HPMC siv los ua cov khoom siv tshuaj

Hydroxypropyl methylcellulose (HPMC)yog siv los ua ib qho ntawm cov tshuaj loj tshaj plaws hauv tsev thiab txawv teb chaws. HPMC tuaj yeem siv los ua tus neeg sawv cev ua yeeb yaj kiab, nplaum nplaum, tus neeg sawv cev tso tawm, tshem tawm tus neeg sawv cev, emulsifier, disintegrating agent, thiab lwm yam.

Pharmaceutical excipients yog ib feem tseem ceeb ntawm kev npaj tshuaj, thiab lawv lub luag haujlwm yog los xyuas kom meej tias cov tshuaj raug xaiv thauj mus rau cov ntaub so ntswg hauv qee txoj kev thiab cov txheej txheem, kom cov tshuaj tso tawm hauv lub cev ntawm qee qhov ceev thiab sijhawm. Yog li ntawd, kev xaiv cov khoom tsim nyog yog ib qho tseem ceeb rau kev kho cov nyhuv ntawm cov tshuaj npaj.

1 Properties of HPMC

HPMC muaj ntau yam yam ntxwv uas lwm cov excipients tsis muaj. Nws muaj cov dej zoo solubility hauv dej txias. Tsuav nws ntxiv rau hauv dej txias thiab nplawm me ntsis, nws tuaj yeem yaj mus rau hauv cov kua dej pob tshab. Ntawm qhov tsis sib xws, nws yog qhov yooj yim insoluble hauv dej kub siab tshaj 60E thiab tsuas yog yaj. Yog tsis yog-ionic cellulose ether, nws cov tshuaj tsis muaj ionic nqi, thiab hlau ntsev los yog ionic organic tebchaw, thiaj li yuav xyuas kom meej tias HPMC tsis hnov ​​​​mob nrog lwm yam raw khoom nyob rau hauv cov txheej txheem ntau lawm. Nrog rau qhov muaj zog tiv thaiv rhiab heev, thiab nrog kev nce ntawm cov qauv molecular ntawm kev hloov pauv, kev tiv thaiv rhiab heev kuj tau txhim kho, siv HPMC ua cov tshuaj adjuvant, txheeb ze rau kev siv lwm cov tshuaj adjuvants ( starch, dextrin, qab zib hmoov) tshuaj, qhov zoo ntawm lub sijhawm ua haujlwm tau ruaj khov dua. Nws muaj metabolic inertia. Raws li cov khoom siv tshuaj pabcuam, nws tsis tuaj yeem metabolized lossis absorbed, yog li nws tsis muab calories hauv tshuaj thiab zaub mov. Nws muaj qhov tshwj xeeb siv tau rau tus nqi qis calorific, tsis muaj ntsev thiab tsis muaj tshuaj lom thiab cov khoom noj uas xav tau los ntawm cov neeg mob ntshav qab zib. HPMC ruaj khov dua rau cov kua qaub thiab alkali, tab sis yog tias nws siab tshaj pH2 ~ 11 thiab raug kub siab dua lossis lub sijhawm cia ntev dua, qhov viscosity yuav raug txo. Aqueous tov muab kev ua haujlwm saum npoo thiab nthuav tawm qhov nro nruab nrab thiab qhov cuam tshuam ntawm qhov nro. Nws muaj emulsification zoo nyob rau hauv ob-theem system thiab yuav siv tau raws li zoo stabilizer thiab tiv thaiv colloid. Aqueous tov muaj cov yeeb yaj kiab zoo heev thiab yog cov khoom siv zoo rau cov ntsiav tshuaj thiab tshuaj. Zaj duab xis tsim los ntawm nws yog xim tsis muaj xim thiab tawv. Nws cov yas kuj tuaj yeem nce ntxiv los ntawm kev ntxiv glycerol.

2.Kev thov ntawm HPMC hauv cov ntsiav tshuaj ntau lawm

2.1 Txhim kho kev sib cais

Siv HPMC ethanol tov los yog aqueous tov raws li tus neeg sawv cev ntub dej rau granulation, rau kev txhim kho lub dissolution ntawm cov ntsiav tshuaj, cov nyhuv yog zoo kawg li, thiab nias rau hauv zaj duab xis hardness yog zoo dua, cov tsos ntawm du. Solubility ntawm Renimodipine ntsiav tshuaj: solubility ntawm cov nplaum yog 17.34% thiab 28.84% thaum cov nplaum yog 40% ethanol, 5% polyvinylpyrrolidone (40%) ethanol tov, 1% sodium dodecyl sulfate (40%) ethanol tov, 3% HPMC yaj. 10% hmoov txhuv nplej siab, 3% HPMC tov, 5% HPMC daws, feem. 30.84%, 75.46%, 84.5%, 88%. Dissolution tus nqi ntawm piperic acid ntsiav tshuaj: thaum lub nplaum yog 12% ethanol, 1% HPMC (40%) ethanol tov, 2% HPMC (40%) ethanol tov, 3% HPMC (40%) ethanol tov, dissolution tus nqi yog 80.94%. , 86.23%, 90.45%, 99.88%, feem. Dissolution tus nqi ntawm Cimetidine ntsiav tshuaj: thaum cov nplaum yog 10% hmoov txhuv nplej siab slurry thiab 3% HPMC (40%) ethanol tov, tus nqi dissolution yog 76.2% thiab 97.54%, feem.

Los ntawm cov ntaub ntawv saum toj no, nws tuaj yeem pom tau tias HOM ethanol tov thiab aqueous tov ntawm HPMC muaj cov txiaj ntsig ntawm kev txhim kho cov kev sib cais ntawm cov tshuaj, uas feem ntau yog tshwm sim los ntawm kev ncua thiab kev ua haujlwm saum npoo ntawm HPMC, txo qhov nro ntawm cov tshuaj thiab cov tshuaj muaj zog, ua kom cov dej noo, uas yog qhov tsim nyog rau kev tawg ntawm cov tshuaj.

2.2 Txhim kho qhov zoo ntawm txheej

HPMC ua cov ntaub ntawv tsim cov yeeb yaj kiab, piv nrog lwm cov ntaub ntawv tsim cov yeeb yaj kiab (acrylic resin, polyethylene pyrrolidone), qhov zoo tshaj plaws yog nws cov dej solubility, tsis xav tau cov kuab tshuaj organic, kev ua haujlwm zoo, yooj yim. ThiabHPMCmuaj ntau yam viscosity specifications, tsim nyog xaiv, txheej zaj duab xis zoo, zoo li zoo li lwm yam ntaub ntawv. Ciprofloxacin hydrochloride ntsiav tshuaj yog cov ntsiav tshuaj dawb nrog ob sab ntawv. Cov tshuaj no rau nyias zaj duab xis txheej yog qhov nyuaj, los ntawm kev sim, xaiv cov viscosity ntawm 50 mpa # s ntawm cov dej-soluble plasticizer, tuaj yeem txo cov kev ntxhov siab sab hauv ntawm nyias zaj duab xis, txheej ntsiav tshuaj tsis muaj choj / hws 0, 0, 0, 0 / txiv kab ntxwv tev / permeability roj, 0 / tawg, xws li cov teeb meem zoo, txheej ua kua zaj duab xis tsim, zoo adhesion, thiab coj lo lus ntug tsis to, legible, Ib - sided ci, zoo nkauj. Piv nrog cov tshuaj pleev ib ce, cov tshuaj no yooj yim thiab tsim nyog, thiab tus nqi txo qis heev.