Hydroxypropyl methylcellulose (HPMC), raws li cov khoom siv cellulose derivative, yog dav siv hauv kev tsim kho, tshuaj, khoom noj khoom haus, tshuaj niaj hnub thiab lwm yam lag luam. Qhov zoo ntawm HPMC feem ntau yog txiav txim los ntawm cov yam ntxwv ntawm lub cev thiab tshuaj lom neeg, kev ua haujlwm zoo thiab siv cov nyhuv.
1. Cov tsos thiab xim
HPMC feem ntau yog dawb los yog dawb dawb hmoov los yog granules. Yog tias muaj qhov hloov xim tseem ceeb, xws li yellowing, greying, thiab lwm yam, nws yuav txhais tau tias nws cov purity tsis siab los yog tsis muaj kab mob. Tsis tas li ntawd, lub uniformity ntawm particle loj kuj qhia txog kev tswj theem ntawm cov txheej txheem ntau lawm. HPMC cov khoom zoo yuav tsum tau muab faib ua tus sib npaug yam tsis muaj qhov pom tseeb agglomeration lossis impurities.
2. Solubility kuaj
HPMC muaj dej solubility zoo, uas yog ib qho tseem ceeb qhia rau kev txiav txim nws zoo. Los ntawm kev sim yooj yim dissolution, nws cov solubility thiab viscosity tuaj yeem ntsuas. Cov kauj ruam yog raws li nram no:
Siv ib qho me me ntawm HPMC hmoov, maj mam ntxiv rau hauv dej txias lossis dej kub hauv chav, thiab saib xyuas nws cov txheej txheem kev sib cais. High-zoo HPMC yuav tsum sib npaug zos nyob rau hauv ib tug luv luv lub sij hawm tsis muaj pom tseeb flocculent nag lossis daus, thiab thaum kawg tsim ib pob tshab los yog me ntsis turbid colloidal tov.
Qhov kev sib cais ntawm HPMC muaj feem xyuam rau nws cov qauv molecular, qib kev hloov pauv, thiab cov txheej txheem purity. Tsis zoo HPMC yuav yaj maj mam thiab yooj yim tsim cov hlab ntsha uas nyuaj rau decompose.
3. Kev ntsuas viscosity
Viscosity yog ib qho tseem ceeb tshaj plaws rau HPMC zoo. Nws cov viscosity hauv dej yog cuam tshuam los ntawm qhov hnyav molecular thiab qib ntawm kev hloov pauv, thiab feem ntau yog ntsuas los ntawm kev sib hloov viscometer lossis capillary viscometer. Txoj kev tshwj xeeb yog kom yaj ib qho nyiaj ntawm HPMC hauv dej, npaj ib qho kev daws teeb meem, thiab tom qab ntawd ntsuas qhov viscosity ntawm cov tshuaj. Raws li cov ntaub ntawv viscosity, nws tuaj yeem txiav txim siab tias:
Yog tias tus nqi viscosity tsawg dhau, nws yuav txhais tau tias qhov hnyav molecular me me los yog nws tau degraded thaum lub sij hawm tsim khoom;
Yog tias tus nqi viscosity siab dhau lawm, nws yuav txhais tau tias qhov hnyav molecular loj dhau los yog qhov hloov pauv tsis sib xws.
4. Purity nrhiav pom
Lub purity ntawm HPMC yuav cuam tshuam ncaj qha rau nws cov kev ua tau zoo. Cov khoom uas tsis muaj purity feem ntau muaj ntau cov residues los yog impurities. Kev txiav txim ua ntej tuaj yeem ua los ntawm cov txheej txheem yooj yim hauv qab no:
Kev ntsuas qhov seem ntawm kev hlawv: Muab ib qho me me ntawm HPMC tus qauv rau hauv qhov cub kub kub thiab hlawv nws. Tus nqi ntawm cov residue tuaj yeem cuam tshuam cov ntsiab lus ntawm inorganic ntsev thiab hlau ions. High-zoo HPMC residues yuav tsum tsawg heev.
Kev ntsuas pH tus nqi: Siv tus nqi tsim nyog ntawm HPMC thiab yaj hauv dej, thiab siv cov ntawv ntsuas pH lossis pH ntsuas pH ntsuas pH tus nqi ntawm cov tshuaj. Raws li ib txwm muaj, HPMC aqueous tov yuav tsum nyob ze rau nruab nrab. Yog hais tias nws yog acidic los yog alkaline, impurities los yog by-products yuav tshwm sim.
5. Thermal zog thiab thermal stability
Los ntawm cua sov tus qauv HPMC, nws cov thermal stability tuaj yeem pom. High-zoo HPMC yuav tsum muaj kev ruaj ntseg siab thaum lub sij hawm cua sov thiab yuav tsum tsis txhob decompose los yog poob sai sai. Cov kauj ruam yooj yim thermal ua tau zoo suav nrog:
Tshav kub ib qho me me ntawm cov qauv ntawm lub phaj kub thiab saib nws cov ntsiab lus melting thiab decomposition kub.
