A na-enyocha ihe ọgụgụ ndị metụtara ya n'ụlọ na mba ọzọ na ná nkwadebe nke ọgwụ na-eme ọgwụ na-adịbeghị anya, a na-akwado ya na nkwadebe ya, ịkwadebe na-akwado ma na-achịkwa ya, na-akwado ya, Gelatin kacha ọhụrụ Ngwa na usoro nke usoro ọhụrụ dị ka usoro nrapado na biooodeShestives. N'ihi ọdịiche dị iche iche na nsogbu nke HPMC, o nwere njiri mara na emulsification, ngbasa, viscling, na-egbochi, na-egbochi, na-egbochi, na-egbochi, na-egbochi, na-egbochi ya. A na-eji ya ebe niile na ọgwụ na-eme ọgwụ ma na-arụ ọrụ ka ukwuu n'ọhịa nkwadebe. N'ihe omumu nke ihe omuma ya na mmelite nke teknụzụ nhazi, HPMC ga-eji ọtụtụ ebe na nyocha usoro onunu ogwu na usoro nnyefe ọgwụ ọhụụ, si na-akwalite mmepe na-aga n'ihu nke usoro.
hydroxypylthththththylcelllose; Nkwado ọgwụgwụ; .
Ọ bụghị naanị ihe kpatara ọgwụ na-emepụta ọgwụ, kamakwa metụtara ihe isi ike nke usoro ọgwụ, ogo, nkwụsi ike, ọnọdụ ọgwụ, na mmepe nke ọhụụ usoro onunu ogwu na uzo ohuru nke ochichi. nwere njikọ chiri anya. Ihe ngosi nke ogwu ohuru nke na - eme ka ihe omumu nke ogwu na - eme ka oganihu nke nkwadebe nke udiri usoro onunu ogwu. Hydroxypyl Methylcellose (hpmc) bụ otu n'ime ọgwụ ndị kachasị ewu ewu na ụlọ na mba ọzọ. N'ihi ogo molular dị iche iche na viscosity, ọ nwere ọrụ nke emulsifying, jikọtara ya, na-emetụ, na-egbochi, na-enyo. A na-eji atụmatụ ma na-eji ụdị ọnya na ihe nkiri na-eme ọtụtụ ebe na teknụzụ ọgwụ. Ederede a na-enyocha ngwa nke hydropyythylthylthylthylthyl na usoro dị iche iche n'afọ ndị na-adịbeghị anya.
1.Njirimara nke HPMC
Ihe eji eme ihe na - eme ihe na - eme ihe na - eme ihe nkiri (hpmc) nke cellulose. Enwere ike ịmepụta ya n'ụzọ abụọ: otu bụ na methy cellulose nke ọkwa kwesịrị ekwesị na-agwọta ọkwa kwesịrị ekwesị na-emegharị proplene oxide dị arọ n'okpuru okpomọkụ dị elu na nnukwu nrụgide. Oge mmeghachi omume ga-anọrịrị ogologo oge iji kwe ka methyl na hydroxyl ka ejikọtara na mgbanaka nke cellulose n'ụdị mkpụrụ osisi cellulose, ma nwee ike iru ogo ogo; Nke ọzọ bụ iji gwọọ owu ma ọ bụ osisi puoustic na soda na caustic, wee meghachi omume na metlenated methane na proplene oxide na proslene oxide nke ọma, wee mechaa ya. , gwepịa ya n'ime mma na-acha ntụ ma ọ bụ nkọcha.
Agba nke ngwaahịa a na-acha ọcha na milk white, na-enweghị isi na enweghị uto, na ụdị ahụ bụ ntụ ntụ dị mfe. Enwere ike ịgbasa ngwaahịa a na mmiri iji mepụta ihe doro anya na mmiri ara ehi na-acha ọcha na milky na-acha ọcha na ụfọdụ viaty. Ihe na-ewu ewu sonomenon nwere ike ime n'ihi ọnọdụ mgbanwe nke ngwọta ya na ụfọdụ itinye uche.
