1.ʻO keʻano kumu o HPMC
Helo hypomallose, inoa inoa Pelekane hydroxyprooppopalse, Anlia Hpmc. ʻO kāna moʻomeheu Molecularʻo C8h15- (c10hl8o6) n-c8hl54 ʻO kēia huahana kahi mea semi-synthetic,ʻo ia ka'āpana o ka hui miyll a me ka'āpana o ka polyhydropypopypopypopyl o cellulose. Hiki ke hanaʻia e nāʻanoʻelua:ʻo ia ke mālama i ka cellielse cellulouse me ka naoh, a laila e noho hou me ka nui Pono e mālamaʻia ka manawa hoʻomaha eʻae i nā huiʻo Midyl a me HydroxyPyl e hoʻopili me ka Eter. Keʻano o keʻano e pili ana i ke apo anhydronglucose e hiki ai i ka cellouse, a hiki i ka hopena i makemakeʻia; ʻO ka mea'ē aʻe e mālama i ka linter a iʻole nā lāʻau lāʻau lāʻau, a laila e kiʻiʻia e ka crloricated me ka nui a me keʻano nui a me ka nui a me ka uluʻana. ʻO HPMC kahiʻano kumu kūlohelohe maoli, a he mea aloha maikaʻi loaʻo Pharmacetical, he kumu nui. I kēia manawa,ʻoi aku ka nui o ka hale a me waho, aʻo ia kekahi o nā mea hoihoi ma waena o nā lāʻau lapaʻau kiʻekiʻe.
ʻO ke kala o kēia huahana ke keʻokeʻo i ka waiū keʻokeʻo,ʻaʻole maikaʻi a me nā mea momona, a he mau'āpana a iʻole ka nui. Ua paʻa loa ia ma lalo o ka hōʻikeʻana o ka mālamalama a me ka haʻahaʻa. ʻO nā mea nui i loko o ka wai anuanu e hana i kahi sultidal keʻokeʻo keʻokeʻo keʻokeʻo me kahiʻano o ka viscosity. Hiki i ka mea hoʻonā Rel-Gel Interconviversion Phenomenon ma muli o ke hoʻololiʻana i ka mahana o kahi loli o kahiʻano o ka hopena. He mea maʻalahi loa ia e hoʻokaʻawale i nā meaʻona 70% a iʻole kaʻona a iʻole dimomeyl ketone,ʻaʻole e hoʻokaʻawale i loko o ka waiʻona, a etrofyettane.
ʻO ka hybomellose he maikaʻi ke kūpaʻa i ka wā o ka ph ma waena o 4.0 a me 8.0, a hiki iā ia ke noho ma waena o 3.0 a me 11.0. Ma hope o ka mālamaʻana i nā lā 10 ma kahi mahana o 20 ° C a me kahi haʻahaʻa pili o ka 80%,ʻo ka mistiture pili i ka nui o HPMC he 62%.
Ma muli o kaʻokoʻa i loko o nā manaʻo o nā meaʻelua i keʻano o ka hybormellose, methoxyopyl, nā huahana likeʻole iʻikeʻia. Ma kahiʻano likeʻole,ʻanoʻano o nā huahana kūikawā i loaʻa i ka mahana o Siscosity a me ka male maleʻana o ka maleʻana, no laila, he mau meaʻokoʻa a heʻokoʻa paha no nāʻano'ē aʻe. ʻO ka lāʻau lapaʻau i nāʻano likeʻole o nā'āina'ē aʻe a me nā hōʻike no ka hoʻohālike:ʻO ka lāʻau lapaʻau e hoʻonuiʻia i nā helu likeʻole o nā huahana likeʻole o nā huahana'ē aʻe. Ua hōʻikeʻia e ka papa me kahi helu. ʻO ka waihonaʻo MPA • s. Ma hope o ka hoʻohuiʻana i nā helu 4 e hōʻike i nāʻike a me nāʻano o kēlā me kēia o ka nui o ka nui o nāʻano he nui.
2.ʻO keʻano o ka hoʻokuʻuʻana iā HPMC i ka wai
2.1ʻO keʻano wai wela
Mai ka wāʻaʻole i hoʻokaʻawaleʻia ka hyldpromellse i ka wai wela, hiki ke hoʻokaʻawaleʻia i ka wai wela, a laila e weheweheʻia nā ala maʻamau
(1) E kau i ka nui o ka wai i koiʻia ma ka pahu a me ka wela i kahi o 70 ℃. E hoʻohui hou i ka huahana ma lalo o ka lohi lohi. I ka hoʻomaka, hana nā huahana huahana ma luna o ka wai, a he hālulu nō kahi slurry. E hoʻomoe i ka slurry.
(2) E hoʻohui i 1/3 a iʻole 2/3 o ka nui o ka wai i koiʻia i ka pahu wai e hoʻomākaukau ai i ka nui o ka wai wela a iʻole ka wai o ka wai wela i ka wai wai wela i ka slurry,ʻoluʻolu i ke kāwiliʻana ma hope o ka hoʻouluʻana.
