HydroxyPropyyl methylcellose (HPMC) yog ib qho tseem ceeb ntxiv ntxiv, siv ntau yam li kev tsim kho, tshuaj, khoom noj, thiab tshuaj pleev ib ce. Nws muaj cov tuab heev, gelling, emulsifying, zaj duab xis-sib sau, thiab ua ke cov khoom, thiab muaj qee yam ruaj khov rau qhov kub thiab txias thiab? Lub solubility ntawm HPMC yog ib qho ntawm cov teeb meem tseem ceeb hauv nws siv. Nkag siab txog txoj kev daws teeb meem yog qhov tseem ceeb kom ntseeg tau tias nws ua tau zoo.
1. Cov khoom yooj yim ntawm HPMC
HydroxyPropyyl methylulose yog ib qho tsis-ionic dej-soluble cellulose cellulose lossis dej kub kom tsim cov kev daws teeb meem. Nws solubility yog tsuas cuam tshuam los ntawm kub. Nws yog qhov yooj yim rau yaj hauv dej txias thiab yooj yim los ua ib qho kev sib xyaw hauv dej kub. HPMC muaj thermal gelation, uas yog, nws muaj solubility ntau dua li qhov kub siab dua, tab sis tuaj yeem yaj tag thaum qhov kub tau qis dua. HPMC muaj qhov hnyav sib txawv thiab cov viscosities, yog li thaum lub sij hawm ua tiav kev sib cais, cov qauv HPMC tsim nyog yuav tsum tau xaiv raws li cov khoom yuav tsum tau ua.
2. Cov qauv ntawm HPMC
Cov Dej Txias Hlau Txhaum
Cov dej dej txias dispersion cov qauv yog cov kev siv HPMC feem ntau siv HPMC cov lus qhia sib cais thiab haum rau cov xwm txheej feem ntau. Cov kauj ruam tshwj xeeb yog raws li hauv qab no:
Npaj dej txias: ncuav qhov yuav tsum tau haus dej txias rau hauv cov thawv ntim. Cov dej kub feem ntau pom zoo kom qis dua 40 ° C kom tsis txhob muaj HPMC los ntawm kev sib sau lumps ntawm qhov kub.
Maj mam ntxiv hpmc: maj mam ntxiv hpmc hmoov thiab txuas ntxiv nplawm. Txhawm rau kom tsis txhob hmoov agglomeration, qhov tsim nyog stirring ceev yuav tsum tau siv los xyuas kom meej tias HPMC tuaj yeem ua rau dej ntws.
Sawv thiab yaj: Tom qab HPMC tau tawg nyob rau hauv dej txias, nws yuav tsum tau sawv ntsug rau qee lub sijhawm kom yaj. Feem ntau, nws sab laug sawv rau 30 feeb txog ob peb teev, thiab lub sijhawm tshwj xeeb sib txawv nyob ntawm HPMC qauv thiab dej kub. Thaum lub sij hawm sawv txheej txheem, HPMC yuav maj mam ploj mus ua cov tshuaj uas tsis muaj kuab.
Cov dej ua ntej ua ntej
Txoj kev ua dej ua ntej ua ntej yuav haum rau qee HPMC qauv nrog cov viscosity siab lossis nyuaj kom yaj hauv dej txias. Hom qauv no yog thawj zaug sib xyaw HPMC hmoov nrog ib feem ntawm cov dej kub kom tau txais cov dej khov, thiab tom qab ntawd muab cov dej txias kom kawg. Cov kauj ruam tshwj xeeb yog raws li hauv qab no:
Cov Dej Cua Sov: Ua kom sov ib qho dej ntawm cov dej kom txog 80 ° C thiab ncuav nws mus rau hauv lub thawv sib xyaw.
Ntxiv HPMC hmoov: ncuav HPMC hmoov rau hauv dej kub thiab do thaum nchuav los ua cov tshuaj txhuam sib tov. Hauv dej kub, HPMC yuav yaj ib ntus thiab tsim cov tshuaj pleev ib ce.
Ntxiv dej txias kom dilute: tom qab muab tshuaj txhuam cov tshuaj txhuam txias, maj mam muab nplawm kom txog thaum nws ua tiav tag rau hauv cov ntawv qhia pob tshab lossis cov lus tsis yooj yim.
Organic kuab kev rho tawm qauv
Qee zaum, txhawm rau txhawm rau ua kom muaj kev sib cais ntawm HPMC lossis txhim kho cov ntawv thov sib cais ntawm cov ntawv teev tshwj xeeb, cov organic kuab tshuaj tuaj yeem siv tau nrog dej kom yaj HPMC. Piv txwv li, organic cov kuab tshuaj xws li ethanol thiab acetone tuaj yeem siv mus rau Disperse HPMC Ua ntej, thiab tom qab ntawd dej ntxiv los pab HPMC yaj tau sai dua sai sai. Hom no feem ntau yog siv nyob rau hauv kev tsim cov khoom lag luam hnyav, xws li txheej xim thiab pleev xim.
