HPMC (HydroxyPropyyl methylulose) yog cov tuab dua tshiab thiab stabilizer nquag siv hauv cov khoom siv hauv tsev, tsho loj, tshuaj thiab khoom noj. HPMC 15 CPS txhais tau hais tias nws viscosity yog 15 centipoise, uas yog qib viscosity tsawg.
1. Nce HPMC concentration
Qhov ncaj qha thiab txoj hauv kev zoo los nce viscosity ntawm HPMC yog kom nce nws cov kev xav hauv kev daws teeb meem. Thaum qhov pawg feem ntawm HPMC nce, lub viscosity ntawm kev daws teeb meem tseem yuav nce ntxiv. Cov tub ntxhais ntawm hom no yog HPMC nce viscosity ntawm kev daws teeb meem los ntawm kev tsim ib qho kev sib tw ntawm cov qauv network. Raws li tus naj npawb ntawm HPMC lwg me me hauv kev daws teeb meem nce, lub zog thiab lub zog ntawm lub network qauv tseem yuav nce ntxiv, yog li nce lub viscosity ntawm kev daws. Txawm li cas los xij, muaj qhov txwv los ua kom muaj kev nce siab ntxiv. Siab heev ntawm HPMC yuav ua rau cov tshuaj ntawm kev daws teeb meem kom txo tau, thiab tuaj yeem cuam tshuam rau nws cov kev ua tau zoo hauv cov ntawv thov, xws li kev tsim kho thiab ua haujlwm.
2. Tswj qhov kub ntawm kev daws teeb meem
Qhov kub muaj qhov cuam tshuam zoo rau solubility thiab viscosity ntawm HPMC. Ntawm qis dua kub, lub viscosity ntawm HPMC daws tau siab dua; Thaum lub sijhawm kub siab dua, lub viscos ntawm HPMC kev daws yuav tsawg. Yog li ntawd, txo qis qhov ntsuas kub ntawm kev daws qhov kev daws teeb meem thaum siv tuaj yeem nce viscosity ntawm HPMC. Nws yuav tsum raug sau tseg tias kev ua solubility ntawm HPMC hauv kev daws teeb meem yog txawv ntawm ntau qhov kub. Nws yog feem ntau yooj yim rau tawg nyob rau hauv dej txias, tab sis nws yuav siv sij hawm ib lub sij hawm los ua kom tiav. Nws dissolves sai dua hauv dej sov, tab sis cov viscosity yog qis dua.
3. Hloov cov pH tus nqi ntawm cov kuab tshuaj
Lub viscosity ntawm HPMC tseem rhiab rau tus nqi PHIC ntawm kev daws teeb meem. Hauv qab nruab nrab lossis ze-nruab nrab qhov xwm txheej, lub viscosity ntawm HPMC kev daws teeb meem yog qhov siab tshaj plaws. Yog tias tus nqi ntawm tus nqi ntawm cov tshuaj deviates los ntawm nruab nrab, cov viscosity yuav txo qis. Yog li ntawd, cov tshuaj tua kab mob HPMC tau nce ntxiv los ntawm kev hloov kho pH tus nqi kom zoo rau cov kev daws teeb meem (piv txwv li, los ntawm kev tswj hwm cov kua qaub). Txawm li cas los xij, hauv kev ua haujlwm tiag, kev hloov kho ntawm PHIC tus nqi yuav tsum ceevfaj heev, vim tias cov kev hloov loj tuaj yeem ua rau HPMC teeb meem lossis kev ua phem.
4. Xaiv cov kuab tshuaj uas haum
Lub solubility thiab viscosity ntawm HPMC nyob rau hauv cov kuab siv hluav taws xob sib txawv txawv. Txawm hais tias HPMC feem ntau yog siv hauv cov kev daws teeb meem aqueous, xws li ntawm ethanol, isoprodanol, isoppic molecule, yog li cuam tshuam rau viscosity. Piv txwv li, ib qho me me ntawm cov huab cua muaj me tuaj yeem txo qhov kev cuam tshuam ntawm cov roj av molecules ntawm HPMC, yog li nce lub viscosity ntawm kev daws. Hauv kev ua haujlwm tshwj xeeb, nws yog qhov tsim nyog los xaiv cov tshuaj uas tsim nyog raws li cov ntawv thov tiag tiag.