N'ihi ọdịiche dị na ọdịnaya nke ndị a dị n'ụdị ọdịdị nke Methoxy na Hydroxyl, ụdị ngwaahịa dị iche iche apụtala. N'akwụkwọ ndị a kpọmkwem aha ndị a kpọtụrụ aha, ụdị ngwaahịa dị iche iche nwere njiri mara. Visatylọ ọrụ viscosity na ọkụ ọkụ, ya mere nwere akụrụngwa dị iche iche ma enwere ike iji ya mee ihe dị iche iche. Promaktoonaia mba dị iche iche nwere ụkpụrụ na ihe nlereanya dị iche iche na ihe nlereanya ahụ: nke European Photopoea sitere na akara ngosi dị iche iche na ogo dị iche iche, na-egosipụta ọnụọgụ dị iche iche, na ngalaba bụ "MPA s " Na USX poxpoeia, a na-agbakwunye nkeji 4 mgbe aha na-egosi ọdịnaya na ụdị nke ọ bụla nke ọ bụla nke methylcelllose 2208. Mkpụrụ abụọ mbụ na-anọchi anya uru nke Methoxy. Pasent abụọ, ọnụọgụ abụọ ikpeazụ na-anọchi anya pasent nke hydropyyylyl.
Hydroxypypyl Methylcellose nwere usoro 3, ya bụ e usoro, gị usoro, gị na usoro, usoro nke ọ bụla nwere ọtụtụ ndị dị iche iche ịhọrọ site na. A na-eji usoro dị ka ihe nkiri, eji maka usoro mkpuchi mbadamba, ihe mkpuchi tebụl emechiela; A na-eji usoro dị ka viscosimiers ma hapụ ndị ọrụ maka nkwadebe maka Ophthalmic, na-enyo enyo maka mmiri mmiri na-akwadebe, mbadamba na bindets nke granules; A na-eji ọtụtụ ihe eji eme ihe dị ka ndị na-egbochi ndị na-egbochi ihe na ihe na-enye matriks nke ọma na-akwado.
Ndị na - emepụta ụlọ na - ebute Fuzhou 1 2 Chemical Factory na Chemical Foolarlọ ọrụ, Hubei JENDEG BOOTED COTEENTED CO ., Ltd., kemịkal kemịkal sian, wdg.
2.Uru nke HPMC
HPMC aghọọla otu n'ime ọgwụ na-eme ka mma dị n'ụlọ na mba ọzọ, n'ihi na HPMC nwere uru ndị ọzọ na-enweghị ike.
2.1 mmiri oyi solublity
Na-agbanye na mmiri oyi n'okpuru 40 ℃ ma ọ bụ 70% ethanol, n'ụzọ bụ isi na-egbochi mmiri ọkụ karịa 60 ℃, mana ọ nwere ike ga-aga.
2.2 Chectually inter
HPMC bụ ụdị nke na-abụghị nke Iic, ihe ngwọta ya enweghị ụgwọ ionic ma ọ bụ na-emekọrịta ihe ma ọ bụ usoro ihe ndị ọzọ anaghị emeghachi omume ya n'oge nkwadebe.
2.3 kwụ ọtọ
Ọ dị ntakịrị nke acid na alkali, enwere ike ịchekwa ya ogologo oge n'etiti PH 3 na 11 enweghị mgbanwe dị ukwuu na viscosity. Ngwọta ala nke HPMC nwere ihe mgbochi mgbochi ma na-enwekwa ụdị viscosity dị mma n'oge nchekwa. Ọgwụ ọgwụ na-eji HPMC dị mma karịa nke na-eji mgbanwe ọdịnala (dịka DEXTrin, Starch, wdg).
Nchọgharị viscosity 2.4
Enwere ike ịgwakọta viscositivesdị viscositives nke HPMC dị iche iche, na enwere ike ịgbanwe mgbanwe ya, yana enwere ike ịhọrọ mmekọrịta dị mma, yabụ a ga-ahọrọ ndị dị mma dị ka iwu si dị.
2.5 metabolic intersness
A naghị etinye hpmc na-edekọ ma ọ bụ metabolized n'ahụ, ma ọ naghị enye okpomọkụ, yabụ, ọ bụ nkwadebe ọgwụ na-adịghị mma. 2.6 nchekwa na hpmc bụ ihe na-adịghị egbu egbu na nke na-adịghị egbu mgbu, dose lime nke ụmụ oke bụ 5 G ·, na ọgwụ Median - 1 G · vootu - 1. Thebọchị ahụ kwa ụbọchị adịghị emetụta ahụ mmadụ.
