Dab tsi yog lub cev nqaij daim tawv ntawm hydroxypropyl methylculose?

1. Tsos thiab solubility

HPMC feem ntau yog cov hmoov dawb lossis tawv dawb, tsw, tsis muaj qab hau thiab tsis muaj tshuaj lom. Nws tuaj yeem raug yaj nyob rau hauv dej txias thiab qee cov kuab tshuaj orgalic (xws li cov kuab tshuaj uas sib xyaw nrog ethanol / dej), tab sis yog insoluble hauv ethanol, ether thiab chloroform. Vim tias nws cov xwm txheej tsis-ionic, nws yuav tsis yauv tsis muaj cov tshuaj aqueous thiab yuav tsis cuam tshuam dab tsi los ntawm PH tus nqi.

2. Viscosity thiab rheology

HPMC aqueous daws muaj cov thickenopen zoo thiab thixotrotropy zoo. Txawv ntau hom kev txhawj xeeb ® Nws cov kev qhia daws teeb meem Pseudoplastic, uas yog, tsim nyog rau cov ntawv teev cov xwm txheej, slurries, thiab lwm yam uas yuav tsum tau ua kom zoo.

3. Thermal gelation

Thaum HPMC yog rhuab hauv dej, cov pob tshab ntawm kev daws teeb meem tsawg thiab gel yog tsim nyob rau ntawm ib qho kub. Tom qab txias, lub xeev gel yuav rov qab mus rau lub xeev daws teeb meem. Ntau hom HPMC muaj ntau qhov chaw kub sib txawv, feem ntau ntawm 50 thiab 75 ° C. Cov cuab yeej no yog qhov tshwj xeeb tshaj nyob rau hauv cov ntawv thov xws li cug cug thiab cov tshuaj ntsiav tshuaj caparden.

4. Cov kev ua si saum npoo

Vim tias HPMC lwg me me muaj cov pab pawg hydrophilic, lawv pom qee qhov kev ua si ntawm cov nplaim dej thiab tuaj yeem ua ib qho emulsifying, dispersing thiab stuffilizing lub luag haujlwm. Piv txwv li, hauv cov tsho tiv no thiab emulsions, HPMC tuaj yeem txhim kho kev ruaj ntseg ntawm emulsion thiab tiv thaiv sedimentation ntawm cov xim.

5. Hygroscopicity

HPMC muaj qee yam kev hygroscopicity thiab tuaj yeem nqus cov dej noo hauv ib puag ncig noo. Yog li ntawd, hauv qee cov ntawv thov, saib xyuas yuav tsum tau them rau ntim sealing kom tiv thaiv kev nqus dej noo thiab agglomeration.

6. Zaj duab xis-ua cov cuab yeej

HPMC tuaj yeem tsim cov yeeb yaj kiab tawv thiab pob tshab, uas yog siv dav hauv cov zaub mov, tshuaj (xws li cov tshuaj pleev ib ce) thiab pleev xim. Piv txwv li, hauv kev ua lag luam HPMC tuaj yeem siv ua cov ntsiav tshuaj txheej los txhim kho cov tshuaj ruaj khov thiab tswj tso tawm.

7. Biocompatibility thiab kev nyab xeeb

HPMC yog tsis muaj tshuaj lom thiab tsis muaj mob, thiab tuaj yeem muaj kev nyab xeeb metabolized los ntawm tib neeg lub cev, yog li nws tau siv dav hauv cov teb ntawm cov tshuaj thiab cov khoom noj. Raws li cov tshuaj uas muaj kev zam, feem ntau nws yog siv los tsim cov ntsiav tshuaj-tso cov ntsiav tshuaj, tshuaj ntsiav zoo li plhaub, thiab lwm yam.

8. Pho kev daws teeb meem

HPMC yog qhov ruaj khov nyob rau hauv lub Ph Thaj Tsam ntawm 3 txog 11, thiab tsis yooj yim los yog precipitated los ntawm cov khoom siv tshuaj thiab cov khoom siv tshuaj txhua hnub thiab cov khoom siv tshuaj lom neeg.