Kws tsim kho cov neeg siv tau yog expipients thiab excuomets siv nyob rau hauv kev tsim cov tshuaj thiab cov qauv tshuaj, thiab yog ib feem tseem ceeb ntawm kev npaj tshuaj. Raws li lub ntuj polymer muab cov khoom siv, cellulose ether muaj cov yam ntxwv ntawm biodebrose, thiab tus nqi qis, hydroxyprropyl cellulose,Neeg muaj neeg ua haujlwmxws li hydroxyethyl cellulose thiab cellulose cellulose muaj cov ntawv thov tseem ceeb hauv chaw tsim tshuaj. Tam sim no, cov khoom lag luam ntawm cov xov tooj ntawm cov xov tooj etheric feem ntau yog siv rau hauv nruab nrab thiab qis-kawg ntawm kev lag luam, thiab tus nqi ntxiv tsis yog. Kev lag luam ceev yuav tsum tau hloov pauv thiab hloov kho thiab txhim kho cov ntawv thov high-kawg ntawm cov khoom lag luam.
Kws tsim kho cov tshuaj kom zoo nkauj ua lub luag haujlwm tseem ceeb hauv kev txhim kho thiab kev tsim cov qauv ntawm cov qauv. Piv txwv li, hauv kev npaj ua kom raug rau cov tshuaj uas muaj kev tiv thaiv cellulines, muaj ntau yam tshuaj pleev cov tshuaj, thiab cov khoom siv hluav taws xob tso tawm. Npaj thiab ua kua ua kom tiav-tso tawm tau siv dav. Hauv cov kab ke no, cov polymers xws li cov kws kho mob cellulose feem ntau siv los tswj cov neeg muaj tshuaj hauv tib neeg lub cev kom ua tiav lub hom phiaj ntawm kev kho mob.
Raws li kev txheeb cais thiab kev tshawb fawb, muaj txog 500 yam ntawm kev ua lag luam hauv kuv lub tebchaws (ntau tshaj 3000 tshaj li 3000 yam), muaj ntau yam sib txawv), thiab cov hom tseem me. Kuv lub teb chaws cov tshuaj uas tau saib xyuas cov peev txheej ntawm kev ua lag luam yog loj heev. Nws yog to taub tias lub kaum lub tsev pheeb suab ntaub hauv kuv lub teb chaws nplai yog tshuaj ntsuab gelcol, pvp, zaj duab xis, duab dhos ua yeeb yaj kiab methylropeny (HPMC), thiab microcrystalline fibers. Tus neeg tsis noj nqaij, HPC, lactose.
"Ntuj cellulose ether yog cov lus dav dav rau cov tshuaj tiv thaiv kab mob hydrounds thiab yog cov khoom noj hauv tsev, tshuaj noj, tshuaj thiab txhua daim teb, Kws Kho Mob-Cov Khoom lag luam yog qhov tseem ceeb ntawm kev lag luam etards kuj yog qhov nyuaj ntawm cov tshuaj etarder. Matrix ntsiav tshuaj, pahtric-soluble coating cov ntaub ntawv, txhawb nqa microcapsule ntim cov khoom, siv cov khoom siv tshuaj yeeb yaj kiab, thiab lwm yam.
Sodium Carboxymethyl cellulose (CMC-NA) yog lub cellulose ether nrog cov loj tshaj plaws thiab noj nyob hauv tsev thiab txawv teb chaws. Nws yog Ionic cellulose ither ua los ntawm cov paj rwb thiab ntoo los ntawm kev sib dhos thiab etherical nrog chloroacetic acid. CMC-NA yog ib feem uas siv cov kws tshuaj kom zoo. Nws yog feem ntau siv los ua binder rau kev npaj khoom thiab raws li lub thickening, thickening thiab ncua rau kev npaj kua. Nws kuj tseem siv tau los ua cov dej-soluble matrix thiab cov duab ua yeeb yaj kiab. Nws yog feem ntau siv los ua cov ntaub ntawv sau tshuaj yeeb yaj kiab thiab cov ntsiav tshuaj kom raug tshem tawm (tswj tau) tso tawm cov qauv.
