HydroxyPropyyl Metylcellulose (HPMC), tseem hu ua Hypromellose, yog ib qho kev lag luam polymer ntau yam hauv kev lag luam kws tshuaj. Nws yog lub shatthetic, inert, StotSictic polymer muab tau los ntawm cellulose, lub ntuj polysaccharide. HPMC yog muaj nuj nqis rau nws solubility hauv dej, qhov tsis muaj kuab, thiab nws lub peev xwm los ua cov yeeb yaj kiab thiab cov kua pleev.
1. Binder nyob rau hauv ntsiav tshuaj tsim
Ib qho ntawm thawj daim ntawv thov ntawm HPMC hauv cov chaw muag tshuaj yog ib phau ntawv sau ua hauv ntsiav tshuaj. HPMC tau ua hauj lwm kom ntseeg tau tias cov khoom xyaw hauv ib lub ntsiav tshuaj nyob rau hauv ib ntsiav tshuaj nyob rau hauv ib ntsiav tshuaj ua ke thiab nyob ruaj khov kom txog thaum kev siv. Nws cov khoom siv khi ua kom txhim kho cov mechanical lub zog ntawm cov ntsiav tshuaj, ua rau lawv tsis tshua muaj kev sib tsoo lossis tawg thaum lub sijhawm thauj, tsheb thauj mus los, thiab tuav. Tsis tas li ntawd, HPMC cov xwm tsis yog ua kom nws tsis hnov mob nrog lwm cov khoom xyaw, tswj kev ruaj ntseg thiab kev ua tau zoo ntawm cov khoom xyaw ua haujlwm (API).
2. Tshuaj Tso Tawm Matrix
HPMC yog qhov tseem ceeb heev nyob rau hauv kev loj hlob ntawm kev tswj hwm kev tso tawm (CR) thiab txhawb nqa kev tso tawm (SR). Cov qauv no yog tsim los tso cov tshuaj ntawm tus nqi ua ntej, tswj cov tshuaj raws cai raws li cov hlab ntshav hla ncua sijhawm. HPMC cov kev ua kom muaj peev xwm muaj peev xwm sib cuag nrog cov pa roj plab ua rau nws zoo tagnrho rau lub hom phiaj no. Nws tsim cov qauv viscous gel ib ncig ntawm cov ntsiav tshuaj, tswj qhov diffusion ntawm cov tshuaj. Cov xeeb ceem no tshwj xeeb tau txais txiaj ntsig rau cov tshuaj nrog txoj hlab ntshav uas xav tau, yog li txhim kho kev ua tau zoo thiab txo cov kev mob tshwm sim.
3. Zaj duab xis txheej
Lwm daim ntawv teev npe tseem ceeb ntawm HPMC yog nyob rau hauv zaj duab xis txheej ntawm cov ntsiav tshuaj thiab tsiav tshuaj. HPMC-based txheej tiv thaiv cov ntsiav tshuaj los ntawm ib puag ncig cov khoom xws li ya raws, lub teeb, uas tuaj yeem ua rau cov khoom xyaw nquag. Zaj duab xis txheej tseem txhim kho lub tshuaj zoo nkauj ntawm cov ntsiav tshuaj, txhim kho cov tshuaj txhuam, thiab tuaj yeem siv cov tshuaj sib xyaw rau hauv qee qhov ntawm txoj hnyuv. Ntxiv mus, HPMC tsho tiv thaiv tuaj yeem tsim los kho cov tso tawm cov kev tso tawm ntawm cov tshuaj, pab hauv lub tshuab xa khoom.
4. Thickening tus neeg sawv cev
HPMC ua haujlwm raws li tus neeg sawv cev ua kom ua tau cov tshuaj ua kom zoo xws li syrups thiab raug ncua. Nws lub peev xwm los nce viscosity tsis muaj kev hloov kho ntxiv ntawm cov qauv siv tau kom muaj kev sib raug zoo ntawm cov kua, tiv thaiv kev ua kom zoo nkauj ntawm cov nplais uas raug tshem tawm, thiab muab lub qhov ncauj xav tau. Cov cuab yeej no yog qhov tshwj xeeb tshaj yog nyob rau hauv kev ua yeeb yam pediatric thiab geriatric formulations, uas yooj yim ntawm cov thawj coj yog qhov tseem ceeb.
