Ka hopena o ka maʻiʻo hydroxypropyl ma ka mahana gel HPMC

Hydroxypropyl methylcellulose (HPMC) he polymer hiki ke hoʻohana maʻamau i ka wai, hoʻohana nui ʻia i nā lāʻau lapaʻau, nā mea hoʻonaninani, nā meaʻai a me nā ʻoihana ʻoihana, ʻoi loa i ka hoʻomākaukau ʻana i nā gels. He hopena koʻikoʻi kona ʻano kino a me kāna hana hoʻoheheʻe ʻana i ka hopena i nā noi like ʻole. ʻO ka mahana gelation o ka gel HPMC kekahi o kāna mau waiwai kino nui, e pili pono ana i kāna hana i nā hoʻomākaukau like ʻole, e like me ka hoʻokuʻu ʻia ʻana, hoʻokumu kiʻiʻoniʻoni, kūpaʻa, etc.

1. Hoʻolālā a me nā waiwai o HPMC

ʻO ka HPMC he polymer hiki ke hoʻoheheʻe ʻia i ka wai i loaʻa ma ka hoʻokomo ʻana i ʻelua mau mea pani, hydroxypropyl a me methyl, i loko o ka ʻiʻo molekole cellulose. Aia i loko o kona hale molekala ʻelua ʻano mea pani: hydroxypropyl (-CH2CHOHCH3) a me methyl (-CH3). ʻO nā mea e like me nā ʻano hydroxypropyl ʻokoʻa, degere o ka methylation, a me ke degere o ka polymerization e loaʻa i kahi hopena koʻikoʻi i ka solubility, ka hana gelling, a me nā waiwai mechanical o HPMC.

I loko o nā hāʻina wai, hoʻokumu ʻo AnxinCel®HPMC i nā hoʻonā colloidal paʻa ma o ka hoʻokumu ʻana i nā paʻa hydrogen me nā molekole wai a me ka launa pū ʻana me kāna iwi iwi cellulose. Ke hoʻololi ke kaiapuni o waho (e like me ka mahana, ka ikaika ionic, a me nā mea'ē aʻe), e loli ka pilina ma waena o nā molekala HPMC, e hopena i ka gelation.

2. Ka wehewehe a me ka hoʻololi ʻana i nā kumu o ka mahana gelation

ʻO ka mahana Gelation (Gelation Temperature, T_gel) e pili ana i ka mahana i hoʻomaka ai ka hoʻololi ʻana o ka HPMC mai ka wai a i ka paʻa ke piʻi ka mahana o ka hopena i kekahi pae. I kēia mahana, e kaupalena ʻia ka neʻe ʻana o nā kaulahao molekala HPMC, e hana ana i kahi ʻano pūnaewele ʻekolu-dimensional, e loaʻa ai kahi mea e like me ka gel.

Hoʻopili ʻia ka mahana gelation o HPMC e nā kumu he nui, ʻo kekahi o nā mea koʻikoʻi ʻo ka hydroxypropyl content. Ma kahi o ka hydroxypropyl content, nā mea ʻē aʻe e pili ana i ka mahana o ka gel e pili ana i ke kaumaha molecular, ka hoʻonā ʻana, ka waiwai pH, ke ʻano solvent, ka ikaika ionic, etc.

3. Ka hopena o ka maʻiʻo hydroxypropyl ma ka mahana gel HPMC

3.1 ʻO ka hoʻonui ʻana i ka ʻike hydroxypropyl e alakaʻi i ka piʻi ʻana o ka mahana gel

ʻO ka mahana gelation o HPMC pili loa i ke degere o ka hoʻololi ʻana o ka hydroxypropyl i kāna mole. Ke piʻi aʻe ka ʻike hydroxypropyl, piʻi ka helu o nā mea pani hydrophilic ma ke kaulahao molekala HPMC, e hopena i ka pilina ma waena o ka mole a me ka wai. ʻO kēia kaʻina hana e hoʻolōʻihi i nā kaulahao molekala, a laila e hōʻemi ana i ka ikaika o ka pilina ma waena o nā kaulahao mole. I loko o kahi pae hoʻonaʻauao, hoʻonui i ka ʻike hydroxypropyl e kōkua i ka hoʻonui ʻana i ke kiʻekiʻe o ka hydration a hoʻoikaika i ka hoʻonohonoho like ʻana o nā kaulahao mole, i hiki ke hoʻokumu ʻia kahi ʻōnaehana pūnaewele ma kahi wela kiʻekiʻe. No laila, piʻi pinepine ka mahana gelation me ka piʻi ʻana o ka hydroxypropyl me ka hoʻonui ʻana i ka ʻike.

