Hydroxypropyrl cellulose, na-ekewa ọgwụ ọjọọ, a na-ekewa obere celdropose (l-h-hpc) na hydropopyl cellulose (h-hpc) dị ka ọdịnaya nke hydropoxy hydropoxy ya. L-hpc azagharị n'ime mmiri colloidal na mmiri, nwere akụrụngwa nke adhesion, mepụta ihe nkiri, emulsification, wdg, ma na-ekechi ihe na-ekesa ya; Ọ bụ ezie na H-HPC na-agbanye mmiri na mmiri dị iche iche dị iche iche dị iche iche na ụlọ okpomọkụ, ma nwee ezigbo ọkụ ọkụ. , Cohesesiveness na Njirimara Njirimara na ihe nkiri na-akpụ akpụ, fim ahụ e guzobere siri ike, na-egbuke egbuke, na-ejikwa ya mee ihe dị ka ihe na-akpụ akpụ akwụkwọ na ihe mkpuchi. A na-ewepụta ngwa a kapịrị ọnụ nke hydropyy cellulose na nkwadebe siri ike.
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Elu nke hydropopylyyl Celllose kristal na-enweghị eriri, nke nwere oke egwu dị ka usoro. A na-eme ka ọ dị elu na-eme ka ọ bụrụ ebe dị elu, kamakwa mgbe a na-eme ka ọ bụrụ mbadamba ọnụ, a na-etolite pores na poret isi, nke mere na mbadamba nkume nwere ike ime ka mmiri dị elu Ntinye aka na mmiri na-abawanye. IjiL-hpcDị ka ihe na-enweghị atụ nwere ike ime ka mbadamba ụrọ na-agbasa ngwa ngwa na-acha ntụ ntụ, ma nwee ike imeziwanye nkewa, mgbasa na bioapality nke mbadamba. Dịka ọmụmaatụ, iji L-HPC mee ngwa ngwa nke mbadamba paracetamol, mbadamba aspirin, mbadamba ụrọ chlorphamimamine, ma meziwanye ọnụego mgbasa. Ndakpọ na mgbasa ozi nke ọgwụ dị iche iche dị ka mbadamba ụrọ nke L-HPC dị ka ndị nwere PVPP-na CMC - na CMS - na CMS - na CMS-na. Iji L-HPC dị ka ihe dị n'ime ala nke ndị na-enweghị atụ na capsules bara uru na mkpokọta nke granules, na-abawanye mgbasa ozi na ọkara, ma na-eme ka bioapailabilililition. Nkwadebe siri ike siri ike na-anọchi anya nkwadebe siri ike na ngwa ngwa na-eme ngwa ngwa na ngwa ngwa, na-akpasu iwe ngwa ngwa, na-akpasu iwe ngwa ngwa ma nwee ezigbo nnabata. Uru ndị ọzọ, jiri ọnọdụ dị mkpa na-ere ahịa ọgwụ. L-HPC abụrụla otu ihe kachasị mkpa maka nkwadebe ozugbo n'ihi ndọtị ozugbo n'ihi hydroscolicity ya siri ike, mmụba, mkpụmkpụ mkpụmkpụ ngwa ngwa, na mmiri mmiri na-agba mmiri ngwa ngwa. Ọ bụ ihe dị mma maka mbadamba. Paracetamol Ornals na-agbasa mbadamba nkume L-HPC dị ka ihe na-adịghị mma, na mbadamba ndị ahụ na-emebi ngwa ngwa n'ime 20s. A na-eji l-hpc dị ka ihe na-enweghị atụ maka mbadamba, na usoro onunu ogwu ya bụ 2% ruo 10%, nke kachasị 5%.