3.Ngwa nke HPMC na nhazi
3.1 ka ihe nkiri na-ese ihe na ihe nkiri
Iji HPMC dị ka akwụkwọ mpịakọta nke ihe nkiri, mbadamba nkume a enweghị uru doro anya na mbadamba nkume ọdịnala dị ka mbadamba shuga ọdịnala dịka mbadamba shuga ọdịnala, na-enweghị atụ, ogo mmiri. , mkpuchi ibu dị elu na ihe ndị ọzọ dị mma dị mma. A na-eji ọkwa viscosis dị ka ihe nkiri na-egbochi ihe nkiri maka mbadamba ihe nkiri dị ka ihe nkiri dị elu maka sistemụ ihe mgbaze, ọ na-abụkarị na ịta 2% ruo 20 %.
Zhang Jixing et al. Jiri mmetụta dị elu na-ebulikwa premix na HPMC dị ka mkpuchi mkpuchi. Na-eme ihe nkiri na-eme ihe nkiri na-egbu egbu na polizene na-eme ihe nkiri na polyethylene glycoly, ike nyocha nke ihe nkiri ahụ bụ ngbanwe nke nyocha ahụ, yana mmekọrịta dị n'etiti nyocha ahụ Ntụgharị na usoro nyocha nke mgbakọ na mwepụ, a na-enwekarị usoro nhazi. Ihe oriri na-eme ihe nkiri na-eme ka ihe nkiri na-eme ihe nkiri na-eme ka ihe nkiri na-eme ihe nkiri (HPMCOPLYLY) (Polyvinyl Polethylene 24.12 g, Pollativene Glycol 13.12) . Zang yuan mepere nkwadebe usoro, jiri HPMC dị ka ihe mgbochi iji melite ogo ya, mbadamba nkume ya, mbadamba ndị na-emebi emebi, na nsogbu ndị ọzọ, Kwado steepụ mbadamba. A na-ekpebi ezigbo usoro usoro site na nnwale nke Orthogonal, ya bụ, ịta ụta na-adabara 2% na-agbaze na 70% ethanol na 70% Ethancle, na oge na-akpali akpali n'oge ị na-ekwu okwu n'oge. Na-ebute mbadamba ihe a na-eme nke ọma site na usoro a na-emepụta ihe na ndenye ọgwụ, na-enweghị atụ na usoro ọgwụ mepụtara nke ọma. ruru ihe karịrị 95%. Lang Meiyi, Lu Xiahui, wdg jiri hydypylthym ihe nkiri iji dozie mbadamba patina. na-emetụta ụkọ ọgwụ. Huang Yunran njikere nke mbadamba ọbara nke ọbara ọgbụgba, yana etinyere HPMC na mkpuchi mkpuchi nke ọzịza oyi akwa, na nkebi ya bụ 5%. Enwere ike ịhụ ya na enwere ike iji HPMC rụọ ọrụ n'ọtụtụ ebe nnyefe ọgwụ mgbochi ọgwụ mgbochi.
Hydroxypyl Methylcellose abụghị ihe nkiri mkpuchi mara mma, kamakwa enwere ike iji ihe na-eme ihe nkiri na-emepụta ihe nkiri. Wangghand Esc. na -acha na ndenye ndenye ihe nkiri Zinc licorice na ihe nkiri Aminolexanol, na-enweta ya na Nchọpụta Nchọpụta dị ka PVA 6.5 g, HPMC 0.1 g na 6.0 g nke Proplenene glycol na-ezute ihe achọrọ nke mwepụta na nchekwa, enwere ike iji ya dị ka ndenye ọgwụ nke fim.
3.2 dị ka ihe mgbochi na ibelata
Enwere ike iji ọkwa viscosity nke ngwaahịa a dị ka ihe mgbochi na ikpochapụ akwụkwọ maka mbadamba, ọgwụ na grafsses dị elu dị ka ihe mgbochi. Usoro onunu ogwu di iche na uzo di iche na ihe achoro. N'ozuzu, usoro nke ihe mgbochi na mmiri mbadamba granilation bụ 5%, na usoro nke ihe mgbochi maka mbadamba mmiri mmiri bụ 2%.
