Hydroxypropyl methylcellulose (HPMC) yog cov khoom siv hluav taws xob ntau yam siv dav hauv ntau yam lag luam, suav nrog tshuaj, tshuaj pleev ib ce, khoom noj khoom haus, thiab kev tsim kho. Nws lub peev xwm los tsim cov gels, cov yeeb yaj kiab, thiab cov kev daws teeb meem ua rau nws muaj txiaj ntsig rau ntau daim ntawv thov. Kev ywg dej ntawm HPMC yog ib kauj ruam tseem ceeb hauv ntau cov txheej txheem, vim nws ua rau cov polymer tuaj yeem nthuav tawm nws cov khoom xav tau zoo.
1. Nkag siab txog HPMC:
HPMC yog derivative ntawm cellulose thiab yog synthesized los ntawm kev kho cellulose nrog propylene oxide thiab methyl chloride. Nws yog tus cwj pwm los ntawm nws cov dej-solubility thiab muaj peev xwm tsim pob tshab, thermally reversible gels. Qhov degree ntawm hydroxypropyl thiab methoxyl hloov pauv cuam tshuam rau nws cov khoom, suav nrog solubility, viscosity, thiab gelation cwj pwm.
2. Qhov tseem ceeb ntawm Dej:
Kev ywg dej yog qhov tseem ceeb los qhib cov haujlwm ntawm HPMC. Thaum HPMC hydrated, nws absorbs dej thiab swells, ua rau tsim ib tug viscous kua los yog gel, nyob ntawm seb cov concentration thiab tej yam kev mob. Lub xeev hydrated no ua rau HPMC ua nws txoj haujlwm npaj, xws li thickening, gelling, film-forming, thiab sustaining tshuaj tso tawm.
3. Txoj Kev Ua Dej:
Muaj ntau ntau txoj hauv kev rau hydrating HPMC, nyob ntawm daim ntawv thov thiab cov txiaj ntsig xav tau:
a. Dej txias Dispersion:
Txoj kev no suav nrog cov hmoov HPMC dispersing hauv dej txias thaum nplawm maj mam.
Cov dej txias dispersion yog nyiam los tiv thaiv clumping thiab xyuas kom meej hydration uniform.
Tom qab dispersion, cov tshuaj feem ntau tso cai rau hydrate ntxiv nyob rau hauv maj mam agitation kom ua tau raws li qhov xav tau viscosity.
b. Kub Dej Dispersion:
Nyob rau hauv txoj kev no, HPMC hmoov yog dispersed nyob rau hauv dej kub, feem ntau ntawm kub siab tshaj 80 ° C.
Cov dej kub ua kom yooj yim hydration sai thiab tawg ntawm HPMC, ua rau muaj kev daws teeb meem.
Kev saib xyuas yuav tsum tau ua kom tsis txhob muaj cua sov ntau dhau, uas tuaj yeem ua rau HPMC degrade los yog ua rau pob tsim.
c. Neutralization:
Qee daim ntawv thov tuaj yeem cuam tshuam nrog kev daws HPMC cov kev daws teeb meem nrog cov tshuaj alkaline xws li sodium hydroxide lossis potassium hydroxide.
Neutralization kho cov pH ntawm cov tshuaj, uas tuaj yeem cuam tshuam cov viscosity thiab gelation ntawm HPMC.
d. Solvent Exchange:
HPMC kuj tseem tuaj yeem ua dej los ntawm cov kuab tshuaj txauv, qhov uas nws tau tawg mus rau hauv cov dej-miscible hnyav xws li ethanol lossis methanol thiab tom qab ntawd pauv nrog dej.
Kev hloov pauv hnyav tuaj yeem pab tau rau cov ntawv thov uas xav tau kev tswj xyuas meej txog dej thiab viscosity.
e. Pre-hydration:
Pre-hydration suav nrog soaking HPMC hauv dej lossis hnyav ua ntej muab tso rau hauv cov qauv.