ʻO ka HPMC me ka maʻiʻo hydroxypropyl kiʻekiʻe (e like me HPMC K15M) ke ʻano e hōʻike i kahi mahana gelation kiʻekiʻe ma ka ʻike like ma mua o AnxinCel®HPMC me ka haʻahaʻa hydroxypropyl maʻiʻo (e like me HPMC K4M). ʻO kēia no ka mea ʻoi aku ka paʻakikī o ka ʻike hydroxypropyl kiʻekiʻe i nā molekala e hoʻopili a hana i nā ʻupena ma nā haʻahaʻa haʻahaʻa, e koi ana i nā mahana kiʻekiʻe e lanakila ai i kēia hydration a hoʻoikaika i nā pilina intermolecular e hoʻokumu i kahi hoʻolālā pūnaewele ʻekolu. .

3.2 Ka pilina ma waena o hydroxypropyl maʻiʻo a me ka hoʻonā

He mea koʻikoʻi nō hoʻi ka neʻe ʻana o ka hopena e pili ana i ka mahana gelation o HPMC. I nā hāʻina HPMC kiʻekiʻe, ʻoi aku ka ikaika o nā pilina intermolecular, no laila ke kiʻekiʻe ke kiʻekiʻe o ke ana o ka gelation inā ʻoi aku ka haʻahaʻa o ka hydroxypropyl content. Ma nā haʻahaʻa haʻahaʻa, nāwaliwali ka pilina ma waena o nā molekala HPMC, a ʻoi aku ka maikaʻi o ka hopena i ka gel i nā haʻahaʻa haʻahaʻa.

Ke piʻi aʻe ka ʻike hydroxypropyl, ʻoiai ke piʻi nei ka hydrophilicity, koi ʻia kahi mahana kiʻekiʻe e hana i kahi gel. ʻOi aku ma lalo o nā kūlana haʻahaʻa haʻahaʻa, piʻi nui ka mahana gelation. ʻO kēia no ka mea ʻoi aku ka paʻakikī o ka HPMC me ka hydroxypropyl kiʻekiʻe e hoʻoulu i ka pilina ma waena o nā kaulahao mole ma o ka hoʻololi ʻana i ka mahana, a ʻo ke kaʻina gelation e koi i ka ikehu wela hou e lanakila ai i ka hopena hydration.

3.3 Ka hopena o ka maʻiʻo hydroxypropyl ma ke kaʻina hana gelation

I loko o kekahi mau ʻano o ka hydroxypropyl content, ua hoʻomalu ʻia ke kaʻina hana gelation e ka pilina ma waena o ka hydration a me nā kaulahao mole. Ke haʻahaʻa ka ʻike hydroxypropyl i loko o ka mole HPMC, nāwaliwali ka hydration, ikaika ka pilina ma waena o nā molekala, a hiki i kahi haʻahaʻa haʻahaʻa ke hoʻoikaika i ka hoʻokumu ʻana o ka gel. Ke kiʻekiʻe ka ʻike hydroxypropyl, hoʻonui nui ʻia ka hydration, ʻoi aku ka nāwaliwali o ka pilina ma waena o nā kaulahao mole, a piʻi ka mahana gelation.

Hiki ke alakaʻi i ka maʻi hydroxypropyl kiʻekiʻe i ka piʻi ʻana o ka viscosity o ka solution HPMC, kahi hoʻololi e hoʻonui ai i ka wela hoʻomaka o ka gelation.

ʻO ka maʻiʻo Hydroxypropyl he hopena koʻikoʻi i ka mahana gelation oHPMC. Ke piʻi aʻe ka ʻike hydroxypropyl, piʻi ka hydrophilicity o HPMC a nāwaliwali ka pilina ma waena o nā kaulahao molekala, no laila e piʻi mau ana ka mahana o ka gelation. Hiki ke wehewehe ʻia kēia ʻano ma muli o ke ʻano hana pili ma waena o ka hydration a me nā kaulahao mole. Ma ka hoʻoponopono ʻana i ka ʻike hydroxypropyl o HPMC, hiki ke hoʻokō pololei ʻia ka mana o ka mahana gelation, a laila e hoʻonui i ka hana o HPMC i ka lāʻau lapaʻau, ka meaʻai a me nā noi ʻoihana ʻē aʻe.