Kev Sib Tw Qhuav
Cov txheej txheem sib xyaw qhuav yog qhov haum rau kev tsim khoom loj. HPMC feem ntau ua ntej ua ntej nrog lwm cov khoom hmoov (xws li MAAs, thiab lwm yam) ntxiv rau kev sib tov thaum siv. Cov txheej txheem no ua haujlwm ua haujlwm thiab zam cov teeb meem agglomeration thaum ntxiv dej kom ntseeg tau tias HPMC muaj tusyees liam thiab ua rau muaj kev ua siab ntev.
3. Qhov ntau yam cuam tshuam HPMC kev sib cais
Qhov kub thiab txias: lub solubility ntawm HPMC yog qhov kev nkag siab kub heev. Tsawg qhov kub yog pab kom nws dispersion thiab kev sib cais hauv dej, thaum lub sij hawm siab kub yooj yim ua rau HPMC los ua cov colloids, tabkuaj nws cov kev ua tiav. Yog li ntawd, nws yog qhov pom zoo kom siv cov dej txias lossis tswj cov dej kub qis dua 40 ° C thaum kawg HPMC.
Stirring ceev: kom zoo stirring tuaj yeem zam zam HPMC agglomeration, yog li ua kom nrawm dua qhov kev txiav txim siab. Txawm li cas los xij, dhau nrawm stirring ceev yuav ua kom muaj ntau ntawm cov npuas thiab cuam tshuam rau kev sib txawv ntawm kev daws teeb meem. Yog li ntawd, hauv kev ua haujlwm tiag, tsim nyog stirring ceev thiab khoom siv yuav tsum tau xaiv.
Cov dej ua tau zoo: impurities, hardness, pus, thiab lwm yam. Hauv dej yuav cuam tshuam rau solubility ntawm HPMC. Tshwj xeeb, calcium thiab magnesium ions hauv dej nyuaj tuaj yeem hnov mob nrog HPMC thiab cuam tshuam nws solubility. Yog li ntawd, siv dej ntshiab lossis cov dej ntshiab pab txhim kho kev ua tiav ntawm HPMC.
HPMC qauv thiab cov qauv hnyav: Cov qauv sib txawv ntawm HPMC sib txawv hauv kev sib txawv, nrawm thiab ua kom sov. HPMC nrog cov siab loj molecular hnyav dissolves maj mam, muaj siab viscosity, thiab siv ntev dua kom yaj tag. Xaiv cov qauv HPMC yog txhim kho kev ua kom muaj kev ua haujlwm sib txawv thiab ua tau raws li kev thov sib txawv.
4. Cov teeb meem thiab kev daws teeb meem hauv HPMC sib cais
Agglomeration Teeb meem: Thaum HPMC yog yaj hauv dej, agglomerations yuav tsim yog tias cov hmoov tsis meej. Txhawm rau zam cov teeb meem no, HPMC yuav tsum tau ntxiv maj thaum muaj qhov tsim nyog stirring ceev, thaum zam kev ntxiv HPMC hmoov ntawm qhov kub.
Kev daws tsis ncaj: Yog tias lub stirring tsis txaus los yog lub sijhawm sawv tsis txaus, HPMC yuav tsis yaj tag nrho, ua rau muaj kev daws tsis ncaj. Nyob rau lub sijhawm no, lub sijhawm stirringring yuav tsum tau txuas ntxiv lossis lub sijhawm sawv yuav tsum tau nce siab kom ua tiav kev ua tiav.
Cov teeb meem npuas: dhau nrawm nplawm los yog impurities nyob rau hauv cov dej yuav ua kom paub ntau ntawm cov npuas, cuam tshuam qhov zoo ntawm kev daws teeb meem. Vim li no, nws raug nquahu kom tswj tau lub starring ceev thaum Dissolving HPMC kom tsis txhob muaj npuas ntau dhau, thiab ntxiv rau defosamer yog tias tsim nyog.
Kev sib cais ntawm HPMC yog qhov txuas tseem ceeb hauv nws daim ntawv thov. Mastering txoj kev daws teeb meem tseeb yuav pab txhim kho cov khoom lag luam zoo thiab ntau lawm. Raws li hom HPMC sib txawv thiab cov ntawv thov yuav tsum muaj, dej txias tshem dej Nyob rau tib lub sijhawm, saib xyuas yuav tsum tau them nyiaj rau kev tswj hwm kom sov thiab dej ceev thiab dej ua kom tsis txhob muaj teeb meem xws li agglomeration, npuas thiab tsis ua tiav kev txiav txim siab. Los ntawm kev ua kom zoo dua kev sib cais ntawm kev sib cais, nws tuaj yeem ua kom tiav HPMC tuaj yeem muab cov kev daws teeb meem tag nrho rau ntau yam kev lag luam thiab cov ntawv thov txhua hnub.
Lub Sijhawm Post: Sep-30-2024