare da hydrophilicity. Amfani da wakilin dakatarwa a cikin wakilcin dakatarwa na iya rage saurin saurin barbashi, kuma ana iya haɗe shi zuwa farfajiya na barbashi don hana barbashi daga polymerizing a cikin taro. Dattawa wakilan suna taka muhimmiyar rawa wajen samar da dakatarwar. HPMC kyakkyawan nau'ikan wakilan masu dakatarwa ne. Magani na Colloidal ya narke cikin shi na iya rage tashin hankali na ruwa mai ƙarfi da makamashi kyauta akan tsarin watsawa na haɗari. Wannan samfurin babban kayan vici ne na dakatar da shirye-shiryen ruwa wanda aka shirya azaman wakili na dakatarwa. Yana da kyakkyawan dakatar da sakamako, mai sauƙin warware shi, mara ƙwanƙwasa, da kyawawan barbashi mai tarin yawa. Adadin da aka saba shine 0.5% zuwa 1.5%.
4.4 amfani da wakili, jinkirin da wakilin saki da wakilin pore-forming wakili
Ana amfani da matakin girma na wannan samfurin don shirya allunan sakin Hydrophilic gel Yana da tasirin jinkirin miyagun ƙwayoyi. Amfani da hankali shine 10% ~ 80% (w / w). Ana amfani da darajar danko mai ƙarancin kayan gani a matsayin wakili mai ɗaukar hoto don ci gaba ko sarrafa saki mai sarrafawa. Za a iya amfani da tsarin warkewa na tasirin wannan nau'in kwamfutar hannu, sannan kuma ana ci gaba da aiwatar da sakamako ko sarrafawa, kuma ana kiyaye ingantaccen magungunan jini a jiki. Hypromlocecose hydrates don samar da gel Layer lokacin da ya dace da ruwa. Hanyar sakin magani daga kwamfutar talla ta matrix ita ce yaduwa da gel Layer da kuma zuriyar Gel Layer.
4.5 Manne mai kariya da aka yi amfani da shi azaman Thickener da Colloid
Lokacin da ake amfani da wannan samfurin azaman mai kauri, aiyukan da aka saba shine 0.45% ~ 1.0%. Wannan samfurin zai iya ƙara haɓakawa na manne mai kariya ta hydrophobic, samar da colloid colloid da agglomeration, ta hakan ta hana samuwar kayan kwalliya. Taro na yau da kullun shine 0.5% ~ 1.5%.
4.6 AN AS CAPSELE
Yawancin lokaci, kayan harsashi na capsule shine gelatin. Tsarin samarwa na ming capsulee kwasfa mai sauki ne, amma akwai wasu matsaloli da kuma wasu magunguna masu kyau, sun rage yawan kwayoyi na capsule yayin ajiya. Saboda haka, ana amfani da hyplomlocese a madadin kayan capsule a cikin shirye-shiryen capsules, wanda ke inganta matsalar da kuma amfani da shi a gida da kuma kasashen waje.
4.7 a matsayin bioadheve
Fasahar bioadhesive, aikace-aikacen compifis tare da manufofin bioadadpive, ta hanyar yin rizurin da mucosa, saboda cutar da mucosa, saboda cimma manufar Jiyya. Ana amfani dashi yanzu yanzu ana amfani dashi don magance cututtukan cututtukan hanci da kuma al'aura mucosa. Fasahar biorheinal na ciki sabon salo ne sabon nau'in isar da tsarin magani a cikin 'yan shekarun nan. Ba wai kawai tsawanta lokacin zama na shirye-shiryen miyagun ƙwayoyi ba a cikin gastrointestestal na ƙwayoyin cuta tare da membrane na sel nmbrane. Ikon shiga cikin miyagun ƙwayoyi zuwa ga sel na epithelial na ƙaramin hanjin an inganta, don haka inganta bioavailability na miyagun ƙwayoyi.
4.8 a matsayin babban gel
A matsayinka na kayan adon fata, gel yana da jerin fiyya kamar lafiya, kyakkyawa, mai sauƙin tsabtatawa, ƙarancin farashi, tsari mai sauƙi tare da kwayoyi. A cikin 'yan shekarun nan, ya sami kulawa mai yawa kuma ya zama ci gaban shirye-shiryen duniya na yau da kullun. shugabanci.
4.9 A matsayin hazo inhibitor a cikin tsarin emulsification
Lokaci: Dec-16-2021