HydroxypropylraylSylcellulose (HPMC) yog cov multifunctional polymer dav siv hauv kev lag luam kws tshuaj. Nws zwm rau lub cellulose ether qeb lij thiab tau los ntawm ntuj ntawm lub ntsej muag. HPMC yog synthesized los ntawm kev kho cellulose nrog cov tshuaj pleev cov antellene oxide thiab methyl chloride, ua rau muaj kev sib txuas nrog solubility thiab lwm yam khoom xav tau. Qhov kev zam tshwj xeeb yog siv dav hauv kev txhim kho thiab tsim cov ntsiav tshuaj ntawm cov ntsiav tshuaj, suav nrog cov ntsiav tshuaj, cov ntsiav tshuaj, ophthalmic npaj tshuaj kho mob.
Taw qhia rau hydroxyPropyyl methylulose:
Cov qauv tshuaj thiab cov khoom:
HydroxyPropyyl methylulose yog ib nrab hluavtaws, inert, dej-soluble polymer. Nws cov qauv tshuaj lom neeg suav nrog hydroxypropyl thiab mexoxy cov pab pawg txuas rau lub cellulose caj qaum. Cov proportions ntawm cov neeg hloov no tuaj yeem sib txawv, ua rau cov qib sib txawv ntawm HPMC nrog cov khoom sib txawv. Cov qauv hloov pauv puas cuam tshuam xws li viscosity, solubility, thiab gel khoom.
Txheej txheem tsim khoom:
Zeem ntawm HPMC cuam tshuam nrog lub etherification ntawm cellulose nrog cov tshuaj pleev cov arelene oxide thiab methyl chloride. Cov qib ntawm kev hloov pauv (DS) ntawm cov pab pawg ntawm hydroxyyls muaj peev xwm tswj tau thaum synthesis, tso cai rau kev ua si HPMC cov khoom lag luam kom paub meej cov tshuaj.
Cov ntawv thov hauv kev lag luam kws tshuaj:
Kev kho nyob hauv cov qauv ntaub ntawv qauv:
HPMC tau dav siv raws li phau ntawv qhia hauv ntsiav tshuaj ua qauv. Nws cov khoom siv khi cov khoom hauv compressing cov hmoov rau hauv cov ntsiav tshuaj. Kev tso tawm cov khoom xyaw uas muaj zog (APIs) tuaj yeem ua tiav los ntawm kev siv cov qib kawm ntawm HPMC nrog cov kab mob viscosity thiab cov qib hloov.
Zaj Duab Xis Txheej Txheem:
HPMC yog siv los ua zaj duab xis txheej tus neeg sawv cev rau cov ntsiav tshuaj thiab granule. Nws muab cov txheej txheem tiv thaiv tsis sib haum uas txhim kho cov tsos, saj masking thiab ruaj ntseg ntawm cov ntaub ntawv tshuaj. Tsis tas li ntawd, HPMC cov txheej txheem hpmc tuaj yeem hloov kho cov tshuaj yeeb tshuaj.
Txhawb nqa thiab tswj kev tso tawm:
Lub Hydrophilic xwm ntawm cov polymer no ua rau nws tsim nyog rau kev siv hauv kev txhawb nqa- thiab tswj-tso tawm. HPMC matrix tso cai tswj cov tshuaj tso tawm tshaj ncua sijhawm, txhim kho cov neeg mob ua raws cai thiab txo cov nqi kho mob.
Ophthalmic npaj:
Hauv ophthalmic tsim, HPMC yog siv los ua kom lub viscosity ntawm qhov muag poob, yog li muab lub sijhawm nyob ntev dua nyob rau hauv Ocular nto. Qhov kev txhim kho cov tshuaj bioavailability thiab kho cov txiaj ntsig.
Thickening stabilizer:
HPMC yog siv los ua cov thickener thiab stabilizer nyob rau hauv cov kua thiab semi-cov qauv tsim qauv xws li gels, cream thiab kev ncua. Nws imparts viscosity rau cov qauv no thiab txhim kho lawv cov khoom muaj tag nrho.