LO HOUTAO ET na-enyocha ihe mgbochi nke mbadamba tinidazle. 8% polyvinylyrrolidronerronerronerronerronerronerrone (PVP-K30 sirop, 100 phroxyl methylcellose k4, hpmckyl na-enyocha dị ka adhesion nke mbadamba ụrọ tinidazle. Nkwadebe nke mbadamba ụrọ tinidazle. A na-eji ọdịdị mbadamba anya na mgbe a tụnyere mkpuchi, na friability na-enweghị atụ, na-enweghị atụ na ọnụego mbadamba nke mbadamba ihe dị iche iche. Na-ebulite mbadamba a kwadebere site na 2.0% hydropyylthylthylthylllilose na-egbuke egbuke, na ndị na-eme achịcha na-enweghị isi na ịkọ nkọ, ahụ dị mma ma ọdịdị ahụ dị mma. Ya mere, mbadamba tinidazole kwadebere ya na 2.0% hpmc-K4 na 50% ethanol dị ka eji ya. Guan Shihai gụrụ usoro usoro nke mbadamba Fugans, na nyocha nke 50%, 10% na-egosiputa ihe ngosi. , 5% cmc-na na 15% HPMC Ngwọta (5 MPA s). Rụpụta mpempe akwụkwọ 50% a kwadebere, paste starche, 10% starch 50% ethanol 50%, ma na-enweghị isi na oke ike, nke na-enweghị ike igbo mkpa nke mkpuchi; 15% HPMC Ngwọta (5 MPACH), elu mbadamba nkume dị larịị, na-efe efe ahụ ruru eru, ma na-enwe ike igbo mkpa nke mkpuchi. Ya mere, ahọpụtara HPMC (5 MPA s) ka a họọrọ ka ọ bụrụ ihe nrapado.
3.3 dị ka onye na-achụchi anya
A na-eji ọkwa viscosise nke ngwaahịa a dị ka a na-achụgide gị maka ịkwadebe nkwadebe mmiri. Ọ nwere ezigbo igbochi obi, dị mfe ịgbagharị, anaghị arapara na mgbidi ahụ, ma nwee ezigbo ahịhịa. Ihe onunu ogwu bu 0,5% ka 1.5%. Abụ taant et al. Ejiri ihe polymer na-ejikarị (Hydroxyylyyyyyyyythylcellose, podium chịmyylcellose, na methylcellseth, methylcellose, wdg) dị ka ịgbachitere ndị ọrụ iji kwadebe backadotril. Nkwụsị akọrọ. Site na olu ndabara nke nkwụghachi ụgwọ dị iche iche, usoro mgbapụta, na Voyoology, na-ahụkarị viscosiology morphopic, na nkwụsi ike nke ihe na-eme nke ọgwụ n'okpuru. Na-arụpụta nkwusioru nke akọrọ na 2% hpmc dị ka onye na-ahụ maka ịnọchi anya na-enwe usoro dị mfe na nkwụsi ike dị mma.
E jiri ya tụnyere Methyl Cellulose, Hydroxyl Methyl Cellulose nwere njiri mara nke ndị na-anaghị agbagha, yabụ HPMC na-egbochi ndị ọrụ na Ophthalmic. Liu Jie et al. Ejiri HPMC, HDDOXYPROPLOSE (HPC), Carbomer 940, Polyylene Glycol (pegyylene glycol (HPMC HYTHOLENENENTENTER (HA) na ngwakọta nke Caplovir Ophthovir, nha nha anya, ogo olu ya na ngbanwe olu A na-ahọrọ ka ndị na-enyocha nyocha ka ihuenyo kacha mma kwụsịtụrụ. Nsonaazụ na-egosi na nkwusioru ACTHTLIC nkwụsị kwa kwadoro site na 0.05% HPMC dị ka onye nnọchi anya dị ka onye nnọchi anya, mgbapụta ahụ dị mma, na nkwadebe ahụ bụ ụlọ nkwadebe ahụ na-akwụsi ike na-abawanye.