Txoj kev no ua kom cov dej huv huv thiab tuaj yeem ua tau zoo rau kev ua tiav cov txiaj ntsig zoo ib yam, tshwj xeeb tshaj yog nyob rau hauv cov txheej txheem nyuaj.
4. Tej yam cuam tshuam rau dej:
Muaj ntau yam cuam tshuam rau hydration ntawm HPMC:
a. Particle Loj: Finely milled HPMC hmoov hydrates yooj yim dua li ntxhib hais vim qhov chaw saum npoo.
b. Kub: Qhov kub siab dua feem ntau ua kom lub cev qhuav dej tab sis tuaj yeem cuam tshuam qhov viscosity thiab gelation tus cwj pwm ntawm HPMC.
c. pH: Lub pH ntawm cov dej nruab nrab tuaj yeem cuam tshuam rau lub xeev ionization ntawm HPMC thiab yog li nws cov dej kinetics thiab rheological zog.
d. Kev sib xyaw: Kev sib xyaw kom zoo lossis kev ntxhov siab yog qhov tseem ceeb rau cov dej tsis sib xws thiab dispersion ntawm HPMC hais hauv cov kuab tshuaj.
e. Concentration: Lub concentration ntawm HPMC nyob rau hauv lub hydration nruab nrab cuam tshuam lub viscosity, gel lub zog, thiab lwm yam khoom ntawm lub resulting tov los yog gel.
5. Daim ntawv thov:
Hydrated HPMC pom ntau daim ntawv thov thoob plaws ntau yam kev lag luam:
a. Pharmaceutical Formulations: Nyob rau hauv cov ntsiav tshuaj coatings, tswj-tso matrices, ophthalmic daws, thiab suspensions.
b. Khoom noj khoom haus: Raws li ib tug thickener, stabilizer, los yog zaj duab xis-tsim tus neeg sawv cev nyob rau hauv cov kua ntses, hnav khaub ncaws, khoom noj siv mis, thiab confectionery.
c. Tshuaj pleev ib ce: Nyob rau hauv cream, lotions, gels, thiab lwm yam formulations rau viscosity hloov thiab emulsification.
d. Cov Khoom Siv Siv: Hauv cov khoom siv cement, cov nplais nplaum, thiab cov khoom siv los txhim kho kev ua haujlwm, dej tuav, thiab adhesion.
6. Kev Tswj Xyuas Zoo:
Kev siv dej zoo ntawm HPMC yog qhov tseem ceeb rau cov khoom ua tau zoo thiab sib xws. Kev tswj xyuas qhov zoo yuav suav nrog:
a. Particle Size Analysis: Xyuas kom meej qhov sib xws ntawm particle loj tis rau optimize hydration kinetics.
b. Kev ntsuas viscosity: Saib xyuas viscosity thaum lub sij hawm hydration kom ua tiav qhov xav tau sib xws rau daim ntawv thov npaj.
c. Kev saib xyuas pH: Tswj pH ntawm cov dej nruab nrab kom ua kom zoo dua dej thiab tiv thaiv kev degradation.
d. Microscopic Examination: Kev kuaj pom ntawm cov qauv hydrated nyob rau hauv lub tshuab ntsuas ntsuas ntsuas particle dispersion thiab kev ncaj ncees.
7. Cov lus xaus:
Hydration yog txheej txheem tseem ceeb hauv kev siv cov khoom ntawm HPMC rau ntau yam kev siv. Kev nkag siab txog cov txheej txheem, yam, thiab kev tswj xyuas qhov zoo uas cuam tshuam nrog hydration yog qhov tseem ceeb rau kev txhim kho cov khoom lag luam thiab ua kom muaj kev sib luag hauv cov qauv. Los ntawm kev paub txog cov dej ntawm HPMC, cov kws tshawb fawb thiab cov kws tsim qauv tuaj yeem qhib nws lub peev xwm thoob plaws ntau yam kev lag luam, tsav tsheb tshiab thiab kev tsim khoom.
Post lub sij hawm: Mar-04-2024