Cov tub ntxhais muaj feem nyob hauv tsev thiab txawv txav hauv kev npaj hydroxypropulose, tshuaj lom thiab muab tso tawm kev npaj, thiab npaj txhij txhua, gelatin qhov tseeb Cov ntawv thov hauv thaj chaw ntawm cov qauv tshiab xws li cov qauv nplaum thiab cov roj biadhesives. Vim tias qhov sib txawv hauv tus txheeb ze molecular hnyav thiab pencosity ntawm tus yam ntxwv thiab cov tshuaj nplaum, thickening, kev ncua, kev tshaj tawm, kev ua yeeb yam thiab yeeb yaj kiab-ua yeeb yaj kiab. Nws yog dav siv hauv cov chaw npaj khoom thiab yuav ua lub luag haujlwm zoo dua qub hauv kev npaj. Nrog rau kev kawm tob ntawm nws cov khoom thiab kev txhim kho ntawm cov qauv kev tshawb fawb thiab cov khoom siv tshuaj tshiab, yog li txhawb kev txhim kho kev ua lag luam tshiab.
HydroxyPropyyl Methylcellulose; Kws npaj ua tshuaj; Kws tsim kho cov tshuaj.
Kws Tshuaj Ntsuam Xyuas tsis yog tsuas yog cov txheej txheem kev npaj tshuaj ua kom muaj kev npaj tshuaj, tab sis kuj muaj kev nyab xeeb ntawm kev npaj tshuaj ua kom zoo, hom kev ua yeeb yam, kev ua tau tshuaj kho mob, thiab kev txhim kho tshiab Muab cov ntawv thiab cov kev coj noj coj ua tshiab. Hais txog. Qhov tshwm sim ntawm cov khoom siv tshiab uas txhawb tau feem ntau txhawb txoj kev txhim kho ntawm kev npaj ua tau zoo thiab kev txhim kho cov ntaub ntawv tshiab. HydroxyPropyyl methylcellueculose (HPMC) yog ib qho ntawm cov tshuaj uas muaj kev nyiam hauv tsev thiab txawv teb chaws. Vim nws cov txheeb ze sib txheeb thiab viscosity, nws muaj cov haujlwm ntawm emulsifying, thickening, thickening, thickening, thiab kua nplaum. Nta thiab siv xws li kev sib xyum thiab zaj duab xis yog siv dav hauv cov tshuaj thev naus laus zis. Kab lus no feem ntau tshuaj xyuas daim ntawv thov ntawm hydroxypropyl methylulose (HPMC) hauv cov qauv nyob rau xyoo tas los no.
1.Cov Khoom Yooj Yim ntawm HPMC
HydroxyPropy cellulose (HPMC), cov qauv molecular yog li ntawm cov methyl thiab ib feem ntawm methyl thiab ib feem ntawm polyhydroxypropy ether ntawm cellulose. Nws tuaj yeem tsim nyob rau hauv ob txoj kev: ib qho yog cov qib methyl ntawm ib qib tsim nyog tau kho nrog propylene oxide hauv qab kub thiab siab siab. The reaction time must last long enough to allow the methyl and hydroxypropyl to form ether bonds It is connected to the anhydroglucose ring of cellulose in the form of cellulose, and can reach the desired degree; Lwm tus yog kho cov paj rwb linter lossis ntoo pulp fiber nrog caustic dej qab zib, thiab tom qab ntawd tshuaj pleev cov tshuaj me, thiab tom qab ntawd ntxiv rau nws. , crushed rau hauv nplua thiab hnav khaub ncaws hmoov los yog granules.
Cov xim ntawm cov khoom no yog dawb rau milky dawb, tsw thiab tsis muaj qab hau, thiab daim ntawv yog granular lossis fibrous yooj yim-ntws hmoov. Cov khoom no tuaj yeem tawm hauv dej los ua kom pom tseeb rau milky dawb colloidal tov nrog qee yam viscosity. Lub sol-gel interconversion kawg tshwm sim tuaj yeem tshwm sim vim qhov ntsuas kub hloov ntawm kev daws nrog qee qhov kev xav tau.
