HydroxyPropyyl methylcellulose (HPMC)yog cov hluavtaws cellulose derivative thiab ib semi-hluav taws xob polymer compound. Nws yog dav siv nyob rau ntau yam kev lag luam xws li kev tsim kho, tshuaj, khoom noj, pleev xim thiab pleev xim. Raws li cov tsis-ionic cellulose ether, HPMC muaj cov dej solubility, ua yeeb yaj kiab thiab yog li ntawd muaj cov ntawv thov tseem ceeb hauv ntau thaj teb.
1. Cov qauv tshuaj lom neeg thiab cov khoom ntawm HPMC
Cov qauv molecular ntawm HPMC yog muab tau los ntawm cov cellulose ntuj. Tom qab kev hloov kho tshuaj lom neeg, methyl (-ochiv) thiab hydroxypropyl (-ochchchtoh) pawg tau qhia rau hauv cov saw cellulose. Nws cov qauv tshuaj lom neeg muaj raws li hauv qab no:
Cellulose molecules yog tsim ntawm cov dej qab zib txuas nrog los ntawm β-1,4-glycosidic bonds;
Methyl thiab hydroxypropropyl pawg tau qhia rau hauv cov saw cellule los ntawm kev hloov pauv.
Tus qauv tshuaj no muab HPMC cov khoom hauv qab no:
Dej Solubility: Los tswj cov qib ntawm kev hloov chaw ntawm methyl thiab hydroxypropropyl pawg, HPMC tuaj yeem hloov kho nws cov dej solubility. Feem ntau hais lus, HPMC tuaj yeem tsim cov tshuaj tua kab hauv dej txias thiab muaj cov dej solubility zoo.
Viscososity Haum: Lub viscosity ntawm HPMC tuaj yeem raug tswj hwm yog los ntawm kev kho cov molecular hnyav thiab qib kev hloov pauv kom tau raws li cov cai thov sib txawv.
Thaum tshav kub kub ua: Txij li HPMC yog cov khoom siv thermoplastrastic polymer yog qhov ua tau zoo thiab nws tuaj yeem tswj tau ruaj khov nyob rau hauv ib qho ntsuas kub.
Biocompatibility: HPMC yog cov tsis muaj tshuaj lom thiab tsis yog cov khoom siv tsis zoo, yog li nws tau nyiam tshwj xeeb hauv kev kho mob.
2. Kev npaj txoj kev HPMC
Qhov kev npaj txoj kev npaj ntawm HPMC feem ntau yog ua tiav los ntawm cov tshuaj ntsuab esterification ntawm cellulose. Cov kauj ruam tshwj xeeb yog raws li hauv qab no:
Cellulose yaj: ua ntej, sib xyaw ntuj cellulose nrog cov kuab tshuaj (xws li chloroform, cawv, thiab lwm yam) kom yaj tawm hauv lub cellulose tov.
Tshuaj kho mob tshuaj: methyl thiab hydroxypropropyl cov tshuaj reagents (xws li chloromethyl compounds thiab allyl cawv) tau ntxiv rau kev daws teeb meem.
Neutralization thiab kom qhuav: Tus nqi pH raug hloov kho los ntawm kev ntxiv cov kua qaub los yog siv sib cais, ua kom huv si yog cov tshuaj tiv thaiv tom qab tau txais hydroxypropylencellulose.
3. Cov ntawv thov tseem ceeb ntawm HPMC
Cov khoom tshwj xeeb ntawm HPMC ua rau nws dav siv hauv ntau thaj teb. Hauv qab no yog qee qhov chaw thov tseem ceeb:
(1) Kev tsim kho teb: HPMC tau siv dav hauv kev tsim kho kev tsim kho, feem ntau hauv tsev xws li cement, tshuaj khib, thiab pleev roj. Nws tuaj yeem txhim kho cov kua txiv, cov nplaum thiab dej khaws cia ntawm cov sib tov. Cug cug, HPMC tuaj yeem txhim kho kev ua qauv zoo, nce cov nplaum ntawm lub tshuaj khib, thiab zam kom tsis txhob tawg hauv txoj kab xis xis nyob thaum lub txheej txheem tawv.