2.2ʻO keʻano hui hui hui
ʻO nā'āpana nui a me nā mea nui'ē aʻe o nā mea nui a iʻole ka nui o ka nui a iʻole ka nui o ka nui e hoʻopiliʻia e ka maloʻoʻana, a laila e hoʻohuiʻia ka wai e hoʻokaʻawale. I kēia manawa, hiki ke hoʻopauʻia ka hypromellase me ka wāʻole.
3. Pono nā HPMC
3.1ʻO ka wai wai anuanu
He meaʻala ma ka wai anuanu ma lalo o 40 ° C a iʻole 70% ethanol. He mea kūponoʻole loa i ka wai wela ma luna o 60 ° C, akā hiki ke kiʻiʻia.
3.2 ka mea hōʻino
ʻO ka hyphmellose ʻAʻohe o kāna hopena i ka ukuʻole a me ke kamaʻilioʻana me nā mea aloha a me keʻano o nā mea hoʻohui a me keʻano o nā mea hui a iʻole. No laila,ʻaʻole e hana hou nā mea hoihoi'ē aʻe me ia i ka wā o ke kaʻina hoʻomākaukau.
3.3 Huli
He paʻa mau loa ia i ka acid a me alkali, a hiki ke mālamaʻia no ka manawa lōʻihi ma waena o PH 3 a iʻole he hercosity. ʻO ka hopena o ka aqueous o ka hypromellose (hpmc) he hopena anti-mold ʻO nā mea nui o nā mea hoihoi e hoʻohana ana i ka HPMCʻoi aku ka maikaʻi o ka HPMC ma mua o ka hoʻohanaʻana i nā mea ola maʻamau (e like me DXTRIN, ATC.).
3.4 Hoʻoponopono i kaʻike o ka viscosity
Hiki ke hoʻohuiʻia nā loiloi Viscosity ma HPMC i nāʻano likeʻole, a hiki i konaʻano maka ke like me kekahi rula, a he pilina linear pono, no laila e hiki ke kohoʻia e like me nā koi.
3.5 metaboli i loko
ʻAʻole kuhiʻiaʻo Hpmc a iʻole metabilized i ke kino,ʻaʻole e hāʻawi i nā kalo, no laila he mea kōkua palekana no nā lāʻau lapaʻau.
3.6 palekana
Ua manaʻo pinepine ia ua loaʻaʻo HPMC i kahi meaʻoleʻole a me nā meaʻoleʻole. ʻO ka Dose Median Dose no nā moice he 5g / kg, a me ka median lethal dos no nā rats he 5.2g / kg. ʻAʻole maikaʻi ka hana o kēlā me kēia lā i ke kino o ke kanaka.
4.ʻO ka noiʻana o HPMC i ka hoʻomākaukau
4.1 Hoʻohanaʻia e like me ke kiʻi kiʻi kiʻiʻoniʻoni a me nā kiʻi kiʻi kiʻi kiʻi
Ua hoʻohanaʻiaʻo HYPPERLLOSE (HPMC) e like me ke kiʻi paʻi kiʻi kiʻiʻoniʻoni. Hoʻohālikelikeʻia me nā papaʻaina Coated e like me nā papaʻaina Sugar-COP-coated,ʻaʻohe pono o nā papa hana a me nā mea paʻakikī loa. Hoʻohanaʻia ka papa kiʻekiʻe o ka huahana o kēia huahana ma keʻano he mea kāwili wai-wai liʻiliʻi liʻiliʻi no nā papaʻaina a me nā paliwe kiʻekiʻe e like me keʻanoʻoniʻoni nui. ʻO ka hana hoʻohana hoʻohanaʻo ia ka maʻamau he 2.0% -20%.
4.2 ma kahiʻano a me ka mea hanaʻole
Hiki ke hoʻohanaʻia ka papa haʻahaʻa haʻahaʻa o kēia huahana e like me kahi mea paʻa a me ka meaʻole paha no nā papa, nā papa kiʻekiʻe, a me nā granuna Hoʻololi ka Dosage me nā hiʻohiʻona likeʻole a me nā koi. ʻO ka maʻamau,ʻo ka nui o ka binder i hoʻohanaʻia no nā papa papaʻaina maloʻo he 5%, aʻo ka nui o ka binder i hoʻohanaʻia no nā papa papa he 2%.
