HydroxyPropyyl Methylcellulose (HPMC)yog siv los ua ib qho ntawm cov tshuaj uas muaj kev cia siab hauv tsev thiab txawv teb chaws. HPMC tuaj yeem siv ua zaj duab xis ua tus neeg sawv cev, cov nplaum, tus neeg saib xyuas kev tso tawm, tus neeg sawv cev rov qab, thiab lwm yam.
Kws tsim kho cov tshuaj yog ib feem tseem ceeb ntawm kev nqa tshuaj, thiab lawv cov tshuaj muaj qee txoj kev thauj mus los hauv lub cev ntawm lub cev nrawm thiab sijhawm. Yog li ntawd, kev xaiv ntawm haum zoo yog ib qho ntawm cov ntsiab lus tseem ceeb rau kev kho cov nyhuv ntawm cov tshuaj npaj.
1 thaj chaw HPMC
HPMC muaj ntau tus yam ntxwv uas lwm tus neeg siv tsis muaj. Nws muaj cov dej zoo heev solubility hauv dej txias. Ntev npaum li nws tau ntxiv rau hauv dej txias thiab nplawm me ntsis, nws tuaj yeem yaj mus rau hauv cov kev daws teeb meem. Ntawm qhov tsis sib xws, nws yog qhov tseem insoluble hauv dej kub saum 60E thiab tuaj yeem tsuas yog yaj. Yog cov tsis muaj iamall cellulose ether, nws txoj kev daws teeb meem tsis muaj kev tiv thaiv ionic, yog li cov khoom siv hlau ua kom meej, yog li cov khoom siv hlau ua kom pom tseeb, yog li cov khoom siv hlau ua kom muaj kev cuam tshuam nrog lwm cov txheej txheem kev npaj ua haujlwm. Nrog rau anti-rhiab, thiab nrog kev nce molecular qauv ntawm kev siv cov khoom siv lwm yam kev ua haujlwm sib txawv (cov hmoov txhuv nplej siab, Dextrin, cov hmoov nplej piam, Qhov zoo ntawm lub sijhawm zoo yog qhov ruaj khov. Nws muaj metabolic inertia. Raws li cov khoom siv tshuaj uas muag tshuaj, nws tsis tuaj yeem siv metabolized lossis nqus tau, yog li nws tsis muab calories hauv tshuaj thiab khoom noj. Nws muaj kev siv tshwj xeeb rau cov nqi qis dua, ntsev-dawb thiab tsis muaj tshuaj thiab cov khoom noj uas yuav tsum muaj los ntawm cov neeg mob ntshav qab zib. HPMC yog qhov ruaj khov dua rau cov kua qaub thiab alkali, tab sis yog ntau tshaj li PH2 ~ 11 thiab yog lub sijhawm kub siab dua lossis lub sijhawm viscosity yuav raug txo kom tsawg. Cov kua aqueous muab cov kev ua si saum npoo av thiab nthuav tawm thaj npoo nruj thiab cuam tshuam cov txiaj ntsig cuam tshuam. Nws muaj cov emulsification zoo nyob rau hauv ob-theem system thiab tuaj yeem siv tau raws li cov khoom siv khov kho thiab tiv thaiv kev tiv thaiv zoo. Cov kua tshuaj aqueous muaj cov yeeb yaj kiab zoo nkauj tsim cov khoom thiab yog cov khoom siv zoo kom zoo rau cov ntsiav tshuaj thiab tshuaj noj. Zaj duab xis tsim los ntawm nws yog tsis muaj xim thiab tawv. Nws cov plasticity tseem tuaj yeem nce ntxiv los ntawm kev ntxiv glycerol.
2.Application ntawm HPMC nyob rau hauv cov ntsiav tshuaj ntau lawm
2.1 txhim kho kev sib tham
Siv HPMC ethanol daws los yog aqueous daws teeb meem ntawm cov ntsiav tshuaj, thiab nias rau hauv zaj duab xis hardness yog qhov zoo dua, cov tsos ntawm du. Solubility ntawm renimodipine ntsiav tshuaj: lub solubility ntawm adhesive yog 17.34% thaum cov nplaum dodecyl suleclate (40%) ethanol daws, 3% hpmc yaj mus rau hauv 10% hmoov txhuv nplej siab, 3% kev daws teeb meem hpmc, 5% hpmc, ntsig txog. 30.84%, 75.46%, 84.5%, 88%. Tus lej ntawm cov piperic acid: thaum cov nplaum yog 12% kev daws teeb meem, 3% ntawm HPMC (40% , 86.23%, 90.45%, 99.8%, feem. Tus nqi yaj xwm ntawm cov ntsiav khib nyiab: thaum cov nplaum yog 10% cov kua nplaum slurry thiab 3% hpmc (40%) etyololly ethold yog 76.2% thiab 97.54%, feem.
Los ntawm cov ntaub ntawv saum toj no, nws tuaj yeem pom tau tias ethanol daws thiab cov kev daws teeb meem ua ntej ntawm HPMC, txo cov kev ua ub no ntawm HPMC, txo cov nro hauv nruab nrab ntawm kev daws teeb meem thiab Cov tshuaj tawv, nce cov dej noo, uas yog qhov ua rau muaj cov tshuaj sib cais.
2.2 Txhim kho qhov zoo ntawm txheej
HPMC ua zaj duab xis ua qauv siv, piv nrog lwm zaj duab xis tsim cov ntaub ntawv (polyethylere pyrrolidone), tsis tas ua haujlwm organic, kev ua haujlwm zoo, yooj yim. ThiabHPMCMuaj ntau yam viscosity specifications, kev xaiv tsim nyog, txheej yeeb yaj kiab zoo, tsos zoo dua li lwm cov ntaub ntawv. Ciprofloxacin hydrochloride ntsiav tshuaj yog cov ntsiav tshuaj dawb nrog cov ntawv sau ob sab. Cov tshuaj no rau cov zaj duab xis nyias nyias yog qhov nyuaj, los ntawm cov yeeb yaj kiab uas tsis muaj tus choj / tawm hws 0, 0, 0 / Txiv kab ntxwv Tev / permeability roj, 0 / tawg, xws li cov teeb meem zoo, thiab nqa lo lus zoo nkauj yam tsis muaj xau, ib leeg - sided ci, zoo nkauj. Piv nrog cov lig kev txiav cov khoom siv ua kua, cov tshuaj no yog qhov yooj yim thiab tsim nyog, thiab tus nqi tau txo qis.
Lub Sijhawm Post: Apr-25-2024