Yog hypromellose acid tiv taus?

Hypromellose, tseem hu ua HydroxyPropyyl methylcellose (HPMC), tsis yog inherently acid-resistant. Txawm li cas los xij, cov acid tsis kam ntawm hypromellose tuaj yeem txhim kho los ntawm ntau cov qauv tsim.

Hypromellose yog soluble nyob rau hauv dej tab sis yog kuj tseem tsis tau insoluble hauv cov kuab tshuaj yeeb yaj kiab thiab cov kua tsis muaj-ncej. Yog li ntawd, nyob rau hauv acidic ib puag ncig, xws li lub plab, hypromellose yuav yaj tuaj yeem yaj los yog kev ua siab zoo xws li kev sib luag, pH, thiab sijhawm ntev.

Txhawm rau txhim kho cov kua qaub tiv thaiv ntawm hypromellose hauv cov tshuaj, cov txheej txheem kev sib sau ua haujlwm feem ntau ua haujlwm. Cov txheej txheem nkag mus siv rau cov ntsiav tshuaj lossis cov tsiav tshuaj los tiv thaiv lawv ntawm cov hnyuv ib puag ncig ua ntej tso cov khoom xyaw nquag.

Cov txheej txheem interic feem ntau yog tsim los ntawm cov polymers uas tiv thaiv pthtricate (cell), lossis polyvinyl acetate phthalate (pvap). Cov polymers no tsim cov kev tiv thaiv ib puag ncig ntawm cov ntsiav tshuaj lossis tshuaj ntsiav, tiv thaiv kev xaus kev ua ntej ntxov lossis teeb meem hauv plab.

Hauv cov ntsiab lus, thaum hypromellose nws tus kheej tsis yog kua qaub-resistant, nws cov kua qaub ua tuaj yeem txhim kho los ntawm kev tsim cov txheej txheem xws li cov txheej txheem sib nkag siab xws li enteric txheej. Cov tswv yim no feem ntau siv hauv cov tshuaj ua haujlwm hauv cov khoom siv tau zoo rau cov khoom xyaw nquag rau ntawm qhov chaw ntawm lub cev.