HPMC (Hydroxypropyl Methylcellulose) yog ib qho nonionic cellulose ether dav siv nyob rau hauv kws, khoom noj khoom haus, kev tsim kho thiab tshuaj pleev ib ce. Cov qib sib txawv ntawm HPMC feem ntau yog cais raws li lawv cov qauv tshuaj, lub cev muaj zog, viscosity, qib kev hloov pauv thiab kev siv sib txawv.
1. Cov qauv tshuaj thiab qib kev hloov pauv
Cov qauv molecular ntawm HPMC muaj cov pab pawg hydroxyl ntawm cov saw cellulose hloov los ntawm methoxy thiab hydroxypropoxy pawg. Lub cev thiab tshuaj lom neeg ntawm HPMC sib txawv nyob ntawm seb qhov kev hloov pauv ntawm methoxy thiab hydroxypropoxy pawg. Lub degree ntawm kev hloov pauv ncaj qha cuam tshuam rau solubility, thermal stability thiab nto ua haujlwm ntawm HPMC. Tshwj xeeb:
HPMC nrog cov ntsiab lus methoxy siab nyiam ua kom pom qhov kub thiab txias dua, uas ua rau nws tsim nyog rau kev siv kub-rhiab heev xws li tswj-tso tshuaj npaj.
HPMC nrog cov ntsiab lus siab hydroxypropoxy muaj cov dej solubility zoo dua, thiab nws cov txheej txheem kev sib cais tsis tshua muaj kev cuam tshuam los ntawm qhov kub thiab txias, ua rau nws tsim nyog siv rau hauv qhov chaw txias.
2. Qib viscosity
Viscosity yog ib qho tseem ceeb ntawm HPMC qib. HPMC muaj ntau yam viscosities, los ntawm ob peb centipoise mus rau kaum tawm txhiab centipoise. Qib viscosity cuam tshuam rau nws siv hauv ntau daim ntawv thov:
Tsawg viscosity HPMC (xws li 10-100 centipoise): HPMC qib no feem ntau yog siv rau hauv cov ntawv thov uas yuav tsum tau qis viscosity thiab siab fluidity, xws li zaj duab xis txheej, ntsiav tshuaj adhesives, thiab lwm yam. fluidity ntawm kev npaj.
Nruab nrab viscosity HPMC (xws li 100-1000 centipoise): Feem ntau siv rau hauv cov khoom noj, tshuaj pleev ib ce thiab qee yam kev npaj tshuaj, nws tuaj yeem ua cov thickener thiab txhim kho kev ntxhib los mos thiab ruaj khov ntawm cov khoom.
High viscosity HPMC (xws li saum toj no 1000 centipoise): HPMC qib no feem ntau yog siv rau hauv cov ntawv thov uas xav tau cov viscosity siab, xws li cov nplaum, nplaum thiab cov khoom siv hauv tsev. Lawv muab cov thickening zoo heev thiab ncua kev muaj peev xwm.
3. Lub cev muaj zog
Lub cev lub cev ntawm HPMC, xws li solubility, gelation kub, thiab lub peev xwm nqus dej, kuj txawv nrog nws qib:
Solubility: Feem ntau HPMCs muaj solubility zoo nyob rau hauv dej txias, tab sis cov solubility txo qis raws li cov ntsiab lus methoxy nce. Qee qib tshwj xeeb ntawm HPMC kuj tuaj yeem yaj hauv cov kuab tshuaj organic rau cov ntawv thov tshwj xeeb.
Gelation kub: Lub gelation kub ntawm HPMC nyob rau hauv aqueous tov nws txawv nrog cov hom thiab cov ntsiab lus ntawm substituents. Feem ntau hais lus, HPMC nrog cov ntsiab lus methoxy siab nyiam tsim cov gels ntawm qhov kub siab dua, thaum HPMC nrog cov ntsiab lus hydroxypropoxy siab qhia qhov ntsuas kub qis dua.
Hygroscopicity: HPMC muaj hygroscopicity tsawg, tshwj xeeb tshaj yog cov qib siab hloov. Qhov no ua rau nws zoo heev nyob rau hauv ib puag ncig uas yuav tsum tau noo noo tsis kam.
