HydroxyPropyyl methylcellulose (HPMC) yog ib qho kev lag luam polymer ntau yam hauv kev lag luam, suav nrog cov tshuaj, suav nrog cov tshuaj, tshuaj pleev ib ce, thiab kev tsim kho. Nws lub peev xwm los tsim cov gels, cov yeeb yaj kiab, thiab cov kev daws teeb meem ua rau nws muaj txiaj ntsig rau ntau daim ntawv thov. Cocky HPMC yog ib qib tseem ceeb nyob rau hauv ntau cov txheej txheem, raws li nws ua rau lub polymer los nthuav tawm cov khoom xav tau zoo.
1. Nkag Siab HPMC:
HPMC yog qhov ua kom muaj txiaj ntsig ntawm cellulose thiab yog synthesized los ntawm kev kho cellulose nrog cov tshuaj pleev cov arelene thiab methyl chloride. Nws yog tus cwj pwm los ntawm nws cov dej-solubility thiab muaj peev xwm ua pob tshab, cov gels remersible. Cov qib ntawm hydroxypropyl thiab mehoxyl hloov kev cuam tshuam cuam tshuam nws cov khoom siv, suav nrog solubility, viscosity, thiab gelation tus cwj pwm.
2. Qhov tseem ceeb ntawm cov dej:
Kev khiav dej yog qhov tseem ceeb kom qhib lub luag haujlwm ntawm HPMC. Thaum HPMC yog hydrated, nws nqus dej thiab swells, coj mus rau kev tsim cov tshuaj uas khov los yog gel, nyob ntawm cov kev xav thiab cov xwm txheej. Lub xeev hydred pab hpmc los ua nws cov haujlwm npaj, xws li thickening, gelling, zaj duab xis-ua yeeb yaj kiab, thiab txhawb tshuaj yeeb.
3. Txoj kev ntawm cov dej:
Muaj ntau txoj hauv kev rau hydrating HPMC, nyob ntawm daim ntawv thov thiab xav tau ua tiav:
a. Dej Txias:
Hom no cuam tshuam nrog dispersing HPMC hmoov hauv dej txias thaum kov maj mam muab.
Cov dej dej txias tawg yog nyiam kom tiv thaiv clumping thiab kom ntseeg tau tias ib qho hydration zoo li qub.
Tom qab dispersion, cov kev daws teeb meem feem ntau tso hydrate ntxiv nyob rau hauv maj ntxhov siab kom ua tiav qhov xav tau.
b. Dej cub:
Hauv hom no, HPMC hmoov tau tawg nyob rau hauv dej kub, feem ntau ntawm qhov kub siab tshaj 80 ° C.
Dej Dej Pab Txhawb Nqa Cov Dej Haus Ceev thiab Ntxov ntawm HPMC, ua rau muaj kev daws teeb meem meej.
Yuav tsum tau saib xyuas kom tsis txhob muaj cua sov ntau dhau, uas tuaj yeem txwv HPMC lossis ua rau pob.
c. Neutralization:
Qee qhov kev thov yuav suav nrog HPMC cov kev daws teeb meem nrog cov neeg sawv cev alkaline xws li sodium hydroces lossis potassium hydroxide.
Neutralization hloov kho lub Ph ntawm kev daws teeb meem, uas tuaj yeem cuam tshuam cov viscosity thiab gelation khoom ntawm HPMC.
d. Hnyav txauv:
HPMC kuj tseem tuaj yeem haus dej los ntawm cov kuab tshuaj pauv, qhov twg nws tau tawg hauv cov dej tsis raug zoo li ethanol lossis methanol thiab tom qab ntawd hloov nrog dej.
Cov kuab tshuaj pauv hloov tuaj yeem muaj txiaj ntsig rau cov ntawv thov uas xav tau kho kom meej tswj cov dej thiab viscosity.
e. Pre-hydration:
Pre-hydration cuam tshuam nrog HPMC hauv dej lossis hnyav ua ntej koom nrog nws ua yeeb yam.
