Hydroxypropyl methylcellulose (HPMC)yog ib qho dej-soluble polymer compound uas siv dav hauv cov chaw muag tshuaj, zaub mov, khoom siv hauv tsev, tshuaj pleev ib ce thiab lwm yam. HPMC muaj cov yam ntxwv zoo solubility thiab viscosity thiab tuaj yeem tsim cov tshuaj colloidal ruaj khov, yog li nws ua lub luag haujlwm tseem ceeb hauv ntau daim ntawv thov. Txhawm rau muab kev ua si tag nrho rau kev ua haujlwm ntawm HPMC, txoj kev sib cais kom raug yog qhov tseem ceeb tshwj xeeb.
1. Cov txheej txheem dej kub li qub
HPMC tuaj yeem yaj hauv dej txias, tab sis feem ntau yuav tsum muaj qee qhov kev txawj ntse kom tsis txhob muaj qhov sib xyaw ua ke. Txhawm rau txhim kho cov nyhuv dissolution, cov kauj ruam hauv qab no tuaj yeem siv:
Kauj Ruam 1: Ntxiv HPMC rau dej
Nyob rau hauv chav tsev kub, ua ntej sprinkle HPMC tusyees ntawm cov dej saum npoo av kom tsis txhob nchuav ntau ntawm HPMC rau hauv dej ib zaug. Vim tias HPMC yog cov khoom siv polymer, ncaj qha ntxiv ntau ntawm HPMC yuav ua rau nws nqus dej thiab o sai sai hauv dej los tsim cov khoom zoo li gel.
Kauj ruam 2: stirring
Tom qab ntxiv HPMC, ua kom sib npaug sib npaug. Vim tias HPMC muaj cov khoom zoo, nws yuav o tom qab nqus dej los tsim cov khoom zoo li gel. stirring pab tiv thaiv HPMC los ntawm agglomerating mus rau hauv clumps.
Kauj ruam 3: Sawv ntsug thiab ntxiv do
Yog tias HPMC tsis yaj tag, cov tshuaj tuaj yeem tso rau sawv ntsug ib ntus thiab txuas ntxiv do. Nws feem ntau yuav yaj tag li ntawm ob peb teev.
Txoj kev no tsim nyog rau lub sijhawm uas tsis tas yuav tsum muaj cua sov, tab sis nws yuav siv sij hawm ntev los xyuas kom meej tias HPMC yog yaj tag.
2. Cov txheej txheem dej kub dissolution
HPMC dissolves sai dua nyob rau hauv dej sov, yog li cov cua kub ntawm cov dej kub yuav ua rau kom cov txheej txheem dissolution. Feem ntau siv cov dej kub kub yog 50-70 ℃, tab sis kub dhau (xws li tshaj 80 ℃) tuaj yeem ua rau HPMC degrade, yog li qhov kub thiab txias yuav tsum tau tswj.
Kauj Ruam 1: Cua sov dej
Kub dej kom txog li 50 ℃ thiab ua kom nws ruaj khov.
Kauj ruam 2: Ntxiv HPMC
Sprinkle HPMC maj mam rau hauv dej kub. Vim yog dej kub, HPMC yuav yaj yooj yim dua, txo cov agglomeration.
Kauj Ruam 3: stirring
Tom qab ntxiv HPMC, txuas ntxiv mus do cov tshuaj aqueous. Kev sib xyaw ua ke ntawm cov cua sov thiab nplawm tuaj yeem txhawb kev tawg sai ntawm HPMC.
Kauj Ruam 4: Khaws qhov kub thiab txias mus ntxiv
Koj tuaj yeem tswj tau qhov kub thiab txias ntxiv kom txog thaum HPMC yaj tag.
3. Txoj Kev Cuam Tshuam Dej Cawv
HPMC tuaj yeem yaj tsis yog hauv dej xwb, tab sis kuj muaj qee yam cawv cawv (xws li ethanol). Lub ntsiab kom zoo dua ntawm txoj kev haus cawv dissolution yog tias nws tuaj yeem txhim kho cov solubility thiab dispersibility ntawm HPMC, tshwj xeeb tshaj yog rau cov tshuab uas muaj dej ntau.
Kauj Ruam 1: Xaiv cov kuab tshuaj cawv uas tsim nyog
Cov kua dej cawv xws li ethanol thiab isopropanol feem ntau yog siv los ua kom HPMC yaj. Feem ntau hais lus, 70-90% ethanol tov muaj txiaj ntsig zoo rau kev ua kom HPMC.
Kauj Ruam 2: Kev Txiav Txim Siab
Maj mam sprinkle HPMC rau hauv cov kuab tshuaj cawv, nplawm thaum ntxiv kom paub meej tias HPMC tau tawg tag nrho.