4. Cov chaw thov
Vim tias cov qib sib txawv ntawm HPMC muaj qhov sib txawv ntawm lub cev thiab tshuaj lom neeg, lawv cov ntawv thov hauv ntau qhov chaw kuj txawv:
Kev lag luam kws tshuaj: HPMC feem ntau yog siv rau hauv cov ntsiav tshuaj txheej, kev npaj tso tawm, cov nplaum, thiab cov thickeners. Pharmaceutical qib HPMC yuav tsum ua kom tau raws li cov qauv tshuaj pharmacopoeia, xws li Tebchaws Meskas Pharmacopoeia (USP), European Pharmacopoeia (EP), thiab lwm yam. Cov qib sib txawv ntawm HPMC tuaj yeem siv los kho qhov tso tawm thiab ruaj khov ntawm cov tshuaj.
Kev lag luam khoom noj khoom haus: HPMC yog siv los ua cov thickener, emulsifier, stabilizer thiab zaj duab xis qub. Khoom noj khoom haus qib HPMC feem ntau yuav tsum tsis muaj tshuaj lom, tsis qab, tsis muaj ntxhiab, thiab yuav tsum ua raws li cov cai tswj kev noj zaub mov, xws li US Food and Drug Administration (FDA) thiab European Food Safety Authority (EFSA).
Kev tsim kho kev lag luam: Kev tsim kho qib HPMC feem ntau yog siv rau hauv cov khoom siv cement, cov khoom siv gypsum thiab coatings kom thicken, khaws dej, lubricate thiab txhim kho. HPMC ntawm cov qib viscosity sib txawv tuaj yeem cuam tshuam rau kev ua haujlwm ntawm cov khoom siv hauv tsev thiab kev ua haujlwm ntawm cov khoom kawg.
5. Cov qauv zoo thiab cov kev cai
Cov qhab nia sib txawv ntawm HPMC kuj raug rau cov qauv zoo thiab cov kev cai sib txawv:
Pharmaceutical grade HPMC: yuav tsum ua kom tau raws li cov cai ntawm pharmacopoeia, xws li USP, EP, thiab lwm yam. Nws cov txheej txheem tsim khoom thiab kev tswj xyuas kom zoo yog qhov siab kom ntseeg tau tias nws muaj kev nyab xeeb thiab ua tau zoo hauv kev npaj tshuaj.
Khoom noj khoom haus-qib HPMC: Nws yuav tsum ua raws li cov kev cai tseem ceeb ntawm cov khoom noj ntxiv kom ntseeg tau tias nws muaj kev nyab xeeb hauv cov zaub mov. Ntau lub teb chaws thiab cheeb tsam yuav muaj qhov sib txawv ntawm cov zaub mov-qib HPMC.
Kev lag luam qib HPMC: HPMC siv hauv kev tsim kho, txheej txheej thiab lwm yam kev lag luam feem ntau tsis tas yuav ua raws li cov qauv zaub mov lossis tshuaj, tab sis tseem yuav tsum ua kom tau raws li cov qauv kev lag luam, xws li ISO cov qauv.
6. Kev nyab xeeb thiab kev tiv thaiv ib puag ncig
HPMC ntawm qib sib txawv kuj txawv ntawm kev nyab xeeb thiab kev tiv thaiv ib puag ncig. Pharmaceutical-qib thiab zaub mov-qib HPMC feem ntau raug soj ntsuam kev nyab xeeb kom ntseeg tau tias lawv tsis muaj mob rau tib neeg lub cev. Muaj-qib HPMC, ntawm qhov tod tes, them nyiaj ntau rau nws qhov kev tiv thaiv ib puag ncig thiab kev degradability thaum siv los txo qhov cuam tshuam rau ib puag ncig.
Qhov sib txawv ntawm cov qib sib txawv ntawm HPMC feem ntau yog tshwm sim hauv cov qauv tshuaj, viscosity, lub cev muaj zog, daim ntawv thov, cov qauv zoo thiab kev nyab xeeb. Raws li cov ntawv thov tshwj xeeb, xaiv cov qib zoo ntawm HPMC tuaj yeem txhim kho kev ua tau zoo thiab zoo ntawm cov khoom. Thaum yuav HPMC, cov yam ntxwv no yuav tsum tau txiav txim siab ua tiav kom ntseeg tau tias siv tau thiab ua haujlwm tau zoo ntawm cov khoom.
Post lub sij hawm: Aug-20-2024