Hypromellose (HPMC) siv li cas hauv cov ntsiav tshuaj ntev-tso tawm matrix?

Hauv kev lag luam kws tshuaj, hypromellose (HPMC, METHOCEL ™) tuaj yeem siv los ua cov muab tub lim, khi, ntsiav tshuaj txheej polymer thiab cov khoom siv tseem ceeb los tswj cov tshuaj tso tawm. Hypromellose tau siv rau hauv cov ntsiav tshuaj rau ntau tshaj 60 xyoo thiab yog ib qho tseem ceeb excipient dav siv nyob rau hauv hydrophilic gel matrix ntsiav tshuaj.

Ntau lub tuam txhab tshuaj siv hypromellose rau kev tswj cov tshuaj tso tawm, tshwj xeeb tshaj yog nyob rau hauv hydrophilic gel matrix ntsiav tshuaj formulations. Thaum nws los txog rau cov khoom lag luam hypromellose, tej zaum koj yuav xav tsis thoob yuav ua li cas xaiv - tshwj xeeb tshaj yog tias koj tab tom nrhiav ib yam dab tsi uas zoo thiab ruaj khov rau kev lag luam rau koj cov neeg siv khoom. Hauv phau ntawv qhia no, peb yuav tham txog yam tseem ceeb uas koj yuav tsum paub txog hypromellose.

Hypromellose yog dab tsi?

Hypromellose, tseem hu uaHydroxypropyl methylcellulose (HPMC), yog ib qho polymer siv los ua cov tshuaj siv tshuaj los tswj kev tso tawm cov tshuaj los ntawm qhov ncauj hydrophilic gel matrix ntsiav tshuaj.

Hypromellose yog ib qho khoom siv hluav taws xob semi-synthetic muab los ntawm cellulose, uas muaj ntau tshaj polymer nyob rau hauv cov xwm. Qee yam ntawm nws cov khoom muaj xws li:

. soluble nyob rau hauv dej txias

. insoluble hauv dej kub

. Tsis yog

. Selectively soluble nyob rau hauv cov organic solvents

. Reversibility, thermal gel zog

. Dej thiab viscosity ywj siab ntawm pH

. Surfactant

. tsis muaj tshuaj lom

. Saj thiab tsw yog me me

. Enzyme kuj

. pH (2-13) ntau stability

. Nws tuaj yeem siv ua thickener, emulsifier, binder, tus nqi tswj, zaj duab xis qub

Hydrophilic Gel Matrix Tablet yog dab tsi?

Hydrophilic gel matrix ntsiav tshuaj yog ib daim ntawv ntau npaum li cas tuaj yeem tswj cov tshuaj tso tawm ntawm cov ntsiav tshuaj nyob rau lub sijhawm ntev.

Hydrophilic gel matrix ntsiav tshuaj npaj:

. kuj yooj yim

. Yuav tsum tau tsuas yog cov txheej txheem ntsiav tshuaj compression khoom

. Tiv thaiv kom tsis txhob siv tshuaj pov tseg

. Tsis cuam tshuam los ntawm cov ntsiav tshuaj hardness lossis compression quab yuam

. Cov tshuaj tso tawm tuaj yeem hloov kho raws li tus nqi ntawm excipients thiab polymers

Kev siv hypromellose hauv cov ntsiav tshuaj hydrophilic gel-matrix tau txais kev pom zoo los ntawm kev tswj hwm, thiab hypromellose yooj yim siv thiab muaj cov ntaub ntawv kev nyab xeeb zoo, uas tau pom los ntawm ntau cov kev tshawb fawb. Hypromellose tau dhau los ua qhov kev xaiv zoo tshaj plaws rau cov tuam txhab tshuaj los tsim thiab tsim cov ntsiav tshuaj uas tau tso tawm.

Yam Tseem Ceeb cuam tshuam rau kev tso tshuaj los ntawm cov ntsiav tshuaj Matrix:

Thaum tsim cov ntsiav tshuaj txuas ntxiv, muaj ob yam tseem ceeb los xav txog: kev tsim thiab kev ua tiav. Kuj tseem muaj cov ntsiab lus tseem ceeb los txiav txim siab thaum txiav txim siab txog kev tsim thiab tso tawm profile ntawm cov khoom siv tshuaj zaum kawg.

Formula:

Yam tseem ceeb uas yuav tau xav txog rau kev loj hlob thaum ntxov:

1. Polymer (hloov hom, viscosity, tus nqi thiab particle loj)

2. Tshuaj (particle loj thiab solubility)

3. Bulking agents (solubility and dosage)

4. Lwm yam excipients (stabilizers thiab buffers)

Khoom siv tes ua:

Cov yam tseem ceeb no muaj feem xyuam nrog yuav ua li cas cov tshuaj raug tsim:

1. Cov txheej txheem ntau lawm

2. Ntsiav tshuaj loj thiab zoo li

3. Tablet quab yuam

4. pH ib puag ncig

5. Zaj duab xis txheej

Yuav ua li cas skeleton chips ua haujlwm:

Hydrophilic gel matrix ntsiav tshuaj tuaj yeem tswj tau cov tshuaj tso tawm los ntawm cov txheej txheem gel, suav nrog ob lub tswv yim ntawm kev nthuav dav (cov khoom xyaw ua kom muaj kuab lom) thiab yaig (cov khoom xyaw tsis muaj kuab lom), yog li cov viscosity ntawm cov polymer muaj kev cuam tshuam zoo rau kev tso tawm profile. Siv hypromellose, cov tuam txhab lag luam tuaj yeem siv cov tshuaj hydrophilic gel matrix ntsiav tshuaj los kho qhov kev tso tawm ntawm cov tshuaj, muab cov koob tshuaj zoo dua thiab ua raws li tus neeg mob zoo dua, yog li txo lub nra ntawm cov tshuaj rau cov neeg mob. Txoj kev noj tshuaj ib zaug ib hnub yog qhov zoo tshaj qhov kev paub ntawm kev noj ntau cov ntsiav tshuaj ob peb zaug hauv ib hnub.