HPMC (Hydroxypropyl Methylcellulose)yog cov khoom siv uas feem ntau siv hauv cov tshuaj gel capsules (nyuaj thiab mos capsules) nrog ntau yam tshwj xeeb zoo.
1. Biocompatibility
HPMC yog cov nroj tsuag ntuj tsim cellulose derivative uas muaj biocompatibility zoo heev tom qab hloov tshuaj. Nws muaj peev xwm ua tau zoo nrog lub cev ib puag ncig ntawm tib neeg lub cev thiab tuaj yeem txo qhov kev pheej hmoo ntawm kev tsis haum tshuaj. Yog li ntawd, nws yog feem ntau siv rau hauv kev npaj tshuaj, tshwj xeeb tshaj yog nyob rau hauv cov tshuaj uas yuav tsum tau noj rau lub sij hawm ntev. HPMC cov ntaub ntawv tsis tshua muaj kev ua xua rau lub plab zom mov, yog li nws muaj kev nyab xeeb siab raws li kev xa tshuaj, tshwj xeeb tshaj yog nyob rau hauv sustained-tso thiab tswj-tso tshuaj npaj.
2. Adjustable tso cov khoom
HPMCtuaj yeem tswj hwm nws qhov kev ruaj ntseg hauv ib puag ncig sib txawv (dej thiab pH), yog li nws tsim nyog rau kev tswj hwm tus nqi tso tawm ntawm cov tshuaj. Hauv cov tshuaj gel capsules, cov khoom ntawm HPMC tuaj yeem hloov kho los ntawm kev hloov nws qib ntawm polymerization (qhov hnyav ntawm molecular) thiab qib ntawm hydroxypropylation, ua rau nws yog ib qho kev xaiv zoo tshaj plaws rau kev tso tawm thiab tswj-tso tshuaj npaj. Nws tuaj yeem ncua kev tso tawm ntawm cov tshuaj los ntawm kev tsim ib txheej ntawm cov khoom siv hydrated gelatinous, kom ntseeg tau tias cov tshuaj tuaj yeem raug tso tawm tusyees thiab tsis tu ncua nyob rau hauv ntau qhov chaw ntawm lub plab zom mov, txo cov tshuaj thiab ua kom cov neeg mob ua raws.
3. Tsis muaj tsiaj keeb kwm, haum rau cov neeg tsis noj nqaij
Tsis zoo li cov tshuaj ntsiav tshuaj gelatin, HPMC yog cov nroj tsuag muab los thiab yog li ntawd tsis muaj cov khoom xyaw tsiaj, ua rau nws tsim nyog rau cov neeg tsis noj nqaij thiab cov pab pawg uas nws txoj kev ntseeg muaj kev txwv ntawm cov khoom xyaw tsiaj. Tsis tas li ntawd, HPMC capsules kuj tau pom tias yog kev xaiv ib puag ncig zoo dua vim tias lawv cov txheej txheem ntau lawm yog ib puag ncig zoo thiab tsis koom nrog kev tua tsiaj.
4. Cov khoom ua yeeb yaj kiab zoo
HPMCNws muaj qhov zoo solubility hauv dej thiab tuaj yeem tsim cov gel zaj duab xis sai. Qhov no tso cai rau HPMC los ua lub luag haujlwm tseem ceeb hauv kev tsim cov yeeb yaj kiab sab nrauv ntawm cov tshuaj ntsiav. Piv nrog rau lwm cov ntaub ntawv, tsim ntawm HPMC zaj duab xis yog smoother thiab ruaj khov, thiab tsis yooj yim cuam tshuam los ntawm cov av noo hloov. Nws tuaj yeem tiv thaiv cov khoom xyaw tshuaj hauv cov tshuaj ntsiav kom tsis txhob cuam tshuam los ntawm ib puag ncig sab nraud thiab txo cov tshuaj degradation.
5. Tswj kev ruaj ntseg ntawm cov tshuaj
HPMC muaj cov dej noo zoo thiab tuaj yeem tiv thaiv tau cov tshuaj los ntawm absorbing noo noo nyob rau hauv lub capsule, yog li txhim kho cov stability ntawm cov tshuaj thiab ncua lub txee lub neej ntawm cov tshuaj. Piv nrog gelatin capsules, HPMC capsules tsis tshua muaj peev xwm nqus dej, yog li lawv muaj kev ruaj ntseg zoo dua, tshwj xeeb tshaj yog nyob rau hauv qhov chaw muaj av noo.