3.4 dị ka onye na-egbochi ihe mgbochi, nwayọ nwayọ ma na-achịkwa ya na onye na-edebe akwụkwọ
A na-eji ọkwa viscosit nke ngwaahịa a maka nkwadebe nke ahịhịa gel matrix na-achịkwa mbadamba matrix na-achịkwa matrix na mbadamba matrik, ma nwee mmetụta nke igbu oge ịgha mkpụrụ ọgwụ. Nta ya bụ 10% ruo 80%. A na-eji akara ule dị ala dị ka porogens maka nkwadebe ma ọ bụ njikere ma ọ bụ na-achịkwa. Ihe mbụ achọrọ maka mmetụta ọgwụgwọ nke mbadamba ndị dị otú ahụ nwere ike iru ngwa ngwa, mgbe ahụ, a na-akwadebe nsonaazụ ọgwụ ọjọọ na ahụ. . HyDroxypylthyththyththyththylcelllose bụ iji mepụta gel oyi akwa mgbe ọ na-ezute mmiri. Usoro nke ịtọhapụ ọgwụ matrik tumadi gụnyere mgbasa nke gel na mbuze nke gel oyi akwa. Jung Bom Shim et alpored cardulol kwadoro na Hpmc dị ka ihe eji eme ya.
A na-ejikwa Methylcelllose na-ejikarị mbadamba ụrọ nke ọgwụ ndị China, na ọtụtụ n'ime ihe ndị na-arụ ọrụ na otu nkwadebe nke ọgwụ ndị China. Liu wen et al. Ejiri 15% hydropyylthylthylthylthyl methylix ihe, 1% microcrystalline cellulose dị ka filters, ma kwadebere Jungfan table mbadamba Mpaghara Mattix. Ihe nlereanya bụ njikọta Huguchi. Usoro usoro usoro usoro dị mfe, nkwadebe dị mfe, na data mwepụta dịtụ steble, nke na-emezu ihe ndị China chọrọ. Tangung Tanguant et al. Ejirila mbadamba nke Astragaelu dị ka ọgwụ na-edozi, ma nyochaa ihe na-emetụta ọgwụ ịtọhapụ ọgwụ ndị China na mbadamba ube HPMC. Nsonaazụ dị ka usoro nke HPMC mụbara, ntọtọ nke Astragaloside belatara, na pasent nke ọgwụ ahụ nwere ihe fọrọ nke nta ka ọ bụrụ mmekọrịta dị na ya na ụkọ nke matriks. Na mbadamba Hypromellose HPMC HPMC HPMC HPMC HPMC Matrix, enwere ụfọdụ mmekọrịta dị n'etiti nke ọgwụ ndị China na usoro ọgwụgwọ na ụdị HPMC, yana usoro ntọhapụ nke ndị iro kemịkalụ hydrophilic dị ka ya. Hydroxypyl Methylcellose abụghị naanị adabara maka ogige hydrophilic, kamakwa maka ihe ndị na-abụghị nke hydrophilic. Liu Guhua jiri 17% ji 17% methylcelllose (hpmck15m) dị ka ihe matriks na-akwado ya - mbadamba nke Tianshaan nke Tianshaan na-ahapụ matrik matrik na-agbada. Mmetụta a ga-esi na ya pụta ìhè, usoro nkwadebe ahụ kwụsiri ike ma kwekọọ.
Ọ bụghị naanị na ọ bụghị naanị na-etinye mbadamba ube na-arụ ọrụ nke ọma na akụkụ dị irè nke ọgwụ China, kamakwa ọtụtụ ndị ọzọ na-arụ ọrụ mgbasa ozi ọdịnala. WU HUCHAO na al. Ejiri 20% hydropopyyl methyl cellulose (hpmck4m) dị ka ihe eji eme ya, ma jiri ntụ ntụ ntụ ntụ mmiri nke nwere ike ịkwadebe ọgwụ gel na-aga n'ihu na 12 awa. A na-eji sapnonin RB1, ginsenosinsiseng saponin R1 dị ka ihe na-egosi ntule iji nyochaa ntọhapụ na vitro, a na-etinye ọgwụ mgbapụta ọgwụ na-akwado usoro ịzaghachi ọgwụ ọgwụ. Na-eweta ọgwụ mwepụta ọgwụ na-eme ka ihe ọ bụla na-eme ka ọ bụrụ ihe efu - nke na-ejikọ mkpụrụ osisi na-acha uhie uhie, nke a na-ahapụ ihe atọ na-adịghị mma.
