Pharmaceutical Excipient
Hydroxypropyl methylcellulose (HPMC) yog dawb los yog milky dawb, tsis muaj ntxhiab, tsis qab, fibrous hmoov los yog granule, yuag poob ntawm ziab tsis tshaj 10%, soluble nyob rau hauv dej txias tab sis tsis kub dej, maj mam nyob rau hauv dej kub o, peptization, thiab ua ib tug viscous colloidal tov, uas dhau los ua ib qho kev daws thaum txias, thiab dhau los ua gel thaum rhuab. HPMC yog insoluble hauv ethanol, chloroform thiab ether. Nws yog soluble nyob rau hauv ib qho hnyav hnyav ntawm methanol thiab methyl chloride. Nws kuj yog soluble hauv cov kuab tshuaj sib xyaw ntawm acetone, methyl chloride thiab isopropanol thiab qee cov kuab tshuaj organic. Nws cov tshuaj aqueous tuaj yeem tiv taus ntsev (nws cov tshuaj colloidal tsis raug puas tsuaj los ntawm ntsev), thiab pH ntawm 1% aqueous tov yog 6-8. Cov mis mos molecular ntawm HPMC yog C8H15O8-(C10H18O6) -C815O, thiab cov txheeb ze molecular loj yog li 86,000.
HPMC muaj dej solubility zoo heev hauv dej txias. Nws tuaj yeem yaj mus rau hauv cov tshuaj pob tshab nrog me ntsis nplawm hauv dej txias. Ntawm qhov tsis sib xws, nws yog qhov yooj yim insoluble hauv dej kub siab tshaj 60 ℃ thiab tuaj yeem o tuaj. Nws yog non-ionic cellulose ether. Nws cov tshuaj tsis muaj ionic nqi, tsis cuam tshuam nrog hlau ntsev los yog ionic organic tebchaw, thiab tsis hnov mob nrog lwm cov ntaub ntawv raw thaum lub sij hawm kev npaj; nws muaj zog tiv thaiv kev ua xua, thiab nrog kev nce qib ntawm kev hloov pauv hauv cov qauv molecular, nws muaj zog tiv thaiv kev ua xua thiab ruaj khov dua; Nws tseem yog metabolically inert. Raws li ib tug kws tshuaj excipient, nws tsis yog metabolized los yog absorbed. Yog li ntawd, nws tsis muab calorie ntau ntau hauv cov tshuaj thiab zaub mov. Nws muaj calorie tsawg, tsis muaj ntsev, thiab tsis muaj ntsev rau cov neeg mob ntshav qab zib. Cov tshuaj tsis haum tshuaj thiab cov khoom noj muaj qhov tshwj xeeb siv tau; Nws yog qhov ruaj khov rau cov kua qaub thiab alkalis, tab sis yog tias PH tus nqi siab tshaj 2 ~ 11 thiab cuam tshuam los ntawm qhov kub thiab txias dua lossis muaj lub sijhawm cia ntev dua, nws cov viscosity yuav txo; nws cov tshuaj aqueous tuaj yeem muab cov kev ua ub no, uas qhia txog qhov nro nruab nrab thiab qhov sib txuam ntawm qhov nro; nws muaj emulsification zoo nyob rau hauv ob-theem system, yuav siv tau raws li ib tug zoo stabilizer thiab tiv thaiv colloid; nws cov tshuaj aqueous muaj cov yeeb yaj kiab zoo heev, nws yog cov ntsiav tshuaj thiab cov ntsiav tshuaj Cov khoom siv zoo. Cov zaj duab xis txheej tsim los ntawm nws muaj qhov zoo ntawm cov xim tsis muaj xim thiab toughness. Ntxiv glycerin tuaj yeem txhim kho nws cov yas.
QualiCell HPMC cov khoom tuaj yeem txhim kho los ntawm cov khoom hauv qab no hauv Pharmaceutical Excipient:
· Ib zaug soluble hauv dej thiab volatilized los ntawm hnyav, HPMC ua rau pob tshab zaj duab xis nrog lub zog tensile siab.
· Txhim khu kev khi lub zog.
· Hydrophilic matrix siv nrog rau HPMC hydrates los tsim ib txheej gel, tswj cov tshuaj tso tawm qauv.
| Qhia Qib: | Thov TDS |
| HPMC 60 AX5 | Nyem qhov no |
| HPMC 60 AX15 | Nyem qhov no |