5. Stabilizer nyob rau hauv cov ntsiab lus
Nyob rau hauv cov duab kos duab zoo li cream, gels, thiab tshuaj pleev, HPMC ua raws li lub stabilizer thiab emulsifier. Nws pab kom muaj xwm yeem thiab kev ruaj khov ntawm cov qauv tsim, kom ntseeg tau tias cov khoom xyaw nquag yog cov khoom siv cuav. HPMC kuj tseem muab cov qauv du, txhim kho daim ntawv thov thiab nqus ntawm cov khoom ntawm daim tawv nqaij. Nws qhov tsis yog-irritant xwm ua rau nws haum rau kev siv hauv cov qauv rau rhiab tawv.
6. Ophthtalmic Npaj
HPMC yog qhov dav dav nyob rau hauv ophthalmic npaj, xws li cov kua muag cuav thiab cov kua ntxwv sib chwv. Nws cov khoom siv Viscoelastic muaj lub kua muag ua zaj duab xis, muab lubrication thiab noo noo rau lub qhov muag. HPMC-raws li qhov muag tau txais txiaj ntsig tshwj xeeb rau cov tib neeg uas muaj lub qhov muag qhuav, muab kev nyem los ntawm kev khaus thiab tsis xis nyob. Ib qho ntxiv, HPMC yog siv nyob rau hauv ocular cov zaub mov siv cov tshuaj siv sijhawm, uas nws pab hauv lub sijhawm ntev lub sijhawm ntawm cov tshuaj nrog nraim cov nplaim dej, txhim kho kho cov tshuaj tiv thaiv.
7. Tshuaj ntsiav tshuaj
HPMC kuj tseem siv rau hauv kev tsim cov tawv thiab cov muag muag muag muag. Nws ua haujlwm ua lwm txoj hauv kev ua rau Gelatin, muab cov neeg tsis noj qab noj rau capsule plhaub. HPMC cov tsiav tshuaj tau zoo dua rau lawv cov ntsiab lus noo noo cov ntsiab lus, uas yog qhov zoo rau cov dej noo-rhiab. Lawv tseem muab cov khoom muaj zog zoo dua nyob rau hauv kev sib txawv ib puag ncig thiab tsis tshua muaj kev sib txuas, ib qho teeb meem uas muaj cov ntsiav tshuaj uas muaj peev xwm cuam tshuam nrog cov tshuaj tawm tshuaj.
8. Bioavailability txhim kho
Hauv qee qhov kev tsim qauv, HPMC tuaj yeem txhim kho cov xyoob ntoo tsis muaj zog ntawm cov tshuaj tsis zoo. Los ntawm kev sib sau cov gel Matrix, HPMC tuaj yeem nce cov tshuaj sib yaj no ntawm cov tshuaj nyob rau hauv lub plab zom mov, ua kom haum rau kev nqus tau zoo dua. Qhov no yog qhov tseem ceeb tshwj xeeb rau cov tshuaj nrog dej so dej tsawg, raws li txhim kho kev sib cuam tshuam tuaj yeem cuam tshuam cov tshuaj no cuam tshuam.
9. MiCoadhesive daim ntawv thov
HPMC cov khoom ua pov thawj HPMOdhesive, ua rau nws haum rau buccal thiab sublolle cov kev xa tshuaj. Cov kab ke no yuav tsum tau cov tshuaj kom ua raws li cov kua mis uas muaj kev tso tawm thiab nqus tau mus rau hauv cov hlab ntshav, bypassing cov metabolism hauv thawj. Qhov no txoj kev tau txais txiaj ntsig zoo rau cov tshuaj uas ua rau muaj cov acidic ib puag ncig ntawm lub plab lossis muaj qhov ncauj tsis zoo ntawm qhov ncauj.
Cov versatility ntawm hydroxypropyl methylcellueculose (HPMC) hauv cov tshuaj tsis tuaj yeem ua kom dhau. Nws cov ntawv thov ncua los ntawm cov ntsiav tshuaj khi thiab zaj duab xis kom thickening thiab ruaj khov tus neeg sawv cev hauv ntau yam qauv. HPMC lub peev xwm los hloov kho cov tshuaj tawm suab, txhim kho cov mucomhesion txuas ntxiv nws qhov tseem ceeb hauv kev txhim kho cov tshuaj muaj kev hloov tshuaj tau. Raws li kev lag luam kev lag luam txuas ntxiv mus evolve, lub luag haujlwm ntawm HPMC yuav nthuav dav, tsav los ntawm kev tshawb fawb tsis tu ncua thiab kev txhim kho cov tshuaj zoo thiab cov txiaj ntsig tus neeg mob.
Lub Sijhawm Post: Jun-05-2024