HydroxyPropyyl methylcellose (HPMC) yog ib qho siv polymer hauv cov tshuaj, tshuaj pleev ib ce, khoom noj khoom haus, thiab ntau lwm cov ntawv thov. Nws yog dav siv vim nws biocompatibility, tsis muaj txiaj ntsig, thiab muaj peev xwm hloov kho lub thaj chaw rheological ntawm kev daws teeb meem. Txawm li cas los xij, nws yog ib qho tseem ceeb kom nkag siab yuav ua li cas yaj HPMC kom tau siv nws cov khoom tau zoo.
Dej: HPMC yog soluble heev nyob rau hauv dej, ua rau nws xaiv tau xaiv ntau rau ntau daim ntawv thov. Txawm li cas los xij, tus nqi ntawm kev sib txawv tuaj yeem sib txawv raws li cov lus xws li kub, pH, thiab qib hpmc siv.
Organic cov kuab tshuaj: ntau yam kuab tshuaj kuab tshuaj tuaj yeem yaj HPMC rau ntau yam sib txawv. Qee cov lus pom zoo organic xws li:
Cawv: IsoPropanol (IPA), ethanol, thiab lwm yam ntawm cov dej cawv no feem ntau siv nyob rau hauv cov tshuaj yeeb yaj kiab thiab tuaj yeem ua tau zoo hpmc.
Acetone: acetone yog cov kuab tshuaj muaj zog uas tuaj yeem ua rau HPMC tau zoo.
Ethyl acetate: nws yog lwm organic kuab uas tuaj yeem rhuav HPMC zoo.
Chloroform: chloroform yog cov kuab tshuaj hnyav dua thiab yuav tsum tau siv nrog kev ceev faj vim nws lom.
Dlethyl sulfoxide (DMOPS): DMOs yog polar agor farvent uas tuaj yeem yaj ntau ntawm cov tebchaw, suav nrog HPMC.
Propylene Glycol (Pg): PG feem ntau siv los ua cov tshuaj sib xyaw hauv cov tshuaj yeeb yaj kiab. Nws tuaj yeem yaj HPMC zoo thiab feem ntau siv nrog dej nrog dej lossis lwm yam kuab tshuaj.
Glycerin: glycerin, tseem hu ua glycerol, yog cov kuab tshuaj uas ib txwm muaj hauv cov tshuaj thiab cov tshuaj pleev ib ce. Nws feem ntau siv hauv kev sib xyaw nrog dej kom yaj HPMC.
Polyethylene Glycol (Peg): Peg yog cov polymer nrog solubility zoo heev hauv dej thiab ntau cov kuab tshuaj muaj organic. Nws tuaj yeem siv los yaj HPMC thiab feem ntau ua haujlwm hauv kev tso tawm-tso tawm.
Surfactants: qee qhov surfactants tuaj yeem pab tau nyob rau hauv kev sib cais ntawm HPMC los ntawm kev txo cov npoo nro thiab txhim kho kev ntub dej. Piv txwv li Tween 80, Sodium LauriumL Sulfate (SLS), thiab Polysorbate 80.
Muaj zog acids lossis bases: thaum tsis tau siv vim muaj kev txhawj xeeb txog kev nyab xeeb thiab cov pa roj ntsha (piv txwv li, sodium hydroxide) tuaj yeem yaj HPMC nyob rau hauv cov xwm txheej tsim nyog. Txawm li cas los xij, kev mob siab heev yuav ua rau kev mob siab ntawm cov polymer.
Cov neeg sawv cev ua haujlwm: qee cov neeg sawv cev ua ke zoo li Cyclodextrins tuaj yeem tsim cov kev suav nrog HPMC, pab nyob rau hauv nws cov kev sib cais thiab txhim kho nws solubility.
Qhov kub thiab txias: Feem ntau, qhov kub siab dua txhim kho kev sib cais ntawm HPMC hauv cov kuab tshuaj zoo li dej. Txawm li cas los xij, kev kub siab ntau dhau yuav ua rau cov polymer, yog li nws yog qhov tseem ceeb ua haujlwm tsis pub muaj kev nyab xeeb.
Cov kev ntseeg ua tshuab sib xyaw: nplawm lossis ua kom yooj yim tuaj yeem pab txhawb kev sib cais ntawm HPMC los ntawm kev nce ze ntawm cov polymer thiab cov kuab tshuaj.
Qhov loj me me: Fined hmoov HPMC yuav yaj tau ntau dua ntau dua li cov khoom loj dua vim nce thaj chaw thaj chaw.
Nws yog qhov tseem ceeb kom nco ntsoov tias cov kev xaiv ntawm cov kuab tshuaj thiab kev sib cais yog nyob ntawm cov ntaub ntawv tshwj xeeb thiab cov khoom xav tau ntawm cov khoom kawg. Compatibility nrog lwm cov khoom xyaw, kev saib xyuas kev nyab xeeb, thiab cov kev cai tswj hwm kuj tseem muaj feem rau kev xaiv ntawm cov kuab tshuaj thiab cov txheej txheem sib cais. Ib qho ntxiv, nws yog qhov tseem ceeb rau kev coj ua kev kawm thiab kev ruaj ntseg kev ua kom ntseeg tau tias qhov txheej txheem sib cais tsis cuam tshuam rau qhov ua tau zoo lossis ua haujlwm ntawm cov khoom kawg.
Lub sij hawm ncua: Mar-22-2024