3.5 Chebe gluu dị ka nke na-ekpo ọkụ na colloid
Mgbe eji ngwaahịa a dị ka nke na-eme, ị na-atụ anya itinye ego bụ 0.45% ruo 1.0%. Ọ nwekwara ike ịbawanye nkwụsi ike nke gluu nke hydrophobic, na-etolite colloid, na-egbochi mkpụrụ osisi sitere na peakiting na agglomerating, si otú ahụ na-egbochi iguzobe ndagide. Nta ya juru ebe niile bụ 0.5% ruo 1.5%.
Wang Zhen et al. Ejiri usoro nnwale nke L9 nke L9 iji nyochaa usoro nkwadebe nke ọgwụ na-arụ ọrụ carbon Senaima. Ọnọdụ kachasị mma maka mkpebi nke ọma nke ọgwụ na-arụ ọrụ cellobori bụ 4,5%) dị ka onye na-eme ihe nkiri, ọnọdụ usoro na-enyere aka ịkwalite nke nkwụsi ike nke ọgwụ carbon. Zhang zhiqiag et al. Mepụtara Vevokhocin hydhofloxacin nke Ophthalmidi nke Ophthalmal-iji nkpuchi ejikọtara ọnụ, na-eji Carbol dị ka GEL matriks na hydroxyl Methylcellose dị ka ndị na-ahụ maka ndị na-eme mkpọtụ. Ezigbo ndenye ọgwụ site na nnwale, mechaa nweta ndenye ọgwụ dị mma bụ Levofloxin hydrogen Methylcellose 0.15 g nke sodium dihydrogen, 0,50 g nke sodium chloride , 0.03 g nke etyl papen, na mmiri tụkwara iji mee 100 ml. Na ule ahụ, onye edemede dere hydyypPropylithyl usoro ụlọ ọrụ Memoropy na nkọwa dị iche iche (E4m) iji dozie tpmc e50 LV dị ka thickener. Ndị dị ala maka Svevoxloxin hydrochloxacin hydrochlorodide.
3.6 dị ka consele ihe
Ọtụtụ mgbe, capsule shei nke capsules bụ Gelatin. Usoro mmepụta nke capsule Shell dị mfe, mana enwere nsogbu na ihe ọ bụla na-adịghị mma, belata ọgwụ oxygen, na-egbu oge na-egbu oge nke capsule shei n'oge nchekwa. Ya mere, a na-eji Hydroxylithythyththyththyththyththyththyththyththyththyththylcelllose dị ka ihe dochie anya gelatin maka ịkwadebe capsules, nke na-eme ka ọ bụrụ nke na-arụ ọrụ na-arụ ọrụ na iji rụọ ọrụ, ma na-akwalite ụlọ na ọganihu na mba ọzọ.
Iji Amaffyylline dị ka ọgwụ nchịkwa, podczeck et al. Achọpụtara na ọnụego ọgwụ mkpụrụ nke capsules na hydroxyylthyl shells methylcellose karịrị nke nke gelatin. Ihe kpatara nyocha ahụ bụ na ịkatọ HPMC bụ mkpofu nke capsule niile n'otu oge, ebe ịkatọ nke ihe eji eme ihe na mbụ, mgbe ahụ, ịkatọ nke capsole niile HPMC Capsule dị mma maka capsule shells maka usoro ntọhapụ ahazi ozugbo. Chiwele et al. Enwekwara nkwubi okwu yiri ya ma jiri ya tụnyere mgbasa nke gelatin, gelatin / polyethylene glycol na hpmc shells. Nsonaazụ gosiri na HPMC shells na-agbaze ngwa ngwa n'okpuru ọnọdụ pọpụ dị iche iche, ebe ọ na-emetụta ọnọdụ pọpụ dị iche iche. Tang yue et al. Nyochaa ụdị capsule ọhụrụ nke obere ọgwụ na-acha odo odo na-agba ngwa ngwa. E jiri ya tụnyere capsule Shell nke Hydropyythylthyl Methylcellose na capsule shei na akụrụngwa nke ntụ ntụ na shei ahụ n'ọnọdụ dị iche iche na-enyocha, a na-enyocha ya n'ọnọdụ dị iche iche. Nsonaazụ na-egosi na e jiri ya tụnyere osisi gelatin, sheils HPMC ka mma na nkwụsi ike, nwee ike iguzogide mmiri karịa gelatin shells dị mma maka capsules maka okpu ntụ ntụ.
