Daim ntawv thov ntawm HydroxyPropyyl methylcellose (HPMC) raws li lub chaw muag tshuaj saib xyuas

1. Physicochemical cov khoom ntawm HPMC

HPMC yog cov khoom siv hluavtaws semi-hluav taws xob polymer tau los ntawm methylating thiab hydroxyping cov cellulropy, nrog rau cov dej solubility zoo nkauj thiab biocompatibility. Nws cov solubility yog tsawg dua kev cuam tshuam los ntawm qhov kub thiab nws tuaj yeem o hauv dej los ua cov tshuaj uas khov, uas pab tswj cov tshuaj yeeb tshuaj. Raws li qhov viscosity, HPMC tuaj yeem muab faib ua peb pawg: cov mposposity tsis muaj zog (100-4000 tus txiv neej siab), 4000-100000 mpa ·, uas haum rau Qhov kev npaj sib txawv yuav tsum tau ua.

2. Daim Ntawv Thov HPMC hauv Kev Npaj Ua Lag Luam

2.1 Daim ntawv thov hauv cov ntsiav tshuaj
HPMC tuaj yeem siv los ua cov phau ntawv, tsis sib haum, txheej khoom thiab tswj-tso cov khoom siv pob txha pob txha hauv cov ntsiav tshuaj.
Phau Ntawv:HPMC tuaj yeem siv los ua phau ntawv hauv ntub cov granulation ntub los yog cov granulation qhuav los txhim kho cov particle, ntsiav tshuaj nyuaj thiab siv tshuaj.
Dismintegrant:Low-viscos tuaj yeem siv los ua kev tsis sib xws los txhawb cov ntsiav tshuaj tua tsis taus thiab nce cov tshuaj dissolution ntxiv tom qab o tuaj yeem vim qhov dej nqus.
Cov Khoom Siv Txheej Txheej:HPMC yog ib qho ntawm cov ntaub ntawv tseem ceeb rau cov tshuaj ntsiav, npog tau cov tshuaj phem, thiab tuaj yeem siv rau hauv cov txheej txheem nkag los yog zaj duab xis.
Cov ntaub ntawv tso tawm tawm: High-viscosity HPMC tuaj yeem siv los ua cov khoom siv cev pob txha kom ncua kev tso tawm thiab ua tiav kev tso tawm. Piv txwv li, HPMC K4M, HPMC K15M thiab HPMC K100M feem ntau tau siv los npaj cov ntsiav tshuaj tswj.

2.2 thov hauv tshuaj ntsiav npaj npaj
HPMC tuaj yeem siv los tsim cov tsoom tshuaj hollow los hloov cov tshuaj ntsuab thiab cov neeg muaj kev ua xua rau cov tsiaj txhu tsiaj. Tsis tas li ntawd, HPMC tuaj yeem siv rau kev sau ua kua lossis cov ntsiav tshuaj semisolid txhawm rau txhim kho kev ruaj khov thiab tso cov yam ntxwv ntawm cov tshuaj.

2.3 daim ntawv thov hauv Ophthalmic npaj
HPMC, raws li lub ntsiab tiv thaiv ntawm cov kua muag dag zoo, tuaj yeem ua kom lub sijhawm viscosity ntawm cov tshuaj nyob rau hauv cov tshuaj ntawm qhov chaw ntawm cov yeeb tshuaj ntawm thaj chaw, thiab txhim kho Bioavailability. Tsis tas li ntawd, HPMC kuj tseem siv tau los npaj cov yeeb yaj kiab qhov muag, thiab lwm yam, txhawm rau txhim kho cov khoom siv tau txais cov qhov muag.

2.4 Daim ntawv thov nyob rau hauv kev xa tshuaj
Kev ntxhov siab ® RHPMC muaj cov yeeb yaj kiab zoo-tsim cov khoom thiab biocompatibility, thiab tuaj yeem siv los npaj thaj ua rau thaj chaw hloov chaw, cov kua nplaum thiab cream. Piv txwv li, hauv kev hloov tshuaj Transdermal, HPMC tuaj yeem siv los ua cov khoom sib npaug los ua kom cov tshuaj nkag mus rau kev nqis tes ua.