Ntxiv nrog rau sodium carboxymethyl cellulose raws li cov tshuaj siv tshuaj, cov ncauj lus paj hlwb los kuj tuaj yeem siv ua cov tshuaj uas tau siv. Hla tus carboxymethyl cellulose sodium (CCMC-NA) yog cov tshuaj uas muaj roj hlau uas muaj qhov sib tw ntawm cov acidganic acid catalyst thiab yog huv. Tus neeg sawv cev hla tuaj yeem yog propylene glycol, succinic anhydride, txiv neej anhydride, adipic anhydride, thiab zoo li. Croscarmellose sodium yog siv los ua ib tug neeg ua txhaum rau cov ntsiav tshuaj, tsiav tshuaj thiab granules hauv kev npaj rau qhov ncauj. Nws tso siab rau capillary thiab officiping kom ua tiav kev sib tua. Nws muaj cov kev hloov kho zoo thiab muaj zog ua kom tawg. Cov kev tshawb fawb tau qhia tias qhov ource ntawm cov dej qab zib hauv dej yog ntau dua li cov neeg tsis sib haum xeeb xws li cov khoom siv tsis tshua muaj zog xws li cov roj cellulose ntau dua.
Methyl Cellulose (MC) yog cov neeg tsis-ionic cellulose monoether ua los ntawm cov paj rwb thiab ntoo los ntawm kev sib dhos thiab methyl cettication ethermication. Methyl Cellulose muaj cov dej ua dej zoo heev thiab ruaj khov hauv phua ntawm 2.0 txog 13.0. Nws yog dav siv nyob rau hauv cov tshuaj uas zoo siab, thiab yog siv nyob rau hauv cov ntsiav tshuaj subloft, intramuscular kev npaj, kev tshem tawm qhov ncauj, tshem tawm qhov ncauj, cov ntsiav tshuaj thiab kev npaj cov ncauj. Tsis tas li ntawd, hauv cov qauv tso tawm, MC tuaj yeem siv los ua cov khoom siv hydroxilagent, txhawb nqa cov me me cov khoom siv, siv cov khoom siv tshuaj yeeb yaj kiab, thiab lwm yam.
HydroxyPropyyl methylcellose (HPMC) yog qhov tsis-ionic cellulose sib xyaw los ntawm cov paj rwb thiab ntoo los ntawm cov tshuaj pleev xim rau cov tshuaj pleev antylene oxide thiab methyl chloride. Nws yog tsis muaj ntxhiab, cov tsis tau, tsis muaj tshuaj lom, soluble hauv dej txias, thiab gels hauv dej kub. HydroxyPropyf methylculose yog lub cellulose sib xyaw ua ke rau ntau yam nyob rau hauv kev tsim khoom, noj thiab tau zoo nyob rau 15 xyoo dhau los. Nws tseem yog ib qho ntawm cov tshuaj uas tsim nyog tshaj plaws hauv tsev thiab txawv teb chaws. Nws tau raug siv los ua cov khoom siv tshuaj uas tau txais kev zam rau ze li 50 xyoo. Xyoo keeb kwm. Tam sim no, daim ntawv thov ntawm HPMC yog xav tau nyob rau hauv tsib yam hauv qab no:
Ib qho yog ib phau ntawv sau thiab tsis sib haum. HPMC ua phau ntawv yuav ua rau cov tshuaj yooj yim ntub dej, thiab nws tuaj yeem nthuav ntau pua lub sijhawm tom qab nqus tau cov ntsiav tshuaj lossis tso tawm ntawm cov ntsiav tshuaj. HPMC muaj cov viscosity muaj zog, thiab tuaj yeem txhim kho cov particle viscosity thiab txhim kho lub tshuab nias ntawm cov ntaub ntawv nyoos nrog cov ntawv siv tawv me. HPMC nrog cov viscosity qis tuaj yeem siv tau los ua cov binder thiab ua tsis taus, thiab HPMC nrog viscosity siab tuaj yeem siv los ua phau ntawv.