2. Dị ka ihe mgbochi maka nkwadebe dị ka mbadamba na granules
Ihe siri ike nke L-HPC na-emekwa ka ọ bụrụ mmetụta dị ukwuu na ọgwụ na irighiri ọgwụ, nke na-abawanye ogo cohesion, ma nwee ezigbo mkpakọ na-arụ ọrụ. Mgbe a pịrị n'ime mbadamba, ọ na-egosi ihe siri ike na gloss, si otú ahụ na-eme ka ọdịdị mbadamba ahụ. Karịsịa maka mbadamba ndị adịghị mfe iji mepụta, rụrụ ma ọ bụ dị mfe ikpughe, na-agbakwunye l-hpc nwere ike imeziwanye mmetụta. Mbadamba ciprofloxinloride enweghị nghọtahie, mfe kewaa na ngụgụ, na ọdịdị ọma, na ọnụ ọgụgụ dị mma na-ezute ọkọlọtọ chọrọ. Mgbe agbakwunye L-hpc n'ime mbadamba a na-achụpụ, ọdịdị ya, frisbility, a na-eme ka ahụ dị mma ma dịkwa mma. Mgbe stachi na-edochi nke L-hpc, nke siri ike nke mbadamba Anithromycin na-abawanye ụba, a na-emezigharị okwu ndị ahụ, na nsogbu ndị a na-efu na mbadamba ụrọ mbụ. A na-eji l-hpc dị ka ihe mkpuchi maka mbadamba, na usoro onunu ogwu bụ 5% ruo 20%; Ọ bụ ezie na a na-eji H-HPC dị ka ihe mkpuchi maka mbadamba, granules, wdg, na usoro onunu ogwu bụ 1% ruo 5% nke nkwadebe.
3. Ngwa na ihe nkiri mkpuchi na ịkwadebe ma na-achịkwa ya
Ka ọ dị ugbu a, ihe eji eme mmiri na-ejikarị ya na ihe nkiri gụnyere hpdropyylmcellose (hpdyylcelllose (hpdropyylcelllose, polyethylopy glycol (peg) na ndị ọzọ. A na-ejikarị cellopose na-eme ihe nkiri na ihe nkiri na-akwụ ụgwọ na ihe nkiri na-ese ihe n'ihi ihe nkiri ya siri ike. Ọ bụrụ na celdroposel cellosel na ndị ọzọ na-eguzogide okpomọkụ, a ga-emekwa arụmọrụ nke mkpuchi ya.
Iji usoro mmụta dị mma na-eme ka ọgwụ ike dị na mbadamba ụrọ, mbadamba nkume dị iche iche, mbadamba nkume dị iche iche na-achịkwa ya, na-abawanye ogo ọgwụ na-eme ihe ọgwụ na ọbara. Ileba anya, belata mmeghachi omume ọjọọ, belata ọnụ ọgụgụ ọgwụ, ma na-agbalị iji bulie nsonaazụ curative na nke pere mpe, ma belata mmeghachi omume ọjọọ. Hydroxyppropyl cellulose bụ otu n'ime ihe kachasị mkpa maka nkwadebe ndị dị otú ahụ. A na-achịkwa mgbasa na mbadamba sodium diclofenac site na iji hydroxypropyl cellulose na etyl cellulose dị ka nkwonkwo na ihe ọkpụkpụ na ọkpụkpụ. Mgbe nchịkwa ọnụ na kọntaktị na ihe ọ juiceụ gastric, elu mbadamba diclofenac na mbadamba ihe a ga-eme ka ọ bụrụ gel. Site na mgbasa nke gel na ngbasa nke molulu ogwu na oghere gel, ebumnuche nke iwepụta ego ọgwụ ọgwụ ọgwụ. A na-eji Hydroxypyrylyl mkpara na-achịkwa matrix nke mbadamba ụrọ ahụ, mgbe ọdịnaya ya na mbadamba ya na-ekpebi ọnụego nke ọgwụ ahụ, ọgwụ ndị ahụ na mbadamba nkume ahụ nwere ọdịnaya dị elu Nke ịhapụ Sydroxyppropy Cellulose na-eji nwayọ. A kwadebere pellet ahụ site na ijiL-hpcOtu ihe mkpuchi mkpuchi maka mkpuchi dị ka ọzịza dị ka ọzịza, yana dị ka akwa na-achịkwa ya na ịmịcha ethyl. Mgbe ndenye ọgwụ na-awụpụta na usoro onunu ogwu na-edozi, site na ịchịkwa ọkpụrụkpụ nke a na-achịkwa ya, pellets ekike nwere ike wepụta n'oge a tụrụ anya. A na-agwakọta ọtụtụ ụdị pellets dị iche iche nke nwere uru dị iche iche nke a na-achịkwa ya na-agwakọta shuxoong na-eme ka okpueze hapụ ya. Na mgbakwunye, pellet dị iche iche nwere ike ịhazi ọgwụ n'usoro dị iche iche, nke mere na a na-enweta ihe ndị ahụ na kemịkalụ dị iche iche na-arụ ọrụ n'otu oge
Oge post: Apr-25-2024