Hydroxypyl methyplulose (HPMC) polymer ne mai amfani sosai a masana'antu masu kama daga magunguna na musamman don gini saboda na musamman kaddarorin sa. Yana da asali na selulose ne, tare da kungiyoyin hydroxyl wanda Metoxypypyl ƙungiyoyi, haɓaka haɓakar sa cikin ruwa kuma wasu magungunan kwayoyin halitta.
Slebility Halin HPMC
1. Rage ruwa
HPMC shine galibi ruwa mai narkewa. Abubuwan da ke cikin ruwa suna rinjayi abubuwan da yawa da yawa:
Zazzabi: HPMC ta narke cikin ruwan sanyi ko zazzabi. Bayan dumama, hpmc na iya samar da gel; A sanyaya, gel yana sake warware shi, yana sa shi ya juyawa. Wannan yanayin thermal yana da amfani a aikace-aikace kamar ana sarrafa magunguna da aka saki a cikin magunguna.
Taro: low maida hankali ne (0.5-2%) gaba daya narke sosai a hankali. Mafi girman maida hankali (har zuwa 10%) na iya buƙatar ƙarin motsawa da lokaci.
PH: Maganin HPMC ya tabbata a duk faɗin yanki mai fadi (3-11), yana sanya su gwargwado a cikin tsari daban-daban.
2. Abubuwan kwayoyin cuta
Duk da yake da farko ruwa mai narkewa, HPMC na iya narkar da su a wasu cututtukan ƙwayoyin cuta, musamman waɗanda suke da wasu matakan halaye na polar. Waɗannan sun haɗa da:
Alcohan: HPMC tana nuna kyakkyawan soli a ƙananan giya kamar methanol, ethanol, da isopropannol. Mafi girma giya ba su da tasiri saboda yawan sarƙoƙi na hydrophobic.
Glycols: propylene glycol da polyethylene glycol (Peg) na iya soke HPMC. Ana amfani da waɗannan hanyoyin sau da yawa a haɗe tare da ruwa ko barasa don haɓaka ƙwararrun masani da kwanciyar hankali na bayani.
Kettones: Wasu ketones kamar acetone da mettl ethyl ketone na iya dakatar da hpmc, musamman idan aka gauraye da ruwa.
3. Cakuda
Hakanan za'a iya narkar da HPMC a cikin cakuda gaurayawar. Misali, hada ruwa tare da giya ko glycols na iya inganta kariyar kayayyaki. Hankali tsakanin abubuwan sha zai iya rage maida hankali ne na kowane irin ƙarfi, inganta rushewar warwarewa.
Hanyar rushewa
Rage HPMC a cikin sauran ƙarfi ya ƙunshi lalata sojojin masu rikitarwa tsakanin sarƙoƙi na HPMC da kuma samar da sabuwar ma'amala tare da kwayoyin kwayoyin. Abubuwa waɗanda ke tasiri wannan aikin sun haɗa da:
Hydrogen Bading: HPMC ya samar da shaidu na hydrogen tare da ruwa da sauran abubuwan sha polar, suna sauƙaƙe solubility.
Polymer-yayyafa ma'amala: Ikon kwayoyin da zasu tilasta su shiga ciki kuma suna hulɗa tare da silsila na HPMC yana rinjayar ingancin warwarewa.
Tashin hankali na inji: motsa su yana taimakawa wajen rushe ƙarin tara da haɓaka rigar ado.
Da hankali don narkar da HPMC
1.
Don tsananin haihuwa, bi waɗannan matakan:
Bugu da kari: a hankali ƙara HPMC zuwa ga sauran ƙarfi tare da kullun motsa jiki don kauce wa clumping.
Ikon zazzabi: narke hpmc a cikin ruwan sanyi don gujewa gyaran gelation. Ga wasu abubuwan da ke tattare da kwayoyin halitta, kadan dumama na iya taimakawa.
Haɗuwa da dabaru: Yi amfani da miretrers na inji ko homogenizers don ingantaccen haɗuwa, musamman a matuƙar taro.
2. Maida hankali da danko
HPMC na maida hankali kan danko na mafita:
Karancin taro: yana haifar da mafi ƙarancin bayani, wanda ya dace da aikace-aikacen kamar coatings ko ɗaure.
Babban taro: Yana haifar da ingantaccen bayani ko gel, mai amfani a cikin tsarin magunguna don saki mai sarrafawa.
3. Karfinsu
Lokacin amfani da HPMC a cikin tsari, tabbatar da dacewa da sauran sinadaran:
Juyawar PH: Tabbatar da wasu abubuwan ba su canza PH bayan tsayayyen kewayon HPMC.
Jin daɗin zafin jiki: Yi la'akari da dukiyar herational ɗin lokacin da ke tsara hanyoyin aiwatar da canje-canje na zazzabi.
Aikace-aikacen SOPMC
Ana amfani da hanyoyin HPMC a cikin masana'antu daban-daban saboda na musamman kaddarorin su:
1. Magana
HPMC yana aiki a matsayin mai ban sha'awa, fim na tsohon wakili, mai sarrafawa:
Allunan da capsules: mafita na HPMC suna taimakawa wajen haɓaka kayan abinci da samar da fina-finai don sakin magani.
Gels: Amfani da tsari na takaice don thickening da kuma daidaita kaddarorin.
2. Masana'antar abinci
A matsayin abinci mai abinci, ana amfani da HPMC don daidaitawarta da kaddarorin emulsify:
Thikkeers: Inganta zane-zane da kwanciyar hankali a cikin biredi da sutura.
Kirkirar fim: Yana haifar da finafinan edibled don coftings da versipsulasulasulations.
3. Gina gini
Hanyoyin HPMC suna inganta kaddarorin kayan gini:
Ciminti da turmi: Amfani da shi azaman mai kauri da wakilin riƙe kaya a cikin samfuran ciminti.
Paints da Coftings: Ba da ikon sarrafawa da kwanciyar hankali a cikin zanen.
Tasirin rushewa
1. Ultrasonication
Ta amfani da raƙuman ruwa na ultrasonic don narke HPMAC na iya haɓaka ƙimar rushewa da inganci ta hanyar rushe barbashi da haɓakar waraka.
2. High-Shar-kai hadawa
High-karfi miers samar da m hadawa, rage yawan rushewa da inganta hade da juna.
Muhalli da aminci la'akari
1
HPMC ita ce a ciki, yin abokantaka da tsabtace muhalli. Yana lalata cikin kayan aikin halitta, yana rage tasirin muhalli.
2. Lafiya
HPMC ba mai guba ba ne da aminci don amfani da abinci, magunguna, da kayan kwaskwarima. Koyaya, yakamata a sake nazarin zanen gado (SDS) don kulawa da jagororin ajiya.
Narkar hpmc yadda ya kamata yana buƙatar fahimtar halayenta na narkewa da kuma faɗakarwa tare da abubuwa daban-daban. Ruwa ya rage fifikon farko, yayin da barasa, glycols, da kuma hanyoyin da aka sayo suna ba da damar musanya don takamaiman aikace-aikace. Hanyoyin da suka dace da la'akari suna tabbatar da ingantaccen Risuwa, Inganta Ingantaccen Amfani da HPMC a kan masana'antu.
Lokaci: Jun-14-2224