HydroxyPropyyl Methylcellulose (HPMC)yog cov feem ntau siv cellulose derivative nrog ntau cov ntawv thov, tshwj xeeb yog nyob hauv cov chaw tshuaj, tshuaj pleev ib ce, thiab khoom siv hauv tsev. Nws tsis yog cov kuab tshuaj, tab sis cov dej-soluble polymer uas tuaj yeem yaj hauv dej thiab ua ib lub pob tshab colloidal daws. Lub solubility ntawm kev txhawj xeeb ®hpmc yog nyob ntawm tus naj npawb thiab txoj hauj lwm ntawm methyl thiab hydroxypropyl chaw nyob hauv nws cov qauv molecular.
1. Cov teeb meem yooj yim ntawm hydroxypropyl methylcellose
HydroxyPropyyl methylulose tau txais los ntawm methylation thiab hydroxyproperylation ntawm cellulose. Cellulose nws tus kheej yog lub ntuj siab polysaccharide uas muaj nyob hauv cov phab ntsa cell. Cov qauv tshuaj ntawm HPMC yog tsim los ntawm cov roj ham o, uas yog cov lwg me me uas txuas nrog los ntawm β-1,4 glycosidic bonds. Hauv cov qauv molecular, qee pawg hydroxyl tau hloov los ntawm methyl (-chiv) thiab hydroxypropyl (-c₃h₃oh), muab nws zoo solubility thiab tshuaj lom neeg lub cev.
Lub solubility ntawm HPMC cuam tshuam los ntawm cov qauv molecular thiab feem ntau muaj cov yam ntxwv hauv qab no:
Dej solubility: HPMC tuaj yeem tsim kev daws teeb meem hauv dej thiab yaj sai. Nws solubility yog ze rau qhov kub ntawm dej thiab txoj kev molecular hnyav ntawm HPMC.
High viscosity: Ntawm qee qhov kev xav, kev daws teeb meem HPMC qhia txog kev visccosity ntau dua, tshwj xeeb tshaj yog nyob ntawm siab molecular hnyav thiab siab siab.
Thermal Stability: HPMC muaj kev ruaj khov zoo nyob rau qee qhov chaw kub thiab tsis yooj yim rau decomple, yog li nws muaj qee yam zoo hauv cov txheej txheem ua haujlwm thermal.
2. Solubility ntawm HPMC
HPMC yog cov khoom siv dej-soluble, tab sis nws tsis yog yaj los ntawm txhua cov kuab tshuaj. Nws qhov kev coj ua tau cuam tshuam nrog polarity ntawm cov kuab tshuaj thiab kev sib cuam tshuam ntawm cov kuab tshuaj molecules thiab HPMC lwg me me.
Dej: HPMC tuaj yeem yaj nyob hauv dej. Dej yog nws cov kuab tshuaj feem ntau, thiab thaum lub sij hawm sib cais ® Cov degree ntawm kev sib cais tau cuam tshuam los ntawm cov yam ntxwv xws li molecular qhov hnyav ntawm HPMC, cov qib ntawm methylation thiab hydroxypropation, kub, thiab lub pH nqi ntawm dej. Feem ntau, cov solubility ntawm HPMC yog qhov zoo tshaj plaws nyob rau hauv ib puag ncig HT nruab nrab.
Organic cov kuab tshuaj: HPMC yuav luag tsis muaj qhov sib xws hauv feem ntau cov kuab tshuaj muaj kuab, xws li dej cawv, yog neeg siv tshuaj, thiab hydrocarbons. Qhov no yog vim nws cov qauv molecular muaj cov pab pawg hydroxyl thiab lipophilic methyl thiab hydroxypropropyl thiab hydroxypropropyl pawg. Txawm hais tias nws muaj kev muaj zog muaj zog rau dej, nws muaj kev sib xyaw tsis zoo nrog feem ntau cov kuab tshuaj organic.
Dej sov solubility: hauv dej sov (feem ntau 40 ° C Raws li qhov ntsuas kub ntxiv nce ntxiv, qhov kev cais tawm thiab solubility yuav nce, tab sis thaum muaj kev daws teeb meem siab, lub viscosity ntawm kev daws teeb meem yuav cuam tshuam.
3. Daim Ntawv Thov HPMC
Vim nws cov dej ua yeeb yam zoo, tsawg toxicity, thiab kho viscosity, hpmc tau dav siv nyob rau hauv ntau yam kev lag luam.
Kws Tshuaj Kho Mob: Hauv kev lag luam hauv lub tsev kws tshuaj, HPMC tau siv nyob rau hauv kev tsim cov tshuaj, cov ntsiav tshuaj molding, cov roj ntsha moulding, gels, thiab cov nqa tshuaj. Nws tuaj yeem pab cov tshuaj dably yaj hauv dej thiab tswj hwm tus nqi ntawm kev tso yeeb tshuaj.
Kev lag luam khoom noj: HPMC, ua zaub mov ntxiv, yog siv rau emulsification, thickening, thiab moisturizing. Nyob rau hauv cov khoom ci, nws tuaj yeem txhim kho kev ducility thiab ruaj khov ntawm cov khob noom cookie. HPMC kuj muaj feem ntau siv hauv cov mis nyuj khov, dej haus thiab cov khoom noj muaj roj tsawg.
Kev lag luam kev tsim kho: hauv kev tsim kho kev tsim kho, HPMC feem ntau siv los ua cov tuab rau kev ua tshuaj khib nyiab, dej kom huv thiab sib khi zog ntawm cug.
Cov tshuaj pleev ib ce: hauv tshuaj pleev ib ce, txhawj xeeb yog siv los ua cov tuab, siv tau dav, thiab yog siv cov tshuaj tsw qab xws li cov tshuaj pleev zawv plaub hau, thiab cov gels da dej.
HPMCyog dej-soluble thiab cov cellous cellulose cellulose derivative uas tuaj yeem tsim cov pa colloids hauv dej. Nws tsis yog cov kuab tshuaj, tab sis cov molecular ntau sib xyaw uas tuaj yeem yaj hauv dej. Nws cov solubility yog feem ntau yog ua kom zoo solubility hauv dej, tab sis insoluble nyob rau hauv feem ntau cov kuab tshuaj. Cov yam ntxwv ntawm HPMC ua tau dav hauv ntau qhov kev lag luam, suav nrog cov tshuaj, kev tsim khoom, tsim kho, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce, thiab tshuaj pleev ib ce.
Lub Sijhawm Post: Feb-17-2025