Vim tias qhov sib txawv hauv cov ntsiab lus ntawm ob tus qauv ntawm cov methoxy thiab hydroxypropyl, ntau hom khoom tau tshwm sim. Hauv kev sib txawv, ntau hom khoom muaj cov yam ntxwv tshwj xeeb. Viscosity thiab thermal gelation kub, yog li muaj cov khoom sib txawv thiab tuaj yeem siv rau cov laj thawj sib txawv. Pharmacopoeia ntawm ntau lub teb chaws muaj cov kev cai sib txawv thiab cov kev sawv cev ntawm cov khoom lag luam sib txawv ntawm cov lej, thiab chav ntsuas yog "mpa s ". Nyob rau hauv Asmeskas Pharmacopoeia, 4 tus lej yog ntxiv tom qab lub npe tseem ceeb los qhia cov ntsiab lus ntawm hydroxyprescellulose 2208. Tus thawj ob tus nqi sawv cev rau cov neeg kwv yees ntawm pawg methoxy. Feem pua, ob tus lej kawg sawv cev rau kev kwv yees feem pua ntawm hydroxypropyl.
Calocan lub hydroxypropylencellulose muaj 3 series, namely e series, f series thiab K series, txhua series muaj ntau yam qauv xaiv los ntawm. E koob tshuaj no feem ntau yog siv ua cov yeeb yaj kiab ua yeeb yaj kiab, siv rau cov ntsiav tshuaj txheej, kaw cov ntsiav tshuaj cores; E, F series yog siv los ua viscosifiers thiab tso cov neeg sawv cev retarding, txo qis cov neeg sawv ntxov, cov tshuaj lom muag rau kev npaj kua, ntsiav tshuaj thiab cov khoom siv sib tsoo; K series tau siv feem ntau siv los ua cov khoom tso tawm thiab hydrophilic gel Matrix cov khoom kom qeeb thiab tswj tso kev npaj.
Cov chaw tsim tshuaj hauv tsev tsuas yog suav nrog Fuzhou No. 2 Lub Hoobkas Tshuaj lom neeg thiab tshuaj lom neeg cov tshuaj Co. Cov., Ltd., Xi'an Huian cov nroj tsuag tshuaj, thiab lwm yam.
2.Qhov zoo ntawm HPMC
HPMC tau dhau los ua ib qho ntawm feem ntau cov tshuaj uas muaj kev cia siab nyob hauv tsev thiab txawv teb chaws, vim tias HPMC muaj qhov zoo uas tsis muaj kev cia siab.
2.1 Cov Dej Txias Dej
Soluble hauv dej txias hauv qab 40 ℃ lossis 70% ethanol, hauv paus insoluble hauv dej kub saum 60 ℃, tab sis tuaj yeem gel.
2.2 Tshuaj nyob rau hauv
HPMC yog hom tsis muaj uj-ionic cellulose, nws txoj kev daws tsis tau them tus nqi, yog li lwm yam kev txiav txim siab tsis muaj kev cuam tshuam nrog nws thaum lub sijhawm npaj khoom.
2.3 ruaj khov
Nws yog qhov sib luag rau ob qho tib si qaub thiab alkali, thiab tuaj yeem khaws cia ntev li ntawm PH 3 thiab 11 yam tsis muaj kev hloov pauv tseem ceeb hauv viscosposity. Cov tshuaj aqueous ntawm HPMC muaj cov nyhuv anti-mildew effect thiab tswj cov viscosity zoo thaum lub sij hawm ntev cia. Cov tshuaj uas tau siv tshuaj siv HPMC muaj cov khoom ruaj khov zoo dua li cov uas siv cov khoom siv tshuaj lom neeg (xws li Dextrin, cov hmoov txhuv nplej siab, thiab lwm yam).
2.4 Viscosity Adjusability
Qhov sib txawv viscosity ntawm HPMC tuaj yeem sib xyaw ua ke, thiab nws txoj cai viscosity, thiab muaj kev sib txheeb tau zoo, yog li kev sib koom ua feem yuav raug xaiv raws li qhov xav tau.
2.5 metabolic inertness
HPMC tsis nqus tau lossis metabolized nyob rau hauv lub cev, thiab tsis muab cua sov, yog li nws yog ib qho kev nyab xeeb kev ua lag luam kev ua lag luam. 2.6 Kev nyab xeeb nws yog feem ntau suav tias HPMC yog cov tshuaj uas tsis muaj tshuaj lom rau nas 5, thiab cov tshuaj tsis sib xws rau nas yog 5. 2 GG - 1. Cov koob tshuaj txhua hnub yog tsis muaj mob rau tib neeg lub cev.