4.3 Ma keʻano he mea hoʻokele
ʻO ka Agenting Agent he mea kūʻai Viscous Gel i ka Viscous Gel me ka hydrophilicity. Hiki i ka hoʻohanaʻana o ka mea i hoʻopiʻi i ka luna i hiki ke hoʻopau i ka wikiwiki o ka sediment o ka pāpū, a hiki ke hoʻopiliʻia i nā'āpana o nā'āpana Ke hoʻokūkū nei nā mea hoʻokele i kahi hana koʻikoʻi ma ka hanaʻana o nā sullbons. ʻO HPMC kahiʻano maikaʻi loa o nā mea hoʻopiʻi hoʻopiʻi. Hiki i ka hoʻonā colliodal i hiki ke hōʻemi i ka luhi o ka wai-paʻa a me ka ikaika manuahi ma nā'āpana liʻiliʻi o ka heterower ʻO kēia huahana kahi mea kūʻai aku kiʻekiʻe kiʻekiʻe o ke koho balota i hoʻomākaukauʻia e hoʻomākaukauʻia ma keʻano he mea hoʻokele. He hopena paʻakikī maikaʻi loa, maʻalahi e hoʻihoʻi houʻia, nā mea ponoʻole, a me nā meaʻala maikaʻi. ʻO ka nui maʻamau he 0.5% i 1.5%.
4.4 Hoʻohanaʻia e like me ka blocker, lohi a mālama i ka hoʻokele a me ka hoʻokele a me ka luna
Hoʻohanaʻia ka papa kiʻekiʻe o kēia huahana o kēia huahana e hoʻomākaukau i nā papa geldrophilic Geldrophil Loaʻa iā ia ka hopena o ka hoʻokuʻuʻana i ka hoʻokuʻuʻana i nā lāʻau. ʻO kāna hoʻohana hoʻohanaʻana he 10% ~ 80% (W / W). Hoʻohanaʻia ka papa haʻahaʻa haʻahaʻa haʻahaʻa e like me ka luna o ka mea hana pore ʻO ka hana mua i koiʻia no ka hopena o ka wbrapeutic o kēiaʻano o nā papaʻaina, a laila mālama kokeʻia ka hopena o ka memo a i mālamaʻia. ʻO ka hybopellose hydrates e hana i kahiʻano gel i ka wā e hālāwai ai me ka wai. ʻO keʻano o ka hanaʻana o ka lāʻau lapaʻau mai ka papa matrix ka mea nui loa o keʻano o keʻano o ka gel i luna a me ka manaʻo o ka gel tweeter.
4.5 pale pale i hoʻohanaʻia e like me ka skickener a me ka colloid
I ka manawa i hoʻohanaʻia ai kēia huahana e like me ka shaickener,ʻo kaʻike maʻamau he 0.45% ~ 1.0%. Hiki i kēia huahana ke hoʻonui i ka kūpaʻa o ka gluedophobic glue, e pale i kahi color i paleʻia, e pale ai i keʻano o nā sedidents. ʻO konaʻike maʻamau he 0.5% ~ 1.5%.
4.6 Hoʻohanaʻia e like me nā mea capsule
ʻO ka maʻamau,ʻo ka mea hana capsulet o nā mea kilokilo o ka capsule he gelatin nui. ʻO ke kaʻina hana o ka ming ming ma maʻalahi, akā aia kekahi mau pilikia a me ka phenomen e like me ka paleʻana o ka'ōpala i ka mālamaʻana. No laila, hoʻohanaʻo Hospomellose i keʻano he mea i koho ai nā capsule no nā capus i ka hale a me nā mea'ē aʻe i hāpaiʻia ma ka hale a me nā meaʻole loa i hāpai i ka hale a me nā mea'ē aʻe.
4.7 e like me ka bioadhesive
ʻEnehana bioadheve mālama. Ua hoʻohana nuiʻia ia i kēia manawa ua hoʻohanaʻia ia e mālama i nā maʻi o ka nasal cavity a me ka mucosa. ʻO Gastrointestinal Biodhestioneʻenehana heʻano hou o ka'ōnaehana o ka mea kūʻai aku i kūkuluʻia i nā makahiki i hala iho nei. ʻAʻole wale ka mea i kuhiʻia i ka manawa noho o ka lawaiʻaʻana i ka lāʻau lapaʻau i loko o ka pākuhiʻo Gastroinstinal, akā e hoʻomaikaʻi i ka hoʻopiliʻana o ka lāʻau kuʻikahi me ka naloʻana o ka pahu kuʻikahi me ka haʻahaʻa o ka lāʻau. ʻO ka mana o ka lāʻau lapaʻau i ka lāʻau pipi i ka mapo o ka palupalu liʻiliʻi o kaʻili liʻiliʻi, e hoʻomaikaʻi ana i ka bianoilability o ka lāʻau lapaʻau.
4.8 e like me keʻano topical
Me keʻano o ka hoʻohālikelikeʻana no kaʻili,ʻo Gel keʻano he hana kūpono e like me ka palekana, ka hoʻomaʻemaʻe maʻamau, a me nāʻano uku maʻamau. I nā makahiki i hala iho nei, ua loaʻa iā ia ka manaʻo nui a lilo i ka hoʻolālāʻana o ka hana o waho. kuhikuhi.
4.9 ma keʻano he inshibitator i loko o ka'ōnaehana emohosification
POST manawa: Dec-16-2021