Qhov zoo tshaj ntawmHydroxyPropyyl Methylcellulose (HPMC)tuaj yeem ntsuas los ntawm ntau qhov ntsuas. HPMC yog lub cellulose derivative dav siv hauv kev tsim kho, tshuaj, zaub mov thiab tshuaj pleev cov tshuaj pleev ib ce, thiab nws qhov zoo cuam tshuam rau kev ua haujlwm ntawm cov khoom.
1. Tsos thiab particle loj
Cov tsos ntawm HPMC yuav tsum dawb los yog cov hmoov dawb dawb. Cov hmoov zoo HPMC yuav tsum muaj cov khoom siv tsis zoo, tsis muaj agglomeration, thiab tsis muaj kev cuam tshuam txawv teb chaws. Qhov loj me thiab kev sib txuam ntawm cov khoom cuam tshuam cuam tshuam rau nws solubility thiab dispersibility. HPMC nrog loj dhau los yog agglomerated hais tsis yog cuam tshuam rau solubility, tab sis kuj tseem yuav ua rau muaj kev cuam tshuam tsis sib xws hauv cov ntawv thov tsis xwm yeem. Yog li ntawd, uniform particle loj yog lub hauv paus rau kev ntsuas nws cov khoom zoo.
2. Dej solubility thiab kawg discolution tus nqi
Cov dej ua yeeb yaj kiab ntawm HPMC yog ib qho ntawm nws cov ntsuas kev ua tau zoo. Zoo HPMC Black sib cais sai dua hauv dej, thiab cov tshuaj tiv thaiv yaj yuav tsum yog pob tshab thiab niaj hnub sib xws. Kev kuaj cov dej solubility tuaj yeem raug txiav txim los ntawm kev ntxiv tus lej HPMC rau dej thiab saib seb nws tuaj yeem ploj sai thiab ua cov tshuaj ruaj khov. Qeeb qeeb los yog tsis xwm yeem daws yuav txhais tau tias cov khoom zoo tsis tau raws li tus qauv.
3. Viscosity tus yam ntxwv
Lub viscosity ntawm HPMC yog ib qho ntawm cov tsis tseem ceeb rau kev ntsuas nws cov khoom zoo. Nws viscosity nyob rau hauv dej feem ntau nce nrog kev nce ntawm nws cov molecular hnyav. Txoj kev viscosity hom yog siv cov vis volcoster lossis viscais ntsuas qhov viscosity muaj nuj nqis ntawm kev daws teeb meem. Feem ntau hais lus, zoo HPMC yuav tsum muaj qhov ruaj khov viscosity, thiab lub viscosity hloov pauv yuav tsum tau ua kom haum rau qee txoj cai. Yog tias viscosity tsis ruaj khov los yog hauv qab tus qauv txheem, nws yuav txhais tau tias nws cov qauv molecular tsis ruaj khov lossis muaj impurities.
4. Cov ntsiab lus noo noo
Cov dej noo cov ntsiab lus hauv HPMC tseem yuav cuam tshuam nws cov khoom zoo. Ntau dhau noo noo yuav ua rau nws tuaj pwm lossis tsis zoo thaum lub sijhawm cia. Tus qauv rau cov ntsiab lus noo noo yuav tsum tau tswj tsis pub dhau 5%. Cov qauv xeem xws li cov qauv ziab lossis Karl Fischer yuav siv tau los txiav txim siab cov ntsiab lus noo noo. Siab HPMC muaj cov ntsiab lus noo noo tsawg thiab tseem qhuav thiab ruaj khov.
5. Py tus nqi ntawm kev daws teeb meem
Tus nqi PHF ntawm HPMC kev daws teeb meem tseem tuaj yeem pom tias nws zoo. Feem ntau, tus nqi PHF ntawm HPMC kev daws yuav tsum yog nruab nrab ntawm 6.5 thiab 8.5. Tshaj tawm acidic lossis overly alkaline daws teeb meem yuav qhia tau tias cov khoom lag luam muaj cov tshuaj tiv thaiv cov tshuaj tiv thaiv lossis tau kho tsis raug thaum lub sijhawm tsim khoom. Los ntawm PHT kev kuaj, koj tuaj yeem nkag siab txog kev nkag siab tias qhov zoo HPMC ua tau raws li qhov yuav tsum tau ua.