3.Daim ntawv thov HPMC hauv cov qauv
3.1 Raws li zaj duab xis txheej khoom thiab zaj duab xis-ua cov khoom siv
Siv HPMC ua cov ntsiav tshuaj ua yeeb yam, cov ntsiav tshuaj coated hauv cov ntsiav tshuaj thiab cov tsos piv rau cov ntsiav tshuaj uas muaj suab thaj, noo noo, noo noo, ua kom muaj kev sib cais. , txheej ceeb thawj nce thiab lwm yam ntsuas zoo tau zoo dua. Cov khoom lag luam qis-viscosity yog siv los ua cov khoom siv ua yeeb yaj kiab rau cov ntsiav tshuaj %.
Zhang jixing li al. Siv cov nyhuv cov txheej txheem saum npoo los kom ua kom zoo tshaj plaws ntawm cov txheej txheem HPXC nrog HPMC raws li zaj duab xis txheej. Noj cov lus qhia ua yeeb yaj kiab HPMC, tus nqi ntawm polyvinyl cawv thiab cov yas ntawm cov duab ua yeeb yaj kiab yog qhov kev soj ntsuam qhov ntsuas, thiab kev sib raug zoo ntawm kev kuaj xyuas Performance index thiab cov qauv tshuaj xyuas tau piav qhia los ntawm cov qauv lej, thiab cov txheej txheem txheej txheem kev ua kom zoo tshaj plaws yog thaum kawg tau txais. Nws tau noj tau yog kev ua yeeb yaj kiab forming hydroxypropylence 24.12 g, yas polycolulose (HPMCY5) 11.00 g, lub zog ntawm cov yeeb yaj kiab ntawm zaj duab xis tau txog qhov zoo tshaj plaws Cov. Zhang Yuan txhim kho cov txheej txheem npaj npaj, siv HPMC ua cov ntsiav tshuaj ua kom zoo nkauj, thiab hloov pauv Jargeescopicity, thiab hloov kho cov khoom siv xoob, cais tawm thiab lwm yam teeb meem, txhim kho lub ntsiav tshuaj ruaj khov. Cov txheej txheem txheej txheem txheej txheem zoo tshaj plaws tau txiav txim siab los ntawm kev sim Orthoogonal yog 20% ethanol hauv txheej, thiab lub sijhawm cuam tshuam thaum lub sij hawm granulation yog 15 min. Cov txiaj ntsig ntawm JIKUA Film-Coated ntsiav tshuaj tau npaj los ntawm cov txheej txheem tshiab, thiab cov qauv tsim nyog ntawm cov ntsiav tshuaj-coated ntsiav tshuaj tau zoo heev. Mus cuag ntau tshaj 95%. Liang Meiyi, Lu Xiaohui, thiab lwm yam. Kuj tseem siv hydroxypropylulose li cov matina-shoing khoom siv ntsiav tshuaj thiab txoj hnyuv hnyuv rayinging ntsiav tshuaj, feem. cuam tshuam tshuaj tso tawm. Huang Yunran npaj zaj nyiaj txhiv hlab ntshav, thiab siv HPMC mus rau txheej txheej o o offing txheej, thiab nws pawg feem ntau feem yog 5%. Nws tuaj yeem pom tau tias HPMC tuaj yeem siv dav siv hauv kev xa tshuaj tawm sab hnyuv.
HydroxyPropyyl methylulose tsis yog tsuas yog cov khoom siv txheej ua yeeb yaj kiab zoo heev, tab sis kuj tuaj yeem siv ua zaj duab xis-tsim cov khoom hauv zaj duab xis. Wang Tongshun thiab lwm yam tau zoo rau cov tshuaj uas muaj qhov sib txuas lus, kom tau txais kev ntsuas ntawm zaj duab xis, kom tau txais kev ntsuas ntawm zaj duab xis, kom zoo saib cov tshuaj lom neeg yog PVA 6.5 G, HPMC 0.1 G thiab 6.0 g thiab 6.0 g thiab 6.0 g Propylene Glycol ua tau ntawm cov cai tso qeeb thiab kev nyab xeeb, thiab tuaj yeem siv los ua kev npaj tshuaj ntawm cov yeeb yaj kiab sib xyaw.
3.2 raws li phau ntawv thiab ua txhaum
Qeb qis viscosity ntawm cov khoom lag luam no tuaj yeem siv los ua cov phau ntawv, ntsiav tshuaj yuav tsuas yog siv los ua phau ntawv. Cov tshuaj yaug sib txawv nrog cov qauv sib txawv thiab cov cai. Feem ntau, cov koob tshuaj ntawm binder rau cov ntsiav tshuaj granulation qhuav yog 5%, thiab cov koob tshuaj ntawm phau ntawv rau cov ntsiav tshuaj ntub cov ntsiav tshuaj yog 2%.