Txoj kev no ua kom muaj dej huv thiab muaj txiaj ntsig zoo rau kev ua tiav cov txiaj ntsig, tshwj xeeb hauv cov qauv nyuaj.
4. Qhov xwm txheej cuam tshuam rau kev haus dej:
Ntau yam cuam tshuam rau kev co hydration ntawm HPMC:
a. Qhov loj me me: finely milled hpmc hmoov hydrates ntau dua li yooj yim dua li coarse hais vim nce thaj chaw thaj chaw.
b. Qhov kub thiab txias: Ntau dua kub feem ntau ua kom cov dej nrawm dua tab sis tuaj yeem cuam tshuam cov viscosity thiab kev coj cwj pwm ntawm HPMC.
c. Ph: lub ph ntawm hydration nruab nrab tuaj yeem cuam tshuam rau lub xeev ionization ntawm HPMC thiab yog li nws cov khoom siv hydration thiab rheological.
d. Kev sib xyaw: kev sib xyaw kom zoo lossis kev ntxhov siab yog qhov tseem ceeb heev rau hydration hydration thiab dispersion ntawm HPMC hais hauv cov kuab tshuaj.
e. Cov siab: Kev suav HPMC hauv cov hydration nruab nrab cuam tshuam lub viscosity, gel lub zog, thiab lwm yam khoom ntawm cov kev daws teeb meem lossis gel.
5. Daim Ntawv Thov:
Hydrated HPMC nrhiav ntau txoj kev siv ntau thoob plaws kev lag luam:
a. Kws Tshuaj: Hauv cov ntsiav tshuaj siv tshuaj, tswj kev tso tawm cov matrices, cov kev daws teeb meem ophthalmic, thiab kev ncua.
b. Food Products: As a thickener, stabilizer, or film-forming agent in sauces, dressings, dairy products, and confectionery.
c. Cov tshuaj pleev ib ce: hauv cream, potions, kua txiv, thiab lwm cov ntawv rau kev hloov kho viscosity thiab emulsification.
d. Cov Khoom Siv Siv Tsim Kho: Hauv cov khoom noj khoom haus cement, pobzeb nplaum, thiab cov ris tsho txhawm rau txhim kho cov haujlwm, khaws dej, thiab cov tshuaj nplaum.
6. Tswjhwm Zoo:
HULMC muaj txiaj ntsig ntawm HPMC yog qhov tseem ceeb rau cov khoom ua haujlwm thiab xwm yeem. Kev ntsuas tswj kom muaj xws li:
a. Kev txheeb xyuas me me me: kom muaj kev sib txuam ntawm cov kev faib tawm ntawm particle loj los ua kom zoo dua hydration hepation kinetics.
b. Viscosity ntsuas: Kev saib xyuas viscosity thaum lub sij hawm hydration kom ua tiav cov kev xav tau rau cov ntawv thov.
c. Ph Kev Saib Xyuas: Tswj cov ph ntawm hydration nruab nrab rau kev txhim kho hydration thiab tiv thaiv kev ua tsis taus.
d. Kev soj ntsuam me me: Pom kev ntawm hydrated kuaj hauv qab ib lub tsom iav kev faib tawm cov kev faib tawm thiab muaj kev ncaj ncees.
7. Xaus:
Cock yog qhov ua tau cov txheej txheem tseem ceeb hauv cov khoom siv hauv HPMC rau ntau yam kev siv. To taub cov hau kev, yam, thiab kev tswj hwm zoo thiab kev tswj hwm yog qhov tseem ceeb rau kev ua haujlwm zoo thiab ua kom haum rau cov qauv. Los ntawm mastering cov hydration ntawm HPMC, cov kws tshawb nrhiav thiab cov kws tshawb fawb tuaj yeem xauv nws cov peev xwm thoob plaws hauv ntau yam kev lag luam, tsav kev tsim kho tshiab thiab cov khoom tsim kev tsim kho tshiab.
Lub Sijhawm Post: Mar-04-2024