Hydroxypropyl Methylcellulose (HPMC)aMethylcellulose (MC)ʻelua mau mea hoʻoheheʻe cellulose maʻamau, aia kekahi mau ʻokoʻa koʻikoʻi i ka hoʻolālā kemika, nā waiwai a me nā noi. ʻOiai ua ʻano like ko lākou mau molekala, loaʻa nā mea ʻelua e nā hoʻololi kemika ʻokoʻa me ka cellulose ma ke ʻano o ka iwi maʻamau, akā ʻokoʻa nā waiwai a me nā hoʻohana.
1. ʻOkoʻa i ka hoʻolālā kemika
Methylcellulose (MC): Loaʻa ka Methylcellulose ma ka hoʻokomo ʻana i nā pūʻulu methyl (-CH₃) i loko o nā molekole cellulose. ʻO kāna hana ʻo ia ka hoʻokomo ʻana i nā pūʻulu methyl i loko o nā pūʻulu hydroxyl (-OH) o nā molekula cellulose, maʻamau e hoʻololi i hoʻokahi a ʻoi aku mau pūʻulu hydroxyl. Hoʻokumu kēia ʻano i ka MC i ka wai solubility a me ka viscosity, akā ʻo ka hōʻike kikoʻī o ka solubility a me nā waiwai e pili ana i ke kiʻekiʻe o ka methylation.
ʻO Hydroxypropyl Methylcellulose (HPMC): ʻO ka HPMC kahi huahana i hoʻololi hou ʻia o ka methylcellulose (MC). Ma ke kumu o MC, hoʻolauna ʻo HPMC i nā pūʻulu hydroxypropyl (-CH₂CH(OH)CH₃). ʻO ka hoʻokomo ʻana i ka hydroxypropyl e hoʻomaikaʻi nui i kona solubility i ka wai a hoʻomaikaʻi i kona kūpaʻa wela, ka ʻike a me nā waiwai kino ʻē aʻe. Loaʻa i ka HPMC nā pūʻulu methyl (-CH₃) a me hydroxypropyl (-CH₂CH (OH) CH₃) i loko o kona ʻano kemika, no laila ʻoi aku ka paʻa o ka wai ma mua o ka MC maʻemaʻe a ʻoi aku ka kiʻekiʻe o ka wela.
2. Solubility a me ka hydration
Solubility o ka MC: Methylcellulose kekahi solubility i loko o ka wai, a me ka solubility pili i ka degere o ka methylation. ʻO ka mea maʻamau, ʻo ka methylcellulose ka haʻahaʻa haʻahaʻa, ʻoi aku ka nui o ka wai anuanu, a pono pinepine ka wela i ka wai e hoʻoikaika i kona hoʻoheheʻe ʻana. ʻO ka MC i hoʻoheheʻe ʻia he ʻoi aku ka viscosity kiʻekiʻe, ʻo ia hoʻi kahi hiʻohiʻona nui i nā noi ʻoihana.
Solubility o HPMC: Ma ka hoʻohālikelike, ʻoi aku ka maikaʻi o ka hoʻoheheʻe wai o HPMC ma muli o ka hoʻokomo ʻana o hydroxypropyl. Hiki iā ia ke hoʻoheheʻe koke i ka wai anuanu, a ʻoi aku ka wikiwiki o kāna disolution rate ma mua o MC. Ma muli o ka mana o ka hydroxypropyl, ʻaʻole i hoʻomaikaʻi ʻia ka solubility o HPMC i ka wai anuanu, akā hoʻomaikaʻi pū kekahi i kona kūpaʻa a me ka ʻike ma hope o ka hoʻopau ʻana. No laila, ʻoi aku ka maikaʻi o ka HPMC no nā noi e koi ana i ka hemo wikiwiki.
3. Paʻa wela
ʻO ke kūpaʻa wela o ka MC: He ʻino ke kūpaʻa wela o ka Methylcellulose. E loli nui kona solubility a me ka viscosity i ka wela kiʻekiʻe. Ke kiʻekiʻe ka mahana, hiki ke maʻalahi ka hana o MC e ka thermal decomposition, no laila ua kau ʻia kāna noi ma ke ʻano wela wela i kekahi mau palena.