Li houtao et al tshuaj ntsuam lub rooj zaum ntawm cov ntsiav tshuaj tinidazole. 8% polyvinylprolidine (PVP-K30), 40% Earch Slurry, 2.0% ethancher tau tshawb xyuas raws li cov nplaum ntawm tinidazole ntsiav tshuaj nyob rau hauv lem. Kev npaj ntawm cov ntsiav tshuaj tinidazole. Cov tsos hloov ntawm cov ntsiav tshuaj dawb thiab tom qab txheej tau muab piv, thiab lub siab tawv, tawv tawv ntawm cov ntsiav tshuaj sib txawv tau raug ntsuas. Cov txiaj ntsig tau muab cov ntsiav tshuaj tau npaj los ntawm 2.0% Kev Ntsuas Hluav Taws Xob Methlropyl Yog li ntawd, cov ntsiav tshuaj tinidazole npaj nrog 2.0% hpmc-k4 thiab 50% ethanol li binders tau siv. Guaran shiha kawm cov txheej txheem tsim qauv ntawm fuganning ntsiav tshuaj, tshuaj ntsuam cov kev daws teeb meem nrog kev ntsuas, du, thiab ua kom muaj kev ntxhov siab ua cov ntsuas ntsuas. , 5% cmc-na thiab 15% hpmc tov (5 mpa s). Cov txiaj ntsig tau cov nplooj ntawv npaj los ntawm 50% ETANCE Paste, 10% PVP 50% CMC-NA muaj ib qho kev nruj me me thiab tsis muaj zog, uas tsis tuaj yeem ua tau raws li cov kev xav tau ntawm cov txheej txheem ntawm cov kev xav tau ntawm cov kev xav tau ntawm cov txheej txheem; 15% kev daws teeb meem HPMC (5 MPH ntawm cov ntsiav tshuaj yog tus uas muaj kev sib cav, thiab cov kev siv tau zoo, uas tuaj yeem ua tau zoo ntawm cov txheej txheem. Yog li ntawd, HPMC (5 MPA S) tau raug xaiv ua cov nplaum.
3.3 Raws li cov neeg sawv cev
Lub siab-viscosity qib ntawm cov khoom lag luam no yog siv los ua qhov kev ncua tus neeg sawv cev los npaj kev ua kua tsis raug ncua. Nws muaj cov txiaj ntsig zoo tau txais, yog qhov yooj yim rau redisperse, tsis lo rau phab ntsa, thiab muaj cov flocculation zoo tshaj. Cov tshuaj npaum li ib txwm yog 0.5% txog 1.5%. Nkauj Tian et al. Siv cov khoom siv polymer (hydroxypropylulose, sodium carboxymelencellulose, thiab lwm yam) raws li cov neeg sawv cev los npaj cov neeg sawv cev. kev ncua kev kawm kom qhuav. Los ntawm cov sedimentation ntim sib piv ntawm cov kev ncua sib txawv, ncua kev ntseeg, thiab kev ruaj ntseg morpority tau pom, thiab qhov kev ruaj ntseg morphology tau pom, thiab kev ruaj ntseg ntawm cov tshuaj hais hauv qab sai tau tseem kawm tau sai. Cov txiaj ntsig kev tshem tawm kom qhuav nrog 2% HPMC raws li cov neeg sawv cev tau muaj cov txheej txheem yooj yim thiab ruaj khov.
Piv nrog methyl cellulose, hydroxypropyl cellulose muaj, yog li HPMC tseem siv tau siv raws li kev ncua tus neeg sawv cev hauv Ophthalmic npaj. Liu Jie li al. siv hpmc, hydroxypropyl cellulose (HPB), carbomer 940, sodium fantication, sedimeylene glycol (sedimelation ntim piv, particle loj thiab rov ua dua Puas tau xaiv raws li kev kuaj xyuas cov ntsuas kuaj kom ntsuas qhov muag pom zoo tshaj plaws. Cov txiaj ntsig tau qhia tias ACYCLOVIR kev tshem tawm npaj tau los ntawm 0.05% his thiab 0.998 yog cov khoom siv tsis txaus siab, qhov kev npaj ua kom zoo nkauj yog qhov sib deev ruaj khov.
