HydroxyPropyl cellulose, ib qho kev zam uas muaj kev zam, tau muab faib ua cov khoom siv hydroxypropyl (L-HPC) thiab siab hloov hydropropyl L-hpc swells rau hauv kev daws teeb meem colloidal hauv dej, muaj cov khoom ua yeeb yaj kiab, zaj duab xis, emulsification, thiab feem ntau yog siv los ua tus sawv cev tsis sib xws; Thaum H-HPC yog soluble hauv dej thiab ntau yam kev daws teeb meem ntawm chav tsev kub, thiab muaj qhov zoo thermoplastic. , coheseness thiab zaj duab xis tsim cov khoom, cov yeeb yaj kiab tsim yog qhov nyuaj, thiab tag nrho cov khoom siv ua yeeb yaj kiab thiab txheej txheej. Cov ntaub ntawv tshwj xeeb ntawm hydroxypropyl cellulose hauv kev npaj khoom hauv cov khoom npaj yog tam sim no qhia.
1. Raws li kev ua txhaum rau cov khoom npaj xws li ntsiav tshuaj
Cov nplaim uas tsis muaj nqi hydroxyprropyl cellulose c cellulose crystalline hais yog qhov tsis ncaj, nrog cov huab cua zoo nkauj-xws li qauv. Qhov chaw ntxhib hluav taws no tsis tsuas yog ua rau nws muaj cov ntsiav tshuaj loj dua, tab sis kuj ua ke nrog cov tshuaj ntsiav tshuaj, yog li ntawd cov ntsiav tshuaj tseem ceeb tuaj yeem nce cov dej noo Kev nqus tus nqi thiab cov dej nqus dej nce siab o. Kev sivL-hpcRaws li kev zam tuaj yeem ua rau cov ntsiav tshuaj sai sai tawg rau hauv cov hmoov tsis zoo, thiab ua kom muaj kev sib cav sib ceg, kev sib cais thiab cov kab mob ntawm cov ntsiav tshuaj. Piv txwv li, kev siv L-HPC tuaj yeem kho cov tshuaj Paracetamol, cov ntsiav tshuaj uas cov tshuaj aspirinin, thiab ua kom muaj cov ntsiav tshuaj sib cais. Kev ua kom tawg thiab kev sib cais ntawm cov tshuaj tsis zoo xws li L-HPC uas yog PvPP, hla kev sib txuas nrog CMC-NA thiab CMS-NA AS FORTGRANT. Siv L-HPC raws li kev ua txhaum sab hauv ntawm cov tsiav tshuaj muaj txiaj ntsig ntawm cov yeeb tshuaj thiab cov kev sib chwv ntawm cov tshuaj, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais, thiab txhim kho cov tshuaj sib cais ntawm cov xyoob ntoo. Kev npaj cov khoom npaj tam sim ntawd los ntawm kev npaj cov khoom npaj thiab nrawm, txo qis kev ua tiav, thiab yooj yim coj thiab muaj kev ua raws zoo. thiab lwm yam zoo, nyob ib txoj haujlwm tseem ceeb hauv lub tsev muag tshuaj. L-HPC tau dhau los ua ib qho tseem ceeb tshaj plaws rau kev tso dej tam sim vim nws muaj zog hydrophilicity ceev ceev ceev, thiab dej nrawm kev nqus tau. Nws yog ib qho kev ua txhaum zoo tshaj plaws rau kev sib cais ua kom pom tseeb. Paracetamol tshuaj tua kab mob tau npaj nrog L-HPC raws li kev ua txhaum, thiab cov ntsiav tshuaj ua kom nrawm nrawm tsis pub dhau 20s. L-HPC yog siv los ua tus tsis muaj kev tsis sib haum rau cov ntsiav tshuaj, thiab nws cov kev tshuaj feem ntau yog 2% rau 10%, feem ntau, feem ntau, feem ntau yog 5%.
