Hydroxypropyl methylcellulose (HPMC)yog ib hom tshuaj lom neeg uas tau siv dav hauv ntau lub lag luam xws li kev tsim kho, tshuaj, khoom noj thiab tshuaj pleev ib ce. Txawm li cas los xij, txawm hais tias HPMC muaj ntau yam khoom zoo heev, xws li thickening, emulsification, tsim cov yeeb yaj kiab, thiab lub kaw lus ruaj khov, nws kuj muaj qee qhov tsis zoo thiab kev txwv.
1. Cov teeb meem solubility
Txawm hais tias HPMC tuaj yeem yaj hauv dej thiab qee cov kuab tshuaj organic, nws cov solubility raug cuam tshuam los ntawm qhov kub thiab txias. Nws dissolves maj mam nyob rau hauv dej txias thiab yuav tsum tau stirring txaus kom yaj tag, thaum nws yuav tsim ib tug gel nyob rau hauv high-kub dej, ua rau nws unevenly dispersed. Cov yam ntxwv no tuaj yeem ua rau qee qhov tsis yooj yim rau qee qhov kev thov (xws li cov khoom siv hauv tsev thiab cov chaw muag tshuaj), thiab cov txheej txheem tawg tshwj xeeb lossis cov khoom siv ntxiv yuav tsum tau ua kom zoo dua cov nyhuv dissolution.
2. Tus nqi siab
Piv nrog rau qee qhov ntuj lossis hluavtaws thickeners, cov nqi tsim khoom ntawm HPMC yog siab dua. Vim nws txoj kev npaj complex, uas koom nrog ntau cov kauj ruam xws li etherification thiab purification, nws tus nqi yog siab dua lwm cov thickeners, xws li hydroxyethyl cellulose (HEC) los yog carboxymethyl cellulose (CMC). Thaum siv rau ntawm qhov loj me, tus nqi tseem ceeb yuav dhau los ua qhov laj thawj tseem ceeb los txwv nws txoj kev siv.
3. cuam tshuam los ntawm tus nqi pH
HPMC muaj kev ruaj ntseg zoo nyob rau hauv qhov sib txawv pH ib puag ncig, tab sis nws yuav degrade nyob rau hauv huab pH tej yam kev mob (xws li muaj zog acid los yog muaj zog puag), cuam tshuam nws thickening thiab stabilizing teebmeem. Yog li, qhov kev siv tau ntawm HPMC yuav raug txwv hauv qee qhov kev thov uas yuav tsum muaj pH huab cua (xws li cov tshuaj tiv thaiv tshwj xeeb).
4. Tsawg biodegradability
Txawm hais tias HPMC suav hais tias yog cov khoom siv ib puag ncig zoo, nws tseem siv sijhawm ntev rau nws kom biodegraded tag nrho. Nyob rau hauv ib puag ncig ntuj, tus nqi degradation ntawm HPMC qeeb, uas tej zaum yuav muaj qee yam cuam tshuam rau ecological ib puag ncig. Rau cov ntawv thov uas muaj kev tiv thaiv ib puag ncig siab, qhov degradability ntawm HPMC yuav tsis yog qhov kev xaiv zoo tshaj plaws.
5. Tsawg mechanical zog
Thaum HPMC siv los ua cov khoom siv ua yeeb yaj kiab lossis gel, nws lub zog siv hluav taws xob tsawg thiab nws yooj yim tawg lossis puas. Piv txwv li, hauv kev lag luam tshuaj, thaum HPMC siv los ua cov tshuaj ntsiav, nws muaj qhov tsis zoo ntawm cov tshuaj gelatin capsules, thiab qhov teeb meem ntawm fragility yuav cuam tshuam rau kev ruaj ntseg ntawm kev thauj mus los thiab kev cia khoom. Hauv kev tsim kho kev lag luam, thaum HPMC siv los ua cov thickener, txawm hais tias nws tuaj yeem txhim kho qhov adhesion ntawm mortar, nws muaj kev txwv tsis pub siv rau lub zog txhua yam ntawm cov khoom kawg.