3.4 Ua lub blocker, qeeb thiab tswj tso tawm cov neeg sawv cev thiab tus neeg saib xyuas tus neeg sawv cev
Lub siab-viscosity qib ntawm cov khoom lag luam no yog siv rau kev npaj ntawm hydrix tso tawm cov ntsiav tshuaj-tso cov ntsiav tshuaj, thiab muaj cov txiaj ntsig ntawm kev ncua yeeb tshuaj. Nws txoj kev xav yog 10% rau 80%. Cov qib qis-viscosity yog siv los ua cov porogens rau kev tso tawm-tso tawm lossis muab tso tawm-tso tawm. Qhov pib koob tshuaj yuav tsum muaj rau kev kho cov nyhuv ntawm cov ntsiav tshuaj no tuaj yeem raug tshem tawm sai, thiab cov tshuaj lom neeg ua kom zoo yog tswj hwm hauv lub cev. Cov. HydroxyPropyyl methylulose yog hydrated los ua cov txheej gel thaum nws ua tau dej. Lub tshuab ntawm cov tshuaj tso tawm los ntawm cov ntsiav tshuaj tawm los ntawm cov ntsiav tshuaj matrix feem ntau yog cov diffusion ntawm gel txheej thiab kev yaig ntawm cov gel txheej. Jung Bo Shim thiab ib qho npaj cov ntsiav tshuaj uas muaj HPMC raws li HPMC raws li cov khoom siv tawm-tso tawm.
HydroxyPropy muag methylcellulose tseem dav siv nyob rau hauv cov tshuaj muaj tshuaj lom neeg, thiab feem ntau ntawm cov khoom xyaw ua haujlwm, muaj txiaj ntsig ntawm cov tshuaj suav ib txwm siv. Liu wen li al. Siv 15% HydroxyPropyyl methylulose li cov khoom siv matrix, 1% cov lactose thiab 5% microcrystalline decoction rau hauv qhov ncauj txhais tau-tso cov ntsiav tshuaj. Tus qauv yog Higuchi kab zauv. Cov mis ua kom haum mis yog qhov yooj yim, kev npaj yooj yim, thiab cov ntaub ntawv tso tawm yog qhov ruaj khov, uas ua tau raws li cov kev cai ntawm lub ntsej muag suav cov tshuaj. Tang Loosanguang li al. Siv tag nrho Saponins ntawm Astragalus ua qauv tshuaj, npaj HPMC Matrix cov tshuaj tso tawm los ntawm cov tshuaj suav hauv HPMC Matrix ntsiav tshuaj. Qhov tshwm sim raws li cov tshuaj ntawm HPMC nce, tso tawm cov feem pua ntawm Astragaloside txo qis nrog kev sib raug zoo ntawm kev sib cais ntawm cov lej. Nyob rau hauv hypromellose hpmc matrix ntsiav tshuaj, muaj ib qho kev sib raug zoo ntawm kev tso tawm tshuaj thiab cov txheej txheem HOLMC, thiab cov tshuaj tso tawm ntawm Hydrophilic zoo ib yam li nws. HydroxyPropyyl methylulose tsis yog tsuas yog tsim nyog rau hydrophilic tebchaw, tab sis kuj rau cov tshuaj tsis-hydrophilic. Liu Guihua siv 17% HydroxyPropyyl methylcellose (hpmckellulose (thiab npaj tianshan xellets-tso matrix satully granullices thiab cov ntsiav tshuaj txoj kev. Cov nyhuv-tso tawm tau pom tseeb, thiab cov txheej txheem npaj tau ruaj khov thiab ua tau.
HydroxyPropyyl methylcellulose tsis yog siv rau cov tshuaj tiv thaiv kev ua kom nquag plias thiab muaj ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab ntau dua thiab siv ntau ntxiv Wu huichao thiab al. Siv 20% HydroxyPropy Cellulose (HPMck4m) raws li cov hmoov ncaj qha txoj kev los npaj cov ntsiav tshuaj ncaj qha uas tuaj yeem tso cov tshuaj tsis tu ncua thiab stably rau 12 teev. Saponin RG1, Ginsenoside RB1 thiab Panax Unitedinseng Saponin R1 tau raug siv los soj ntsuam kev tso tawm hauv vitro, thiab cov tshuaj ntsuam xyuas yeeb tshuaj thiab muab cov yeeb tshuaj tso tawm tau ntsuas qhov kev tso yeeb tshuaj tawm ntawm kev tso yeeb. Ua kom cov tshuaj ried regchismed txheej txheem rau lub xoom-peppas sib npaug, thiab peb feem ntawm cov neeg tsis muaj popax
3.5 Cov kua nplaum tiv thaiv kom tuab thiab colloid
Thaum cov khoom lag luam no tau siv los ua cov tuab dua, feem pua sib npaug yog 0.45% rau 1.0%. Nws kuj tseem tuaj yeem nce kev ruaj khov ntawm hydrophobic kua nplaum, tiv thaiv cov lus ntawm couriding thiab agglomerating, yog li inhibiting tsim kev tsim ntawm cov khoom. Nws feem pua feem pua feem ntau yog 0.5% rau 1.5%.