3.7 dị ka onye ọbịa
Teknụzụ Egwuregwu Egwuregwu nke ndị nduzi na-eji polymers na polymesive. Site na ịgbaso MUCOSA ndu, ọ na-eme ka mkparịta ụka dị n'etiti nkwadebe na mucosa, nke mere na a na-ewepụta ọgwụ ahụ site na mucosa iji nweta nzube nke ọgwụgwọ. A na-eji ya ebe niile. Ọgwụgwọ nke eriri afọ traktị, na-eme, mucosa na akụkụ ndị ọzọ.
Teknụzụ GastTerterninal bọọdụ bụ usoro nnyefe ọgwụ ọhụrụ mepụtara n'afọ ndị na-adịbeghị anya. Ọ bụghị naanị mgbe ị na-akwado oge obibi nke ọgwụ ọgwụ, kamakwa ọ na-eme ka ndị na-ahụ maka faili na ụlọ ọrụ na-apụ apụ, ma na-eme ka mmiri nke ọgwụ ahụ banye Obere sel epithelinal epithelinal na-akawanye elu, si otú a na-eme ka bioapality nke ọgwụ ahụ sie ike. Wei Keda et al. Nyochaa ndenye ọgwụ mbadamba mbadamba mbadamba mbadamba ụrọ na carbomer 940 dị ka ihe omume na-arụ ọrụ, ma jiri ihe na-arụ ọrụ nke ọgbọ mee ihe dị n'etiti mbadamba ahụ na akpa rọba. , ma mesịa họrọ ihe ọ bụla nke HPMCK40 na Carbomer 940 ka ọ dị afọ iri na ise na 27.5 mg na-egosi na ngalaba NCAEBT (dị ka hydropylthylthylthyl na-eme ka ọ dị mma) ndọta nke nkwadebe na anụ ahụ.
Nkwadebe ndị biardesation na-eme atụmatụ bụ ụdị nnyefe nke usoro ọgwụ ọjọọ amụrụla karịa n'afọ ndị na-adịbeghị anya. Nkwadebe ndị biardesation nwere ike ịgbaso ọgwụ ndị emetụtara nke oghere ọnụ, nke ọ bụghị naanị ogologo oge obibi nke ọgwụ na onu mucosa, kamakwa ichebe mucosa onu. Mmetụta ọgwụgwọ dị mma ma na-eme ka ọ dị mma. Xue Xiayan et al. Egosiputa usoro nke mbadamba Insulin, na-eji Apple pectin, Chitosan, Carbomer, HPDROMOPLYLIM na-eme ka ihe dị ka ihe dị ka onye na-eme njem. Mpempe akwụkwọ okpukpu abụọ. Mbadamba ụsụụ insulain kwadebere nwere ihe owuwu ntụsara ahụ, nke dị mma maka ịhapụ insulin, nke nwere ike ịgbapụta na mwepụta ọgwụ na-adịghị mma nke ọgwụ ahụ ma zere ọnwụ ọgwụ ahụ. Hao Jifu et al. Jirikwa mpempe akwụkwọ na-acha anụnụ anụnụ na-acha anụnụ anụnụ na-acha anụnụ anụnụ.
N'ime usoro nnyefe ọgwụ ọjọọ, usoro teknụzụ nke nduzi nke njem eme ihe. Zhu Yuing et al. Ejiri carbomer (cp) na hpmc dị ka ihe ndị na-adịghị agbanwe agbanwe ma na-akwadebe matriks na-akwadebe mbadamba osisi clotrimazle na perserages na gburugburu ebe a na-ahụ anya. , a na-enyocha ndemà kwesịrị ekwesị dị ka CP-HPMC1: 1, mpempe akwụkwọ eji arụpụta nke nwere ezigbo ọrụ adhesion, usoro ahụ dị mfe ma kwekọọ.
3.8 dị ka ihe dị ka gel
Dị ka nkwadebe dị mma, gel nwere ọtụtụ uru dị ka nchekwa, ịma mma, nhicha dị mfe, ọnụ ahịa dị mfe, na ezigbo ndakọta. Nduzi nke mmepe. Iji maa atụ, na-adọkpụgharị Gel bụ ụdị usoro ọgwụgwọ ọhụụ nke amụrụla karịa n'afọ ndị na-adịbeghị anya. Ọ nwere ike izere mbibi ọgwụ na eriri afọ ma belata ọdịiche dị elu nke ịta ọgwụ ọjọọ, kamakwa ọ ghọọla sistemụ nrụpụta ọgwụ ọgwụ dị irè. .
