Hydroxypropyl methylcellulose kumu hoʻohālike like ʻole

Hydroxypropyl methylcellulose (HPMC)he mea hoʻohui like ʻole i hoʻohana ʻia i nā ʻoihana like ʻole, me nā lāʻau lapaʻau, nā meaʻai, nā mea hoʻonaninani, a me ke kūkulu ʻana. ʻOkoʻa kona mau waiwai a me kāna mau noi ma muli o kona ʻano molekala, hiki ke hoʻololi ʻia e kūpono i nā pono kikoʻī.

Hoʻolālā Kimia:

ʻO ka HPMC kahi hua o ka cellulose, he polymer maoli i loaʻa i nā mea kanu.
Hoʻopili ʻia ka hydroxypropyl a me ka methyl substituents i nā pūʻulu hydroxyl o ka iwi kuamoʻo cellulose.
Hoʻoholo ka lakio o kēia mau mea pani i nā waiwai o ka HPMC, e like me ka solubility, gelation, a me ka hiki ke hana kiʻiʻoniʻoni.

Papa Hoʻololi (DS):

Hōʻike ʻo DS i ka helu awelika o nā pūʻulu pani i kēlā me kēia ʻāpana glucose i ka iwi kuamoʻo cellulose.
ʻO nā waiwai DS kiʻekiʻe ka hopena i ka hoʻonui ʻana i ka hydrophilicity, solubility, a me ka hiki i ka gelation.
ʻOi aku ka paʻa o ka haʻahaʻa haʻahaʻa DS HPMC a ʻoi aku ka maikaʻi o ka pale ʻana i ka wai, e kūpono ana i nā noi i nā mea hana.

Kaumaha Molekala (MW):

Hoʻopili ke kaumaha molekala i ka viscosity, hiki ke hana kiʻiʻoniʻoni, a me nā waiwai mechanical.
ʻO ka HPMC kiʻekiʻe molecular paona maʻamau he kiʻekiʻe ka viscosity a ʻoi aku ka maikaʻi o nā waiwai hana kiʻiʻoniʻoni, no laila kūpono ia no ka hoʻohana ʻana i nā ʻano lāʻau lapaʻau hoʻokuʻu mau.
ʻOi ʻia nā ʻano ʻokoʻa paona haʻahaʻa haʻahaʻa no nā noi kahi e makemake ʻia ai ka viscosity haʻahaʻa a me ka hoʻoheheʻe wikiwiki ʻana, e like me nā uhi a me nā mea hoʻopili.

Ka nui o ka ʻāpana:

Hoʻopili ka nui o nā ʻāpana i nā waiwai kahe o ka pauda, ​​ka helu hoʻoheheʻe ʻana, a me ka like ʻana o nā hana.
ʻOi aku ka maʻalahi o ka nui o ka ʻāpana ʻāpana HPMC i nā ʻoluʻolu wai, e alakaʻi ana i ka hydration wikiwiki a me ka hoʻokumu ʻana i ka gel.
Hiki ke hāʻawi aku nā ʻāpana ʻoi aku ka maikaʻi o ka kahe ʻana i nā hui maloʻo akā makemake paha i ka manawa hydration lōʻihi.

Ka Mahana Gelation:

Hōʻike ka mahana Gelation i ka mahana kahi e hoʻololi ai nā haʻina HPMC mai kahi hopena i kahi gel.
ʻO nā pae hoʻololi kiʻekiʻe a me nā paona molekala e alakaʻi i ka haʻahaʻa haʻahaʻa haʻahaʻa.
He mea koʻikoʻi ka hoʻomaopopo ʻana i ka mahana gelation i ka hoʻokumu ʻana i nā ʻōnaehana hoʻopuka lāʻau hoʻokuʻu ʻia a me ka hana ʻana i nā gels no nā noi kumuhana.

Nā waiwai wela:

He mea koʻikoʻi ka paʻa wela i nā noi kahi i hoʻopaʻa ʻia ai ka HPMC i ka wela i ka wā e hana ai a mālama ʻia paha.
Hiki i ka DS HPMC kiʻekiʻe ke hōʻike i ke kūpaʻa wela haʻahaʻa ma muli o ka loaʻa ʻana o nā mea hoʻololi labile.
Hoʻohana ʻia nā ʻenehana loiloi wela e like me ka differential scanning calorimetry (DSC) a me ka thermogravimetric analysis (TGA) e loiloi i nā waiwai wela.

Solubility a me ka pehu ʻana:

ʻO ka hoʻoheheʻe ʻana a me ke ʻano pehu e pili ana i ka DS, ke kaumaha molekala, a me ka mahana.
ʻOi aku ka nui o ka DS a me nā ʻano paona molecular e hōʻike pinepine i ka solubility a me ka pehu ʻana i ka wai.
He mea koʻikoʻi ka hoʻomaopopo ʻana i ka solubility a me ka pehu ʻana i ka hoʻolālā ʻana i nā ʻōnaehana hoʻopuka lāʻau hoʻokuʻu ʻia a me ka hoʻokumu ʻana i nā hydrogels no nā noi biomedical.

Nā Pono Rheological:

Pono nā waiwai Rheological e like me ka viscosity, shear thinning behavior, a me ka viscoelasticity i nā noi like ʻole.
HPMCHōʻike nā haʻina i ke ʻano pseudoplastic, kahi e emi ai ka viscosity me ka piʻi ʻana o ka shear rate.
Hoʻopili nā waiwai rheological o HPMC i kona hiki ke hana i nā ʻoihana e like me ka meaʻai, nā mea hoʻonaninani, a me nā lāʻau lapaʻau.

ʻo ka ʻokoʻa ma waena o nā hiʻohiʻona like ʻole o ka HPMC ma muli o nā ʻano like ʻole o ka hana kemika, ke degere hoʻololi, ke kaumaha molekala, ka nui o ka ʻāpana, ka mahana gelation, nā waiwai wela, ka solubility, ka pehu, a me nā waiwai rheological. He mea koʻikoʻi ka hoʻomaopopo ʻana i kēia mau ʻokoʻa no ke koho ʻana i ka ʻano HPMC kūpono no nā noi kikoʻī, mai ka hoʻokumu ʻana i nā lāʻau lapaʻau a hiki i nā mea hana.