5. Siv cov kev pabcuam tuab tuab
Hauv qee kis, lwm yam kev pabcuam ua kom tuab tuaj yeem ntxiv rau HPMC kom ua tiav cov nyhuv ntawm kev nce viscosity. Feem ntau siv cov pa xaim no suav nrog xantening aids, carbomer, thiab lwm yam ntxiv rau cov qauv harterer, thiab lwm yam. Piv txwv li, Xanthan ntawm cov pos hniav yog lub ntsej muag zoo nkauj nrog cov nyhuv tuab tuab. Thaum siv nrog HPMC, ob qho tuaj yeem tsim cov nyhuv synergistic thiab ua kom cov viscosity ntawm lub system.
6. Hloov pauv cov qib ntawm kev hloov pauv ntawm HPMC
Lub viscos ntawm HPMC kuj muaj feem xyuam nrog rau qib ntawm kev hloov pauv ntawm nws cov methoxy thiab hydroxypropoxy pawg. Cov qib ntawm kev hloov pauv cuam tshuam rau nws solubility thiab viscosity ntawm kev daws. Los ntawm xaiv HPMC nrog cov qib sib txawv ntawm qhov hloov chaw, lub viscosity ntawm kev daws teeb meem yuav hloov kho. If a higher viscosity HPMC is required, a product with a higher methoxy content can be selected, because the higher the methoxy content, the stronger the hydrophobicity of HPMC, and the viscosity after dissolution is relatively high.
7. Ncua lub sijhawm xaus
Lub sijhawm thaum HPMC yws yuav tsis cuam tshuam nws cov viscosity. Yog HPMC tsis yog rhuav tshem, lub viscosity ntawm kev daws yuav tsis ncav cuag lub xeev zoo tagnrho. Yog li no, kev sib txuas lus zoo rau lub sijhawm HPMC hauv cov dej kom ntseeg tau tias HPMC yog qhov ua kom cov dej siab dua tuaj yeem ua kom muaj kev daws teeb meem zoo ntxiv. Tshwj xeeb tshaj yog thaum dissolving ntawm cov txheej txheem qis, cov txheej txheem HPMC sib cais yuav qeeb, thiab txuas ntxiv rau lub sijhawm tseem ceeb heev.
8. Hloov Shear
Cov viscosity ntawm HPMC kuj tseem cuam tshuam nrog shear zog nws raug rau thaum siv sijhawm. Nyob rau hauv lub siab muaj kev mob, lub viscosity ntawm HPMC kev daws teeb meem yuav txo qis, tab sis thaum lub viscosity yuav rov qab. Rau cov txheej txheem uas yuav tsum tau nce viscosity, lub zog shear uas cov tshuaj muaj peev xwm tsawg, lossis nws tuaj yeem ua haujlwm hauv qab qis shear mob los tswj cov viscosity qis.
9. Xaiv txoj cai molecular hnyav
Qhov hnyav molecular ntawm HPMC cuam tshuam ncaj qha cuam tshuam nws viscosity. HPMC nrog lub cev hnyav loj dua loj dua cov qauv network loj dua hauv kev daws teeb meem, ua rau visccosity ntau dua. Yog tias koj xav tau nce cov visccosity ntawm HPMC, koj tuaj yeem xaiv HPMC cov khoom lag luam nrog lub cev hnyav dua. Txawm hais tias HPMC 15 CPS yog cov khoom lag luam tsawg-viscosity, cov viscosity tuaj yeem nce los ntawm kev xaiv cov khoom siv high-molecular-hnyav variant ntawm tib cov khoom.
10. Xav txog ib puag ncig ib puag ncig
Qhov tshwm sim ib puag ncig xws li cov av noo thiab lub zog kuj tseem yuav muaj qee yam cuam tshuam rau ntawm cov viscos ntawm HPMC. Nyob rau hauv lub siab av noo ib puag ncig, HPMC nqus dej noo los ntawm huab cua, ua rau nws viscosity kom tsawg dua. Txhawm rau zam qhov no, cov kev cai ib puag ncig ntawm kev tsim khoom lossis siv lub xaib tuaj yeem tswj tau qhov chaw ib puag ncig kom ruaj khov thiab ntawm lub visccs.
Muaj ntau txoj hauv kev los ua kom cov visccosity ntawm hpmc 15 cps daws, tswj hwm kom hnyav dua, thiab lwm yam kom raug xaiv yog nyob ntawm daim ntawv thov tiag tiag Cov xwm txheej thiab cov txheej txheem yuav tsum tau ua. Hauv kev ua haujlwm tiag, feem ntau nws yog feem ntau yuav tsum muaj kev nkag siab thiab ua kom zoo dua kev ua kom ntseeg tau tias HPMC daws hauv cov ntawv thov tshwj xeeb.
Lub Sijhawm Post: Oct-16-2024