HydroxyPropyyl methylcellose (HPMC) yog ib qho kev siv polymer ntau yam hauv cov kws tshuaj zoo li lub tsev muaj zog, ntawm lwm cov haujlwm. Kev ua si ib lub luag haujlwm tseem ceeb hauv kev tsim khoom ntawm cov ntsiav tshuaj, kom muaj cov cohesion ntawm hmoov rau hauv cov ntaub ntawv ntau npaum li cas.
1. Binding Mechanism:
HPMC muaj ob qho tib si hydrophilic thiab hydrophobic muaj vim nws cov qauv tshuaj, uas muaj cov neeg methyl thiab hydroxypropy. Thaum lub sij hawm ntsiav tshuaj compression, HPMC cov yeeb yaj kiab nplaum, hloov tau yooj yim thaum muaj cov kev daws teeb meem, yog li khi cov hmoov nplej ua ke. Cov nplaum no tshwm sim los ntawm hydrogen dendeling muaj peev xwm ntawm cov pab pawg hydroxyl hauv Hydroxyl pawg hauv Hydroxulitions nrog lwm cov qauv molecules.
2. Particle Agglomeration:
HPMC AIDS hauv kev tsim ntawm agglomerates los ntawm kev tsim cov choj ntawm tus kheej cov lus. Raws li cov ntsiav tshuaj cov ntsiav tshuaj yog compressed, hpmc molecules txuas ntxiv thiab interpenerrate ntawm cov khoom, txhawb nqa cov khoom siv particle-rau-particle. Qhov no agglomeration txhim kho cov neeg kho tshuab zog thiab kev ncaj ncees ntawm cov ntsiav tshuaj.
3. Tswj ntawm kev sib cais:
Lub viscosity ntawm HPMC kev cuam tshuam tus nqi ntawm cov ntsiav tshuaj tsis sib xws thiab tso yeeb tshuaj. Los ntawm kev xaiv cov qib tsim nyog thiab cov qauv muaj txiaj ntsig ntawm HPMC, cov qauv tuaj yeem ua kom cov ntaub ntawv tshaj tawm ntawm cov ntsiav tshuaj kom ua tiav cov tshuaj uas xav tau cov tshuaj tso tawm. Qib Voj Ncauj Ntau Qib HPMC feem ntau ua rau qeeb qeeb kawg ntawm kev ua tiav gel.
4. Uniformation:
HPMC AIDS hauv cov khoom sib faib ntawm cov khoom siv tsis muaj zog ntawm cov khoom noj muaj zog (API) thiab ua kom muaj kev cia siab thoob plaws hauv lub ntsiav tshuaj matrix. Los ntawm nws txoj kev khi ua, HPMC pab tiv thaiv kev sib kis cov khoom xyaw, kom muaj kev faib tawm homogeneous thiab cov ntsiab lus siv tshuaj tsis tu ncua hauv txhua ntsiav tshuaj.
5. Sib xyaws nrog cov khoom xyaw nquag:
HPMC yog cov khoom siv tsis sib xws thiab tau tshaj tawm ntau yam ntawm cov khoom xyaw ua lag luam, ua rau nws haum rau tsim ntau yam tshuaj siv yeeb tshuaj. Nws tsis hnov mob nrog lossis degrade feem ntau cov tshuaj, khaws cia lawv cov kev ruaj ntseg thiab kev ua tau zoo nyob thoob plaws lub txee lub neej ntawm cov ntsiav tshuaj.
6. Cov hmoov av tsim:
Thaum lub sij hawm ntsiav tshuaj compression, HPMC tuaj yeem ua raws li cov hmoov av suppressant, txo cov tiam ntawm cov pa pa. Cov cuab yeej no ua kom muaj kev nyab xeeb thiab tswj kev thaj chaw ua kom huv.
7. Phob nyob o:
HPMC cov khoom ua yeeb yam phasent o-nyob nraum o o resent o ouching outtake thiab gel tsim cov khoom sib txawv nrog pH. Cov xeeb ceem no tuaj yeem ua tau zoo rau kev sau cov ntaub ntawv siv tshuaj uas tau tsim los tso cov tshuaj ntawm cov chaw tshwj xeeb raws li txoj kab mob plab.
8. Kev tswj hwm kev lees paub:
HPMC tau lees paub los ntawm cov koom haum tswj hwm xws li Asmeskas Chaw Tswj Xyuas Khoom Noj thiab Tshuaj (FDA) thiab European tshuaj kho cov chaw lag luam (EMA) rau siv tshuaj. Nws yog teev nyob rau hauv ntau yam kws tshuaj ntsuam lub cev thiab ua raws li cov qauv tsim txiaj, kom muaj kev nyab xeeb khoom thiab ua tau zoo.
9. Yooj yim rau cov qauv:
HPMC muaj kev tsim cov khoom siv yooj yim, raws li nws tuaj yeem siv ib leeg lossis sib xyaw ua ke nrog lwm cov khoom siv, fillers, thiab cov khoom siv ua kom tiav kom ua tiav cov tshuaj ntsiav tshuaj xav tau. Cov versatility no tso cai rau cov kws sau ntawv los txiav cov qauv ua kom tau raws li cov neeg xa tshuaj tshwj xeeb.
10. Biocompatibility thiab kev nyab xeeb:
HPMC yog biocompibic, tsis muaj tshuaj lom, thiab tsis-uncardic, ua rau nws haum rau kev noj cov ntaub ntawv. Nws poob qis kev ua tiav ntawm txoj hnyuv tsis muaj kev phom sij lossis kev sib raug zoo ntawm cov ntsiav tshuaj tag nrho.
HydroxyPropyf Metylcellulose kev ua haujlwm yog kev faib tawm hauv cov tshuaj ntsig los ntawm kev faib cov khoom sib xyaw, ua kom muaj kev nyab xeeb thiab tswj kev nyab xeeb. Nws cov khoom tshwj xeeb ua rau nws muaj cov tshuaj tsis tseem ceeb hauv kev txhim kho cov ntsiav tshuaj zoo rau kev xa cov tshuaj.
Lub Sijhawm Post: Tsib Hlis-25-2024