Hydroxypropyl methylcellulose (HPMC) yog semi-synthetic, inert, tsis muaj tshuaj lom dej-soluble polymer dav siv hauv kev lag luam xws li tshuaj, zaub mov, tshuaj pleev ib ce thiab khoom siv hauv tsev. Kev sib raug zoo ntawm nws qhov hnyav molecular thiab viscosity muaj feem cuam tshuam rau nws cov kev ua tau zoo hauv ntau yam kev siv.
1. Solubility thiab film-forming zog
Lub viscosity ntawm HPMC ncaj qha cuam tshuam nws cov solubility hauv dej. HPMC nrog cov viscosity qis dua tuaj yeem yaj hauv dej sai dua thiab tsim cov tshuaj pob tshab thiab zoo ib yam, uas yog tsim rau cov ntawv thov uas yuav tsum tau tawg sai sai, xws li cov dej haus tam sim lossis cov tshuaj tam sim. HPMC nrog cov viscosity ntau dua yuav tsum tau siv sijhawm ntev dua, tab sis tuaj yeem muab cov tuab thiab lub zog zoo dua thaum tsim cov yeeb yaj kiab, yog li nws tsim nyog rau cov ntsiav tshuaj txheej, zaj duab xis tiv thaiv thiab ua cov khoom siv matrix hauv kev npaj tso tawm.
2. Kev ruaj ntseg thiab adhesion
HPMC nrog viscosity siab dua feem ntau muaj zog ruaj khov thiab adhesion. Piv txwv li, thaum siv los ua cov thickener rau cov cement lossis gypsum-raws li cov khoom siv hauv tsev, cov viscosity siab dua HPMC tuaj yeem txhim kho nws cov dej tuav thiab sag tsis kam, pab kom ncua sij hawm tsim kho thiab txo kev tawg. Hauv kev lag luam kws tshuaj, HPMC high-viscosity yog siv los tswj cov tshuaj tso tawm. Nws cov adhesion siab tso cai rau cov tshuaj tso tawm maj mam hauv lub cev thiab txhim kho bioavailability ntawm cov tshuaj.
3. Kev ncua thiab emulsification
Kev hloov pauv hauv viscosity kuj cuam tshuam rau kev ncua thiab emulsification zog ntawm HPMC. Vim nws luv luv molecular saw, low-viscosity HPMC yog haum rau siv los ua tus neeg sawv cev ncua. Nws tuaj yeem tshem tawm cov khoom tsis zoo hauv cov tshuaj ua kua thiab tiv thaiv nag lossis daus. HPMC nrog cov viscosity siab tuaj yeem tsim cov qauv tsim muaj zog hauv kev daws teeb meem vim nws cov saw hlau molecular ntev, yog li nws ua tau zoo dua hauv kev ruaj ntseg ntawm emulsions thiab ncua kev kawm ntawv thiab tuaj yeem tswj tau qhov sib xws rau lub sijhawm ntev.
4. Rheology thiab daim ntawv thov zog
Cov khoom rheological ntawm HPMC kuj yog ib qho tseem ceeb cuam tshuam los ntawm viscosity. Tsawg-viscosity HPMC cov kev daws teeb meem pom zoo dua fluidity, yooj yim rau tshuaj tsuag thiab siv, thiab feem ntau yog siv rau hauv cov khoom tu tawv nqaij thiab xim. High-viscosity HPMC cov tshuaj coj los ua cov kua dej uas tsis yog-Newtonian thiab muaj cov yam ntxwv shear-thinning. Cov yam ntxwv no ua rau cov viscosity siab HPMC yooj yim dua los tuav hauv cov txheej txheem siab shear, thaum tuav lub siab viscosity nyob rau hauv cov xwm txheej zoo li qub, yog li txhim kho cov yeeb yaj kiab tsim thiab ruaj khov ntawm cov khoom.
5. Daim ntawv thov piv txwv
Pharmaceutical teb: Tsawg-viscosity HPMC (xws li 50 cps) feem ntau yog siv rau txheej tam sim-tso ntsiav tshuaj kom ntseeg tau tias cov tshuaj tso tawm sai, thaum lub siab viscosity HPMC (xws li 4000 cps) yog siv rau cov ntsiav tshuaj tso tawm los kho cov tshuaj. tshuaj tso tawm tus nqi.
Cov khoom noj khoom haus: Hauv cov dej haus tam sim, cov viscosity tsawg HPMC tuaj yeem yaj sai sai yam tsis muaj clumping; nyob rau hauv cov khoom ci, high-viscosity HPMC tuaj yeem txhim kho cov dej tuav lub peev xwm ntawm lub khob noom cookie thiab txhim kho cov saj thiab moisturizing zog ntawm cov khoom ci.
Kev tsim kho: Hauv putties thiab coatings, low-viscosity HPMC txhawb kev tsim kho thiab txhim kho kev ua haujlwm; thaum high-viscosity HPMC txhim khu lub thickness thiab sag kuj ntawm txheej.
Lub viscosity ntawm HPMC yog ib qho tseem ceeb parameter uas txiav txim siab nws cov kev ua tau zoo nyob rau hauv daim ntawv thov. Tsis tshua muaj viscosity HPMC feem ntau yog siv nyob qhov twg sai sai dissolution thiab flowability yuav tsum tau, thaum lub siab viscosity HPMC yog zoo dua nyob rau hauv daim ntawv thov uas yuav tsum tau adhesion siab, zoo zaj duab xis tsim thiab stability. Yog li ntawd, xaiv HPMC nrog txoj cai viscosity yog qhov tseem ceeb rau kev ua kom zoo dua nws cov kev ua tau zoo hauv ntau qhov chaw.
Lub sij hawm xa tuaj: Plaub Hlis-08-2024