Puas yog hypromellose acid resistant?

Hypromellose, tseem hu ua hydroxypropyl methylcellulose (HPMC), tsis yog acid-resistant. Txawm li cas los xij, cov kua qaub tsis kam ntawm hypromellose tuaj yeem txhim kho los ntawm ntau yam kev tsim qauv.

Hypromellose yog soluble nyob rau hauv dej tab sis kuj insoluble nyob rau hauv cov organic solvents thiab tsis-polar kua. Yog li ntawd, nyob rau hauv acidic ib puag ncig, xws li lub plab, hypromellose yuav yaj los yog o mus rau qee qhov, nyob ntawm seb muaj pes tsawg leeg ntawm acid, pH, thiab lub sij hawm raug.

Txhawm rau txhim kho cov kua qaub tiv thaiv ntawm hypromellose hauv cov tshuaj formulations, enteric txheej txheej txheem feem ntau siv. Enteric coatings yog siv rau cov ntsiav tshuaj lossis tshuaj ntsiav los tiv thaiv lawv los ntawm acidic ib puag ncig ntawm lub plab thiab tso cai rau lawv dhau mus rau qhov chaw nruab nrab ntawm cov hnyuv me ua ntej tso cov khoom xyaw.

Cov txheej txheej enteric feem ntau yog tsim los ntawm cov polymers uas tiv taus cov kua qaub, xws li cellulose acetate phthalate (CAP), hydroxypropyl methylcellulose phthalate (HPMCP), lossis polyvinyl acetate phthalate (PVAP). Cov polymers no tsim muaj kev tiv thaiv ib puag ncig ntawm cov ntsiav tshuaj lossis tshuaj ntsiav, tiv thaiv kev tawg ntxov ntxov lossis kev puas tsuaj hauv plab.

Hauv cov ntsiab lus, thaum hypromellose nws tus kheej tsis yog acid-resistant, nws cov kua qaub kuj tuaj yeem txhim kho los ntawm kev tsim cov txheej txheem xws li enteric txheej. Cov tswv yim no feem ntau yog siv rau hauv cov tshuaj formulations los xyuas kom meej qhov zoo ntawm cov khoom xyaw nquag mus rau qhov chaw npaj ua haujlwm hauv lub cev.