I kēia manawa, ʻo ka nui o ka hydroxypropyl methylcellulose (HPMC) a me ka pullulan, a me ka hydroxypropyl starch ua hoʻohana ʻia e like me nā mea maka.
Mai ka hoʻomaka ʻana o nā makahiki 2010,HPMCua hoʻohana 'ia i loko o ka Chinese mea kanu capsule manufacturing 'oihana, a ma muli o kona maikai hana, HPMC puha capsules ua paa paa i kahi i loko o ka capsule market, e hoike ana i ka ikaika koi i ka hala mau makahiki mahuahua.
Wahi a ka ʻikepili ʻoihana, i ka makahiki 2020, ʻo ka nui o ke kūʻai aku ʻana o nā capsules hollow hard ma kahi o 200 billion capsules (ʻo nā ʻoihana lāʻau lapaʻau a me nā huahana olakino i hui pū ʻia), kahi o ka nui o ke kūʻai aku ʻana o nā capsules HPMC ma kahi o 11.3 biliona capsules (me ka hoʻokuʻu aku) , he piʻi o 4.2% ma luna o 2019. %, e pili ana i ka 5.5%. ʻO kaʻoihana lāʻau lapaʻauʻole he 93.0% o ka hoʻohanaʻana i nā capsules HPMC ma Kina, aʻo ka uluʻana o kaʻoihana mālama ola kino e alakaʻi i ke kūʻaiʻana i nā capsules HPMC.
Mai 2020 a 2025, ʻo ka CAGR o HPMC capsules me nā gelling agents e manaʻo ʻia he 6.7%, ʻoi aku ka kiʻekiʻe ma mua o ka ulu ʻana o 3.8% no nā capsules gelatin. Eia kekahi, ʻoi aku ka kiʻekiʻe o ka noi no nā ʻāpana HPMC i ka ʻoihana mālama ola olakino ma mua o ka ʻoihana lāʻau lapaʻau.HPMCHiki i nā capsules ke kōkua i nā pilikia o ka lāʻau lapaʻau a hoʻokō i nā makemake moʻomeheu a me nā meaʻai o nā mea kūʻai a puni ka honua. ʻOiai ʻoi aku ka haʻahaʻa o ka noi i kēia manawa no nā capsules HPMC ma mua o nā capsules gelatin, ʻoi aku ka kiʻekiʻe o ka ulu ʻana o ka noi ma mua o nā capsules gelatin.
1) Ka hoʻokumu ʻana a me ke kaʻina hana, me ka ʻole o ka gelling agent; ʻoi aku ka maikaʻi o ka solubility, ka hoʻoheheʻe ʻana i nā ʻano media like ʻole, ʻaʻole i pili i ka pH a me ka ikaika ionic, a hoʻokō i nā koi pharmacopoeia o nā ʻāina nui a me nā ʻāina;
2) No ka maʻiʻo alkaline nāwaliwali, hoʻomaikaʻi i ka bioavailability a hoʻomaikaʻi i ka hoʻonui ʻana i ke ʻano o ka dosage;
3) He nani ka helehelena, a ʻoi aku ka nui o nā koho kala.
ʻO ka capsule palupalu kahi hoʻomākaukau i hana ʻia e ka sila ʻana i ka aila a i ʻole ka ʻaila i hoʻokuʻu ʻia i loko o ka pūpū capsule, a ʻo kona ʻano he poepoe, ʻano ʻoliva, ʻano iʻa liʻiliʻi, ʻano hāʻule, a me nā mea ʻē aʻe. aila, ka mea i hoʻomaka wikiwiki i ka hana a me ka bioavailability kiʻekiʻe ma mua o ka hana ʻana i ka mea hana like i loko o nā papa, a ua hoʻohana nui ʻia i ka hoʻomākaukau ʻana i nā huahana mālama olakino a me nā lāʻau lapaʻau. I kēia mau lā, ʻo nā capsule palupalu me nā ʻano like ʻole e like me ka enteric-coated, chewable, osmotic pump, sustained-release, a me nā suppositories palupalu i kēia manawa ma ka mākeke. ʻO ka pūpū capsule palupalu i haku ʻia me nā colloid a me nā mea hoʻohui kōkua. I waena o lākou, ʻo nā colloids e like me ka gelatin a i ʻole nā mea ʻai meaʻai nā mea nui, a ʻo kā lākou maikaʻi e pili pono i ka hana o nā capsules palupalu. No ka laʻana, ka leakage o ka pūpū capsule, ka hoʻopili ʻana, ka neʻe ʻana o nā mea, ka hoʻoheheʻe lohi, a me ka hoʻoheheʻe ʻana o nā capsules palupalu i ka wā o ka mālama ʻana Ua pili nā pilikia e like me ka hoʻokō ʻole ʻana.
I kēia manawa, ʻo ka hapa nui o nā mea capsule o nā capsule soft pharmaceutical i koʻu ʻāina he gelatin holoholona, akā me ka hoʻomohala hohonu a me ka hoʻohana ʻana i nā capsule palupalu gelatin, ua ʻoi aku kona mau hemahema a me nā hemahema, e like me nā kumu paʻakikī o nā mea maka. a me ka maʻalahi o ka hoʻopili ʻana me nā pūhui aldehyde ʻO nā pilikia maikaʻi e like me ka wā mālama pōkole a me nā "ʻekolu ʻōpala" i hana ʻia i loko o ke kaʻina hana hoʻomaʻemaʻe gelatin ʻoi aku ka hopena i ka pale o ke kaiapuni. Eia kekahi, aia kekahi pilikia o ka paʻakikī i ka hoʻoilo, kahi hopena maikaʻi ʻole i ka maikaʻi o ka hoʻomākaukau. A ʻoi aku ka liʻiliʻi o ka hopena o nā capsules palupalu lau ʻai meaʻai i ke kaiapuni a puni. Me ka hoʻomau ʻana o nā maʻi maʻi maʻi o nā holoholona ma ka honua holoʻokoʻa, ke hopohopo nui nei ka honua e pili ana i ka palekana o nā huahana holoholona. Hoʻohālikelike ʻia me nā capsules gelatin holoholona, ʻoi aku ka maikaʻi o nā capsules mea kanu e pili ana i ka hoʻopili, palekana, kūpaʻa, a me ka pale ʻana i ke kaiapuni.
Hoʻohuihydroxypropyl methylcellulosei ka wai a hoʻopuehu i loaʻa ka hopena A; e hoʻohui i ka gelling agent, coagulant, plasticizer, opacifier a me ka mea kala i ka wai a hoʻopuehu no ka loaʻa ʻana o ka hopena B; hoʻohui i nā hāʻina A a me B, a wela i ka 90 ~ 95 ° C, e hoʻoulu a mālama i ka mahana no 0.5 ~ 2h, e hoʻomaha i ka 55 ~ 70 ° C, e mahana a kū no ka defoaming e kiʻi i ke kāpili;
Pehea e kiʻi koke ai i ka wai glue, ʻo ke kaʻina hana maʻamau e wela mālie i loko o kahi kīʻaha pane no ka manawa lōʻihi,
Ke hele wikiwiki nei kekahi mau mea hana i ka wili colloid ma o ke kāpili kemika
Ka manawa hoʻouna: Apr-25-2024