Zhu jyingjie et al. Gụọ mmetụta nke matriki dị iche iche na mwepụta nke Scoollarin mmanya pọmpụ na vitarish Methylcellose (hpmckyl Methylcellose (hpmckyyli methylcellose (HPMCKOPLYLILILL (ma nweta scoutlarin kwesịrị ekwesị maka scoolarin. GEL Matriks nke Plastids. Nsonaazụ nnwale gosipụtara na 1. . N'oge nnwale ahụ, a chọtara na HPMC nwere ike ịgbanwe ọnọdụ mwepụta ọgwụ Carbomer Gel site na ịbanye na mwepụta ọgwụ ọjọọ, yana 1.0% matriks matriks 1.5% carbomer. Ihe kpatara ya nwere ike ịbụ na a na-agbasa ngwa ngwa, mmụba ngwa ngwa na mmalite nke nnwale ahụ na-eme ka mowocular oghere nke cel carbomer, si otú ahụ na-eme ka ọnụego tọhapụ ọgwụgwụ ọgwụ ya. Zhao wengui et al. Ejiri carbomer-934 na hydroxyl methylcellose dị ka ndị na-ebu ya iji dozie nefloxciin ophthatic gel. Usoro nkwadebe dị mfe ma kwekọọ, na ogo kwekọrọ na mpaghara Ophthalmic gel nke "Chinese Phallopoea" (2010 mbipụta).
3.9 na-egbochi oke maka usoro micromoffuffiffying
Sistemụ Mbupu ọgwụ nkeonwe (Smụọ) bụ ụdị nnyefe ọgwụ ọgwụ ọhụrụ, nke bụ ngwakọta, nke na-akwụsi ike na ngwakọta, usoro mmanụ, emunsufier na co-emulsifier. Ihe mejupụtara ọgwụ dị mfe, nchekwa na nkwụsi ike dị mma. Maka ọgwụ ọjọọ nke fiber nke ọma, dị ka HPMC, polyvinylpyrrolidone (PVP) na-eme ka a na-akwụghị ụgwọ na ọgwụ mgbochi na-adabaghị na eriri afọ, ka Mụbaa ngụgụ ọgwụgwụ ma melite bioapality.
Penn yuan et al. Kwadebere silininin supperated usoro nnyefe ọgwụ ọgwụ na-eme nke onwe ya (S-Swdds). Oxylethylene hydrogenated mmanụ mmanụ (cromphor r40), 12% Capiclic poscric polyethylene glycollide (labylene) dị ka co-1 mgm-1 hpmc. Dinggbakwunye HPMC ka SSEDD nwere ike supersaturate free si silinin iji gbazee na s-dowds ma gbochie silinin site na ịpụ. E jiri ya tụnyere usoro ọdịnala onwe ya, a na-agbakwunye nnukwu ụlọ na-abụkarị iji gbochie ọgwụ ezughị ezu. Ihe mgbakwunye nke HPMC nwere ike idobe ngbasa silinin na ọkara na-agbasa mmiri, belata emulsificons. usoro onunu ogwu.
4.cclusion
Enwere ike ịhụ na HPMC eji eme ihe n'ọtụtụ ebe, n'ihi ihe akụrụngwa ya, mana HPMC nwekwara ọtụtụ adịghị adị na ntọhapụ nke mbụ. Methyl metrylate) imeziwanye ihe. N'otu oge ahụ, ụfọdụ ndị nyocha nyocha nyocha banyere usoro nke Osmotic site na Hpmc site na ịkwadebe carbamazeppine na-emegharị mbadamba ma nweekwa ọkwa mbadamba ị nweta mbadamba ohere ịghaara ya. N'okwu, ndị na-eme nchọpụta na-arụ ọrụ dị mma maka ngwa nke HPMC na nhazi nke akụrụngwa ya na ndozi nke teknụzụ nkwadebe, HPMC ga-eji ọtụtụ ebe onunu ogwu na ụdị onunu ogwu. Na nyocha nke ọgwụ ọgwụ, wee kwalite mmepe ụlọ ahịa na-aga n'ihu.
Oge post: Ọkt-08-2022