(2) Daim Duab Tshuaj: Hauv lub chaw muag tshuaj, HPMC feem ntau siv los npaj cov ntsiav tshuaj, tsiav tshuaj thiab kua tshuaj. Raws li zaj duab xis-ua tus neeg sawv cev, tuab thiab stabilizer, nws tuaj yeem txhim kho cov solubility thiab bioavailability cov tshuaj. Hauv cov ntsiav tshuaj, HPMC tsis tuaj yeem tswj cov tshuaj tso tawm, tab sis kuj tseem txhim kho cov tshuaj ruaj khov.
(3) Cov Khoom Noj Khoom Haus: HPMC tuaj yeem siv hauv kev ua zaub mov noj ua cov tuab tuab, emulsifier thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer thiab stabilizer. Piv txwv li, hauv cov zaub mov tsis muaj roj thiab cov roj muaj rog, HPMC tuaj yeem muab saj zoo dua thiab ua kom ruaj khov thiab nce kev ruaj ntseg ntawm cov khoom. Nws tseem dav siv hauv cov zaub mov khov los tiv thaiv kev sib cais dej lossis dej khov siv lead ua tsim.
(4) tshuaj pleev ib ce: hauv tshuaj pleev ib ce, HPMC feem ntau siv los ua cov tuab dua, emulsifier thiab moisturizer. Nws tuaj yeem txhim kho kev ntxhib los mos, ua rau lawv yooj yim rau kev thov thiab nqus. Tshwj xeeb tshaj yog nyob rau hauv cov nqaij tawv nqaij, tshuaj ntxhua khaub ncaws, ntsej muag, ntsej muag ntsej muag thiab lwm yam khoom lag luam, kev siv HPMC tuaj yeem txhim kho qhov kev xav thiab kev ruaj khov ntawm cov khoom.
(5) Cov tsho tiv no thiab xim pleev xim: hauv kev ua yeeb yam thiab xim kev lag luam, tuaj yeem kho cov rheology ntawm cov txheej txheej, ua kom cov txheej sib txawv thiab du. Nws kuj tseem tuaj yeem txhim kho cov dej tsis kam thiab tiv thaiv cov khoom ntawm cov txheej, thiab nce lub hardness thiab adhesion ntawm txheej.
4. Kev ua lag luam cia siab thiab kev txhim kho cov qauv ntawm HPMC
Raws li cov neeg them ntau dua thiab ntau dua rau kev tiv thaiv ib puag ncig thiab kev noj qab haus huv, HPMC, ua cov khoom ntsuab thiab tsis muaj txiaj ntsig, muaj cov kev cia siab. Tshwj xeeb tshaj yog nyob rau hauv cov tshuaj paus, kev lag luam tshuaj thiab tshuaj pleev ib ce, daim ntawv thov HPMC yuav txuas ntxiv mus ntxiv. Yav tom ntej, cov txheej txheem ntau lawm ntawm HPMC feem ntau yuav tau tsim kho ntxiv, thiab kev nce ntxiv yuav txhawb nws daim ntawv thov hauv ntau yam kev lag luam.
Nrog rau kev txhim kho cov ntaub ntawv ntse thiab kev muab tshuaj thev naus laus zis, daim ntawv thov ntawm HPMC nyob rau hauv cov xov tooj ntse hauv kev tshawb fawb. Piv txwv li, HPMC tuaj yeem siv los npaj cov khoom siv yeeb tshuaj nrog kev tso tawm kev tso tawm ua haujlwm kom ntev lub sijhawm ntawm kev ua tau zoo.
HydroxyPropyyl Methylcelluloseyog cov khoom siv polymer nrog cov khoom siv zoo thiab kev siv dav. Nrog nws cov dej zoo heev solubility, muaj peev xwm kho viscosity thiab thev naus laus zis, cov tshuaj pleev li cas ntawm HPMC tuaj yeem nthuav dav, thiab kev txhim kho khoom siv kev txhim kho tau txuas ntxiv, thiab kev txhim kho kev txhim kho yav tom ntej yog qhov dav heev.
Lub sijhawm Post: Mar-11-2025