Wang Zhen li al. Siv L9 Orthoogen kev tsim qauv los tshawb xyuas cov txheej txheem npaj ntawm cov tshuaj ua haujlwm carbon enema. Cov txheej txheem zoo rau kev txiav txim siab zaum kawg ntawm cov pa roj carbon awben) yog siv 0.5% methoxyl pawg methoxylulose (hydroxylulose cellulopSxylulose ruaj khov ntawm cov tshuaj ntsuab ua rau cov pa roj carbon. Zhang Zhiqiang li al. Tsim cov Ph-rhiab levoflledfoxacin hydrothloride ophthalmic npaj txhij, siv carbopol raws li cov khoom siv gel nrog cov melrix thiab hydroxypropylulose li cov neeg sawv cev tuab. Kev Pom Zoo Tshaj Los ntawm kev sim, thaum kawg tau txais cov tshuaj zoo nkauj yog 0.1 G, PhosTrium Dihylulose 045 g ntawm sohydrogen, 0.50 g ntawm sodium chloride , 0.03 g ntawm ethyl paraben, thiab dej tau ntxiv los ua 100 ml. Hauv kev sim, tus kws sau tshuaj ntsuam lub hydroxyprropylulose methylcellulose cov tshuaj xees (K4M, E -4L) los npaj cov kev sib txawv, thiab cov txiaj ntsig xaiv HPMC E50 LV li cov tuab. Thickener rau ph-rhiab levofloxacin hydrochloride Instant Gels.
3.6 raws li cov tshuaj capsule cov khoom
Feem ntau, cov ntsiav tshuaj plhaub cov ntaub ntawv ntawm cov ntsiav tshuaj yog feem ntau gelatin. Cov txheej txheem capsule yog yooj yim, tab sis muaj qee qhov teeb meem thiab kev tiv thaiv oxygen xws li cov tshuaj tiv thaiv kab mob thaum lub sij hawm cia. Yog li ntawd, hydroxypropyl methylcellulose yog siv los hloov chaw rau cov tshuaj ntsiav, uas txhim kho cov nyhuv ntawm cov ntsiav tshuaj tsim nyog thiab cov nyhuv siv, thiab tau tshaj tawm hauv tsev thiab txawv teb chaws.
Siv theopylline raws li kev tswj tshuaj, podczeck li al. Pom tias cov tshuaj dissolution tus nqi ntawm cov ntsiav tshuaj nrog hydroxypropyl methyllopulose zoo tshaj li ntawm gelatin captules. Qhov laj thawj rau kev tsom xam ntawm HPMC yog kev sib tawg ntawm tag nrho cov tshuaj tsw qab yog qhov kev sib tsoo ntawm cov qauv network ua ntej, thiab tom qab ntawd lub zog ntawm tag nrho cov tshuaj tsw qab, yog li tus HPMC tshuaj ntsiav yog ntau haum rau cov tshuaj ntsiav rau cov khauj khaum rau cov yeeb yaj kiab tam sim ntawd. Chiwele li al. Kuj tau txais cov lus xaus zoo sib xws thiab muab piv rau kev sib cais ntawm cov kua qaub, gelatin / polyethylene glycol thiab hpmc zoo li. Cov txiaj ntsig tau pom tias HPMC shells tau ntiab tawm sai heev nyob rau hauv PH cov kev mob sib txawv, thaum cov txiv qaub msatin tsiav tshuaj nws tau cuam tshuam ntau heev los ntawm cov hom pH sib txawv. Tang Yue li al. Ntsuam xyuas ib hom tshuaj ntsiav tshiab rau cov tshuaj qau tsis muaj tshuaj ntub dej qhuav qhuav hmoov tshuaj tiv thaiv kab mob. Piv nrog cov tshuaj ntsiav hniav ntawm hydroxypropylulose thiab cov ntsiav tshuaj ntawm cov ntsiav hmoov ntawm lub plhaub nyob rau hauv lub plhaub nyob rau hauv cov kev sim sib txawv tau tshawb xyuas. Cov txiaj ntsig qhia tau uas piv nrog gelatin tsiav tshuaj, HPMC capsule plhaub muaj ntau dua rau cov ntsiav tshuaj rau cov tshuaj ntsiav ntau dua rau cov hmoov kom qhuav.
