Dab tsi yog hloov HPMC? Dab tsi yog qhov sib txawv ntawm kev hloov kho HPMC thiab tsis muaj txhij tsis tau txais HPMC?

HydroxyPropyyl Methylcellulose(HPMC) yog lub cellulose derivative dav siv nyob rau hauv ntau yam kev lag luam rau nws cov yam ntxwv. Hloov kho HPMC yog hais txog HPMC uas tau dhau los ntawm kev hloov pauv tshuaj ntxiv los txhim kho lossis hloov kho nws cov yam ntxwv ua tau zoo. UNMOCCED HPMC, ntawm qhov tod tes, hais txog thawj daim ntawv ntawm cov polymer yam tsis muaj tshuaj lom neeg ntxiv. Hauv qhov kev piav qhia dav dav, peb yuav delve rau hauv cov qauv, cov khoom, kev siv, thiab qhov sib txawv ntawm kev hloov kho thiab tsis muaj kev hloov kho hpmc.

1. Cov qauv ntawm HPMC:

1.1. Cov qauv yooj yim:

HPMC yog semisynthetic polymer muab tau los ntawm cellulose, lub ntuj polysaccharide pom nyob hauv cov phab ntsa ntawm tes ntawm cov nroj tsuag. Cov qauv yooj yim ntawm cellulose muaj cov chav ua si uas tau rov qab ua ke nrog hauv β-1,4-glycosidic bonds. Cellulose yog hloov los ntawm kev qhia txog hydroxypropyl thiab methyl pawg mus rau hydroxyl pawg ntawm cov dej qab zib hydroxyl ntawm cov dej qab zib.

1.2. HydroxyPropyl thiab methyl pawg:

• Hydroxypropyl pawg: Cov no tau qhia los txhim kho cov dej solubility thiab nce cov polymer hydrophilicity.
• Cov methyl pawg: Cov no muab cov ntawv sib tsoo stacter, cuam tshuam rau tag nrho cov saw polymer polymer polymer thiab cuam tshuam nws lub cev lub cev.

2. Cov khoom ntawm unmodified HPMC:

2.1. Dej Solubility:

Unmodified HPMC yog dej-soluble, sib sau cov kev daws teeb meem ntawm chav sov. Cov degree ntawm kev hloov chaw ntawm hydroxypropyl thiab methyl pawg cuam tshuam rau cov solubility thiab gelation tus cwj pwm.

2.2. Viscosity:

Lub viscos ntawm HPMC yog pawg los ntawm cov qib ntawm kev hloov pauv. Siab dua cov qib feem ntau ua rau viscosity ntau ntxiv. Unmodified HPMC muaj nyob rau hauv ntau yam ntawm viscosity qib, tso cai rau cov ntawv thov txiav.

2.3. Zaj duab xis-tsim muaj peev xwm:

HPMC muaj zaj duab xis-ua cov khoom, ua kom haum rau txheej txheej. Cov yeeb yaj kiab tsim yog hloov tau thiab ua kom pom zoo adhesion.

2.4. Thermal gelation:

Qee qhov tsis pom zoo HPMC cov qib nthuav qhia kev ua yeeb yam thermal gelation tus cwj pwm, ua cov tshuaj pleev rau ntawm ntug dej kub. Cov cuab yeej no feem ntau zoo dua hauv cov ntawv thov tshwj xeeb.

3. Kev hloov kho ntawm HPMC:

3.1. Lub hom phiaj ntawm kev hloov kho:

HPMC tuaj yeem hloov kho los txhim kho lossis qhia cov khoom tshwj xeeb, xws li hloov viscosity, txhim kho adhesion, tswj kev tawm suab, lossis kev ua kom muaj kev sib cais los yog ua kom pom kev zoo.

3.2. Tshuaj Kho Mob Tshuaj:

• HydroxyProdation: cov qib ntawm hydroxyprropation cuam cuam tshuam cov kua so thiab kev coj ua gelation.
• Methylation: Tswj cov qib ntawm methylation cuam tshuam rau polymer saw yooj yim thiab, yog li, viscosity.

3.3. Eetherification:

Kev hloov kho feem ntau cuam tshuam nrog kev tiv thaiv kab mob ntsig txog hydroxyprropyl thiab methyl pawg mus rau lub cellulose cellebone. Cov kev tawm tsam no yog nqa tawm hauv cov kev tswj hwm kom ua tiav cov kev hloov kho tshwj xeeb.