Thib ob, nws yog siv los ua kev txhawb nqa thiab tswj cov khoom tso tawm rau qhov ncauj npaj. HPMC yog ib feem siv hydrogel matrix cov khoom nyob rau hauv kev tsim txom-tso tawm. HPMC ntawm Qib Viscosity Tsawg (5 ~ 50MPAs Binder rau cov ntsiav tshuaj thiab hydrophilic gel Matrix cov ntsiav tshuaj ruaj khov. HPMC yog soluble nyob rau hauv cov kua roj plab, muaj qhov zoo ntawm cov khoom siv zoo, cov tshuaj zoo, cov yeeb tshuaj muaj zog thiab cov tshuaj tso tawm cuam tshuam los ntawm Ph. Nws yog ib qho tseem ceeb heev hydrophilic cov khoom siv hydrophilic cov khoom hauv kev npaj cov tshuab thiab cov khoom siv tawm hws kom muaj kev npaj tshuaj thiab cov pa hluav taws xob.
Qhov thib peb yog raws li txheej xim yeeb yaj kiab-ua tus neeg sawv cev.HPMCmuaj cov yeeb yaj kiab zoo-ua yeeb yam. Zaj duab xis tsim los ntawm nws yog yam tsis zoo, pob tshab, thiab tawv, thiab nws tsis yooj yim rau kev tsim khoom. Tshwj xeeb tshaj yog rau cov tshuaj uas tau yooj yim nqus noo noo thiab tsis ruaj khov, siv nws ua kev sib cais ntawm cov tshuaj thiab tiv thaiv cov yeeb yaj kiab hloov xim. HPMC muaj ntau yam viscosity specifications. Yog tias xaiv tau zoo, qhov zoo thiab cov tsos ntawm cov ntsiav tshuaj zoo dua li lwm cov ntaub ntawv, thiab nws cov kev sib tw tau yog 2% rau 10%.
Plaub yog siv los ua cov tshuaj ntsiav tshuaj ntsiav. Nyob rau hauv xyoo tsis ntev los no, nrog kev tawm tsam nquag ntawm ntiaj teb tsiaj ntawm lub ntiaj teb tsiaj, piv nrog gelatin tsiav tshuaj, nroj tsuag capsules tau dhau los ua tus tshiab ntawm cov chaw tshuaj thiab khoom noj khoom haus. Pfizer tau ua tiav HPMC los ntawm cov nroj tsuag ntuj thiab npaj vcaptm zaub capsules. Piv nrog tsoos gelatin hollow cafsules, zaub tsiav tshuaj muaj qhov zoo ntawm kev sib txuas, tsis muaj kev sib txuas ntawm cov tshuaj tiv thaiv kev sib txuas, thiab qhov ruaj khov. Tus nqi tso tawm Yeeb Tshuaj yog qhov sib txawv, thiab qhov sib txawv yog me me. Tom qab ua kom tsis tu ncua nyob rau hauv tib neeg lub cev, nws tsis yog nqus thiab tuaj yeem raug tawm. Tawm ntawm lub cev. Hais txog kev cia xwm txheej, tom qab ntau ntawm cov kev ntsuam xyuas, nws yuav luag tsis yog ruaj khov nyob rau hauv cov av noo nyob rau hauv cov nroj tsuag muaj tej yam kev cia khoom tsis muaj kev cuam tshuam. Nrog tib neeg to taub cov nroj tsuag tsiav tshuaj thiab kev hloov pauv ntawm cov tswv yim pej xeem hauv tsev hauv tsev thiab txawv teb chaws rau cov tshuaj ntsiav yuav loj hlob sai.
Thib tsib yog raws li kev ncua tus neeg sawv cev. Raug ncua hom ua kua npaj yog ib qho kev siv tshuaj kho mob uas tsis tshua muaj kev cuam tshuam cov tshuaj uas nyuaj rau cov tshuaj tsis sib xws. Qhov ruaj khov ntawm lub system txiav txim siab qhov zoo ntawm kev ncua kev ua kua npaj. HPMC colloidal kev daws teeb meem yuav txo cov kua-kua interfacial nro, txo cov khoom qab zib dawb ntawm cov khoom, thiab ruaj khov lub heterogeneous system. Nws yog ib tug neeg sawv cev ua tau zoo tshaj plaws. HPMC yog siv los ua cov tuab rau cov tee qhov muag, nrog cov ntsiab lus ntawm 0.45% rau 1.0%.
