HydroxyPropyyl methylcellulose (HPMC)yog ib qho ntau ntau yam polymer feem ntau yog siv nyob rau hauv ntau cov ntawv thov, suav nrog cov tshuaj, khoom noj khoom haus, tshuaj pleev ib ce, thiab siv tshuaj pleev ib ce. Qhov zoo tshaj ntawm HPMC tuaj yeem sib txawv nyob ntawm cov khoom siv molecular, degrity ntawm kev hloov pauv (DS), uas ncaj qha rau nws cov kev ua tau zoo hauv cov ntawv thov.
Cov ntsiab lus tseem ceeb cuam tshuam rau qhov zoo ntawm hydroxypropyl methylulose
Molecular hnyav
Molecular hnyav (MW) yog hais txog qhov loj ntawm kev txhawj xeeb ®hpmc molecule thiab plays lub luag haujlwm tseem ceeb hauv kev txiav txim siab nws viscamility thiab solubility. Lub cev hnyav dua HPMC nyhav kom muaj cov viscosity ntau dua, uas yog pab tau hauv cov ntawv thov zoo li cov tshuaj tso yeeb tshuaj nrog ntau yam qauv.
Tsawg molecular hnyav (LMW): Kev sib txawv sai, qis viscosity, ntau haum rau cov ntawv thov zoo li txheej thiab zaj duab xis-ua.
High molecular hnyav (hmw): Slower Dhuav, viscosity ntau dua rau cov thickening, gelling, thiab tswj cov tshuaj tso tawm.
Degree ntawm hloov (DS)
Cov degree ntawm kev hloov pauv yog hais txog raws li cov pawg hydroxyl ntawm lub cellulose kab mob cellulose tau hloov los ntawm methyl thiab hydroxypropropsyl pawg. Qhov kev cuam tshuam no cuam tshuam rau solubility thiab rheological cov khoom ntawm cov polymer.
Tsawg ds: Txo cov dej solubility, ntau dua gel lub zog.
High DS: Cov kua dej solubility dolubility, txo qis gel lub zog, thiab zoo dua tswj cov khoom hauv cov khoom lag luam.
Viscosity
Viscosity yog qhov tseem ceeb tshaj plaws hauv kev txiav txim siab li cas HPMC tau ua rau muaj cov ntaub ntawv thickening, ruaj khov, thiab kev siv ua kom ruaj khov. Visccosity HPMC siab dua yog siv hauv cov ntawv thov zoo li emulsions, thaum txo viscosity qib yog qhov zoo tagnrho rau cov zaub mov thiab cov tshuaj.
Tsis viscosity: Feem ntau siv hauv cov zaub mov, kev saib xyuas tus kheej, thiab kws tshuaj thiab cov kws tshuaj tsim qauv rau zaj duab xis tsim thiab khi.
Siab viscosity: Siv hauv cov kws tshuaj tswj tau tso tawm-tso tawm, high-zog gels, thiab raws li cov tuab tuab, thiab tuab hauv cov khoom lag luam muaj kev lag luam.
Kev coj dawb huv
The level of impurities, such as residual solvents, inorganic salts, and other contaminants, can significantly affect the performance of AnxinCel®HPMC. Cov qib siab dua feem ntau yuav tsum muaj nyob hauv cov tshuaj thiab khoom siv khoom noj.
Kws Tshuaj Ntsuam Xyuas: Muaj kev coj dawb huv, feem ntau nrog los ntawm kev tswj hwm kev sib zog ntawm cov kuab tshuaj thiab cov paug tsis huv.
Muaj Qeb: Qis kev coj dawb huv, lees txais rau cov ntaub ntawv tsis siv los yog tsis siv tshuaj tsis zoo.
So
Lub solubility ntawm HPMC hauv dej nyob ntawm ob qho tag nrho nws cov molecular hnyav thiab qib degree hloov chaw. Feem ntau, HPMC yog soluble hauv dej txias, ua rau nws xaiv zoo rau ntau cov ntawv thov uas xav tau cov kev siv dej ua ke.
Tsis Muaj Solubility: Tsawg dua soluble, siv rau kev tswj-tso tawm cov tshuab.
Siab solubility: Ntau soluble, zoo tagnrho rau cov ntawv thov uas yuav tsum tau ua tiav.
Thermal ruaj khov
Lub thermal stability ntawm HPMC yog qhov tseem ceeb ntawm kev lag luam, tshwj xeeb tshaj yog nyob hauv kev lag luam uas cuam tshuam nrog kev ntsuas kub. Ntau dua thermal ruaj khov tuaj yeem yog qhov tseem ceeb hauv cov ntawv thov xws li ntsiav tshuaj pleev xim thiab hauv kev lag luam khoom noj khoom haus.
Gel lub zog
Gel lub zog yog hais txog lub peev xwm ntawm HPMC los ua ib qho gel thaum sib xyaw nrog dej. Ntau dua Gel lub zog yog xav tau hauv cov ntawv thov xws li tswj cov tshuaj muaj yees siv tshuaj yeeb, thiab lub zog qis yog nyiam kev ncua thiab emulsions.