3.7 li biollhesive
Cov cuab yeej thev naus laus zis ntawm kev siv cov khoom siv rau cov paj ntaub. Los ntawm adhering rau kev lom neeg mucosa, nws txhim kho kev sib txuas ntxiv thiab cov tshuaj maj mam muab tso tawm thiab nqus tau los ntawm mucosa kom ua tiav lub hom phiaj ntawm kev kho mob. Nws yog dav siv nyob rau tam sim no. Kev kho mob ntawm cov kab mob ntawm lub plab zom mov, Vagina, qhov ncauj Mucosa thiab lwm qhov chaw.
Patrointestion butoadots technology yog qhov kev xa tshuaj tshiab tsim nyob rau xyoo tas los no. Nws tsis yog tsuas yog ncua sij hawm lub sijhawm muaj kev npaj tshuaj hauv plab zom mov, tab sis kuj tseem muaj kev sib chwv ntawm lub ntsej muag, thiab ua rau cov tshuaj nkag rau hauv Lub plab hnyuv plab hnyuv epithelial cell yog txhim kho, yog li kev txhim kho cov xyoob ntoo ntawm cov tshuaj. Wei Keda li al. Ntsuam xyuas cov ntsiav tshuaj Core tshuaj yuav cov tshuaj ntawm HPMck4m thiab siv tus kheej rau cov tshuaj lom neeg thiab cov khoom lag luam simulated los ntawm qhov zoo ntawm cov dej hauv lub hnab yas. , thiab thaum kawg tau xaiv cov ntsiab lus ntawm HPMPERC40 thiab carbomer 940 los ua 15 thiab 27,5 mg hauv cov ntaub ntawv ncaeb) me me (xws li hydroxypropylulose) tuaj yeem txo qhov kev txhim kho cov nplaum ntawm kev npaj rau daim ntaub so ntswg.
Kev npaj rau hauv qhov ncauj bioadhesive kuj yog cov hom tshuaj tshiab uas tau kawm ntau xyoo tsis ntev los no. Kev npaj rau hauv qhov ncauj bioadhesive npaj tuaj yeem ua raws li qhov kev cuam tshuam ntawm qhov ncauj, tab sis kuj tiv thaiv qhov ncauj Mucosa. Zoo dua kev kho cov nyhuv thiab txhim kho yeeb tshuaj los ntawm cov yeeb tshuaj muaj peev xwm. Xue Xeemoyan li al. Optimized cov qauv ntawm cov tshuaj insulin cov ntsiav tshuaj nplaum, siv kua pecectos, carbomer 934p, kom qhuav-kom qhuav los npaj lub qhov ncauj insulin. Nplaum ob npaug txheej ntawv. Cov txheej txheem insulin cov ntsiav tshuaj nplaum tau muaj lub ntxeem tau zoo ib yam, thiab muaj cov txheej txheem hydrophobic tiv thaiv, uas tuaj yeem ua kom cov tshuaj tsis muaj kev tso tawm. Hao jifu li al. Kuj tseem npaj cov hlaws xiav xiav-lub qhov ncauj biadhesive siv baiji kua nplaum, hpbc thiab carbomer raws li cov ntaub ntawv biollhesive.
Hauv Kev Ntsuas Cov Tshuaj Yeeb Tshuaj Yeeb Nkab Cov Tshuab, Cov Tshuab Hluav Taws Xob tau tseem siv dav. Zhu yuting li al. Siv Carbomer (CP) thiab HPMC raws li cov ntaub ntawv nplaum thiab cov khoom siv hluav taws xob sib txawv thiab cov khoom sib txawv, cov khoom noj khoom haus o hauv ib puag ncig ntawm cov paum. , cov ntawv sau haum tsim nyog tau tshuaj xyuas ua CP-HPMC1: 1, cov ntawv npaj nplaum tau muaj cov nplaum ua zoo, thiab cov txheej txheem tau yooj yim thiab ua tau.
3.8 li tshuaj pleev ib ce
Raws li kev npaj ua nplaum, gel muaj cov txiaj ntsig zoo xws li kev nyab xeeb, kev nyab xeeb, kev npaj yooj yim, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo, thiab kev sib raug zoo nrog tshuaj. Kev taw qhia kev txhim kho. Piv txwv li, transdermal gel yog daim ntawv foos tshiab npaum li cas uas tau kawm ntau nyob rau xyoo tas los no. Nws tsis tuaj yeem zam kev puas tsuaj ntawm cov tshuaj uas muaj kev puas tsuaj rau lub plab zom mov thiab txo qis cov tshuaj tso tawm ntshav, tab sis kuj tau ua ib qho ntawm cov tshuaj tso tawm ntshav kom kov cov kev cuam tshuam kev phiv yeeb tshuaj. Cov.