HydroxyPropyl cellulose (HPC) yog cov neeg tsis muaj IONIC ntawm tes ua los ntawm cov paj rwb thiab ntoo los ntawm kev sib dhos thiab pleev etherene etherification etherification. HPC feem ntau soluble nyob rau hauv cov dej hauv qab 40 ° C thiab ntau npaum li cas ntawm polar cov kuab tshuaj, thiab nws cov kev ua tau muaj feem xyuam rau cov ntsiab lus ntawm hydroxypropyl thiab qib ntawm polymerization. HPC tuaj yeem sib haum nrog ntau yam tshuaj thiab muaj cov inertness zoo.
Tsawg-hloov hydroxyprropyl cellulose(L-HPC)Feem ntau yog siv los ua cov ntsiav tshuaj tsis sib xws thiab phau ntawv. Nws cov yam ntxwv yog: yooj yim rau nias thiab tsim, muaj zog siv tau, thiab nws kuj tuaj yeem ua kom cov ntsiav tshuaj muaj kev cuam tshuam tau sai sai, thiab txhim kho cov txiaj ntsig zoo hauv cov curative.
Muaj ntau dua hloov hydroxyprropyl cellulose (H-HPC) tuaj yeem siv los ua tus neeg sawv cev rau cov ntsiav tshuaj, granules thiab cov granules zoo nyob hauv cov chaw muag tshuaj. HPC muaj cov yeeb yaj kiab zoo tshaj plaws, thiab cov yeeb yaj kiab tshwm sim yog qhov nyuaj thiab ywj, uas tuaj yeem piv nrog cov tshuab yas. Los ntawm kev sib xyaw nrog lwm cov neeg tiv thaiv ntub dej los ntawm cov yeeb yaj kiab, thiab nws feem ntau siv los ua cov khoom ua yeeb yaj kiab rau cov ntsiav tshuaj. HPC HPC kuj tseem siv tau los ua cov khoom sib dhos los npaj cov ntsiav tshuaj, kev tso tawm cov pob tw thiab cov txheej txheem ob npaug.
Hydroxyethyl cellulose (HEC) yog cov neeg tsis-ionic cellulose monoether ua los ntawm cov paj rwb thiab ntoo los ntawm kev ua alkalization thiab ethylene oxide ethermication. HEC yog tsuas yog siv los ua tuab, colloidal tiv thaiv tus neeg sawv cev, nplaum, stabilizer, tus neeg sawv cev, cov khoom siv ua yeeb yaj kiab thiab tso cov khoom noj qeeb hauv tsev kho mob. Nws tuaj yeem siv rau emulsions, tshuaj pleev, thiab poob qis rau cov tshuaj pleev. Cov kua ncauj, cov ntsiav tshuaj cov khoom, tsiav tshuaj thiab lwm cov ntawv ntau npaum li cas. Hydroxyethyl cellulose tau muaj nyob hauv Asmeskas Pharmacopoeia / Us Pharmacopoeia / us National Sormulary thiab European Pharpacoeia.
Ethyl cellulose (EC) yog ib qho ntawm feem ntau dav siv dej-insoluble cellulose derivget. EC yog tsis muaj tshuaj lom, ruaj khov, insoluble hauv dej, kua qaub lossis alkaline daws, thiab soluble hauv cov ethanol thiab methanol. Cov kuab tshuaj uas ib txwm siv yog cov kuab tshuaj sib xyaw ntawm Toluene / ethanol 4/1 (qhov hnyav). EC muaj ntau cov siv hauv kev npaj cov tshuaj, thiab cov khoom siv sib dhos, ua cov khoom siv sib dhos, ua cov khoom siv sib dhos, ua cov khoom siv sib xyaw los npaj cov txheej txheem kom raug tshem tawm thiab Kev Tawm Tsam-Tso Tawm Pelapets, raws li encapsulation awberbiliary los npaj cov medaged-relut microcpinsules; Nws tseem tuaj yeem siv dav siv raws li cov khoom siv tuam tsev nws yog siv los npaj cov khoom tawg; Nws tuaj yeem sau tau dav hauv cov tshuaj thev naus laus zis ua cov yeeb yaj kiab ua yeeb yaj kiab thiab cov txheej tiv thaiv, thiab nws kuj tseem tuaj yeem siv ua cov binder thiab muab tub lim. Raws li kev tiv thaiv kev tiv thaiv rau cov ntsiav tshuaj, nws tuaj yeem txo cov ntxeem tau ntawm cov ntsiav tshuaj av noo thiab tiv thaiv cov tshuaj los ntawm kev daws cov dej noo thiab tsis zoo los ntawm kev ya raws; Nws tseem tuaj yeem ua cov kua yas tso tawm thiab microencapsulate lub polymer kom tsis tu ncua cov tshuaj cuam tshuam.
