ʻO ka HPMC (Hydroxypropyl Methylcellulose) kahi ether nonionic cellulose i hoʻohana nui ʻia i ka lāʻau lapaʻau, ka meaʻai, ke kūkulu ʻana a me nā mea hoʻonaninani. Hoʻokaʻawale ʻia nā māka like ʻole o ka HPMC e like me ko lākou ʻano kemika, nā waiwai kino, viscosity, degere o ka hoʻololi ʻana a me nā hoʻohana like ʻole.
1. ʻO ke kinona a me ke degere o ka hoʻololi
ʻO ka molecular structure o HPMC he mau pūʻulu hydroxyl ma ke kaulahao cellulose i pani ʻia e nā hui methoxy a me hydroxypropoxy. ʻOkoʻa nā waiwai kino a me nā kemika o HPMC ma muli o ke ʻano o ka hoʻololi ʻana o nā hui methoxy a me hydroxypropoxy. Hoʻopili pololei ka degere o ka hoʻololi ʻana i ka solubility, thermal stability a me ka hana ʻili o HPMC. kikoʻī:
ʻO ka HPMC me kahi ʻano methoxy kiʻekiʻe e hōʻike ana i kahi mahana gelation thermal kiʻekiʻe, kahi e kūpono ai ia no nā noi e pili ana i ka wela e like me ka hoʻomākaukau ʻana i ka lāʻau hoʻokuʻu.
ʻOi aku ka maikaʻi o ka hoʻoheheʻe ʻana o ka wai i ka HPMC me kahi hydroxypropoxy kiʻekiʻe, a ʻoi aku ka liʻiliʻi o kāna kaʻina hoʻoheheʻe ʻana e ka mahana, no laila kūpono ia no ka hoʻohana ʻana i nā wahi anuanu.
2. Papa viscosity
ʻO Viscosity kekahi o nā hōʻailona koʻikoʻi o ka helu HPMC. Loaʻa i ka HPMC kahi ākea o nā viscosities, mai kahi mau keneta a hiki i nā ʻumi kaukani centipoise. Hoʻopili ka pae viscosity i kona hoʻohana ʻana i nā noi like ʻole:
HPMC viscosity haʻahaʻa (e like me 10-100 centipoise): Hoʻohana nui ʻia kēia ʻano o ka HPMC i nā noi e koi ana i ka viscosity haʻahaʻa a me ka wai kiʻekiʻe, e like me ka uhi kiʻiʻoniʻoni, nā mea hoʻopili papa, a me nā mea ʻē aʻe. ka wai o ka hoomakaukau ana.
HPMC viscosity liʻiliʻi (e like me 100-1000 centipoise): Hoʻohana maʻamau i ka meaʻai, nā mea hoʻonaninani a me kekahi mau hoʻomākaukau lāʻau lapaʻau, hiki ke hana ma ke ʻano he mānoanoa a hoʻomaikaʻi i ke ʻano a me ke kūpaʻa o ka huahana.
HPMC viscosity kiʻekiʻe (e like me ka 1000 centipoise ma luna): Hoʻohana nui ʻia kēia papa o HPMC i nā noi e koi ai i ka viscosity kiʻekiʻe, e like me nā glues, adhesives a me nā mea kūkulu hale. Hāʻawi lākou i ka mānoanoa maikaʻi a me ka hiki ke hoʻokuʻu.
3. Na waiwai kino
ʻO nā waiwai kino o ka HPMC, e like me ka solubility, ka wela o ka gelation, a me ka hiki ke komo i ka wai, ʻokoʻa hoʻi me kona pae:
Solubility: Loaʻa ka solubility maikaʻi o ka hapa nui o nā HPMC i ka wai anuanu, akā e emi ana ka solubility i ka piʻi ʻana o ka methoxy maʻiʻo. Hiki ke hoʻoheheʻe ʻia kekahi mau māka kūikawā o ka HPMC i nā mea hoʻoheheʻe organik no nā noi ʻoihana kūikawā.
ʻO ka mahana gelation: ʻO ka mahana gelation o HPMC i loko o ka wai wai ʻokoʻa me ke ʻano a me ka ʻike o nā mea pani. Ma ka ʻōlelo maʻamau, ʻo ka HPMC me kahi ʻano methoxy kiʻekiʻe e hana i nā gels i nā mahana kiʻekiʻe, ʻoiai ʻo HPMC me kahi ʻano hydroxypropoxy kiʻekiʻe e hōʻike ana i kahi mahana gelation haʻahaʻa.