Piv txwv li lub rooj: Cov yam ntxwv zoo ntawm hydroxypropyl methylcelulose
| Yam tseem ceeb | Qis zoo HPMC | Siab Zoo Hpmc | Cuam tshuam rau kev ua tau zoo |
| Molecular hnyav | Qis dua kev hnyav (LMW) | Siab dua molecular hnyav (hmw) | LMW xaus sai dua, hmw muaj ntau dua viscosity thiab cov kua pleev ntaub tuab dua. |
| Degree ntawm hloov (DS) | Tsawg DS (Hloov Hloov) | High DS (Txiaj Ntsig Ntau) | Tsawg DS muab zoo dua gel lub zog, siab ds txhim kho solubility. |
| Viscosity | Tsis muaj viscosity, yaj sai | Siab viscosity, thickening, gel-thawj | Tsis muaj viscosity haum rau yooj yim dispersion, siab viscosity rau stabilization thiab txhawb nqa kev tso tawm. |
| Kev coj dawb huv | Ntau theem ntawm impurities (inorganic ntsev, cov kuab tshuaj) | Siab dua kev coj dawb huv, tsawg kawg ntawm cov khoom tsis muaj zog | Kev ua kom muaj kev nyab xeeb siab thiab ua tau zoo, tshwj xeeb tshaj yog hauv cov kws tshuaj thiab khoom noj. |
| So | Cov solubility tsis zoo hauv dej txias | Zoo solubility hauv dej txias | Siab solubility yog pab rau cov txheej txheej thiab tso tawm cov ntawv thov tawm sai. |
| Thermal ruaj khov | Qis qis thermal ruaj khov | Siab dua thermal ruaj khov | Siab thermal stability nyiam nyob rau hauv qhov chaw kub-ib puag ncig. |
| Gel lub zog | Tsawg gel lub zog | Siab Gel Zog | High gel zog tsim nyog rau kev tswj hwm kev tso tawm thiab cov nyom. |
| Kev tshwm sim | Daj lossis tawv nqaij dawb, tsis sib haum xeeb | Dawb rau off-dawb, du qauv | Zoo HPMC yuav muaj cov teeb meem tsis zoo, qhia tau xwm yeem hauv kev tsim khoom. |
Daim ntawv thov raws li kev txiav txim siab zoo
Kws Tshuaj Kho Mob: Hauv cov tshuaj yeeb yaj kiab, kev ua yeeb yaj kiab, viscosity, hnyav, thiab lub zog gel yog qhov tseem ceeb ntawm HPMC. Cov tshuaj tawm ntawm cov khoom muaj zog (APIs)
Kev Lag Luam Khoom Noj: Rau cov khoom lag luam khoom noj, tshwj xeeb tshaj yog nyob rau hauv cov ntawv thov xws li cov zaub mov ua zaub mov, thiab emulsifizing, HPMC ntawm qis viscosity thiab solubility solubility feem ntau nyiam. Cov zaub mov zoo-qib kawm HPMC kom cov neeg siv kev nyab xeeb thiab ua tau raws cov qauv rau kev noj.
Kev Lom Zem thiab Kev Kho Mob Tus Kheej: Hauv cov tshuaj pleev ib ce, txhawj xeeb ®hpmc yog siv rau emulsification, thickening, thiab zaj duab xis-ua. Ntawm no, viscosity thiab solubility yog qhov tseem ceeb rau kev tsim cov qauv ruaj khov zoo li muaj cov tshuaj pleev, cov duab, thiab cov khoom siv plaub hau.
Kev Siv Khoom Siv: Hauv cov ntawv thov kev ua, xws li cov xim tha xim, cov nplaum thiab cov qhab nia siab muaj cov qib hpmc feem ntau yog siv rau kev tsim kom tuab thiab ua yeeb yaj kiab. Qhov tsom kwm ntawm thermal stability, huv, thiab viscosity yog inamount hauv kev ua kom muaj txiaj ntsig zoo cov khoom lag luam hauv cov xwm txheej hnyav.
Qhov zoo tshaj ntawmHydroxyPropyyl MethylcelluloseMuaj peev xwm cuam tshuam ntau nws kev ua tau zoo hla kev sib txawv. Los ntawm kev nkag siab txog cov xwm txheej uas ua rau nws zoo li molecular hnyav, solubility, solubity, thiab thermal ruaj khov - koj tuaj yeem xaiv txoj cai qib rau txhua daim ntawv thov. Txawm hais tias rau cov tshuaj siv tshuaj siv, kev tsim khoom noj, ua kom tau kev lag luam hauv HPMC, kom tau raug xaiv tau tias qib siab ntawm HPMC yog qhov xaiv tau zoo thiab ua tau zoo ntawm cov khoom kawg.
Lub Sijhawm Post: Jan-27-2025