2. Raws li phau ntawv npaj xws li ntsiav tshuaj thiab cov granules
Cov qauv ntxhib ntawm L-HPC kuj ua rau nws muaj kev ua yeeb yam ntau dua rau cov tshuaj thiab cov lus, uas nce qib kev cohesion, thiab muaj qhov zoo compression moulding. Tom qab tau nias rau hauv cov ntsiav tshuaj, nws qhia ntau hardness thiab ci, yog li txhim kho qhov zoo ntawm cov ntsiav tshuaj lub ntsej muag. Tshwj xeeb tshaj yog rau cov ntsiav tshuaj uas tsis yooj yim rau daim ntawv, xoob lossis yooj yim los yog yooj yim rau unplover, ntxiv l-hpc tuaj yeem txhim kho cov nyhuv. Cov Ciprofloxacin hydrochloride ntsiav tshuaj muaj kev sib cais tsis zoo, nrog cov tawv ncauj haum, thiab nws yog qhov yooj yim, thiab nws tau yooj yim ua tau raws cov qauv kev ua tau zoo. Tom qab ntxiv l-hPC rau hauv cov ntsiav tshuaj dispersible, nws cov tsos, friability, kev tsis sib xws thiab lwm yam kev txhim kho tau zoo thiab txhim kho. Tom qab cov hmoov txhuv nplej siab nyob rau hauv cov ntawv sau tseg tau hloov los ntawm L-HPC, qhov kev ua kom tiav ntawm cov ntsiav tshuaj ploj thiab lwj ntawm cov ntsiav tshuaj ntawm lub qub ntsiav tshuaj tau daws. L-HPC yog siv los ua cov phau ntawv rau cov ntsiav tshuaj, thiab cov kev tshuaj ntau yog 5% rau 20%; Thaum H-HPC yog siv los ua cov phau ntawv rau cov ntsiav tshuaj, granules, thiab lwm yam, thiab cov kev ntsuas tshuaj yog 1% rau 5% ntawm kev npaj.
3. Daim ntawv thov hauv zaj duab xis txheej thiab txhawb nqa thiab tswj tso kev npaj
Ntawm tam sim no, dej-soluble cov ntaub ntawv feem ntau siv nyob rau hauv zaj duab xis muaj xws li hydroxyprropencellulose, polyethylene glycol (pygethylene glycol (peg) thiab lwm yam. HydroxyPropyl cellulose feem ntau yog siv los ua zaj duab xis-ua tus neeg sawv cev hauv zaj duab xis ntawm cov khoom siv ua ntej tshaj tawm vim nws tawv thiab ci ntsa iab. Yog tias hydroxyprropyl cellulose yog tov nrog lwm cov neeg ua kom txias-tiv taus txheej xim, kev ua tau zoo ntawm nws cov txheej tuaj yeem txhim kho ntxiv.
Siv cov tshuaj uas tsim nyog kom ua rau cov tshuaj ua cov ntsiav tshuaj, muaj cov ntsiav tshuaj qeeb thiab cov tshuaj tsis muaj zog, ua kom muaj kev nqus cov tshuaj kom qeeb thiab ruaj khov tshuaj nyob hauv cov ntshav. Cov kev xav, txo cov tshuaj tiv thaiv kom tsawg, txo cov tshuaj, thiab siv zog ua kom zoo tshaj plaws nrog cov tshuaj tsawg tshaj plaws, thiab txo cov kev cuam tshuam tsawg tshaj plaws. HydroxyPropyl cellulose yog ib qho ntawm cov kev zam ntawm cov kev npaj zoo li no. Kev sib cais thiab tso tawm ntawm Diclofenac Sodium ntsiav tshuaj yog tswj hwm los ntawm kev siv hydroxyprropyl cellulose thiab cov khoom siv Ethylropropyl thiab cov khoom siv tshuaj tiv thaiv kab mob thiab pob txha sib koom ua ke. Tom qab cov thawj coj ntawm qhov ncauj thiab tiv tauj nrog cov kua txiv plab zom mov, cov nplaim dicofenac sodium kev tawm ntawm cov ntsiav tshuaj yuav yog cov ntsiav tshuaj tawm mus rau hauv ib gel. Los ntawm kev sib cais ntawm cov gel thiab qhov sib txawv ntawm cov tshuaj molecules hauv gel sib txawv, lub hom phiaj tso tawm tshuaj molecules tau tiav. HydroxyPropyl cellulose yog siv los ua cov tswj-tso tawm matrix, thaum cov ntsiab lus ntawm cov tshuaj uas muaj kev tso tawm, thiab cov tshuaj los ntawm cov ntsiav tshuaj nrog cov ntsiab lus siab dua ntawm hydroxypropyl cellulose tso tawm yog qeeb. Cov coated pellets tau npaj los ntawm kev sivL-hpcthiab ib qho kev faib ua feem ntawm HPMC ua cov txheej txheej rau txheej ua cov txheej o-tso tawm rau txheej Ethylulose aqueous dispersion. Thaum qhov o txheej txheej tshuaj noj tshuaj thiab noj yog tsau, los ntawm kev tswj cov tuab ntawm cov txheej txheem tso tawm, cov coated pellets tuaj yeem tso tawm ntawm qhov kev xav txawv ntawm lub sijhawm. Ob peb hom coated pellets nrog qhov sib txawv ntawm qhov sib txawv ntawm cov tswj kev tso tawm txheej yog sib xyaw ua ke los ua shuxiong kev siv tshuaj ntsiav. Nyob rau hauv kev sib cais nruab nrab, ntau coated pellets tuaj yeem tso tshuaj ua ntu zus nyob rau lub sijhawm sib txawv thiab tshuaj lom neeg sib txawv tau ua tiav tib lub sijhawm raws li kev tso tawm sai
Lub Sijhawm Post: Apr-25-2024