Zhu Jingjie li al. Kawm txog cov nyhuv ntawm txawv matrices ntawm kev tso tawm ntawm scutellarin cawv me me (Holmcksylulose (Hydmck15m) raws li gel matrices, thiab tau scutellarin haum rau Scutellarin. Gel Matrix ntawm kev haus dej caw. Qhov kev sim sim qhia tau tias 1. 0% carbomer, 1. 5% hpbomer + 1. 5% hpbomer + yog tsim nyog rau scutellarin cawv plastids Cov. Thaum lub sij hawm sim, nws tau pom tias HPMC tuaj yeem hloov cov tshuaj tso tawm ntawm kev tso yeeb tshuaj los ntawm kev ua kom zoo nkauj, thiab 1.0% Carbomer Matrix thiab 1.5% Carbomer Matrix. Qhov laj thawj yuav yog HPMC nthuav nrawm dua, thiab kev sim ua kom zoo dua ua rau cov roj ntsha ua kom loj dua, yog li nrawm nws cov tshuaj tso tawm yeeb tshuaj. Zhao Wecui li al. Siv Carbomer-934 thiab HydroxyPropyyl methylulose li cov nqa khoom los npaj Norfloxacin ophtalmic gel. Cov txheej txheem npaj tau yooj yim thiab ua tau zoo, thiab ua raws li cov khoom zoo rau lub paphalmic gel ntawm "Suav teb cov kev xav tau.
3.9 Nag nrho cov inhibitor rau kev siv tus kheej-microemulsifyifying
Self-microemulsifying drug delivery system (SMEDDS) is a new type of oral drug delivery system, which is a homogeneous, stable and transparent mixture composed of drug, oil phase, emulsifier and co-emulsifier. Qhov sib xyaw ua ke ntawm cov tshuaj yog yooj yim, thiab kev nyab xeeb thiab kev nyab xeeb yog qhov zoo. Rau cov tshuaj tsis zoo, cov kua dej-soluble fiber polymer, polyvinylpictrolidrated nyob rau hauv lub plab zom mov (pvp), thiab lwm yam. Ua kom cov tshuaj solubility thiab txhim kho cov xyoob.
Peng Xuan li al. Npaj cov lus silibinin supersaturated tus kheej-emulsifyifosure cov tshuaj tsis muaj zog (s-sedds). Oxyethylene Hydrogenated Castor Roj (12% caprylic capric acid polyethylene glycolene glycolene glycoles glycol) raws li co-emulsol) raws li coo-emulsifit, thiab 50 mg-1 HPMC. Ntxiv HPMC rau cov SSEDDS tuaj yeem hloov kho kom dawb silibinin kom yaj hauv s-seds thiab tiv thaiv silibinin los ntawm nag lossis daus. Piv nrog tsoos tus kheej-microemulsion formulation, ib tug loj dua ntawm surfactant yog feem ntau ntxiv los tiv thaiv kev phiv yeeb tshuaj tsis tiav. Qhov kev sib txuas ntawm HPMC tuaj yeem khaws cov solubility ntawm silibinin nyob rau hauv lub dissolution nruab nrab txuas ntxiv, txo cov emulsification ua qauv. noj tshuaj ntawm tus neeg sawv cev.
4.Chulus
Nws tuaj yeem pom tias HPMC tau siv dav hauv kev npaj vim nws lub cev, tab sis HPMC kuj muaj ntau yam tshwm sim ntawm kev npaj ua ntej thiab kev tawm suab tom qab. methyl methacrylate) txhawm rau txhim kho. Nyob rau tib lub sijhawm, qee cov kws tshawb nrhiav tshawb xyuas cov ntawv thov OSAPICOTHIDE-tso cov ntsiav tshuaj rau kev kawm ntxiv nws cov txheej txheem kev tshaj tawm. Hauv ib lo lus, ntau dua thiab ntau cov kws tshawb nrhiav tau ua haujlwm ntau rau kev npaj, HPMC yuav siv tau ntau cov ntaub ntawv tshiab thiab cov ntawv ntau npaum li cas. Hauv kev tshawb fawb ntawm cov tshuaj ntawm cov tshuaj, thiab tom qab ntawd txhawb txoj kev txhim kho kev txhim kho ntawm lub tsev muag tshuaj.
Lub Sijhawm Post: Kaum-08-2022