6. Hygroscopicity
HPMC muaj qee qhov hygroscopicity thiab yooj yim absorbs ya raws nyob rau hauv ib tug high humidity ib puag ncig, uas tej zaum yuav cuam tshuam rau nws cov kev ua tau zoo. Piv txwv li, hauv kev npaj zaub mov lossis tshuaj, kev nqus dej tuaj yeem ua rau cov ntsiav tshuaj softening thiab kev hloov pauv hauv kev ua haujlwm tsis zoo, yog li cuam tshuam rau kev ruaj ntseg ntawm cov khoom. Yog li ntawd, thaum khaws cia thiab siv, ib puag ncig cov av noo yuav tsum tau tswj xyuas kom tsis txhob muaj kev ua haujlwm tsis zoo.
7. cuam tshuam rau bioavailability
Hauv kev lag luam kws tshuaj, HPMC feem ntau siv los npaj cov tshuaj tiv thaiv-tso tawm lossis tswj-tso tshuaj, tab sis nws yuav cuam tshuam rau kev tso tawm ntawm qee yam tshuaj. Piv txwv li, rau cov tshuaj hydrophobic, lub xub ntiag ntawm HPMC tuaj yeem txo qhov kev sib cais ntawm cov tshuaj hauv lub cev, yog li cuam tshuam rau nws cov bioavailability. Yog li ntawd, thaum tsim cov tshuaj formulations, cov nyhuv ntawm HPMC ntawm cov tshuaj tso tawm yuav tsum tau ua tib zoo soj ntsuam, thiab ntxiv excipients yuav tsum tau kom optimize tshuaj npaum li cas.
8. Thermal stability
HPMC tuaj yeem degrade lossis hloov pauv hauv kev ua haujlwm ntawm qhov kub siab dua. Txawm hais tias HPMC yog qhov ruaj khov nyob rau hauv qhov kub thiab txias, nws yuav degrade, discolor, los yog deteriorate nyob rau hauv kev ua tau zoo ntawm kub siab tshaj 200 ° C, uas txwv nws daim ntawv thov nyob rau hauv high-temperature txheej txheem. Piv txwv li, nyob rau hauv ib co yas los yog roj hmab ua, HPMC qhov kub tsis txaus kuj yuav ua rau txo qis hauv cov khoom zoo.
9. Compatibility teeb meem nrog lwm cov khoom xyaw
Hauv kev tsim cov ntawv thov, HPMC tuaj yeem cuam tshuam tsis zoo nrog qee cov cationic surfactants lossis cov hlau ions tshwj xeeb, uas ua rau muaj kev kub ntxhov lossis coagulation ntawm cov tshuaj. Qhov teeb meem kev sib raug zoo no tuaj yeem cuam tshuam rau qhov zoo thiab qhov pom ntawm cov khoom kawg hauv qee daim ntawv thov (xws li tshuaj pleev ib ce, tshuaj lossis tshuaj lom neeg cov tshuaj), yuav tsum tau kuaj xyuas kev sib raug zoo thiab kev tsim kho kom zoo.
Txawm tiasHPMCyog cov khoom siv dav siv nrog cov thickening zoo heev, cov yeeb yaj kiab tsim thiab ruaj khov, nws kuj muaj qhov tsis zoo xws li kev solubility tsawg, tus nqi siab, txwv biodegradability, tsis tshua muaj neeg kho tshuab lub zog, muaj zog hygroscopicity, cuam tshuam rau cov tshuaj tso tawm, thiab cov cua sov tsis zoo. Cov kev txwv no yuav cuam tshuam rau kev siv HPMC hauv qee qhov kev lag luam tshwj xeeb. Yog li ntawd, thaum xaiv HPMC raws li cov khoom siv raw, nws yog ib qho tsim nyog yuav tsum tau ua tib zoo xav txog nws qhov zoo thiab qhov tsis zoo thiab ua kom zoo rau nws ua ke nrog cov kev xav tau tiag tiag.
Post lub sij hawm: Apr-01-2025