Kauj Ruam 3: Sawv ntsug thiab nplawm
Cov txheej txheem ntawm cawv solvent dissolving HPMC yog qhov ceev, thiab nws feem ntau yuav siv li ob peb feeb kom ua tiav tiav.
Txoj kev haus dej cawv feem ntau yog siv rau hauv daim ntawv thov scenarios uas yuav tsum tau so kom sai thiab cov ntsiab lus dej tsawg.
4. Cov kuab tshuaj-dej sib tov sib xyaw txoj kev
Qee lub sij hawm HPMC yog yaj nyob rau hauv ib qho sib tov ntawm ib qho kev faib ua feem ntawm dej thiab hnyav. Txoj kev no yog tshwj xeeb tshaj yog haum rau cov xwm txheej uas qhov viscosity ntawm cov tshuaj los yog cov dissolution tus nqi yuav tsum tau kho. Cov kuab tshuaj muaj xws li acetone, ethanol, thiab lwm yam.
Kauj Ruam 1: Npaj cov tshuaj
Xaiv qhov sib piv ntawm cov kuab tshuaj thiab dej (xws li 50% dej, 50% hnyav) thiab cua sov kom haum rau qhov kub thiab txias.
Kauj ruam 2: Ntxiv HPMC
Thaum nplawm, maj mam ntxiv HPMC kom ntseeg tau tias muaj kev sib cais.
Kauj Ruam 3: Kev hloov kho ntxiv
Raws li xav tau, qhov feem ntawm cov dej los yog hnyav tuaj yeem nce ntxiv los kho cov solubility thiab viscosity ntawm HPMC.
Txoj kev no yog tsim nyog rau lub sijhawm uas cov kuab tshuaj organic ntxiv rau cov tshuaj aqueous los txhim kho cov kev sib cais los yog kho cov khoom ntawm cov tshuaj.
5. Ultrasonic-pab dissolution txoj kev
Siv cov nyhuv oscillation siab ntawm ultrasound, cov txheej txheem ultrasonic-pab dissolution tuaj yeem ua kom cov txheej txheem tawg ntawm HPMC. Txoj kev no yog tshwj xeeb tshaj yog haum rau ntau qhov HPMC uas yuav tsum tau yaj sai sai, thiab tuaj yeem txo qhov teeb meem agglomeration uas yuav tshwm sim thaum lub sij hawm ib txwm nplawm.
Kauj Ruam 1: Npaj cov tshuaj
Ntxiv HPMC rau qhov tsim nyog cov dej los yog dej-solvent tov tov.
Kauj Ruam 2: Kev kho ultrasonic
Siv lub tshuab ntxhua khaub ncaws lossis ultrasonic yaj thiab kho nws raws li lub zog thiab lub sijhawm. Cov nyhuv oscillation ntawm ultrasound tuaj yeem ua kom nrawm nrawm ntawm cov txheej txheem ntawm HPMC.
Kauj Ruam 3: Txheeb xyuas cov nyhuv dissolution
Tom qab kev kho mob ultrasonic, xyuas seb cov tshuaj puas yaj tag. Yog hais tias muaj ib qho undissolved, kev kho ultrasonic tuaj yeem ua dua.
Txoj kev no yog tsim rau cov ntawv thov uas xav tau kom muaj txiaj ntsig zoo thiab nrawm nrawm.
6. Pretreatment ua ntej dissolution
Yuav kom zam tauHPMCagglomeration los yog nyuaj rau dissolving, ib co pretreatment txoj kev yuav siv tau, xws li sib tov HPMC nrog ib tug me me ntawm lwm cov kuab tshuaj (xws li glycerol), ziab nws ua ntej, los yog ntub HPMC ua ntej ntxiv hnyav. Cov kauj ruam ua ntej no tuaj yeem txhim kho cov solubility ntawm HPMC.
Muaj ntau txoj hauv kev los rhuav tshem HPMC. Xaiv ib txoj kev puas tsuaj uas tsim nyog tuaj yeem txhim kho qhov kev sib cais thiab cov khoom zoo. Txoj kev sib cais ntawm chav tsev kub yog qhov tsim nyog rau ib puag ncig me me, cov txheej txheem dej kub dissolution tuaj yeem ua kom cov txheej txheem tawg sai sai, thiab cov txheej txheem dej cawv dissolution thiab cov kuab tshuaj-dej sib tov sib xyaw yog tsim nyog rau kev sib cais nrog cov kev xav tau tshwj xeeb. Ultrasonic-pab dissolution txoj kev yog ib tug zoo txhais tau tias yuav daws tau sai sai dissolution ntawm ib tug loj npaum li cas ntawm HPMC. Raws li cov ntawv thov tshwj xeeb, kev xaiv hloov pauv ntawm txoj kev sib cais tsim nyog tuaj yeem ua kom muaj kev ua tau zoo ntawm HPMC hauv ntau qhov chaw.
Post lub sij hawm: Dec-19-2024