6. Cov ntsiab lus impred
Lub impurity cov ntsiab lus ntawm HPMC cuam tshuam rau nws cov kev ua tau zoo, tshwj xeeb yog cov khoom noj, qhov twg tsis tsim nyog siv cov khoom siv tsis zoo yuav ua rau cov khoom tsis zoo lossis cov teebmeem tsis zoo. Impurities feem ntau suav nrog cov khoom siv raw exagent, lwm yam tshuaj lom neeg, lossis cov paug los tsim los ntawm cov txheej txheem ntau lawm. Cov neeg siv tshuab los hauv HPMC tuaj yeem raug kuaj pom los ntawm cov hau kev xws li kev ua kom zoo ua kua chromatography (HPLC) lossis roj chromatography (GC). Siab HPMC yuav tsum ua kom ntseeg tau cov ntsiab lus tsis loj thiab ua tau raws li cov qauv.
7. Transparency thiab daws ruaj khov
Kev sib txuas lus ntawm HPMC kev daws teeb meem tseem yog cov siv uas siv tau zoo siv. Kev daws teeb meem nrog siab transparency thiab ruaj khov feem ntau txhais tau tias HPMC yog cov kev coj siab zoo thiab muaj tsawg dua impurities. Kev daws yuav tsum ua kom meej meej thiab pob tshab thaum lub sijhawm khaws cia ntev, tsis muaj nag lossis daus lossis kev ua kom nag. Yog tias HPMC cov kua los yog ua rau cov tawv nqaij turbid thaum lub sijhawm cia, nws qhia tias nws yuav muaj cov khoom siv tsis raug lossis tsis sib haum.
8. Thermal stability thiab thermal decomposition kub
Qhov ntsuas kev ruaj ntseg thermal feem ntau yog ua los ntawm cov ntsuas kub siab (tga). HPMC yuav tsum muaj cov zoo thermal stability thiab yuav tsum tsis txhob decompose ntawm cov ntawv thov kub ib txwm muaj. HPMC nrog qhov tsis tshua muaj cua sov decomposition kub yuav pom kev ua tsis zoo nyob rau hauv cov kev siv kub siab, yog li zoo thermal stability yog qhov tseem ceeb HPMC.
9. Kev daws teeb meem thiab cov nro
Qhov kev daws teeb meem HPMC tuaj yeem cuam tshuam nws daim ntawv thov kev ua tau zoo, tshwj xeeb tshaj yog ua cov khoom siv hauv tsev. Siab HPMC muaj qhov tsis muaj siab tsawg dua tom qab kev sib cais, uas pab tau txhim kho nws qhov dispersibility, uas pab nws dispersibility thiab fellity hauv cov xov xwm sib txawv. Nws cov nro loj tuaj yeem kuaj los ntawm ib lub deg nro ntsuas. Cov tshuaj hpmc zoo tshaj plaws yuav tsum muaj qhov tsawg thiab ruaj khov sab nro.
10. Kev ruaj khov thiab cia
Lub chaw khaws khoom ruaj khov ntawm HPMC kuj tseem tuaj yeem cuam tshuam nws qhov zoo. Zoo HPMC yuav tsum muaj peev xwm khaws cia stably rau ib lub sij hawm ntev yam tsis muaj kev cuam tshuam lossis kev ua tsis tau zoo. Thaum ua kev soj ntsuam zoo, nws cov ruaj khov tuaj yeem ntsuas los ntawm khaws cov qauv kuaj tau ntev thiab kuaj lawv qhov kev ua tsis tau zoo. Tshwj xeeb tshaj yog nyob rau hauv ib puag ncig nrog cov av noo lossis loj hloov pauv, zoo HPMC yuav tsum muaj peev xwm tswj tau lub cev ruaj khov thiab tshuaj siv tau.
11. Kev sim ntawm kev sim ua nrog cov qauv kev lag luam
Thaum kawg, ib txoj hauv kev ntxim nyiam tshaj plaws los txiav txim siab qhov zoo HPMC yog piv nrog cov qauv kev lag luam. Nyob ntawm daim ntawv thov teb (xws li kev tsim kho, tshuaj, khoom noj, thiab lwm yam ntawm HPMC sib txawv. Thaum xaiv HPMC, koj tuaj yeem xa mus rau cov qauv kev cuam tshuam thiab kev sim thiab ua ke cov txiaj ntsig sim ua kom muaj kev txiav txim siab kom nkag siab zoo.
Qhov kev ntsuas zoo ntawmHPMCYuav tsum txiav txim siab ntau yam, suav nrog cov tsos, solubility, pH nqi, zoo ntawm HPMC tuaj yeem raug txiav txim ntau kev sib nkag siab. Rau cov kev xav tau ntawm cov ntawv thov sib txawv, qee qhov ntsuas ua tau zoo ua tau kuj yuav tsum tau them siab rau. Xaiv HPM cov khoom lag luam uas ua tau raws li cov qauv muaj feem tuaj yeem ua tau zoo thiab ruaj khov ntawm cov khoom kawg.
Lub Sijhawm Post: Dec-19-2024