Hydroxyprropyrcethylcellose (HPMC), raws li ib txwm siv hydroughilic polymer hauv cov tshuaj pleev roj yeeb, yog siv cov qauv tso tawm thiab lwm yam khoom siv tshuaj. Ib qho ntawm cov yam ntxwv tseem ceeb ntawm HPMC yog nws lub peev xwm los khaws cov dej, uas cuam tshuam rau nws cov kev ua tau zoo raws li kev khaws cia. Hauv tsab xov xwm no, peb yuav tshawb txog qhov tseem ceeb ntawm cov dej tuav ntawm HPMC, suav nrog hom kev sib luag, siab hom, thiab pH.
molecular hnyav
Lub cev hnyav molecular ntawm HPMC ua si lub luag haujlwm tseem ceeb hauv kev txiav txim siab nws lub peev xwm kav dej. Nyob rau hauv dav dav, siab molecular hnyav HPMC yog ntau Hydrophilic tshaj li cov rog hnyav HPMC thiab tuaj yeem nqus dej ntau dua. Qhov no yog vim muaj ntau dua molecular hnyav HPMCs muaj cov saw hlau ntev dua uas tuaj yeem tso tawm thiab tsim cov dej ntau ntxiv uas tuaj yeem nqus tau. Txawm li cas los xij, nws yuav tsum tau sau tseg tias ntau dua molecular hnyav HPMC yuav ua teeb meem xws li viscosity thiab kev ua nyuaj.
qho pauv
Lwm qhov cuam tshuam uas cuam tshuam rau lub peev xwm kav dej ntawm HPMC yog hom hloov chaw. HPMC feem ntau los hauv ob daim ntawv: hydroxypropylropylropyl-hloov thiab methoxy-hloov. Lub hydroxypropylropyl-Exstitute hom muaj peev xwm ntau dua dej muaj peev xwm dua li cov methoxy-hloov hom. Qhov no vim tias cov pawg hydroxypropyl tau tam sim no hauv Hydrophilic yog hydrophilic thiab nce kev tawm tsam ntawm HPMC rau dej. Hauv kev sib piv, cov methoxy-hloov hom yog tsawg hydrophilic thiab yog li ntawd muaj qhov muaj peev xwm rov ua haujlwm qis dua. Yog li ntawd, lwm hom HPMC yuav tsum tau ua tib zoo xaiv raws li cov khoom xav tau ntawm cov khoom kawg.
mloog zoo rau
Cov concentration ntawm HPMC tseem cuam tshuam nws lub peev xwm kav dej. Ntawm cov kev sib haum xeeb qis, HPMC tsis ua cov qauv gel zoo li, yog li nws lub peev xwm kav dej kom tsawg. Raws li cov concentration ntawm HPMC nce, cov qauv roj polymules pib rau kev ua haujlwm, tsim cov gel zoo li cov qauv. Qhov no gel network nqus thiab khaws cov dej khaws cia, thiab dej ua kom muaj peev xwm khaws cia ntawm HPMC nce nrog kev saib xyuas. Txawm li cas los xij, nws yuav tsum raug sau tseg tias kev ua haujlwm siab dhau ntawm HPMC yuav ua rau muaj teeb meem xws li viscosity thiab kev ua nyuaj. Yog li ntawd, cov concentration ntawm HPMC siv yuav tsum tau ua kom zoo rau ua kom tiav cov khoom muaj peev xwm uas xav tau thaum tsis txhob muaj teeb meem hais saum toj no.
PH nqi
Tus lej pH ntawm ib puag ncig uas HPMC siv yuav cuam tshuam rau nws lub peev xwm kav dej. HPMC qauv muaj cov pab pawg anionic (-coo-) thiab hydrophilic ethylcellulose pawg (-oh). Lub ionization ntawm -Coo- pawg yog phiv nyob, thiab lawv cov ordization degree nce nrog pH. Yog li, HPMC muaj lub peev xwm rov ua dua nyob rau ntawm PHIC. Ntawm qhov ntev ntev, lub -coo- pawg yog protonothed thiab nws hydrothilicity txo qis, ua rau muaj peev xwm ua kom muaj peev xwm ua kom muaj peev xwm. Yog li no, ib puag ncig ph yuav tsum tau ua kom zoo rau ua kom tiav cov dej uas xav tau ntawm HPMC.
Hauv kev xaus
Hauv kev xaus, lub peev xwm kav dej khaws cia ntawm HPMC yog qhov tseem ceeb cuam tshuam rau nws cov kev ua tau zoo raws li lub chaw muag tshuaj. Cov ntsiab lus tseem ceeb cuam tshuam rau lub peev txheej kav dej ntawm HPMC suav nrog hom hnyav, hloov chaw thiab tus nqi pyc. Los ntawm kev ua tib zoo kho cov xwm txheej no, lub peev xwm kav dej rov qab muaj peev xwm ntawm HPMC tuaj yeem ua tiav rau cov khoom uas xav tau ntawm cov khoom kawg. Cov neeg tshawb nrhiav thiab cov tuam ntxhab yuav tsum tau ua tib zoo saib xyuas cov xwm txheej zoo thiab ua tau zoo ntawm HPMC-raws li cov qauv tshuaj ua haujlwm.
Lub sij hawm Post: Lub Yim Hli 05-2023