4. Hloov kho HPMC: Cov ntawv thov thiab qhov sib txawv:

4.1. Muab tso tawm hauv cov chaw muag tshuaj:

• Unmodified HPMC: Siv los ua phau ntawv sau thiab txheej txheem tus neeg sawv cev hauv cov ntsiav tshuaj.
• Hloov Kho HPMC: kev hloov kho ntxiv tuaj yeem kho cov tshuaj tso tawm Kinetics, ua kom cov qauv tso cai tswj tau.

4.2. Txhim kho adhesion hauv cov khoom siv tsim:

• Unmodified hpmc: siv hauv kev tsim kho cov khoom lag luam rau dej ua kom ruaj khov.
• Hloov Kho HPMC: Alterations tuaj yeem txhim khu cov khoom nplaum, ua rau nws haum rau cov nplaum nplaum.

4.3. Ua raws li cov khoom sib dhos hauv cov xim tha xim:

• Unmodified HPMC: Ua raws li tus neeg sawv cev tuab hauv cov xim tsev.
• Hloov Kho HPMC: kev hloov kho tshwj xeeb tuaj yeem muab kev tswj hwm kev tswj hwm zoo dua thiab ruaj khov nyob rau hauv cov txheej txheem.

4.4. Txhim kho kev ruaj khov hauv cov khoom noj:

• Unmodified HPMC: Siv los ua tus neeg sawv cev tuab thiab ua haujlwm ruaj khov hauv ntau yam khoom noj.
• Hloov Kho HPMC: kev hloov kho ntxiv tuaj yeem txhim kho kev ruaj khov nyob rau hauv kev ua zaub mov noj tshwj xeeb.

4.5. Txhim kho zaj duab xis-ua hauv tshuaj pleev ib ce:

• Unmodified HPMC: Siv ua zaj duab xis-ua tus neeg sawv cev hauv cov tshuaj pleev ib ce.
• Hloov Kho HPMC: Alterations tuaj yeem txhim kho cov khoom siv ua yeeb yaj kiab, ua rau muaj kev ntxhib los mos thiab thiav ntawm cov tshuaj pleev ib ce.

5. Qhov sib txawv tseem ceeb:

5.1. Cov Khoom Muaj Peev Xwm:

• Unmodified HPMC: Muaj cov khoom siv tau zoo li cov dej solubility thiab ua yeeb yaj kiab ua yeeb yam.
• Hloov Kho HPMC: cov khoom pov thawj ntxiv lossis txhim kho kev ua haujlwm raws li cov tshuaj muaj kuab lom.

5.2. Daim ntawv thov txiav:

• Unmodified hpmc: siv dav hauv ntau yam kev siv.
• Hloov Kho HPMC: Ua kom haum rau cov ntawv thov tshwj xeeb los ntawm kev tswj hwm kev hloov kho.

5.3. Kev Tso Cai Tso Tawm:

• Unmodified HPMC: Siv hauv Pharpacuicals tsis muaj kev tswj hwm kev tso cai tso tawm muaj peev xwm.
• Hloov Kho HPMC: tuaj yeem tsim los rau kev tswj kom meej dua cov tshuaj tso tawm Kinetics.

5.4. Rheological tswj:

• Unmodified hpmc: muab cov khoom siv yooj yim.
• Hloov Kho HPMC: Tso cai rau ntau dua rateological tswj cov qauv zoo li cov xim pleev xim thiab pleev xim.

6. Xaus:

Hauv cov ntsiab lus, hydroxypropyl methylulose (HPMC) undergoes hloov kho kom tailor nws cov khoom siv tshwj xeeb. Unmodified HPMC ua haujlwm ua ib qho polymer ntau, thaum kev hloov kho kom haum zoo ntawm nws cov yam ntxwv. Qhov kev xaiv nruab nrab ntawm kev hloov kho thiab tsis tau unmodified HPMC nyob ntawm cov kev ua haujlwm yam xav tau thiab kev ua tau zoo hauv daim ntawv thov. Cov kev hloov kho tau tuaj yeem ua kom zoo solubility, adhesion, tshuaj nplaum, thiab lwm yam kev hloov pauv, ua kom haum HPMC muaj cov cuab yeej muaj txiaj ntsig hauv ntau yam lag luam. Nco ntsoov hais txog cov khoom lag luam tshwj xeeb thiab cov lus qhia muab los ntawm cov tuam txhab rau cov ntaub ntawv raug rau ntawm cov khoom thiab cov ntawv thov ntawm HPMC variants.