Hauv cov ntsiab lus, cov dej-soluble sodium carboxymethyl cellulose, hydroxyethylrant cellulose, hydroxyrants, dispolled cov ntaub ntawv rau qhov ncauj Npaj, txheej zaj duab xis-ua cov neeg sawv cev, cov tshuaj ntsiav thiab cov neeg sawv cev tsis ncua. Saib lub ntiaj teb, ntau tus neeg ua haujlwm tuam txhab txawv teb chaws (shin-etsu Kev nqis peev nyob hauv daim ntawv thov. Dow wolff tshaj tawm tias nws yuav nce siab nws ua tib zoo saib rau cov khoom lag luam, cov khoom siv npaj khoom lag luam, thiab nws cov ntawv thov kev pabcuam yuav tseem yuav siv zog kom ze rau kev ua lag luam. Lub woluff cellulose faib ntawm Dow tshuaj thiab xim corconorconorcoration ntawm Tebchaws Meskas tau tsim kev txhawb nqa kev pab nyob thoob ntiaj teb. Nws muaj ntau dua 1,200 tus neeg ua haujlwm hauv 9 lub nroog, 15 lub cuab tam thiab 6 GMP tuam txhab. Cov kws tshaj lij tshawb fawb cov kws tshaj lij muab cov kev pabcuam rau cov neeg muaj kwv yees li 160 lub teb chaws. Ashland muaj cov hauv paus ntau lawm nyob rau hauv Beijing, Tianjin, Nanjaus, Chanshan thiab tau nqis peev rau peb lub chaw tshawb xyuas thev naus laus technology hauv Shanghai thiab Nanjing.
Raws li kev txheeb cais los ntawm lub vev xaib ntawm Suav cellulose koom haum, nyob rau xyoo 2017, lub tsev cellulose ether yog 373,000 tons thiab muag ntim khoom yog 360 txhiab tons. Hauv xyoo 2017, qhov tseeb muag ntawm ionicCmcyog 234,000 tons, nce ntxiv ntawm 18.61% xyoo-nyob rau-xyoo, thiab cov muag muag ntawm cov tsis yog-ionic cmc yog 126,000 tons, nce ntxiv 8.2% thawm xyoo. Ntxiv rau HPMC (tsev khoom siv qib) tsis yog-ionic khoom,HPMC(Kws tsim cov tshuaj), HPMC (HPMC (HPMC (HPMC, HEC, HEC, HPC, MC, HEMC, thiab lwm yam Risen tiv thaiv cov qauv, thiab kev tsim khoom thiab muag tau txuas ntxiv ntxiv. Cov kws kho mob cellulic tau ua rau muaj ntau xyoo, thiab cov zis tau dhau los ua lub ntiaj teb thawj zaug. Txawm li cas los xij, feem ntau ntawm cov tuam txhab etherulose cov khoom lag luam yog tsuas yog siv nyob hauv nruab nrab thiab qis kawg ntawm kev lag luam, thiab tus nqi ntxiv tsis yog.
Tam sim no, feem ntau ntawm cellulic cellulose ether cov kev lag luam yog nyob rau hauv lub sijhawm tseem ceeb ntawm kev hloov pauv thiab txhim kho. Lawv yuav tsum txuas ntxiv kev tshawb fawb cov khoom lag luam thiab kev tsim kho cov khoom lag luam enrick, thiab siv ntau yam kev lag luam thoob ntiaj teb thiaj li tuaj yeem nthuav dav sai li sai tau. Ua kom tiav qhov kev hloov pauv thiab hloov kho dua tshiab, nkag mus rau thaum nruab nrab-rau-siab kawg ntawm kev lag luam, thiab ua tiav benign thiab kev loj hlob ntsuab.
Lub Sijhawm Post: Apr-25-2024