Hygroscopicity: He haʻahaʻa ka hygroscopicity o ka HPMC, ʻoi aku ka nui o nā māka i pani ʻia. He mea maikaʻi kēia i nā kaiapuni e pono ai ka pale ʻana i ka makū.
4. Nā wahi noi
No ka mea he ʻokoʻa nā ʻano o ke kino a me nā waiwai kemika o nā māka like ʻole o ka HPMC, ʻokoʻa hoʻi kā lākou noi ma nā ʻano ʻano like ʻole.
ʻOihana lāʻau lapaʻau: Hoʻohana maʻamau ʻia ka HPMC i nā uhi papa, nā hoʻomākaukau hoʻokuʻu hoʻomau, nā adhesives, a me nā mānoanoa. Pono ka lāʻau lapaʻau HPMC e hoʻokō i nā kūlana pharmacopoeia kikoʻī, e like me ka United States Pharmacopoeia (USP), European Pharmacopoeia (EP), etc. Hiki ke hoʻohana ʻia nā māka like ʻole o ka HPMC e hoʻoponopono i ka helu hoʻokuʻu a me ke kūpaʻa o nā lāʻau.
ʻOihana meaʻai: Hoʻohana ʻia ʻo HPMC ma ke ʻano he mānoanoa, emulsifier, stabilizer a me nā kiʻiʻoniʻoni mua. Pono ʻia ka HPMC meaʻai he mea ʻawaʻawa ʻole, ʻono ʻole, ʻala ʻole, a pono e hoʻokō i nā lula hoʻohui meaʻai, e like me ka US Food and Drug Administration (FDA) a me ka European Food Safety Authority (EFSA).
ʻOihana hana: Hoʻohana nui ʻia ka HPMC kūkulu hale i nā mea sima, nā huahana gypsum a me nā uhi e mānoanoa, mālama i ka wai, lubricate a hoʻonui. Hiki i ka HPMC o nā māka viscosity like ʻole ke hoʻopili i ka hana o nā mea kūkulu hale a me ka hana o ka huahana hope.
5. Nā kūlana kūpono a me nā lula
Aia nā māka like ʻole o ka HPMC i nā kūlana maikaʻi like ʻole a me nā lula:
ʻO ka lāʻau lapaʻau HPMC: pono e hoʻokō i nā koi pharmacopoeia, e like me USP, EP, a me nā mea ʻē aʻe.
HPMC meaʻai: Pono ia e hoʻokō i nā lula pili i nā mea hoʻohui meaʻai e hōʻoia i kona palekana i ka meaʻai. Loaʻa i nā ʻāina a me nā ʻāpana ʻokoʻa nā kikoʻī like ʻole no ka HPMC meaʻai.
ʻAʻole pono ka HPMC i hoʻohana ʻia i ke kūkulu ʻana, ka uhi a me nā ʻano ʻē aʻe i nā kūlana meaʻai a i ʻole nā lāʻau lapaʻau, akā pono nō e hoʻokō i nā kūlana ʻoihana e like me nā kūlana ISO.
6. Ka palekana a me ka palekana kaiapuni
He ʻokoʻa ka HPMC o nā māka like ʻole i ka palekana a me ka pale kaiapuni. Hoʻomaʻamaʻa pinepine ka HPMC i ka papa lāʻau lapaʻau a me ka papa meaʻai i nā loiloi palekana koʻikoʻi no ka hōʻoia ʻana ʻaʻole ia e pōʻino i ke kino kanaka. ʻO ka HPMC ʻoihana ʻoihana, ma ka ʻaoʻao ʻē aʻe, e nānā nui i kona palekana kaiapuni a me ka degradability i ka wā e hoʻohana ai e hōʻemi i ka hopena i ke kaiapuni.
Hōʻike ʻia nā ʻokoʻa ma waena o nā māka like ʻole o ka HPMC i ka hoʻolālā kemika, viscosity, nā waiwai kino, nā wahi noi, nā kūlana maikaʻi a me ka palekana. Wahi a nā koi noi kikoʻī, hiki i ke koho ʻana i ka māka kūpono o HPMC hiki ke hoʻomaikaʻi nui i ka hana a me ka maikaʻi o ka huahana. I ke kūʻai ʻana i ka HPMC, pono e noʻonoʻo ʻia kēia mau mea e hōʻoia i ka hoʻopili a me ka pono o ka huahana.
Ka manawa hoʻouna: ʻAukake-20-2024