Yam cuam tshuam rau lub viscosity ntau lawm ntawm hydroxypropyl methylulose

HydroxyPropyyl Methylcellulose (HPMC)Yog cov dav dav siv polymer nyob rau ntau yam kev lag luam, suav nrog cov tshuaj, kev tsim kho, thiab cov tshuaj pleev ib ce, thiab tshuaj pleev ib ce. Nws cov viscosity ua lub luag haujlwm tseem ceeb hauv nws cov ntawv thov. Nkag siab txog qhov cuam tshuam HPMC viscire ntau lawm yog qhov tseem ceeb rau kev ua haujlwm zoo rau nws cov kev ua tau zoo hauv cov ntsiab lus sib txawv. Los ntawm kev nkag siab cov ntsiab lus, cov neeg muaj feem xyuam tuaj yeem ua tau zoo HPMC cov khoom kom tau raws li cov kev thov tshwj xeeb.

Taw qhia:
HydroxyPropyyl Metylcellulose (HPMC) yog cov khoom siv polymer ntau ntxiv, suav nrog cov dej solubility, ua yeeb yaj kiab ua yeeb yaj kiab, thiab biocompatibility. Ib qho ntawm cov tsis tseem ceeb cuam tshuam rau nws cov kev ua tau zoo yog viscosity. Lub viscos ntawm HPMC cov kev daws teeb meem cuam tshuam nws tus cwj pwm hauv ntau yam kev siv, gelling, zaj duab xis-txheej, thiab muaj txheej txheem tso tawm hauv cov tshuaj yeeb yaj kiab. Nkag siab txog cov yam ntxwv HPMC viscosity ntau lawm yog qhov ntsuas kom ua kom zoo dua nws cov haujlwm hla kev sib txawv.

Yam cuam tshuam rau HPMC Viscosity Production:

Molecular hnyav:
Cov molecular hnyav ntawmHPMCcuam ​​tshuam loj heev nws viscosity. Lub cev yuag ntau dua polymers feem ntau ua rau muaj viscosity ntau dua vim nce saw entanglement. Txawm li cas los xij, kev hnyav molecular hnyav tuaj yeem ua rau cov kev sib tw hauv kev npaj daws teeb meem thiab kev ua haujlwm. Yog li ntawd, xaiv qhov hnyav molecular hnyav ntau yog qhov tseem ceeb rau kev ntsuas viscosity uas xav tau nrog cov kev txiav txim siab.

Qib ntawm kev hloov pauv (DS):
Cov degree ntawm kev hloov pauv yog hais txog tus naj npawb nruab nrab ntawm hydroxypropyl thiab methoxy hloov ib chav nyob rau hauv lub xov tooj cellulogulose. Cov nuj nqis DS ntau dua ib txwm ua rau muaj txiaj ntsig ntau dua vim muaj hydrophilicity thiab cov saw sib cuam tshuam. Txawm li cas los xij, ntau yam hloov pauv tuaj yeem ua rau txo cov solubility thiab gelation ntau. Yog li, ua kom zoo rau DS yog qhov tseem ceeb rau kev ua tiav qhov xav tau viscosity thaum tswj hwm sudubility thiab txheej txheem.

Concentration:
HPMC viscos yog ncaj qha proportional rau nws concentation hauv kev daws teeb meem. Raws li cov polymer convenation nce, tus naj npawb ntawm polymer chains ib lub ntim ntim kuj nce, ua kom muaj kev txhim kho cov saw anentanglement thiab ntau dua viscosity. Txawm li cas los xij, ntawm kev muaj ntau heev, viscosity yuav los yog txawm txo vim yog polymer-polymer sib txuas lus thiab tshwm sim gel tsim. Yog li, ua kom zoo tshaj plaws cov kev xav tau yog qhov tseem ceeb rau kev ua tiav qhov xav tau yam tsis muaj viscosity yam tsis muaj kev cuam tshuam daws teeb meem nyuaj.

Kub:
Kub muaj qhov cuam tshuam tseem ceeb ntawm kev viscos ntawm HPMC. Feem ntau, viscosity txo qis dua nrog kev nce kub vim yog txo cov polymer-polymer sib txuas lus thiab txhim kho molecular. Txawm li cas los xij, cov nyhuv no yuav sib txawv raws li cov xwm txheej xws li lub polymer concentration, hnyav hnyav, thiab kev sib txuam nrog cov kuab tshuaj lossis ntxiv. Qhov kub thiab txias yog xav tias yog thaum tsim cov khoom HPMC los xyuas kom ntseeg tau tias muaj kev ua tau zoo ib yam.

Ph:
Ph PH ntawm kev daws teeb meem HPMC viscosity los ntawm nws cov nyhuv ntawm polymer solubility thiab kev sib txuas lus. HPMC yog feem ntau soluble thiab kev ua yeeb yam siab tshaj plaws viscosity nyob rau hauv me ntsis acidic mus rau nruab nrab phib. Kev sib txawv ntawm cov kab ntau no tuaj yeem ua rau txo cov solubility thiab viscosity vim kev hloov pauv ntawm polymer sib dhos thiab kev sib cuam tshuam nrog cov kuab tshuaj me me. Yog li ntawd, tswj cov qib siab zoo tshaj plaws yog qhov tseem ceeb rau kev ua kom zoo HPMC voscosity hauv kev daws teeb meem.

Ntxiv:
Ntau yam ntxiv, xws li salts, surfactants, thiab co-emvents, tuaj yeem cuam tshuam hpmc viscosity los ntawm kev hloov cov kev daws teeb meem thiab polyment kev sib txuas lus. Piv txwv li, cov ntsev tau ua kom tsis pom kev txawv ua kom tiav los ntawm salting-tawm cov nyhuv, thaum surfactants tuaj yeem cuam tshuam rau saum npoo nro thiab polymer solubility. Co-emvents tuaj yeem hloov kho cov kuab tshuaj polarity thiab txhim kho polymer solubility thiab viscosity. Txawm li cas los xij, qhov sib xyaw thiab kev cuam tshuam ntawm HPMC thiab cov ntxiv yuav tsum tau soj ntsuam kom tsis txhob muaj kev tsis txaus ntseeg ntawm viscosity thiab cov khoom lag luam.

yog ib feem ntau ntau yam polymer dav siv hauv cov tshuaj, kev tsim kho, thiab kev lag luam kom hniav. Lub viscos ntawm HPMC cov kev daws teeb meem ua lub luag haujlwm tseem ceeb hauv kev txiav txim siab nws cov kev ua tau zoo hauv ntau yam kev siv. Nkag siab txog qhov cuam tshuam HPMC viscosity productions, raws li qhov siab, yog qhov tseem ceeb, yog qhov tseem ceeb rau nws ua haujlwm thiab kev ua haujlwm. Los ntawm ua tib zoo txiav txim siab cov yam ntxwv HPMC tuaj yeem ua kom tau HPMC cov khoom kom tau raws li cov cai thov kom zoo. Kev tshawb fawb ntxiv rau hauv kev sib tshuam ntawm cov no yuav txuas ntxiv peb txoj kev nkag siab thiab siv HPMC hauv ntau hom kev sib txawv.