Hydroxypropyl methylcellulose (HPMC) yog qhov tseeb siv los khi, tshwj xeeb tshaj yog nyob rau hauv kev lag luam tshuaj, zaub mov, thiab kev tsim kho.
1. Chemical Composition thiab Properties:
HPMC, tseem hu ua hydroxypropyl methylcellulose, yog ib tug semisynthetic, inert, viscoelastic polymer muab tau los ntawm cellulose, feem ntau cov organic polymer nyob rau hauv lub ntiaj teb no. Nws muaj cov kab sib txuas ntawm cov piam thaj nrog cov pawg hydroxyl uas tau hloov kho los ua hydroxypropyl thiab methyl ether pawg. Cov kev hloov kho no txhim kho nws cov solubility hauv dej thiab ntau yam organic solvents, ua rau nws muaj ntau yam muaj nyob rau hauv ntau yam kev siv.
HPMC paub txog nws txoj kev ua yeeb yaj kiab zoo, ua kom tuab, thiab ruaj khov. Nws lub peev xwm los tsim cov yeeb yaj kiab muaj zog thiab cohesive ua rau nws yog ib qho zoo tagnrho khi rau ntau hom formulations. Tsis tas li ntawd, nws yog nonionic, lub ntsiab lus nws tsis hnov mob nrog ntsev los yog lwm yam ionic tebchaw thiab resistant rau pH hloov, uas ntxiv rau nws versatility.
2. Kev siv HPMC los ua ib qho Binder:
ib. Pharmaceuticals:
Hauv kev lag luam kws tshuaj, HPMC yog siv los ua cov ntawv khi hauv cov ntsiav tshuaj. Binders yog cov khoom tseem ceeb hauv kev tsim cov ntsiav tshuaj raws li lawv xyuas kom meej tias cov hmoov hmoov ua rau ib leeg, muab cov ntsiav tshuaj nrog lub zog tsim nyog. HPMC tshwj xeeb tshaj yog muaj nuj nqis rau nws cov khoom tswj kev tso tawm. Thaum siv cov ntsiav tshuaj txuas ntxiv, nws tuaj yeem tswj hwm kev tso tawm ntawm cov khoom siv tshuaj nquag (API) dhau sijhawm. Tom qab noj tshuaj, HPMC hydrates thiab tsim ib txheej gel nyob ib ncig ntawm lub ntsiav tshuaj, tswj qhov tso tawm ntawm cov tshuaj.
HPMC kuj tseem siv rau hauv txheej txheej txheej txheej, siv nws cov yeeb yaj kiab-tsim muaj peev xwm los tiv thaiv cov ntsiav tshuaj, ua kom cov ntsiav tshuaj ruaj khov, txhim kho lawv cov tsos, thiab npog qhov tsis hnov tsw.
b. Kev lag luam zaub mov:
Hauv kev lag luam khoom noj khoom haus, HPMC yog siv los ua ib qho kev sib khi hauv cov khoom xws li cov neeg tsis noj nqaij cov tshuaj ntsiav, hloov cov gelatin. Nws siv txuas mus rau ntau yam khoom noj, pab tswj cov qauv thiab kev ntxhib los mos. Piv txwv li, nyob rau hauv gluten-dawb qhob cij, HPMC yog siv los simulate lub nplaum thiab elasticity ntawm gluten, yog li txhim kho cov kev ntxhib los mos thiab ntim ntawm lub khob cij.
c. Kev tsim kho kev lag luam:
Hauv kev tsim kho kev lag luam, HPMC yog cov khoom siv tseem ceeb hauv cov khoom sib xyaw qhuav, cov nplais nplaum, thiab cov txheej txheem plaster. Nws ua raws li kev khi los ntawm kev muab adhesion rau cov substrates sib txawv, yog li txhim kho cov txheej txheem thiab kev sib kis ntawm cov ntaub ntawv no. Tsis tas li ntawd, HPMC txhim kho cov dej tuav hauv cov dej sib tov, uas yog qhov tseem ceeb rau txoj kev kho kom zoo nrog rau lub zog thiab kav ntev ntawm cov khoom siv zaum kawg.
3. Qhov zoo ntawm HPMC raws li ib tug binder:
Tsis muaj tshuaj lom thiab biocompatible: HPMC muaj kev nyab xeeb rau tib neeg noj thiab feem ntau siv rau hauv cov khoom uas xav tau cov qauv kev nyab xeeb siab.
Ntau yam solubility: Nws yog soluble hauv dej txias thiab kub, thiab nws cov solubility tuaj yeem hloov kho los ntawm qhov sib txawv ntawm kev hloov pauv ntawm pawg hydroxypropyl thiab methyl.
Kev ruaj ntseg: HPMC tseem nyob ruaj khov ntawm ntau yam ntawm pH qhov tseem ceeb, ua rau nws haum rau kev siv sib txawv yam tsis muaj kev pheej hmoo ntawm degradation.
Tswj kev tso tawm: Hauv cov khoom siv tshuaj, HPMC tuaj yeem tswj tau qhov tso tawm ntawm cov khoom xyaw nquag, yog li txhim kho cov txiaj ntsig ntawm cov tshuaj.
4. Cov kev sib tw thiab kev txiav txim siab:
Txawm hais tias muaj ntau qhov zoo ntawm HPMC, kuj tseem muaj qee qhov kev sib tw hauv kev siv HPMC:
Tus nqi: HPMC tuaj yeem kim dua piv rau lwm cov ntawv khi, tshwj xeeb tshaj yog nyob rau hauv kev lag luam loj.
Moisture Sensitivity: Txawm hais tias HPMC ruaj khov nyob rau hauv ntau yam kev mob, nws yog rhiab heev rau cov av noo siab, uas tuaj yeem cuam tshuam rau nws cov khoom nplaum.
Cov Txheej Txheem Ua Haujlwm: Kev ua tau zoo ntawm HPMC ua cov ntaub ntawv tuaj yeem cuam tshuam los ntawm kev ua haujlwm xws li kub thiab sijhawm sib xyaw.
Hydroxypropyl methylcellulose (HPMC) yog ib qho zoo thiab siv dav hauv ntau lub lag luam vim nws cov yeeb yaj kiab zoo heev, thickening, thiab ruaj khov zog. Nws muaj ntau yam, kev nyab xeeb, thiab muaj peev xwm los tswj kev tso tawm cov khoom xyaw ua kom nws yog ib qho tseem ceeb hauv kev siv tshuaj, khoom noj, thiab kev tsim kho. Txawm li cas los xij, tej yam xws li tus nqi thiab cov dej noo rhiab heev yuav tsum tau txiav txim siab txhawm rau txhim kho nws cov kev siv hauv ntau hom.
Post lub sij hawm: Aug-28-2024