Hydroxypropyl methylcellulose (HPMC)hoʻohana ʻia ʻo ia kekahi o nā mea hoʻohana lāʻau lapaʻau nui loa ma ka home a ma waho. Hiki ke hoʻohana ʻia ka HPMC e like me ka mea hana kiʻiʻoniʻoni, adhesive, sustained release agent, suspension agent, emulsifier, disintegrating agent, etc.
ʻO nā mea kōkua lāʻau lapaʻau he ʻāpana koʻikoʻi o ka hoʻomākaukau ʻana i ka lāʻau lapaʻau, a ʻo kā lākou kuleana e hōʻoia i ka lawe ʻia ʻana o nā lāʻau lapaʻau i nā ʻiʻo ma ke ʻano a me ke kaʻina hana, i hoʻokuʻu ʻia nā lāʻau lapaʻau i loko o ke kino i kahi wikiwiki a me ka manawa. No laila, ʻo ke koho ʻana i nā excipients kūpono kekahi o nā kumu nui no ka hopena therapeutic o nā hoʻomākaukau lāʻau.
1 Na waiwai o HPMC
He nui nā ʻano o ka HPMC i loaʻa ʻole i nā mea kōkua ʻē aʻe. Loaʻa iā ia ka hoʻoheheʻe wai maikaʻi i ka wai anuanu. ʻOiai ka lōʻihi o ka hoʻohui ʻia ʻana i loko o ka wai anuanu a hoʻoluliluli iki ʻia, hiki ke hoʻoheheʻe ʻia i loko o kahi hopena ʻike. ʻO ka mea ʻē aʻe, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka wai wela ma luna o 60E a hiki ke hoʻoheheʻe wale ʻia. He non-ionic cellulose etera, kona hoʻonā 'aʻole i ionic uku, a me ka metala paʻakai a ionic organic pūhui, i mea e hōʻoia i ka HPMC ole react me 'ē aʻe maka mea i loko o ka hoomakaukau production kaʻina. Me ka ikaika anti-sensitivity, a me ka hoʻonui ʻana o ka molecular structure o ke degere o ka hoʻololi ʻana, hoʻonui ʻia ka anti-sensitivity, me ka hoʻohana ʻana i ka HPMC e like me nā lāʻau adjuvant, pili i ka hoʻohana ʻana i nā adjuvants kuʻuna (starch, dextrin, sugar powder) lāʻau lapaʻau, ʻoi aku ka paʻa o ka maikaʻi o ka manawa kūpono. Loaʻa iā ia ka metabolic inertia. Ma ke ʻano he mea kōkua lāʻau lapaʻau, ʻaʻole hiki ke hoʻopili ʻia a hoʻopili ʻia, no laila ʻaʻole ia e hāʻawi i nā calorie i ka lāʻau lapaʻau a me ka meaʻai. Loaʻa iā ia ka hoʻohana kūʻokoʻa no ka waiwai calorific haʻahaʻa, ka paʻakai ʻole a me ka lāʻau allergenic a me ka meaʻai e pono ai ka poʻe maʻi maʻi. ʻOi aku ka paʻa o ka HPMC i ka waika a me ka alkali, akā inā ʻoi aku ia ma mua o ka pH2 ~ 11 a ua kau ʻia i kahi mahana kiʻekiʻe a i ʻole ka lōʻihi o ka mālama ʻana, e hoʻemi ʻia ka viscosity. Hāʻawi ka hoʻonā wai i ka hana o ka ʻili a hōʻike i ka haʻahaʻa haʻahaʻa o ka ʻili a me nā waiwai hoʻopaʻapaʻa interfacial. Loaʻa iā ia ka emulsification kūpono i ka ʻōnaehana ʻelua-phase a hiki ke hoʻohana ʻia e like me ka stabilizer a me ka colloid pale. He mea hoʻoheheʻe kiʻiʻoniʻoni maikaʻi loa ka solution aqueous a he mea uhi maikaʻi no nā papa a me nā pila. ʻO ke kiʻiʻoniʻoni i hana ʻia e ia he kala ʻole a paʻakikī. Hiki ke hoʻonui ʻia kona plasticity ma ka hoʻohui ʻana i ka glycerol.