ʻO ke kūpaʻa wela o HPMC: Ma muli o ka hoʻokomo ʻana o ka hydroxypropyl, ʻoi aku ka maikaʻi o ka wela wela o ka HPMC ma mua o MC. Paʻa ka hana a HPMC i nā wela kiʻekiʻe, no laila hiki iā ia ke mālama i nā hopena maikaʻi ma kahi ākea ākea. ʻO kona kūpaʻa wela e hiki ai ke hoʻohana nui ʻia ma lalo o kekahi mau kūlana wela kiʻekiʻe (e like me ka meaʻai a me ka hana lāʻau).
4. Nā hiʻohiʻona viscosity
Viscosity o MC: Methyl cellulose i ka viscosity kiʻekiʻe i loko o ka aqueous solution a hoʻohana maʻamau i nā kūlana kahi e koi ʻia ai ka viscosity kiʻekiʻe, e like me nā mānoanoa, emulsifiers, a me nā mea ʻē aʻe. Ua pili loa kona viscosity i ka ʻike, ka mahana a me ke degere o ka methylation. ʻO kahi kiʻekiʻe o ka methylation e hoʻonui i ka viscosity o ka hopena.
Viscosity o HPMC: He haʻahaʻa iki ka viscosity o HPMC ma mua o ko MC, akā ma muli o kona kiʻekiʻe o ka wai a me ka hoʻomaikaʻi ʻana i ka wela, ʻoi aku ka maikaʻi o ka HPMC ma mua o MC i nā kūlana he nui e pono ai ka mana viscosity. Hoʻopili ʻia ka viscosity o HPMC e ka paona molekala, ka hoʻonā ʻana a me ka mahana hoʻoheheʻe.
5. Nā ʻokoʻa ma nā kahua noi
Ka hoʻohana ʻana o MC: Hoʻohana nui ʻia ka Methyl cellulose i ke kūkulu ʻana, ka uhi ʻana, ka hana meaʻai, ka lāʻau lapaʻau, nā mea hoʻonaninani a me nā māla ʻē aʻe. ʻOi loa ma ke kahua kūkulu, he mea hoʻohui hale maʻamau i hoʻohana ʻia no ka mānoanoa, hoʻomaikaʻi i ka adhesion a hoʻomaikaʻi i ka hana hana. I ka ʻoihana meaʻai, hiki ke hoʻohana ʻia ka MC ma ke ʻano he mānoanoa, emulsifier a me stabilizer, a loaʻa pinepine ʻia i nā huahana e like me ka jelly a me ka ice cream.
Ka hoʻohana ʻana o HPMC: Hoʻohana nui ʻia ka HPMC i nā lāʻau lapaʻau, meaʻai, kūkulu hale, nā mea hoʻonaninani a me nā ʻoihana ʻē aʻe ma muli o kona solubility maikaʻi loa a me ka paʻa wela. I loko o ka ʻoihana lāʻau lapaʻau, hoʻohana pinepine ʻia ʻo HPMC ma ke ʻano he excipient no nā lāʻau lapaʻau, ʻoi aku ka nui o ka hoʻomākaukau waha, ma ke ʻano he kiʻiʻoniʻoni mua, thickener, sustained-release agent, etc.
6. Hoʻohālikelike i nā waiwai ʻē aʻe
Mākaʻikaʻi: Loaʻa i nā hāʻina HPMC ka māliko nui, no laila ua kūpono lākou no nā noi e koi ana i kahi hiʻohiʻona a i ʻole translucent. ʻO nā hoʻonā MC maʻamau he ʻeleʻele.
Biodegradability a me ka palekana: Loaʻa iā lāua ka biodegradability maikaʻi, hiki ke hoʻohaʻahaʻa maoli ʻia e ke kaiapuni ma lalo o kekahi mau kūlana, a manaʻo ʻia he palekana i nā noi he nui.
HPMCaMCʻO nā mea ʻelua i loaʻa ma ka hoʻololi ʻana o ka cellulose a loaʻa nā ʻano kumu like, akā he ʻokoʻa ko lākou i ka solubility, thermal stability, viscosity, transparency, a me nā wahi noi. ʻOi aku ka maikaʻi o ka hoʻoheheʻe wai ʻana o ka HPMC, ke kūpaʻa wela, a me ke aniani, no laila ʻoi aku ka maikaʻi no nā manawa e koi ai i ka hoʻoheheʻe wikiwiki, ke kūpaʻa wela, a me ke ʻano. Hoʻohana nui ʻia ʻo MC i nā manawa e koi ai i ka viscosity kiʻekiʻe a me ke kūpaʻa kiʻekiʻe ma muli o kona viscosity kiʻekiʻe a me ka hopena mānoanoa maikaʻi.
Ka manawa kau: Apr-06-2025