Cov yam ntxwv tseem ceeb ntawm HPMC:
Solubility:
HPMC yog soluble hauv dej thiab ua kom muaj cov tshuaj ntshiab, tsis muaj kob. Tus nqi ntawm kev sib cais yog cuam tshuam los ntawm cov qib hloov chaw thiab qib Viscosity.
Viscosity:
Lub viscosity ntawm HPMC cov kev daws teeb meem yog qhov tseem ceeb hauv kev txiav txim siab lawv kev ua tau zoo hauv ntau yam kev siv. Cov qhab nia sib txawv muaj nrog cov viscosities sib txawv, tso cai tswj cov khoom ntawm cov khoom ntawm cov qauv.
Thermal gelation:
Qee cov qib ntawm HPMC cov khoom pov thawj thermogelling cov khoom, tsim cov kua pleev ntawm cov kub. Cov cuab yeej no yog siv los txhim kho cov qauv cua sov.
Kev sib haum:
HPMC tau sib haum nrog ntau yam ntawm cov tshuaj uas tau txais thiab APIs, ua thawj qho kev xaiv rau cov kws sau ntawv. Nws tsis hnov mob nrog lossis degrade cov khoom xyaw feem ntau.
Cov kev sib tw thiab kev saib xyuas:
Hygroscopicity:
HPMC yog hygroscopic, lub ntsiab lus nws nqus dej noo los ntawm ib puag ncig. Qhov no cuam tshuam qhov kev ruaj ntseg thiab cov tsos ntawm cov qauv tsim, yog li cov neeg mob cia yuav tsum tau ua.
Compatibility nrog lwm cov khoom siv:
Txawm hais tias feem ntau tau tshaj, cov ntawv yuav tsum xav txog qhov sib txuam ntawm HPMC nrog lwm cov kev zam kom tsis txhob muaj kev sib cuam tshuam nrog kev ua haujlwm.
Nyhuv rau kev nkhaus sib txawv:
Qhov kev xaiv ntawm HPMC qib tau cuam tshuam ntau ntxiv cuam tshuam rau qhov sib txawv ntawm cov tshuaj. Daim qauv tsim nyog yuav tsum ua tib zoo xaiv cov qib tsim nyog kom ua tiav qhov kev xav tso tawm cov yam ntxwv xav tau.
Kev Txiav Txim Siab:
HPMC tau lees paub tias yog kev nyab xeeb thiab ua tau cov tshuaj khaws cia. Nws ntsib ntau yam qauv kev cai thiab muaj nyob hauv Pharmacopoeias thoob ntiaj teb. Cov kev ua lag luam yuav tsum ua raws cov kev ua lag luam zoo (GMP) kom ntseeg tau tias qhov zoo thiab muaj cov khoom lag luam uas muaj HPMC.
Hauv kev xaus:
Hydroxypropylencellulose (HPMC), raws li ntau yam thiab dav siv expient, plays lub luag haujlwm tseem ceeb hauv kev lag luam kws tshuaj. Nws cov khoom tshwj xeeb ua rau nws haum rau siv ntau yam tshuaj ntau npaum li cas, suav cov ntsiav tshuaj, tsiav tshuaj thiab ophthalmic thiab ophthalmic npaj. Cov kws sau ua cov txiaj ntsig los ntawm kev tuaj yeem ua kom cov peev txheej ntawm HPMC kom tau raws li cov kev xav tau tshwj xeeb, xws li kev tso tawm thiab txhim kho kev ruaj khov. Txawm hais tias qee cov kev sib tw, HPMC tseem yog cov khoom siv tseem ceeb hauv kev txhim kho cov khoom lag luam zoo, ua rau muaj kev nyab xeeb thiab ua tau zoo ntawm ntau cov tshuaj ua.
Lub Sijhawm Post: Dec-15-2023