2.Application o HPMC i ka papa hana
2.1 Hoʻomaikaʻi i ka wehe ʻana
Ke hoʻohana nei i ka HPMC ethanol solution a i ʻole ka wai wai e like me ka mea hoʻomaʻemaʻe no ka granulation, no ka hoʻomaikaʻi ʻana i ka hoʻoheheʻe ʻana o nā papa, ʻoi aku ka maikaʻi o ka hopena, a ʻoi aku ka maikaʻi o ka paʻakikī o ke kiʻiʻoniʻoni, ʻoi aku ka maikaʻi o ka helehelena. Solubility o ka papa Renimodipine: ʻo ka solubility o ka mea hoʻopili he 17.34% a me 28.84% i ka wā i hoʻopaʻa ʻia ai he 40% ethanol, 5% polyvinylpyrrolidone (40%) ethanol solution, 1% sodium dodecyl sulfate (40%) ethanol solution, 3% HPMC i hoʻoheheʻe ʻia. 10% starch pulp, 3% HPMC solution, 5% HPMC hoʻonā, pakahi. 30.84%, 75.46%, 84.5%, 88%. ʻO ka helu hoʻoheheʻe ʻana o nā papa ʻakika piperic: inā he 12% ethanol ka mea hoʻopili, 1% HPMC(40%) ethanol solution, 2% HPMC(40%) ethanol solution, 3% HPMC(40%) ethanol solution, dissolution rate is 80.94% , 86.23%, 90.45%, 99.88%. ʻO ka helu hoʻoheheʻe ʻana o nā papa Cimetidine: i ka wā o ka hoʻopili ʻana he 10% starch slurry a me 3% HPMC(40%) ethanol solution, ʻo 76.2% a me 97.54% ka helu hoʻoheheʻe ʻana.
Mai ka ʻikepili i luna aʻe, hiki ke ʻike ʻia ʻo THE ethanol solution a me ka wai wai o HPMC ka hopena o ka hoʻomaikaʻi ʻana i ka hoʻoheheʻe ʻana o nā lāʻau lapaʻau, ʻo ia ka hopena o ka hoʻokuʻu ʻana a me ka hana ʻili o HPMC, e hōʻemi ana i ka ʻili o ka ʻili ma waena o ka hopena a nā lāʻau paʻa, hoʻonui i ka wai, kahi e hoʻopau ai i nā lāʻau lapaʻau.
2.2 E hoʻomaikaʻi i ka maikaʻi o ka uhi
ʻO ka HPMC ma ke ʻano he kiʻiʻoniʻoni, hoʻohālikelike ʻia me nā mea hana kiʻiʻoniʻoni ʻē aʻe ( resin acrylic, polyethylene pyrrolidone), ʻo ka pōmaikaʻi nui loa ʻo ia ka hoʻoheheʻe wai, ʻaʻole pono nā mea hoʻoheheʻe organik, hana palekana, kūpono. AHPMCLoaʻa i nā ʻano kikoʻī viscosity, koho kūpono, ʻoi aku ka maikaʻi o ka kiʻiʻoniʻoni, ʻoi aku ka maikaʻi ma mua o nā mea ʻē aʻe. ʻO nā papa Ciprofloxacin hydrochloride nā papa keʻokeʻo keʻokeʻo me nā leka ʻelua ʻaoʻao. He paʻakikī kēia mau pila no ka uhi ʻana i nā kiʻi ʻoniʻoni lahilahi, ma o ka hoʻokolohua, koho i ka viscosity o 50 mpa # s o ka plasticizer hiki ke hoʻoheheʻe ʻia i ka wai, hiki ke hoʻemi i ke koʻikoʻi kūloko o ka kiʻiʻoniʻoni lahilahi, ka uhi ʻana i ka papa me ke alahaka ʻole 0, 0, 0, 0 / ʻalani. ʻaila ʻili/permeability, 0 / māwae, e like me ka pilikia maikaʻi, ka uhi ʻana i ka wai kiʻiʻoniʻoni, hoʻopili maikaʻi, a lawe mai i ka ʻaoʻao huaʻōlelo me ka leakage, hiki ke heluhelu, Hoʻokahi – ʻaoʻao ʻālohilohi, nani. Ke hoʻohālikelikeʻia me ka wai hoʻopili maʻamau, he mea maʻalahi a kūpono kēia kauoha, a ua hoʻemi nuiʻia ke kumukūʻai.
Ka manawa hoʻouna: Apr-25-2024