HydroxyPropyyl methylcellueculose (HPMC) yog cov neeg polymer ntau yam uas tau siv dav hauv ntau yam kev lag luam vim nws cov khoom tshwj xeeb. Raws li lub cellulose derivative, HPMC yog muab tau los ntawm ntuj cellulose thiab muaj hydroxypropyl thiab methyl pawg txuas rau lub cellulose caj qaum. Qhov kev hloov kho no muab HPMC cov khoom siv HPMC, ua rau nws haum rau ntau cov ntawv thov, suav nrog cov tshuaj, suav nrog cov khoom noj, thiab cov khoom lag luam zoo.
Xaiv cov qib kawm kom raug ntawm HPMC tseem ceeb heev rau kev ua tiav cov kev ua tau zoo hauv ib daim ntawv thov. Ntau yam cuam tshuam HPMC xaiv, suav nrog viscosity, methoxy thiab hydroxypropyl cov ntsiab lus, thiab loj me me. Hauv kev sib tham no, peb yuav ua tib zoo saib ntawm cov xwm txheej no thiab tshawb nrhiav seb lawv cuam tshuam HPMC xaiv rau cov ntawv thov sib txawv.
1. Viscosity:
Ib qho kev txiav txim siab tseem ceeb thaum xaiv HPMC yog nws viscosity. Viscosity hais txog qhov tsis kam ntawm cov kua dej ntws. Hauv HPMC, viscosity yog ib qho kev ntsuas ntawm cov tuab tuab lossis sib xws ntawm kev daws teeb meem. TxawvSiv cov ntawv thov yuav tsum muaj qib viscosity sib txawv ntawm HPMC. Piv txwv li:
Kws Tshuaj: Hauv cov tshuaj, hauv cov tshuaj, HPMC feem ntau siv los ua cov neeg sawv cev ua tuab thiab ua kom zoo nkauj. Qhov kev xaiv ntawm qib viscosity nyob ntawm cov xav tau ntawm cov khoom kawg, seb ntsiav tshuaj, tshuaj ntsiav lossis kua tsim ua.
Kev tsim kho: Hauv kev tsim kho kev tsim kho, HPMC tau dav siv hauv kev sib nphhuab tov. Lub viscos ntawm HPMC cuam tshuam rau cov dej ua kom dej, ua haujlwm thiab sag tiv thaiv cov tshuaj cug. Ntsug cov ntawv thov feem ntau nyiam viscosity qib siab kom tiv thaiv sag.
2. Methoxy thiab hydroxypropyl cov ntsiab lus:
Qeb degree ntawm kev hloov pauv (DS) Cov nuj nqis ds sib txawv tuaj yeem ua to Hloov pauv hauv solubility, gelation, thiab lwm yam khoom. Xav txog:
Zaj duab xis hauv cov kws tshuaj: HPMC nrog qis methoxyl cov ntsiab lus feem ntau yog nyiam rau cov yeeb yaj kiab ua yeeb yam vim tias nws txhim kho cov khoom ua yeeb yaj kiab thiab txo cov zogNws tau tawm tsam rau ib puag ncig.
3. Lwm Yam Hom:
Hloov hom yog lwm qhov tseem ceeb. HPMC tuaj yeem yaj tau sai sai (tseem hu ua "hydration nrawm") lossis yaj qeeb. Qhov kev xaiv yog nyob ntawm qhov kev tso tawm profile yuav tsum muaj nyob hauv cov ntaub ntawv thov tshuaj. Piv txwv li:
Cov Ntawv Tso Tawm Tso Tawm: Rau kev tswj hwm kev tso tawm, qib qeeb dispolves ntawm HPMC tuaj yeem ua tiav kom ua tiav cov khoom siv hluav taws xob ingredient.
4. Paus taus loj:
Qhov loj me me cuam tshuam rau kev dispersion thiab solubility ntawm HPMC hauv kev daws teeb meem. Cov ntaub ntawv ua kom tiav yuav yaj yooj yim dua, cuam tshuam cov kev ua tau zoo tag nrho hauv ntau cov ntawv thov:
Kev lag luam khoom noj khoom haus: hauv kev lag luam khoom noj khoom haus, HPMC yog siv rau hauv cov ntawv thov xws li thickening thiab ruaj khov. Khoom nplua-LisEd HPMC feem ntau nyiam rau nws cov hydration ceev thiab dispersion cov khoom hauv cov khoom noj khoom haus.
5. Sib xyaws nrog lwm cov khoom xyaw:
Qhov sib xyaw ntawm HPMC nrog lwm cov khoom xyaw rau hauv cov qauv tsim yog qhov tseem ceeb rau nws cov kev ua tau zoo tag nrho. Qhov no suav nrog kev sib raug zoo nrog cov khoom xyaw ua tshuaj (APIs) hauv tshuaj lossis sib xyaw nrog lwm cov khoom siv hauv tsev.
Cov khoom lag luam: HPMC yuav tsum be Tshaj tawm ntawm API kom ntseeg tau tias muaj kev ruaj khov thiab kev faib tawm hauv kev faib tawm hauv cov koob tshuaj no.
6. Kev tswj hwm ua raws li:
Rau cov tshuaj thiab cov ntawv thov khoom noj khoom haus, tswj kev cai lij choj yog qhov tseem ceeb. HPMC qib xaiv tau xaiv tau ua raws li cov tshuaj uas cuam tshuam lossis cov qauv muaj khoom noj ntxiv.
Tshuaj thiab Khoom Noj: Ua raws li cov qauv kev cai (piv txwv li, USP, EP, JP) lossis khoom noj muaj roj av ntxivNS (piv txwv li cov kev cai FDA) yog qhov tseem ceeb los xyuas kom muaj kev nyab xeeb thiab ua hauj lwm zoo.
7. Kev txiav txim siab them nyiaj:
Tus nqi yog ib qho kev txiav txim siab hauv ib qho kev siv khoom siv. Thaum xaiv cov qib kawm yog HPMC, ntsuas kev ua tau zoo thiab kev txiav txim siab tau txais kev txiav txim siab tseem ceeb.
Kev lag luam tsim kev tsim kho: Hauv kev tsim kho kev tsim kho, HPMC yog siv ntau yam hauv kev sib xyaw qhuav, qhov twg tus nqi-ua tau zoo yog qhov kev txiav txim siab tseem ceeb.
Yuav tsum xaiv kom tsim nyog ntawm hydroxypropyl methylcellose kev txiav txim siab txog ntau yam khoom, suav nrog lwm yam khoom xyaw, kev tswj hwm kev ua haujlwm thiab tus nqi. Txhua daim ntawv thov muaj cov kev cai tshwj xeeb, thiab xaiv cov qib HPMC yog qhov ua tau zoo thiab cov yam ntxwv xav tau ntawm cov khoom kawg. Nws raug nquahu kom ua haujlwm nrog cov chaw muab khoom thiab cov chaw tsim khoom uas tuaj yeem pab koj xaiv HPMC qib zoo tshaj plaws rau koj daim ntawv thov.
Lub Sijhawm Post: Jan-02-2024