Hydroxypylththththththylcelllose (hpmc)Bụ nondic cellulose na ezigbo ihe nkiri, adhesion, na-eto eto ma na-achịkwa ihe ndị na-emepụta ọgwụ, ma na-ejikwa ụlọ ọrụ ọgwụ. Dị ka ọgwụ na-emepụta ọgwụ, enwere ike iji ọgwụ na-emepụta ọgwụ, enwere ike iji ya na mbadamba, capsules, na-akwado njikere na sistemụ nnyefe ọgwụ ọgwụ.
1. Ngwa ọdịnala nke HPMC
HPMC bụ ihe polymer polymetic na-enwetara site na methylating na hydroxyyyliting eke sellose, nwere ezigbo mmiri solubality na biocompative. Ọgwụ ya na-adịghị emetụta ya site na ogo ya na uru ph, ọ nwere ike ịba na mmiri iji mepụta ngwọta viscous, nke na-enyere aka ị nweta ọgwụ mgbochi. Dabere na viscosity, enwere ike ekewa ụzọ atọ: viscosis (5-100 mpaghara) na viscissity (4000-100), nke dị mma maka Nkwado nkwadebe di iche.
2. Ngwa nke HPMC na-akwado ọgwụ
2.1 Ngwa na mbadamba
Enwere ike iji HPMC mee ihe dị ka ihe mgbochi, na-etinye ihe, mkpuchi ihe na ihe ọkpụkpụ wepụrụ na mbadamba.
Runder:Enwere ike iji HPMC mee ihe dị ka ihe mkpuchi mmiri ma ọ bụ granilation mmiri ma ọ bụ granilation akọrọ iji meziwanye ike - mbadamba mbadamba ụrọ na nkwụsi ike nke ọgwụ.
Ichebe:Enwere ike iji HPMC nke viscosity dị ka ihe na-enweghị nsogbu iji kwalite mbadamba mbadamba ma bulie oke ọgwụgwụ ọgwụ mgbe ọ na-arị elu n'ihi mmiri mmiri.
Ibe ihe:HPMC bụ otu ihe dị mkpa maka mkpuchi mkpuchi, nke nwere ike ime ka ọdịdị nke ọgwụ, kpuchie uto ọgwụ, ma nwee ike iji ya na-ekpuchi ya ma ọ bụ ihe nkiri na fọdụrụnụ.
Enwere ike iji ihe ndị a na-ahụ anya na-achịkwa: Enwere ike iji ihe ndị dị elu na-achịkwa: enwere ike iji HPMC dị elu dịka ọkpụkpụ iji gbuo oge ịhapụ ma ọ bụ wepụta ya. Dịka ọmụmaatụ, HPMC K4M, HPMC K15M na HPMC K100M na-ejikarị mbadamba mbadamba a na-achịkwa.
2.2 ngwa na mpempe akwụkwọ
Enwere ike iji HPMC mepụta okpu osisi dị omimi iji dochie okpu Gelatin, nke dị mma maka ndị na-eri nri na ndị na-anụ ụtọ nke anụmanụ. Na mgbakwunye, enwere ike iji HPMC mee ihe maka jupụta mmiri mmiri ma ọ bụ capsules semisolid iji meziwanye nkwụsi ike ma hapụ njirimara ọgwụ.
2.3 Ngwa na nkwadebe Opehthalmic
HPMC, dịka ihe bụ isi ihe bụ isi anya mmiri, nwere ike ime ka viscosity anya, mee ka oge obibi nke ọgwụ ọjọọ, ma melite anụ ezi. Na mgbakwunye, enwere ike iji HPMC kwadebe nku anya anya, fim, wdg, iji meziwanye mmetụta nke ọgwụ ọjọọ.
2.4 Tinye na Nkwado Ọgwụ Nkwado Ọgwụ
Nchekwa nwere ezigbo ihe nkiri na nnweta bayompatibility, ma enwere ike ijikwa pattermal pattermal, gels na ude. Iji maa atụ, na usoro nnyefe ọgwụ nke transdermal, enwere ike iji HPMC mee ihe dị ka ihe odide matrix iji mee ka ọgwụ ókè ọgwụ na -eme ka oge ọ bụla mee ihe.
Ngwaọrụ 2.5 na mmiri mmiri na nkwusioru
Enwere ike iji HPMC mee ihe dị ka nke na-eme ihe dị ka nke na-eme ihe na mma mmiri nke mmiri mmiri na nkwụsị, na-eme ka ịdị n'otu na nkwụsi ike na nkwụsi ike.
2.6 Ngwa na nkwadebe inhalation
Enwere ike iji HPMC mee ihe dị ka onye na-ebu ya maka ntụ ntụ (DPIS) iji meziwanye ọgwụ ọjọọ ma gbasa ọgwụ ike, ma si otú ahụ kwalite mmetụta ọgwụgwọ ahụ.
3. Uru nke HPMC na nkwadebe na njikere
HPMC nwere njirimara ndị a dị ka onye na-emegharị ya
Ezigbo mmiri solubility:Ọ nwere ike ịmịcha ngwa ngwa na mmiri iji mepụta ihe mgbochi gel ma chịkwaa ọnụego ntọhapụ ọgwụ.
Ezigbo biocompatalitibity:Ahụ ndị na-adịghị egbu egbu na ndị na-enweghị mgbaka, ọ bụghị ahụ mmadụ na-adịghị etinye aka, ma nwee usoro metabolic.
Ike Ike:Kwesịrị ekwesị maka ụdị ọgwụ dị iche iche, gụnyere ọgwụ mgbochi na nke hydrophobic.
Usoro dị mfe:Kwesịrị ekwesị maka usoro nkwadebe dị ka mbadamba ụrọ na mgbochi mmiri.
Dị ka ọgwụ dị mkpa na-adịghị mma,HpmcA na-eji ọtụtụ ebe dị ka mbadamba, capsules, nkwadebe ophthaltic, nkwadebe dị na njikere - nhazi nke a na-akwado ya. N'ọdịnihu, na-aga n'ihu na mmepe nke teknụzụ ọgwụ, a ga-esiwanye ike ngwa ahịa, na-enye ụlọ ọrụ ọgwụ na nhọrọ kachasị mma na nchekwa.
Oge Post: Feb-08-2025