6. Tsawg solubility thiab tso tawm qeeb qeeb
HPMC muaj qis solubility nyob rau hauv lub plab zom mov, uas ua rau nws yaj ntau qeeb nyob rau hauv lub plab, yog li nws muaj peev xwm nyob rau hauv lub plab rau lub sij hawm ntev, uas yog haum rau kev npaj ntawm sustained-tso tshuaj. Piv nrog rau gelatin capsules, HPMC capsules muaj lub sij hawm dissolution ntev dua, uas tuaj yeem ua kom ntseeg tau tias cov tshuaj tso tawm ntau dua hauv cov hnyuv me lossis lwm qhov chaw.
7. Muaj feem xyuam rau ntau yam kev npaj tshuaj
HPMC yog sib xws nrog ntau yam khoom xyaw tshuaj. Txawm hais tias nws yog cov tshuaj muaj zog, cov tshuaj ua kua, lossis cov tshuaj soluble tsis zoo, lawv tuaj yeem ua tau zoo los ntawm HPMC capsules. Tshwj xeeb tshaj yog thaum encapsulating roj-soluble tshuaj, HPMC capsules muaj kev sib khi zoo dua thiab kev tiv thaiv, uas tuaj yeem tiv thaiv kom tsis txhob muaj kev kub ntxhov thiab degradation ntawm cov tshuaj.
8. Tsawg dua kev tsis haum tshuaj thiab cov kev mob tshwm sim
Piv nrog rau gelatin capsules, HPMC muaj qhov tshwm sim qis dua ntawm kev tsis haum tshuaj, ua rau nws yog qhov kev xaiv zoo tshaj plaws rau cov neeg uas nkag siab rau cov khoom xyaw tshuaj. Txij li HPMC tsis muaj tsiaj protein, nws txo cov teeb meem kev tsis haum xeeb los ntawm cov khoom xyaw tsiaj los ntawm cov tsiaj txhu thiab tshwj xeeb tshaj yog haum rau cov neeg mob uas tsis haum rau gelatin.
9. Yooj yim rau tsim thiab txheej txheem
Cov txheej txheem ntau lawm ntawm HPMC yog qhov yooj yim thiab tuaj yeem nqa tawm ntawm chav tsev kub thiab siab. Piv nrog rau gelatin, cov txheej txheem tsim khoom ntawm HPMC capsules tsis xav tau kev tswj kub thiab ziab, txuag nqi ntau lawm. Tsis tas li ntawd, HPMC capsules muaj cov cuab yeej zoo thiab lub zog, thiab tsim nyog rau cov khoom siv loj loj.
10. Transparency thiab tsos
HPMC capsules muaj cov pob tshab zoo, yog li qhov pom ntawm cov tshuaj ntsiav zoo nkauj dua, uas yog qhov tseem ceeb tshwj xeeb rau qee cov tshuaj uas yuav tsum tau ua kom pom tseeb. Piv nrog rau cov tshuaj ntsiav tshuaj gelatin, HPMC capsules muaj qhov pom tseeb dua thiab tuaj yeem tso tawm cov tshuaj hauv cov tshuaj ntsiav, ua rau cov neeg mob nkag siab txog cov ntsiab lus ntawm cov tshuaj ntau dua intuitively.
Kev siv ntawmHPMCnyob rau hauv cov tshuaj gel capsules muaj ntau yam zoo, nrog rau zoo heev biocompatibility, adjustable tshuaj tso cov yam ntxwv, haum rau cov neeg tsis noj nqaij, zoo zaj duab xis tsim cov yam ntxwv, thiab txhim kho tshuaj stability. Yog li ntawd, nws yog dav siv nyob rau hauv kev lag luam tshuaj, tshwj xeeb tshaj yog nyob rau hauv sustained-tso, tswj-tso tshuaj npaj thiab cog-raws li tshuaj npaj. Nrog rau kev xav tau ntawm cov neeg siv khoom ntau ntxiv rau kev noj qab haus huv thiab kev tiv thaiv ib puag ncig, kev cia siab ua lag luam ntawm HPMC capsules tau dhau los ua ntau thiab dav.
Post lub sij hawm: Nov-28-2024