Cellulose cov neeg ua kom tau kev tswj hwm cov tshuaj hauv hydrophilic matrix

Cellulose neeg muaj cai, tshwj xeebHydroxyPropyyl methylcellulose (HPMC), tau ua haujlwm dav hauv cov tshuaj ntawm cov tshuaj rau cov tshuaj tso tawm hauv cov tshuaj hydrix. Cov tshuaj tso tawm yog qhov tseem ceeb rau kev txhim kho kho kom zoo, txo cov kev mob tshwm sim, thiab txhim kho tus neeg mob ua raws. Ntawm no yog li cas cellulose tsim muaj kev ua haujlwm nyob rau hauv hydxhilic matrix rau tswj cov tshuaj tso tawm:

1. Hydrophilic matrix system:

• Kev Txhais Lus: Ib lub tshuab Hydroxilic yog cov tshuaj uas muaj tshuaj lom neeg uas nquag muaj cov tshuaj ntsuab (API
• Lub Hom Phiaj: Cov Matrix tswj txoj kev tso tawm ntawm cov tshuaj los ntawm kev hloov kho nws diffusion los ntawm cov polymer.

2. Lub luag haujlwm ntawm Cellulose neeg muaj kev pab hais (piv txwv li, HPMC):

• Viscosity thiab gel-thawj txoj kev lag luam:
  • HPMC paub txog nws lub peev xwm los tsim cov gels thiab nce viscosity ntawm cov kua aqueous.
  • Hauv Matrix systems, HPMC ua rau muaj kev tsim ntawm cov gelatinous matrix uas encapsulates cov tshuaj.
• Hydrophilic Xwm:
  • HPMC muaj lub zog hydrophilic, pab nws muaj kev cuam tshuam nrog dej hauv txoj hnyuv plab.
• Tshuaj o:
  • Thaum muaj kev sib cuag nrog cov kua dej plab zom mov, lub hydrophilic matrix swells, tsim cov txheej gel ib ncig ntawm cov yeeb tshuaj hais.
• Kev siv yeeb tshuaj envapsulation:
  • Cov tshuaj yog uniformed dispersed lossis encapsulated nyob rau hauv gel matrix.

3. Mechanism Kev Tso Tawm:

• Diffusion thiab yaig:
  • Cov kev tso tawm tswj tau tshwm sim los ntawm kev sib txuas ntawm diffusion thiab erosion tshuab.
  • Dej nkag mus ntawm matrix, ua rau gel o, thiab cov tshuaj diffuses los ntawm cov txheej gel.
• Xoom-xaj tso tawm:
  • Lub tswj tso tawm cov ntaub ntawv tso tawm feem ntau ua raws cov xoom-xaj kinetics, muab tus nqi tso cai siv tshuaj raws li sijhawm.

4. Qhov ntau yam cuam tshuam tshuaj yeeb tshuaj:

• Polymer concentration:
  • Cov concentration ntawm HPMC nyob rau hauv lub Matrix cuam tshuam txoj kev ntawm cov tshuaj tso tawm.
• Molecular qhov hnyav ntawm HPMC:
  • Cov qib sib txawv ntawm HPMC nrog kev hnyav molecular yuav raug xaiv los txiav tawm cov ntaub ntawv tso tawm.
• Tshuaj yeeb yaj kiab:
  • Lub solubility ntawm cov tshuaj nyob hauv Matrix cuam tshuam rau nws cov yam ntxwv tso tawm.
• Matrix Porosity:
  • Cov Qib Ntawm Gel o thiab Matrix Porosity Haiv Tshuaj Txom Tshuaj Txawv Yeeb.

5. Qhov zoo ntawm cellulose muaj cov neeg muaj kev pab hais hauv Matrix Systems:

• Biocompatibility: Cov neeg hais txog cellulose feem ntau yog biocompampible thiab kev ua kom zoo-tiv taus nyob rau hauv lub plab zom mov.
• Versatility: Cov qib kev sib txawv ntawm cov neeg hais txog cellulose tuaj yeem xaiv kom ua tiav cov ntaub ntawv tso tawm yam xav tau.
• Stability: Cellulose muaj neeg muaj kev ruaj khov rau kev ua haujlwm matrix, ua kom cov tshuaj tso tawm raws sijhawm.

6. Daim ntaub ntawv:

• Qhov ncauj tshuaj tau: Hydrophilic matrix siv tau siv rau qhov ncauj daim ntawv siv yeeb yaj kiab, muab kev txhawb nqa thiab tswj kev tso tawm.
• Cov xwm txheej mob ntev: Qhov zoo tagnrho rau cov tshuaj siv hauv kev mob voos qhov xwm txheej txuas ntxiv tau txais txiaj ntsig.

7. Saib xyuas:

• Tsim kom zoo tshaj plaws: Daim qauv tsim yuav tsum tau ua kom tiav rau ua tiav cov tshuaj tso tawm cov tshuaj uas xav tau ntawm cov tshuaj.
• Kev tswj hwm ua raws li cov neeg tswj hwm cellulose siv hauv cov kws tshuaj yuav tsum ua raws cov qauv kev cai lij choj.

Kev siv cellulose cov neeg muaj kev hais ua hauv Hydrix systems ua piv txwv lawv qhov tseem ceeb hauv cov tshuaj muaj ntau yam hauv kev ua tiav cov tshuaj tso tawm.