Yog tias tus qauv pib decompose los yog hloov xim ntawm qhov kub thiab txias, nws txhais tau tias nws cov thermal stability tsis zoo.
6. Kev txiav txim siab cov dej noo
Cov dej noo ntau dhau ntawm HPMC yuav cuam tshuam rau nws qhov ruaj khov thiab kev ua haujlwm. Nws cov ntsiab lus noo noo tuaj yeem txiav txim siab los ntawm txoj kev hnyav:
Muab cov qauv HPMC tso rau hauv qhov cub thiab ziab nws ntawm 105 ℃ kom qhov hnyav tas li, tom qab ntawd xam qhov hnyav qhov sib txawv ua ntej thiab tom qab ziab kom tau cov dej noo. Cov khoom zoo HPMC yuav tsum muaj cov dej noo tsawg, feem ntau tswj tau qis dua 5%.
7. Degree ntawm kev hloov kho kom pom
Lub degree ntawm kev hloov ntawm methoxy thiab hydroxypropoxy pawg ntawm HPMC ncaj qha cuam tshuam rau nws cov kev ua tau zoo, xws li solubility, gel kub, viscosity, thiab lwm yam. Cov degree ntawm kev hloov pauv tuaj yeem txiav txim siab los ntawm cov tshuaj titration lossis infrared spectroscopy, tab sis cov txheej txheem no nyuaj thiab xav tau. yuav tsum tau ua nyob rau hauv ib qho chaw kuaj. Hauv luv luv, HPMC nrog kev hloov pauv qis muaj qhov tsis zoo solubility thiab tuaj yeem tsim cov gels tsis sib xws hauv dej.
8. Gel ntsuas kub
Lub gel kub ntawm HPMC yog qhov kub ntawm qhov uas nws tsim ib lub gel thaum cua sov. High-zoo HPMC muaj qhov tshwj xeeb gel qhov kub thiab txias, feem ntau ntawm 60 ° C thiab 90 ° C. Txoj kev kuaj rau gel kub yog:
Dissolve HPMC hauv dej, maj mam nce qhov kub, thiab saib xyuas qhov kub ntawm qhov kev daws teeb meem ntawm pob tshab mus rau turbid, uas yog gel kub. Yog tias qhov kub thiab txias ntawm gel deviates los ntawm qhov ib txwm muaj, nws yuav txhais tau tias nws cov qauv molecular lossis qib hloov pauv tsis tau raws li tus qauv.
9. Kev ntsuas kev ua haujlwm
Daim ntawv thov kev ua haujlwm ntawm HPMC rau ntau lub hom phiaj yuav txawv. Piv txwv li, hauv kev tsim kho kev lag luam, HPMC feem ntau yog siv los ua cov dej tuav cov neeg sawv cev thiab cov thickener. Nws cov dej tuav cov kev ua tau zoo thiab cov nyhuv thickening tuaj yeem raug sim los ntawm kev siv tshuaj khib nyiab lossis kev sim tshuaj. Hauv kev lag luam kws tshuaj thiab khoom noj khoom haus, HPMC yog siv los ua cov yeeb yaj kiab yav dhau los lossis cov khoom siv tshuaj ntsiav, thiab nws cov yeeb yaj kiab tsim cov nyhuv thiab cov khoom colloidal tuaj yeem kuaj los ntawm kev sim.
10. Cov tshuaj tsw qab thiab volatile
High-zoo HPMC yuav tsum tsis muaj ntxhiab tsw. Yog tias tus qauv muaj cov ntxhiab tsw ntxhiab lossis txawv teb chaws, nws yuav txhais tau hais tias cov tshuaj tsis tsim nyog tau qhia thaum nws cov txheej txheem tsim khoom lossis nws muaj cov tshuaj tsis haum tshuaj. Tsis tas li ntawd, cov khoom zoo HPMC yuav tsum tsis txhob tsim cov pa taws kub hnyiab ntawm qhov kub thiab txias.
Qhov zoo ntawm HPMC tuaj yeem raug txiav txim los ntawm kev sim lub cev yooj yim xws li cov tsos, solubility thiab viscosity ntsuas, lossis los ntawm kev siv tshuaj xws li purity testing thiab thermal performance testing. Los ntawm cov txheej txheem no, kev txiav txim siab ua ntej tuaj yeem ua tiav ntawm HPMC qhov zoo, yog li ua kom nws cov kev ua haujlwm ruaj khov hauv cov ntawv thov tiag tiag.
Post lub sij hawm: Sep-25-2024