HydroxyPropyyl methylulose (HPMC) yog hluavtaws semi-hluavtaws polymer dav siv nyob rau hauv ntau qhov kev lag luam, tshwj xeeb hauv cov chaw muag tshuaj. HPMC tau dhau los ua kev npaj ua lag luam tsis tseem ceeb hauv kev npaj ua lag luam vim nws biocompatibility, tsis muaj tshuaj lom thiab tshuaj lom neeg lub cev.
(1) Cov yam ntxwv yooj yim ntawm cov qib kawm HPMC
HPMC yog cov tsis muaj ionic cellulose npaj los ntawm cov tshuaj tiv thaiv ntawm cov tshuaj pleev cov tshuaj pleev cov tshuaj pleev thiab methyl chloride hauv qab alkaline. Nws cov qauv tshuaj tshwj xeeb muab HPMC zoo solubility, thickening, zaj duab xis-ua thiab emulsifying khoom. Cov hauv qab no yog qee tus yam ntxwv tseem ceeb ntawm HPMC:
Dej solubility thiab phiv laj tom qab: hpmc yaj nyob rau hauv dej txias thiab ua lub pob tshab kuab tshuaj. Lub viscosity ntawm kev daws teeb meem yog cuam tshuam txog kev xav thiab lub zog hnyav, thiab nws muaj qhov ruaj khov rau pH thiab tuaj yeem nyob ruaj khov nyob rau hauv ob lub acidic thiab alkaline ib puag ncig.
Qhov hluav taws xob thermogel: HPMC cov khoom pov thawj cim cov khoom siv thermogel tshwj xeeb thaum ua kom sov. Nws tuaj yeem tsim cov gel thaum ua kom sov rau qhov ntsuas kub thiab rov qab ua kua rau lub xeev tom qab txias. Cov cuab yeej no yog tshwj xeeb yog qhov tseem ceeb hauv kev tso tshuaj raws li kev npaj tawm.
Biocompatibility thiab tsis muaj txiaj ntsig: Txij li HPMC yog qhov ua rau muaj kev sib xyaw thiab tsis tau them nqi thiab yuav tsis tau them nqi thiab yuav tsis muaj nqi thiab yuav tsis nqus tau hauv lub cev. Nws yog qhov tsis muaj tshuaj lom.
(2) Daim Ntawv Thov HPMC hauv tshuaj
HPMC tau dav siv hauv kev lag luam kws tshuaj, npog ntau daim teb xws li cov tshuaj, cov tshuaj pleev thiab cov tshuaj muaj pa. Nws cov ntawv thov tseem ceeb yog li nram qab no:
1. Zaj duab xis-ua cov khoom siv hauv cov ntsiav tshuaj
HPMC tau dav siv nyob rau hauv cov txheej txheem txheej txheej ntawm cov ntsiav tshuaj ua cov khoom siv ua yeeb yaj kiab. Ntsiav tshuaj cov txheej tsis tuaj yeem tiv thaiv cov tshuaj los ntawm cov tshuaj tiv thaiv ntawm cov chaw sab nraud, thiab tseem npog cov tshuaj phem thiab saj tau cov neeg mob ua raws. Zaj duab xis tsim los ntawm HPMC muaj cov dej tsis kam thiab lub zog, uas tuaj yeem ua kom zoo txuas lub txee lub neej ntawm cov yeeb tshuaj.
Nyob rau tib lub sijhawm, HPMC kuj tseem siv tau raws li lub ntsiab tivthaiv ntawm kev tso tawm-tso cov ntaub ntawv tso tawm rau kev tso tawm ntawm cov ntsiav tshuaj tawm thiab tswj-tso tawm. Nws cov khoom siv ua hluav taws xob ua rau cov tshuaj muaj kev tso tawm hauv lub cev ntawm tus nqi tso tawm ua ntej, yog li ua tiav cov txiaj ntsig ntawm kev kho tshuaj ntev kev siv tshuaj. Qhov no yog qhov tshwj xeeb tshaj yog nyob rau hauv kev kho mob
2. Raws li tus neeg sawv cev tso tawm
HPMC tau dav siv raws li tus neeg siv tshuaj tawm hauv qhov ncauj. Vim tias nws tuaj yeem tsim cov gel hauv dej thiab cov roj av maj mam ploj mus ua cov tshuaj raug tso tawm, nws tuaj yeem tswj hwm cov tshuaj tso tawm. Daim ntawv thov no yog qhov tseem ceeb tshwj xeeb hauv cov tshuaj uas yuav tsum tau tso tawm tshuaj ntev ntev, xws li cov tshuaj insulin, thiab lwm yam.
Nyob rau hauv lub plab zom mov, txheej txheem gel ntawm HPMC tuaj yeem tswj hwm cov tshuaj luv luv, yog li txo cov kev mob tshwm sim thiab ua kom muaj txiaj ntsig zoo. This sustained-release property is particularly suitable for the treatment of drugs that require stable blood drug concentrations, such as antibiotics, anti-epileptic drugs, etc.
3. Raws li phau ntawv
HPMC feem ntau siv los ua cov phau ntawv hauv cov qauv tshuaj ntau lawm. Los ntawm kev ntxiv HPMC rau cov khoom siv tshuaj lossis hmoov, nws cov kua txiv thiab cov nplaum thiab muaj zog txhim kho lub nyem nyhuv thiab lub zog ntawm cov ntsiav tshuaj. Qhov tsis muaj tshuaj lom thiab muaj kev ruaj ntseg ntawm HPMC ua nws lub cim zoo tshaj plaws hauv cov ntsiav tshuaj, granules thiab capsules.
4. Raws li tuab thiab stabilizer
Hauv kev npaj ua kua, HPMC tau siv dav ua cov tuab thiab ruaj khov nyob rau ntau yam ntawm qhov ncauj kua, qhov muag thiab kua txob. Nws cov khoom siv tuab tuaj yeem nce viscosity ntawm cov tshuaj ua kua, zam kev siv tshuaj lossis nag lossis daus, thiab kom cov khaub ncaws sib luag ntawm cov tshuaj muaj tshuaj. Nyob rau tib lub sijhawm, lubricity thiab moisturizing tej yam ntawm HPMC pab kom nws zoo txo qhov muag tsis xis nyob hauv qhov muag los ntawm kev txob txob sab nraud.
5. Siv hauv tsiav tshuaj
Raws li cov nroj tsuag-muab tau cellulose, HPMC muaj cov biocompatibility zoo, ua rau nws cov khoom tseem ceeb rau kev ua tsob ntoo cantsules. Piv nrog tsoos tsiaj gelatin tsiav tshuaj, HPMC cov tsiav tshuaj muaj qhov ruaj khov zoo dua, tshwj xeeb tshaj yog nyob rau hauv qhov kub thiab txias thiab muaj yooj yim rau deform lossis yaj yooj yim. Tsis tas li ntawd, HPMC cov tsiav tshuaj yog tsim nyog rau cov zaub noj thiab cov neeg mob uas ua xua rau cov tshuaj pleev ntawm cov tshuaj ntsiav tshuaj.
(3) Lwm cov kev siv tshuaj ntawm HPMC
Ntxiv rau cov tshuaj siv cov tshuaj uas tseem ceeb tshaj plaws, HPMC kuj tseem siv tau rau qee cov teb tshuaj tshwj xeeb. Piv txwv li, tom qab phais mob ophthalmic, HPMC yog siv rau hauv cov tee qhov muag raws li cov roj nplua nyeem kom txo kev sib txhuam ntawm cov pob muag thiab txhawb rov qab. Tsis tas li ntawd, HPMC kuj tseem siv tau cov tshuaj pleev thiab cov tshuaj zoo los txhawb kev nqus cov tshuaj sib nqus thiab txhim kho kev ua tau zoo ntawm cov tshuaj hauv zos.
Kws Kho Mob Tshuaj HPMC ua si lub luag haujlwm tseem ceeb hauv kev npaj tshuaj yog nws cov khoom siv lub cev thiab tshuaj lom neeg zoo. Raws li kev zam ntau zog ntawm cov tshuaj yeeb tshuaj, HPMC tsis tuaj yeem txhim kho cov tshuaj muaj feem ntau, tab sis kuj tseem ua kom cov tshuaj tso tawm thiab tseem txhim kho cov tshuaj muaj kev sib raug zoo thiab ua kom tus neeg mob ua raws. Nrog kev nce qib txuas ntxiv ntawm cov tshuab HPMC, daim ntawv thov teb HPMC yuav muaj ntau yam ntxiv rau yav tom ntej kev tsim kho tshuaj.
Lub Sijhawm Post: Sep-19-2024